108 research outputs found
Data-driven criteria to assess fear remission and phenotypic variability of extinction in rats
No full textAbstract:
Fear conditioning is widely employed to examine the mechanisms that underlie dysregulations of the fear system. Various manipulations are often used following fear acquisition to attenuate fear memories. In rodent studies, freezing is often the main output measure to quantify “fear”. Here, we developed data-driven criteria for defining a standard benchmark that indicates remission from conditioned fear and for identifying subgroups with differential treatment responses. These analyses will enable a better understanding of individual differences in treatment responding.
This data set includes all data and code used for the research publication, "Data-driven criteria to assess fear remission and phenotypic variability of extinction in rats", appearing in the journal Philosophical Transactions B
Data and analysis code for "Acetaminophen enhances the reflective learning process"
No full textRaw data and statistical code accompanied by analysis narrative for reproducing key results reported in SCAN article
Remitted depression and temperament: The role of effortful control and attentional mechanisms
No full textTemperamental effortful control and attentional networks are increasingly viewed as important underlying processes in depression and anxiety. However, it is still unknown whether these factors facilitate depressive and anxiety symptoms in the general population and, more specifically, in remitted depressed individuals. We investigated to what extent effortful control and attentional networks explain concurrent depressive and anxious symptoms in healthy individuals (n = 270) and remitted depressed individuals (n = 90). Both samples were highly representative of the US population. Effortful control predicted a substantial decrease in symptoms of both depression and anxiety in the whole sample, whereas decreased efficiency of executive attention predicted a modest increase in depressive symptoms. Remitted depressed individuals did not show less effortful control nor less efficient attentional networks than healthy individuals. Moreover, clinical status did not moderate the relationship between temperamental factors and either depressive or anxiety symptoms. Our study shows that temperamental effortful control represents an important transdiagnostic process for depressive and anxiety symptoms in adults
Temperamental factors in remitted depression : the role of effortful control and attentional mechanisms
No full textTemperamental effortful control and attentional networks are increasingly viewed as important underlying processes in depression and anxiety. However, it is still unknown whether these factors facilitate depressive and anxiety symptoms in the general population and, more specifically, in remitted depressed individuals. We investigated to what extent effortful control and attentional networks (i.e., Attention Network Task) explain concurrent depressive and anxious symptoms in healthy individuals (n = 270) and remitted depressed individuals (n = 90). Both samples were highly representative of the US population. Increased effortful control predicted a substantial decrease in symptoms of both depression and anxiety in the whole sample, whereas decreased efficiency of executive attention predicted a modest increase in depressive symptoms. Remitted depressed individuals did not show less effortful control nor less efficient attentional networks than healthy individuals. Moreover, clinical status did not moderate the relationship between temperamental factors and either depressive or anxiety symptoms. Limitations include the cross-sectional nature of the study. Our study shows that temperamental effortful control represents an important transdiagnostic process for depressive and anxiety symptoms in adults
Pre-print for "Change in Negative Attention Bias Mediates the Association BetweenAttention Bias Modification Training and Depression Symptom Improvement"
No full textPre-print for manuscript titled "Change in Negative Attention Bias Mediates the Association Between Attention Bias Modification Training and Depression Symptom Improvement" by Christopher G. Beevers, Kean J. Hsu, David M. Schnyer, Jasper A.J. Smits, & Jason Shumake to appear in the Journal of Consulting and Clinical Psycholog
Analysis Reports for manuscript "Change in Negative Attention Bias Mediates the Association Between Attention Bias Modification Training and Depression Symptom Improvement"
No full textAnalysis reports used for the manuscript "Change in Negative Attention Bias Mediates the Association Between Attention Bias Modification Training and Depression Symptom Improvement
Analysis Reports for "Efficacy of Attention Bias Modification Training for Depressed Adults: A Randomized Clinical Trial"
No full textAnalysis reports for outcome manuscript titled "Efficacy of Attention Bias Modification Training for Depressed Adults: A Randomized Clinical Trial." Reports are RMarkdowns that include the R code and the results from the R code
Primary analysis code and report for "Inclusion of single nucleotide polymorphisms into an ensemble of gradient boosting decision trees does not improve the prediction of citalopram treatment response in the STAR*D trial"
No full textAnalysis code for the results presented in the manuscript
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