210 research outputs found
Mary Howitt
No full textMary Howitt (1799–1888) was one of the most prolific female writers and translators of her day, producing over a hundred titles in her lifetime. Held in high regard by her contemporaries, Howitt was best known for her Scandinavian interests, particularly for her translations of Frederika Bremer and Hans Christian Andersen. She also published numerous collections of poetry and stories, sometimes in partnership with her husband, the writer William Howitt. This two-volume autobiography was published posthumously in 1889, and was completed and edited by her daughter Margaret. Volume 1 covers the first forty-four years of Howitt's life: a Quaker childhood, marriage to William Howitt, the birth of their children, and family life in Nottingham, Esher, and Heidelberg. It also includes several illustrations of family members and various residences. For more information on this author, see http://orlando.cambridge.org/public/svPeople?person_id=howima.</jats:p
Mary Howitt
No full textMary Howitt (1799-1888) was one of the most prolific female writers and translators of her day, producing over a hundred titles in her lifetime. Held in high regard by her contemporaries, Howitt was best known for her Scandinavian interests, particularly for her translations of Frederika Bremer and Hans Christian Andersen. She also published numerous collections of poetry and stories, sometimes in partnership with her husband, the writer William Howitt. This two-volume autobiography was published posthumously in 1889, and was completed and edited by her daughter Margaret. Volume 2 focuses on the second half of Howitt's life, much of which was spent moving between England, Switzerland, Italy and Austria. It describes the death of two of her sons, her own and William's involvement with spiritualism, the death of her husband, and her eventual conversion to Catholicism. For more information on this author, see
http://orlando.cambridge.org/public/svPeople?person_id=howima</jats:p
A strain of Synechocystis sp PCC 6803 without photosynthetic oxygen evolution and respiratory oxygen consumption: implications for the study of cyclic photosynthetic electron transport
No full textHowitt, Crispin ; Cooley, Jason ; Wiskich, Joseph ; Vermaas, Wi
Nedd4-WW domain-binding protein 5 (Ndfip1) is associated with neuronal survival after acute cortical brain injury
No full textUnderstanding the transcriptional response to neuronal injury after trauma is a necessary prelude to formulation of therapeutic strategies. We used Serial Analysis of Gene Expression (SAGE) to identify 50,000 sequence tags representing 18,000 expressed genes in the cortex 2 h after traumatic brain injury (TBI). A similar tag library was obtained from sham-operated cortex. The SAGE data were validated on biological replicates using quantitative real-time-PCR on multiple samples at 2, 6, 12, and 24 h after TBI. This analysis revealed that the vast majority of genes showed a downward trend in their pattern of expression over 24 h. This was confirmed for a subset of genes using in situ hybridization and immunocytochemistry on brain sections. Of the overexpressed genes in the trauma library, Nedd4-WW (neural precursor cell expressed, developmentally downregulated) domain-binding protein 5 (N4WBP5) (also known as Ndfip1) is strongly expressed in surviving neurons around the site of injury. Overexpression of N4WBP5 in cultured cortical neurons increased the number of surviving neurons after gene transfection and growth factor starvation compared with control transfections. These results identify N4WBP5 as a neuroprotective protein and, based on its known interaction with the ubiquitin ligase Nedd4, would suggest protein ubiquitination as a possible survival strategy in neuronal injury.Qian Sang, Mary H. Kim, Sharad Kumar, Nicole Bye, Maria C. Morganti-Kossman, Jenny Gunnersen, Stephanie Fuller, Jason Howitt, Lavinia Hyde, Tim Beissbarth, Hamish S. Scott, John Silke, and Seong-Seng Ta
Land, Labour, and Gold
No full textIn 1852 William Howitt (1792–1879) set sail for Australia with two of his sons in order to try his luck in the goldfields of Victoria. By then he was already a prolifically published author of both prose and verse. He was only moderately successful as a gold-digger, but his account of life in the new colony, published in 1855 after his return to England, provides an extraordinary snapshot of the rapid early growth of Melbourne. Volume 2 considers the effects of the influx of a great number of immigrants and the continuing presence of convicts. Howitt also reflects on government policy and the draft constitution, and describes visits to Sydney and Tasmania. His colourful account includes descriptions of birds and flowers, extreme heat, and how to cope with flies.
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Land, Labour, and Gold
No full textIn 1852 William Howitt (1792–1879) set sail for Australia with two of his sons in order to try his luck in the goldfields of Victoria. By then he was already a prolifically published author of both prose and verse. He was only moderately successful as a gold-digger, but his account of life in the new colony, published in 1855 after his return to England, provides an extraordinary snapshot of the rapid early growth of Melbourne. Volume 1 covers Howitt's first impressions of Australia, his experiences on the journey to the diggings at Bendigo, the throngs of prospectors, the exorbitant prices charged by profiteering merchants, and the miners' protest over high government licence fees. He describes the hard life endured by the diggers and warns against women coming to the colony.
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On Growth and Income Distribution in a Globalizing World
No full textThe basic idea explaining the relationship between economic growth and income distribution is the “U- shaped hypothesis” postulated by Simon Kuznets. This can be shown in a dual-economy model with technical progress. Initially, inequality is low, but as labour participation in the modern sector increases, higher wages in this sector tend to increase inequality. However, if enough labour is incorporated in the modern sector, wage inequality begins to diminish. Income inequality continues to worsen between the two sectors, if a new modern economy (e.g. IT-based technical change) is introduced and potential GDP shifts to a new trajectory before the turning point is reached. In a globalised word, the substantial unskilled-labour-saving technical progress puts pressure on wages of unskilled workers (in industrialized countries). Also, globalization may be blamed for leaving many nations and millions of people out from reaping the benefits of globalization. This problem can only be overcome by appropriate reforms of the international economic system.Economic Growth, Income Distribution, Globalization
Nedd4 Family-interacting Protein 1 (Ndfip1) Is Required for the Exosomal Secretion of Nedd4 Family Proteins
No full textThe ability to remove unwanted proteins is an important cellular feature. Classically, this involves the enzymatic addition of ubiquitin moieties followed by degradation in the proteasome. Nedd4 proteins are ubiquitin ligases important not only for protein degradation, but also for protein trafficking. Nedd4 proteins can bind to target proteins either by themselves or through adaptor protein Ndfip1 (Nedd4 family-interacting protein 1). An alternative mechanism for protein removal and trafficking is provided by exosomes, which are small vesicles (50–90-nm diameter) originating from late endosomes and multivesicular bodies (MVBs). Exosomes provide a rapid means of shedding obsolete proteins and also for cell to cell communication. In the present work, we show that Ndfip1 is detectable in exosomes secreted from transfected cells and also from primary neurons. Compared with control, Ndfip1 increases exosome secretion from transfected cells. Furthermore, while Nedd4, Nedd4-2, and Itch are normally absent from exosomes, expression of Ndfip1 results in recruitment of all three Nedd4 proteins into exosomes. Together, these results suggest that Ndfip1 is important for protein trafficking via exosomes, and provides a mechanism for cargoing passenger proteins such as Nedd4 family proteins. Given the positive roles of Ndfip1/Nedd4 in improving neuronal survival during brain injury, it is possible that exosome secretion provides a novel route for rapid sequestration and removal of proteins during stress.Ulrich Putz, Jason Howitt, Jenny Lackovic, Natalie Foot, Sharad Kumar, John Silke, and Seong-Seng Ta
Estimating Disaggregate Production Functions: An Application to Northern Mexico
No full textThis paper demonstrates a robust method for achieving disaggregation in the estimation of flexible-form farm-level multi-input production functions using minimally-specified data sets. Since our ultimate goal is to address important questions related to the distributional effects of policy changes, we place emphasis on the ability of the model to reproduce the characteristics of the existing production system and to predict the outcomes of these changes at a high level of disaggregation. Achieving this requires the use of farm-level models that are estimated across a wide spectrum of sizes and types, which is often difficult to do with traditional econometric methods, due to limitations of data. The approach to estimating flexible-form production functions used in this paper overcomes these limitations, and also avoids the problems that frequently hinder the application of budget-based representative farm models to these type of analyses namely, that of poor calibration to observed behavior. In our estimation procedure, we use a two-stage approach that first generates a set of observation-specific shadow values for incompletely priced inputs, such as irrigation water or family labor, which are used in the second stage, along with the nominal input prices, to produce estimates of crop-specific production functions using Generalized Maximum Entropy (GME) methods. These functions are able to capture the individual heterogeneity of the local production environment, while still allowing the production function to replicate the input usage and outputs produced in the sample data. Since we are able to generate demand, supply, and substitution elasticities, a wide range of policy responses can be modeled. Our paper demonstrates this methodology through an empirical application to Mexico, drawing from a small set of cross-section data collected in the northern Rio Bravo regions. The estimates show that there is considerable heterogeneity in the behavioral response of farmer households of different sizes, both in terms of the returns to scale, as well as in the elasticities of substitution and derived demands for water. Compared to the aggregate-level estimation, we obtain much more accurate and informative policy response behavior, when shocks are imposed on the model.Research Methods/ Statistical Methods,
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