4,991 research outputs found
Portrait of author David Foster at the National Library of Australia, Canberra, 8 June 2011 /
No full textTitle from acquisitions documentation.; Part of the collection: Portraits of author David Foster at the National Library of Australia, Canberra, 8 June 2011.; Acquired in digital format; access copy available online.; Mode of access: Online.; Photographed by a staff member of the National Library of Australia
Author David Foster with academic Jeff Doyle at the National Library of Australia, Canberra, 8 June 2011 /
No full textTitle from acquisitions documentation.; Part of the collection: Portraits of author David Foster at the National Library of Australia, Canberra, 8 June 2011.; Acquired in digital format; access copy available online.; Mode of access: Online.; Photographed by a staff member of the National Library of Australia
Author David Foster and academic Jeff Doyle at the National Library of Australia, Canberra, 8 June 2011 /
No full textTitle from acquisitions documentation.; Part of the collection: Portraits of author David Foster at the National Library of Australia, Canberra, 8 June 2011.; Acquired in digital format; access copy available online.; Mode of access: Online.; Photographed by a staff member of the National Library of Australia
On Campus Video, featuring Millie Cooper, author of the book Aerobics for Women and wife of Kenneth Cooper of the Cooper Clinic.
No full textA videorecording of an interview with Millie Cooper, author of the book Aerobics for Women and wife of Kenneth Cooper of the Cooper Clinic. The interview is conducted by Dr. Gary McCaleb of Abilene Christian University
Mosaic portraits of variety entertainers of the century, Waterfront City, Docklands, Melbourne, May 2007 [picture] /
No full textTitle devised by cataloguer based on information from acquisition documentation.; Part of collection: Changes to the built environment in the City of Melbourne, Southbank and Docklands, 4-7 May 2007; Acquired in digital format; access copy available online.; Mode of access: Internet via World Wide Web.; Photographed by the National Library's photographers, Damian McDonald and Greg Power, 4-7 May 2007. "A mosaic tribute of 100 great Australian entertainers of the past century, Australian actors, comedians, singers and dancers. Includes portraits of Dame Edna Everage, Russell Crowe and Kylie Minogue. Created by Melbourne Mural Studios, April 2006, adapted from a painting by Jamie Cooper"--Information from reference source
Investigating the role of extracellular vesicles and glycosylation in cancer metastasis
No full textBreast and colorectal cancers present significant challenges for the UK healthcare system, placing a substantial burden on the National Health Service (NHS). Early detection is crucial for improving survival rates and reducing healthcare strain, especially as metastasis, the primary cause of mortality in these cancers, remains poorly understood. Protein glycosylation, a post-translational modification of carbohydrate structures, is a significant contributor to cancer progression and metastasis. Small extracellular vesicles (sEVs) have emerged as key players in cancer development and metastasis, facilitating intercellular communication through bioactive cargo transfer. Despite mounting evidence, the importance of sEV glycosylation in cancer and metastasis is often overlooked. Liquid biopsies, including sEV biomarker analysis, offer promising non-invasive diagnostic approaches. Given the prevalence of glycoproteins among blood cancer biomarkers, exploring the glycosylation of sEVs as biomarker targets could revolutionise early detection strategies for breast and colorectal cancer.
Efforts initially focused on optimising single-vesicle flow cytometry for sEV characterisation to ensure maximum signal and sample integrity. Subsequent analysis of breast and colorectal epithelial cells and their derived sEVs revealed pronounced HPA lectin binding in the metastatic phenotypes. A lectin microarray identified increased lectin binding of LCA and TL in ‘CD81-positive’ sEVs derived from breast cancer-associated cell lines in comparison to normal cells. Validation through single-vesicle flow cytometry confirmed these observations, prompting investigations into the diagnostic application of these lectins in distinguishing plasma-enriched sEVs from breast cancer patients and ‘healthy’ individuals. However, lectins alone did not show diagnostic significance, in contrast to the diagnostic capability of the well-established breast cancer marker EpCAM.
Overall, these results underscore the importance of optimising single-vesicle flow cytometry for comprehensive characterisation of sEVs. They also highlight the HPA lectin binding patterns of breast and colorectal metastatic cell phenotypes, which mirror the observations of their derived sEVs but with nuanced specificity attributed to tetraspanin composition. Additionally, other glycosylated targets, as recognised by TL and LCA, show increased abundance in breast cancer cell-derived sEVs. Moreover, the diagnostic capability of these lectins and EpCAM in distinguishing plasma-enriched sEVs derived from breast cancer patients from those derived from ‘healthy’ individuals is demonstrated
Portrait of Paul Ham at the National Library of Australia, 15 November 2011 /
No full textTitle from nformation supplied by photographer.; Part of the collection: Podcast photograph of author Paul Ham at the National Library of Australia, 15 November 2011.; Mode of access: Online.; Photographed by a staff member of the National Library of Australia
INVESTIGATING THE ROLE OF EXTRACELLULAR VESICLES AND GLYCOSYLATION IN CANCER METASTASIS
No full textBreast and colorectal cancers present significant challenges for the UK healthcare system, placing a substantial burden on the National Health Service (NHS). Early detection is crucial for improving survival rates and reducing healthcare strain, especially as metastasis, the primary cause of mortality in these cancers, remains poorly understood. Protein glycosylation, a post-translational modification of carbohydrate structures, is a significant contributor to cancer progression and metastasis. Small extracellular vesicles (sEVs) have emerged as key players in cancer development and metastasis, facilitating intercellular communication through bioactive cargo transfer. Despite mounting evidence, the importance of sEV glycosylation in cancer and metastasis is often overlooked. Liquid biopsies, including sEV biomarker analysis, offer promising non-invasive diagnostic approaches. Given the prevalence of glycoproteins among blood cancer biomarkers, exploring the glycosylation of sEVs as biomarker targets could revolutionise early detection strategies for breast and colorectal cancer.
Efforts initially focused on optimising single-vesicle flow cytometry for sEV characterisation to ensure maximum signal and sample integrity. Subsequent analysis of breast and colorectal epithelial cells and their derived sEVs revealed pronounced HPA lectin binding in the metastatic phenotypes. A lectin microarray identified increased lectin binding of LCA and TL in ‘CD81-positive’ sEVs derived from breast cancer-associated cell lines in comparison to normal cells. Validation through single-vesicle flow cytometry confirmed these observations, prompting investigations into the diagnostic application of these lectins in distinguishing plasma-enriched sEVs from breast cancer patients and ‘healthy’ individuals. However, lectins alone did not show diagnostic significance, in contrast to the diagnostic capability of the well-established breast cancer marker EpCAM.
Overall, these results underscore the importance of optimising single-vesicle flow cytometry for comprehensive characterisation of sEVs. They also highlight the HPA lectin binding patterns of breast and colorectal metastatic cell phenotypes, which mirror the observations of their derived sEVs but with nuanced specificity attributed to tetraspanin composition. Additionally, other glycosylated targets, as recognised by TL and LCA, show increased abundance in breast cancer cell-derived sEVs. Moreover, the diagnostic capability of these lectins and EpCAM in distinguishing plasma-enriched sEVs derived from breast cancer patients from those derived from ‘healthy’ individuals is demonstrated
Mini Cooper 1961-2000
No full textFrom its launch on 20 September 1961 the Mini Cooper caused a sensation. The world’s first sports saloon, the diminutive Cooper combined the glamour and racing heritage of 1959 and 1960 Formula 1 champions the Cooper Car Company with the outstanding handling and downright practicability of the Austin Mini Seven and Morris Mini Minor. Alec Issigonis’s little people’s car had been launched by the manufacturer, the British Motor Corporation (BMC), two years earlier. A winner almost from the word go, the Mini Cooper not only ruled the racetracks and rally stages of the early and mid-1960s but proved to be a practical and fun sporting family saloon car. After over 100,000 examples were sold between 1961 and 1971, the Mini Cooper is still a practical sporting saloon in the guise of the BMW-owned MINI Cooper sixty years after the introduction of the original model.This remarkable product of the United Kingdom merits a fresh examination as it nears its sixtieth birthday. Based upon over fifty face-to-face interviews carried out by the author over more than a decade, this book quotes the Mini Cooper’s designers, developers, and professional race and rally drivers plus a host of contemporary owners. Here then in the words of its originators, is the story of the Mini Cooper
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