197 research outputs found
Implementation and Deployment of a Library of the High-level Application Programming Interfaces (SemSorGrid4Env)
No full textThe high-level API service is designed to support rapid development of thin web applications and mashups beyond the state of the art in GIS, while maintaining compatibility with existing tools and expectations. It provides a fully configurable API, while maintaining a separation of concerns between domain experts, service administrators and mashup developers. It adheres to REST and Linked Data principles, and provides a novel bridge between standards-based (OGC O&M) and Semantic Web approaches. This document discusses the background motivations for the HLAPI (including experiences gained from any previously implemented versions), before moving onto specific details of the final implementation, including configuration and deployment instructions, as well as a full tutorial to assist mashup developers with using the exposed observation data
Linked Sensor Data: RESTfully serving RDF and GML
No full textPublishing sensor observations on the Linked Data web is the first step in enabling the development of semantic web applications and mashups that can utilise sensor data. We present the design for a prototype API exposing data from the Channel Coastal Observatory in the UK. By combining REST and Linked Data principles we support both Semantic Web clients, OGC GML clients, and hybrid applications that can transpose between these, and other, representations
RESTfully serving RDF and GML semantic sensor grids for rapid application development for environmental linked data on the semantic web
No full textPublishing sensor observations on the Linked Data web is the first step in enabling the development of semantic web applications and mashups that can utilise sensor data. We present the design for a prototype API exposing data from the Channel Coastal Observatory in the UK. By combining REST and Linked Data principles we support both Semantic Web clients, OGC GML clients, and hybrid applications that can transpose between these, and other, representations
Interview with Eugene Sadler‐Smith, author of <i>The Intuitive Mind</i>
No full textPurposeThe purpose of this paper is to provide an interview with Eugene Sadler‐Smith, Professor of Management Development and Organizational Behaviour, at the University of Surrey's School of Management and author of The Intuitive Mind.Design/methodology/approach:This briefing is prepared by an independent interviewerFindingsEugene Sadler‐Smith's research interests are centered upon the role of intuitive judgment in management decision making and management development. His research has been published widely in peer‐reviewed journals such as the Academy of Management Executive, Academy of Management Learning and Education, British Journal of Psychology, Journal of Occupational & Organizational Psychology, Journal of Organizational Behavior, Management Learning, and Organisation Studies. He has researched and published widely in the field of learning and development (L&D) and is author of several books, including Inside Intuition (Routledge, 2008) and The Intuitive Mind (John Wiley and Sons, 2010). His intuition research has featured on BBC Radio 4 and in The Times.Practical implicationsProvides strategic insights and practical thinking that have influenced some of the world's leading organizations.Originality/valueThis interview give some insight into the underlying scientific principles that explain the intuitive mind, offering tools and techniques for developing and deploying informed intuition in leadership and management.</jats:sec
SemSorGrid4Env Architecture
No full textThis document specifies, designs, and validates the Semantic Sensor Grid Rapid Application Development for Environmental Management (SemSorGrid4Env) software architecture. The architecture enables the publication and querying of both stored (e.g. database) and streaming (e.g. sensor) data to support the rapid development of applications for environmental monitoring. Significant benefits are provided by the use of semantic technology for service discovery and data integration. The infrastructural backbone of the architecture is provided by four service-oriented services: Stored Data Service for the publication of databases, Streaming Data Service for the publication of sensor data, Registration and Discovery Service to enable resources to found, and Integration and Querying Service to enable multiple data sources to be accessed through a single model. These services will be supplemented with application domain specific services which may offer RESTful interfaces
Specification of high-level application programming interfaces (SemSorGrid4Env)
No full textThis document defines an Application Tier for the SemsorGrid4Env project. Within the Application Tier we distinguish between Web Applications - which provide a User Interface atop a more traditional Service Oriented Architecture - and Mashups which are driven by a REST API and a Resource Oriented Architecture. A pragmatic boundary is set to enable initial development of Web Applications and Mashups; as the project progresses an evaluation and comparison of the two paradigms may lead to a reassessment of where each can be applied within the project, with the experience gained providing a basis for general guidelines and best practice. Both Web Applications and Mashups are designed and delivered through an iterative user-centric process; requirements generated by the project case studies are a key element of this approach
Interaction of smoothened with integrin‐linked kinase in primary cilia mediates Hedgehog signalling
No full textHere we report that ILK localizes in the mouse primary cilium, a sensory organelle required for signalling by the Hedgehog (Hh) pathway. Genetic or pharmacological inhibition of ILK blocks ciliary accumulation of the Hh pathway effector smoothened (Smo) and suppresses the induction of Gli transcription factor mRNAs by SHh. Conditional deletion of ILK or Smo also inhibits SHh-driven activation of Gli2 in the embryonic mouse cerebellum. ILK regulation of Hh signalling probably requires the physical interaction of ILK and Smo in the cilium, and we also show selective cilia-associated interaction of ILK with β-arrestin, a known mediator of Smo-dependent signalling.Badia Barakat, Liang Yu, Camden Lo, Duc Vu, Elisabetta De Luca, Jason E. Cain, Luciano G. Martellotto, Shoukat Dedhar, Anthony J. Sadler, Die Wang, D. Neil Watkins, Gregory E. Hanniga
Systematic review and narrative synthesis of the experiences of individuals with chronic pain participating in digital pain management interventions.
No full textBACKGROUND: The use of digital pain management interventions has grown since the Covid 19 pandemic. The aim of this study was to systematically review and synthesise evidence from qualitative studies regarding the experiences of individuals with chronic pain participating in digital pain management interventions in primary care and community settings. METHODS: Fourteen databases were searched, as well as citation tracking and hand-searching reference lists of included articles. The latest search was completed by 07/07/2023. Qualitative studies of patient and carer perspectives of digital pain management interventions for adults aged 18 and over with non-malignant chronic pain were included. All studies were appraised for quality using the Critical Appraisal Skills Programme Qualitative Checklist. A narrative synthesis approach was used to synthesise the findings. Normalisation Process Theory was used to understand how individuals with chronic pain make sense of digital pain management interventions and incorporate knowledge, skills and strategies learnt into their day-to-day lives. RESULTS: Eleven studies, encompassing both digital applications for use on smartphones/ mobile devices and user-directed online modular programmes, were included in the synthesis. Three main themes and related subthemes were identified from the included studies: 1) Making sense of the digital intervention (Subthemes: Tailoring to user's needs; Human contact and support; Accessibility of the digital intervention; Personal and environmental factors affecting engagement with digital interventions); 2) Initiating and Maintaining Behaviour Change (Subthemes: Planning activity; Being active); and 3) Personal Growth (Subthemes: Gaining understanding and skills; Gaining and acting on feedback; Negotiating a new relationship with pain). CONCLUSION: Recommendations. The key recommendations from our findings are that digital pain management interventions should provide: Specific and tailored information for individual participants.Focus on changing attitudes and behaviours and reframing perceptions of pain.Structured goal setting with prompts to review goals.Potential healthcare professional support alongside the digital intervention.Limitations of the review. To reduce bias, it would have been preferable for more than one author to independently fully analyse each paper and to identify themes and sub-themes. Instead, the identified themes and sub-themes were discussed with two other authors in the team (ES, LW) to reach a consensus view on final themes and sub-themes. One author (JS) received a Research Internship and Research Initiation Award funded by NIHR Applied Research Collaboration (ARC) Wessex (https://www.arc-wx.nihr.ac.uk/) and NHS England (https://www.england.nhs.uk/). The protocol for this review was registered with the National Institute of Health Research (NIHR) PROSPERO international database for registering systematic reviews (PROSPERO Registration Number CRD42021257768)
Higher Post-transplant Costs and Resource Utilization in Adult Living Donor Liver Transplant Recipients Compared to Deceased Donor Liver Transplant Recipients
No full textLiving donor liver transplantation (LDLT) is an alternative to traditional deceased donor liver transplantation (DDLT) that has grown out of the shortage of deceased donor livers available for transplantation. The two procedures have similar clinical outcomes, but costs have been shown to be higher in living donor liver transplantation (LDLT) than in deceased donor liver transplantation (DDLT). The aim of this study was to compare the medical resource utilization, costs, and complication rates between LDLT and DDLT. Data were collected on the first 24 LDLT recipients performed at the University of North Carolina at Chapel Hill School of Medicine and were compared to 24 DDLT recipients matched on age, etiology of liver disease, year of transplant, and model for end stage liver disease (MELD) score at the time of transplantation. The study time period was the first 30 days after transplantation. Compared to DDLT recipients, LDLT recipients had significantly longer lengths of stay, 23.2 vs. 15.9 days, p<0.001, as well as number of laboratory tests 2,403 vs. 1,509, p=0.001 and radiology tests, 29.9 vs. 14.7, p<0.001. Costs for ICU care were higher in the LDLT recipients compared to DDLT recipients, 7,243, p=0.006. Total costs for LDLT recipients was higher at 34,973 for DDLT recipients, p=0.001. The increase in total costs in the LDLT group was largely driven by complications, with a re-transplantation rate of 25%. Resource utilization and costs are higher in LDLT recipients than in DDLT recipients, and may be due the higher complication and re-transplantation rates seen in LDLT. These data may be useful to institutions planning to initiate a LDLT program.Master of Public Healt
John von Neumann and the National Accounting Machine
No full textA visit to D. H. Sadler, Superintendent, H.M. Nautical Almanac Office in 1943 by von Neumann and the author led to one of von Neumann's early contacts with programming
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