1,182 research outputs found
Cardiovascular effects of tight versus usual blood-pressure control. Authors' reply
No full textstatus: Publishe
Hormonal regulation of human adipocytes at the cross-roads between obesity and hypertension
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How to reliably diagnose arterial hypertension: lessons from 24 h blood pressure monitoring
No full textBACKGROUND: Hypertension is a common condition in modern society. As blood pressure fluctuates with time, a single blood pressure measurement is useless to diagnose hypertension. Nevertheless, no well-defined number of measurements is often used for this purpose. Diagnosis and therapeutic control of hypertension are therefore suboptimal. OBJECTIVE: To determine the number and timing of measurements needed to give a trustworthy approximation of an individual's average blood pressure. METHODS: In this observational study 306 clinically indicated 24h ABPM datasets were analysed. Hypertension was defined as a daytime blood pressure mean exceeding 135/85 mm Hg. Kappa coefficients determined the best time of day for measuring blood pressure. The optimal number of measurements was estimated using canonical correlation. RESULTS: 162 (53%) patients were diagnosed with hypertension. Kappa statistics indicated that measuring during the afternoon gave the best agreement with the 24h blood pressure mean (κ = 0.78). According to canonical correlation, about 8-10 blood pressure readings give enough information for hypertension diagnosis. CONCLUSIONS: Eight to ten blood pressure measurements between 01:00 and 05:00 p.m. are sufficient to give a clinically useful approximation of the daytime mean blood pressure and therefore for diagnosing hypertension accurately. Future research should determine the ideal dispersion of measurements and include patient characteristics which could influence the required number and timing of measurements. These results may increase the future importance of telemonitoring in diagnosing hypertension.status: Publishe
Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial
No full textstatus: Publishe
Cadmium from zinc smelter emission and variation in cancer incidence: the hierarchy of evidence.
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Cadmium praktijkgids voor artsen
No full textDe cadmiumpraktijkgids is een praktische leidraad voor artsen die zorgen verlenen aan patiënten met vragen over hoe blootstelling aan cadmium via hat leefmilieu mogelijke geovlgen kan hebben voor hun gezondheid
Cadmium praktijkgids voor artsen
No full textDe cadmiumpraktijkgids is een praktische leidraad voor artsen die zorgen verlenen aan patiënten met vragen over hoe blootstelling aan cadmium via hat leefmilieu mogelijke geovlgen kan hebben voor hun gezondheid
Compared with whom? Addressing the prognostic value of ambulatory blood pressure categories
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Modulation of genetic cardiovascular risk by age and lifestyle
No full textCardiovascular disease remains the leading cause of death worldwide. In this review, we briefly summarize new insights on the modulation of genetic cardiovascular risk by host factors such as sex and age and lifestyle factors such as salt intake. As phenotypes (genotypes) of interest, we considered left ventricular structure and function (ADD1 Gly460Trp; AGTR2 G1675A; ACE D/I), the incidence of heart failure (ADD1 Gly460Trp), heart rate variability (CYP11B2 C-344T; AGTR1 A1166C), carotid distensibility (IL6 G-174C), and serum lipid levels (APOE e{open} 2/ e{open} 3/ e{open} 4; APOA1 A 75G). In each case, the associations with the genetic cardiovascular risk factor were modulated by sex, age, sodium intake, or a combination thereof. These interactions highlight that genetic risk factors and phenotype-genotype associations can only be interpreted within their ecogenetic context. Perhaps a better understanding of these phenomena will lead researchers to target in a more specific way the pathophysiologic mechanisms operating within each individual. © 2008 Current Medicine Group LLC
Vermindering van de zoutinname: van een bevolkingsoverkoepelende naar een gepersonaliseerde benadering. Een reactie van professor Jan A. Staesen
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