1 research outputs found
N: Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferongamma transcription
No full textWe reported previously that daily injections of isophane insulin prevented both hyperglycemia and insulitis in non-obese diabetic (NOD) mice (Atkinson, M., N. Maclaren; and R. Luchetta. 1990. Diabetes. 39:933-937). The possible mechanisms responsible include reduced immunogenicity of pancreatic fl-cells from ",B-cell rest " and induced active immunoregulation to insulin (Aaen, K., J. Rygaard, K. Jo
