78 research outputs found
Pesticide Mixture Induced DNA Damage in Peripheral Blood Erythrocytes of Freshwater Fish, Oreochromis niloticus
No full textMetal Mixtures Toxicity and Bioaccumulation in \u3cem\u3eTilapia nilotica\u3c/em\u3e at 96-Hr LC\u3csub\u3e50\u3c/sub\u3e Exposure
No full textLaboratory tests were conducted on fingerlings of Tilapia nilotica to check the bioaccumulation patterns of lead (Pb), cadmium (Cd) and cobalt (Co) during acute toxicity at constant water temperature, pH and total hardness. Metal mixtures viz. Lead + Cadmium, Cobalt-Lead and Cadmium-Cobalt were selected to assess the acute toxicity in terms of 96-hr LC50 along with bioaccumulation patterns in selected organs of Tilapia nilotica (skin, muscles and liver). Sensitivity of Tilapia nilotica in terms of 96-hr LC50 for all mixtures varied significantly. The 96-hr LC50 of binary metal mixtures agreed in that order: cadmium-cobalt \u3e lead-cadmium \u3e cobalt-lead with statistically significant differences at
Characterization of spliceosome assembly in cyanidioschyzon merolae.
No full textPre-mRNA splicing is the removal of intervening sequences from pre-messenger RNA in a reaction catalyzed by the spliceosome, which contains five small nuclear RNAs (snRNAs) and more than 100 proteins. Assembly of the spliceosome occurs in a highly ordered manner, making the spliceosome a very complex and dynamic particle. The spliceosome has been studied in yeast and humans but a simpler system would simplify splicing studies. Cyanidioschyzon merolae (Cm) has been shown to have a simpler spliceosome. The goal of this study was to characterize the Cm spliceosome beginning with the question of how large it is. To measure the size of the Cm spliceosome I used glycerol gradient centrifugation and assembly gels to study the assembly pathways. Lastly an attempt was made to study the components of Cm spliceosome by developing an assay in yeast (Saccharomyces cerevisiae) where small molecule inhibitors were used to stall the spliceososme, which could then be purified and its composition studied. --Leaf ii.The original print copy of this thesis may be available here: http://wizard.unbc.ca/record=b197654
Laughing with an Iranian American Woman: Firoozeh Dumas\u27s Memoirs and the (Cross-) Cultural Work of Humor
No full textThis essay critically analyzes Firoozeh Dumas\u27s humorous memoirs and situates them in the multiple contexts of post-9/11 Muslim American responses to Islamophobia, women\u27s humor, and Iranian American women\u27s life writing. Drawing on philosophical, feminist, ethnic, and contemporary scientific theories of humor and the methods of literary criticism, the author argues that Dumas employs the beneficial and inclusive (not malign and exclusive) positive mode of humorous personal storytelling to build connection through laughter via the emotional and cognitive shifts structurally central to humor. Dumas addresses multiple audiences and engages in important (cross-) cultural work in a particularly fraught political and cultural climate of anti-Muslim sentiment and tense Iran-U.S. relations
Toxic Effect of Lead Chloride on Antioxidant Enzyme in the Liver and Kidney of Fish
No full textThe contamination of aquatic habitats has become a serious problem for sustainability of the fisheries sector in Pakistan. Among different pollutants, heavy metals are very toxic. Their toxicity can be assessed by using antioxidant enzymes as biomarkers. These enzymes protect the living organisms from the oxidative stress caused by the heavy metals. Therefore, the effect of lead chloride (PbCl2) on the peroxidase enzyme activity in the tissues (liver and kidney) of Cirrhinamrigala was investigated. Four groups of Cirrhinamrigala were exposed, separately, to 96-hr LC50 concentration of PbCl2 along with its sub-lethal concentrations, viz.2/3rd, 1/4th and 1/5th for a period of 30 days. Another group of fish was kept in metal free media as a control. After 30 days, fish were dissected and their liver and kidney isolated and preserved for enzyme assay. Peroxidase activity in the tissues of PbCl2 exposed Cirrhinamrigala was compared with the control group. Results revealed that the activity of peroxidase enzyme in fish organs increased significantly (
Activity Based Quality Model for Evaluating Web2.0 Applications
No full textAbstract-Quality is key term to be considered when developing the Web applications. If this is not adequately measured; there will be little to force users to use web applications. The focus of Web2.0 is to enhance the interactions between the application and end users and among users. The main challenge of this research is to identify the key quality attributes that gain the end user attention towards the Web applications. There are many Quality Models available for measuring the W2A (Web2.0 Applications). This paper has a critical review of the previously defined quality models. It defines a theoretical quality model containing essential attributes to assess the quality of W2A
Randomised Prospective Study to Compare Outcomes of Para Umbilical Hernia On-Lay Open Mesh Repair, with and without Drain
No full textObjective: To compare the outcomes of open on-lay mesh hernia repair with and without the use of a drain in PUH cases, with the goal of determining the most favorable post-operative outcome.
Methodology: A prospective clinical study was conducted at the Department of General Surgery, Islamabad Medical Complex, NESCOM, a tertiary care hospital in Islamabad, Pakistan from January 2022 to December 2022. Fifty patients were enrolled and divided equally into two treatment groups (Groups A and B), with and without drain placement, respectively. The occurrence of complications such as seroma, hematoma formation, wound dehiscence, mesh infection, and length of hospital stay were compared between the two groups.
Results: Postoperative complications were more prevalent in Group A (with drain placement) compared to Group B. Seroma formation was more common in Group A (40% on the 5th day and 16% on the 14th day post-repair) compared to Group B (16% on the 5th day and 4% on the 14th day). Hematoma formation was also higher in Group A (12% on the 5th day) compared to Group B (8% on the 5th day); however, both groups showed a 4% incidence on the 14th day. Infected mesh was more frequent in Group A (8%) compared to Group B (4%), resulting in increased morbidity.
Conclusions: In small-sized para-umbilical hernia cases undergoing open on-lay mesh repair, the presence of a drain did not significantly affect the rate of postoperative complications. Seroma formation and infection incidence did not vary significantly between groups. However, patients with drain placement experienced a significantly longer hospital stay post-surgery
Colonizing Kashmir: state-building under Indian occupation Colonizing Kashmir: state-building under Indian occupation , by Hafsa Kanjwal, Stanford, Stanford University Press, 2023, xiii + 366 pp., $32, ISBN 978-1-5036-3603-3
No full textKashmiri life is expendable for the Indian state. While the love for the land is close to national imaginaries, the people have been subjected to decades of abuse and violence, and infringement of their basic human rights. In this book, Hafsa Kanjwal delves into the history of Kashmir, tracing the role of two pivotal political figures – Sheikh Abdullah (1947–1953) and Bakshi Ghulam Mohammad (1953–1963) – and their relationship with the Indian project of state-building in Kashmir. The author characterizes this as the ‘politics of life’ (9), where the Indian government and client regimes in Kashmir have normalized occupation with the propagation of ‘development, empowerment and progress’ along with bureaucratic integration and the forging of affective intimate relationships with the people of the state. However, the politics of life and appeals to emotions did not mean that there was an absence of coercive measures used by the Indian state to shape conforming and confronting subjectivities
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