59 research outputs found
Cardiac transplantation and mechanical circulatory support
No full textCardiac transplantation is the treatment of choice for selected patients with advanced heart failure: median survival exceeds 10 years and recipients enjoy an excellent quality of life, but availability is severely limited by shortage of donor organs. The need for lifelong immunosuppression is associated with side effects, including an increased incidence of malignancy. Newer immunosuppressive agents offer promise in reducing nephrotoxicity of conventional regimens and in delaying the onset of (currently inevitable) cardiac allograft vasculopathy....</p
The Arab Avant-Garde: Musical Innovation in the Middle East
No full textIn the early nineteenth century, the term “avant-garde” began to capture greater semantic territory. Once purely a military phrase used to distinguish crack troops, it then assumed a high-ranking position within cultural expression, marking out art work that forged ahead and broke new ground. What can it mean to conjoin this French phrase with the word “Arab”? French forces, along with other imperial intruders, are no strangers to Arab terrain. The colonisation of Algeria, Tunisia, Morocco and Greater Syria followed in the wake of the brief Napoleonic “mission” to Egypt between 1798 and 1801. It was during this military foray that some of modern Europe’s most expansive data on Egyptian music was collected, information that comprised two whole volumes of Guillaume André Villoteau’s Description de l’Egypte. The Napoleonic campaign gathered not only military, but also cultural intelligence, if the two can be so easily separated
Listing criteria for heart transplantation: International Society for Heart and Lung Transplantation guidelines for the care of cardiac transplant candidates--2006
No full textMalignancy after Heart Transplantation: Analysis of 24-Year Experience at a Single Center
No full textBackground: Malignancy is an important complication after heart transplantation. The incidence, spectrum, risk factors, and clinical impact of posttransplant malignancy were investigated in a cohort of patients with long-term follow-up at a single center. Methods: Data for 835 patients who underwent heart transplantation between 1979 and 2002 and survived beyond one month were retrospectively evaluated for posttransplant skin cancer, solid organ tumors, and lymphoma. Results: One hundred thirty-ninemalignancies developed in 126 patients (15.1%). Skin cancer, solid organ tumors, and lymphoma represented 49%, 27%, and 24% of the malignancies, respectively. Mean patient age at transplantation for patients developing skin cancer, solid organ tumor, and lymphoma were 50 years, 51 years, and 46 years, respectively (p = 0.024). Risk factors for skin cancer were: age greater than 40 at transplantation, number of treated rejection episodes in the first year after transplantation, and smoking history. Variables associated with solid organ malignancy development were age and smoking history. There was no variable related to the development of posttransplant lymphoma. Median survival after diagnosis of skin cancer, solid organ tumor, and lymphoma were 5.0 years, 0.3 years, and 0.7 years, respectively (p < 0.001). Conclusions: Posttransplant malignancies have different risk factors and variable clinical impact. Older age at transplantation, smoking history, and more episodes of treated rejection were related to increased incidence of nonlymphoid malignancy incidence after heart transplantation, whereas no variable was associated with lymphoid malignancy. Skin cancers have a benign course, while solid organ malignancies and lymphomas carry an unfavorable prognosis. doi: 10.1111/j.1540-8191.2009.00858.x (J Card Surg 2009; 24: 572-579
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