40 research outputs found
Correction:Is treatment with pimobendan associated with an increased risk of arrhythmias in dogs with heart disease? (Veterinary Record (2018) 183 (693-695) DOI: 10.1136/vr.k5167)
No full textThe author list was incomplete on publication of this article. The author list should have included Rebecca Tedford, Samantha Partridge and Edward Cooper and the author list order should have been as below. Hillyer S, Tedford R, Partridge S, Cooper E, Hezzell MJ, Place E.</p
Antichiropus patriciae Car & Harvey & Hillyer & Huey 2019, n. sp.
No full text<i>Antichiropus patriciae</i> Car, n. sp. <p>(Figs 25, 26 A–F)</p> <p> <b>ZooBank LSID:</b> urn:lsid:zoobank.org:act: 0E936CE3-19B4-47A4-885A-21BA2E7D286A</p> <p> <b>Type material examined.</b> <b> Australia: <i>Western Australia:</i></b> holotype male (badly damaged), 53 km NNE of Whim Creek Hotel, site DRE03, 20°25’48”S, 118°03’50”E, May 2004, CALM staff (Pilbara Biological Survey) (WAM T146652). Paratypes: 1 male, 9 km NE. of Cowra Line Camp, Pilbara Biological Survey site RHNW11, 22°17’38.8”S, 119°03’40.9”E, May 2004, CALM staff (Pilbara Biological Survey) (WAM T76079).</p> <p> <b>Other material examined.</b> <b> Australia: <i>Western Australia:</i></b> 1 male, 2 females, 4 juveniles (damaged), 20 km ESE of Whim Creek Hotel, site DRE12, 20°54’36”S, 117°58’58”E, May 2004, CALM staff (Pilbara Biological Survey) (WAM T76057); 2 males, 2 females, 53 km NNE of Whim Creek Hotel, site DRE03, 20°25’48”S, 118°03’50”E, May 2004, CALM staff (Pilbara Biological Survey) (WAM T76074); 1 male, 1 female, 13 km SSE of Wodgina, site MBW10, 21°16’47”S, 118°41’56”E, 23 September 2005 – 15 May 2006, ethylene glycol pitfall traps, CALM staff (Pilbara Biological Survey) (WAM T124592); 1 male, 5km NNE. of Wodgina, site MBW09, 21°07’41”S, 118°41’22”E, 23 September 2005 – 15 May 2006, ethylene glycol pitfall traps, CALM staff (Pilbara Biological Survey <b>) (</b> WAM T124595); 1 male, 1 female (damaged), 22.5 km SSE of Wodgina, site MBW11, 21°21’52”S, 118°42’04”E, 23 September 2005 – 15 May 2006, ethylene glycol pitfall traps, CALM staff (Pilbara Biological Survey) (WAM T124624); 3 males, 1 females, 13 km SSE of Wodgina, site MBW10, 21°16’47”S, 118°41’56”E, 23 September 2005 – 15 May 2006, ethylene glycol pitfall traps, CALM staff (Pilbara Biological Survey) (WAM T124625).</p> <p> <b>Diagnosis.</b> Gonopod: <i>Antichiropus patriciae</i> Car, <b>n. sp.</b> is unmistakeable: it has two long solenomere processes halfway along the length of the solenomere and a second femoral process with a distinct anvil-shaped structure at its base.</p> <p> <b>Description.</b> <i>Male holotype:</i> <b>Body</b> ca. 20 mm long; midbody ring ca. 2 mm wide, with distinct, smooth waist, metazonite slightly wider than prozonite.</p> <p> <b>Colour</b> (in alcohol) dark brown, cream ventrally (Fig 26A): leg colour, paler. No paranota (Fig 26B).</p> <p> <b>Sternites</b> without obvious processes/tubercles, sternal lamella short, square, broad. Leg coxal processes absent. Anterior spiracles at midbody, small, ovoid, slightly folded.</p> <p> <b>Head</b> smooth without noticeable sculpturing; frons smooth, setose; face narrow, cardines visible when viewed face-on, maximum width ca. 4x the distance between antennal sockets; sockets separated by ca. 2x width of sock- et.</p> <p> <b>Antennae</b> relatively slender, of moderate length, reaching to ring 2, antennal segments of similar length and width.</p> <p> <b>Collum</b> 1x long as head (in lateral view) (Fig 26A).</p> <p> <b>Gonopod</b> short, reaching ring 6; coxa (C)much more robust, shorter, than femorite, with very slight ridge on anterior surface; prefemur (PF) much shorter than femorite, with few setae, prefemoral lip low but pronounced; femorite (F) short, squat, curved, broader at apex; main femoral process (MFP), long with pointed tip reaching solenomere. Distinctive anvil-shaped structure at base; second femoral process (fp1) at least 1/2 femorite length, robust, pointed, curves upwards towards solenomere; prolongation of femorite (prof) absent; solenomere (S) relatively long, forming a loop/circle, narrower than femorite, of similar width along its length but broadest mid-length, narrowing to slender squared-off tip; solenomere process (sp1) not at tip, paired with second solenomere process (sp2) halfway along length of solenomere; both processes long, pointed (Figs 26 C–F).</p> <p> <i>Female:</i> Similar to the male but slightly broader legs (WAM T76057).</p> <p> <b>Distribution.</b> This species has been collected from several sites in the northern Pilbara (Fig 25).</p> <p> <b>Etymology.</b> This species is named for the senior author’s younger daughter, Patricia Mellows.</p>Published as part of <i>Car, Catherine A., Harvey, Mark S., Hillyer, Mia J. & Huey, Joel A., 2019, The millipede genus Antichiropus (Diplopoda: Polydesmida: Paradoxosomatidae), part 3: species of the Pilbara bioregion of Western Australia, pp. 1-71 in Zootaxa 4617 (1)</i> on pages 44-46, DOI: 10.11646/zootaxa.4617.1.1, <a href="http://zenodo.org/record/3248154">http://zenodo.org/record/3248154</a>
Antichiropus lucyae Car & Harvey & Hillyer & Huey 2019, n. sp.
No full text<i>Antichiropus lucyae</i> Car, n. sp. <p>(Figs 22 A–F, 25)</p> <p> <b>ZooBank LSID:</b> urn:lsid:zoobank.org:act: 28AA5641-5ECF-4D7E-9319-30DC9A3C4809</p> <p> <b>Type material examined.</b> <b> Australia: <i>Western Australia:</i></b> holotype male (badly damaged, tail segments missing), 24 km WSW. of Mt Marsh, site RHNW02, 22°32’09”S, 118°59’51.3”E, May 2004, ethylene glycol pitfall traps, CALM staff (Pilbara Biological Survey) (WAM T144605). Paratypes: 1 males, collected with holotype (WAM T76054); 2 males, 10 females (damaged remains), collected with holotype (WAM T146717).</p> <p> <b>Diagnosis.</b> Gonopod: <i>Antichiropus lucyae</i> Car, <b>n. sp.</b> is recognisable by its distinctive urn-shaped gonopodal femorite (posterior and anterior views) together with its, curved main femoral process in close association with a second femoral process.</p> <p> <b>Description.</b> <i>Male holotype:</i> <b>Body</b> ca. 10 mm long, slightly dimpled; midbody ring ca. 1.5 mm wide, with indistinct, smooth waist, prozonite and metazonite of similar width.</p> <p> <b>Colour</b> chestnut brown, lighter ventrally: rugose dorsally and laterally (Fig 22A): leg colour, similar to body. No paranota (Fig 22B).</p> <p> <b>Sternites</b> without obvious processes/tubercles, sternal lamella narrow, rounded. Leg coxal processes absent. Anterior spiracles at midbody, tiny, ovoid, flat.</p> <p> <b>Head</b> smooth without noticeable sculpturing, slight stippling; frons moderately setose; face moderately nar- row, cardines visible when viewed face-on, maximum width ca. 4x the distance between antennal sockets; sockets separated by ca. 2x width of socket.</p> <p> <b>Antennae</b> relatively long, reaching to ring 3, antennal segments of similar length and width, lightly clavate.</p> <p> <b>Collum</b> ca. 0.6x length of head (in lateral view) (Fig 22A).</p> <p> <b>Gonopod</b> of medium length, reaching ring 5; coxa (C) more robust than femorite, 1/2 femorite length with pronounced ridge on anterior surface; prefemur (PF) similar length to coxa, moderately setose, prefemoral lip pronounced; femorite (F) 2/3 acropodite length, upright, slender for proximal half, then thickening noticeably to a bulbous hourglass shape when viewed anteriorly; main femoral process (MFP) curved claw-shape, pointing towards femorite base second femoral process (fp1) slender, pointed, prolongation of femorite (prof) 1/4 length femorite, triangular, pointed, in very close association with fp1; solenomere (S) relatively short, curled in a C-shape, slender, narrowing to flattened asymmetrical point; solenomere process (sp1) at solenomere tip, upright pointed (Figs 22C- F.).</p> <p> <i>Female:</i> Similar to the male but slightly broader and stouter (body width ca. 1.75 mm when viewed dorsally), less rugose with shorter, more slender legs (WAM T76054).</p> <p> <b>Distribution.</b> All specimens of this species have been found in only one location in the Pilbara, WSW. of Mt Bruce (Fig 25).</p> <p> <b>Etymology.</b> This species is named for Lucy Hogan, daughter of the senior author.</p>Published as part of <i>Car, Catherine A., Harvey, Mark S., Hillyer, Mia J. & Huey, Joel A., 2019, The millipede genus Antichiropus (Diplopoda: Polydesmida: Paradoxosomatidae), part 3: species of the Pilbara bioregion of Western Australia, pp. 1-71 in Zootaxa 4617 (1)</i> on pages 39-40, DOI: 10.11646/zootaxa.4617.1.1, <a href="http://zenodo.org/record/3248154">http://zenodo.org/record/3248154</a>
Examining Delayed Recall in Cochlear Implant Users Using the Montreal Cognitive Assessment, California Verbal Learning Test, Third Edition, and Item Specific Deficit Approach: Preliminary Results
No full textPurpose: Recent studies using the Montreal Cognitive Assessment (MoCA) suggest delayed recall is challenging for cochlear implant (CI) users. To better understand the underlying processes associated with delayed recall in CI users, we administered the MoCA and the California Verbal Learning Test, Third Edition (CVLT-3), which provides a more comprehensive assessment of delayed recall ability. Methods: The MoCA and CVLT-3 were administered to 18 high-performing CI users. For the CVLT-3, both the traditional scoring and a newer scoring method, the Item-Specific Deficit Approach (ISDA), were employed. Results: The original MoCA score and MoCA delayed recall subtest score did not relate to performance on any CVLT-3 measures regardless of scoring metric applied (i.e., traditional or ISDA). Encoding performance for both the CVLT-3 and ISDA were related. Consolidation, which is only distinctly defined by the ISDA, related to CVLT-3 cued delay recall performance but not free delay recall performance. Lastly, ISDA retrieval only related to CVLT-3 measures when modified. Conclusion: Performance on the MoCA and CVLT-3 in a high performing CI patient population were not related. We demonstrate that the ISDA can be successfully applied to CI users for the quantification and characterization of delayed recall ability; however, future work addressing lower performing CI users, and comparing to normal hearing controls is needed to determine the extent of potential translational applications. Our work also indicates that a modified ISDA retrieval score may be beneficial for evaluating CI users although additional work addressing the clinical relevance of this is still needed. Copyright © 2021 Brumer, Elkins, Parada, Hillyer and Parbery-Clark.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
The Impact of Host-Microbe Interactions on Nasonia Evolution
No full textThe interactions between a host and its associated microbes can convey either beneficial or harmful traits on the host, such as dietary supplementation or reproductive parasitism, respectively. Through host interactions between vertically-transmitted endosymbionts or horizontally-transmitted microbiota, the microbially-conferred traits may be selected for and drive host evolution. In this dissertation, members of the parasitoid wasp genus Nasonia comprised of closely related wasp species were studied for their interaction with a Wolbachia endosymbiont and their gut microbiota. Nasonia must regulate their Wolbachia endosymbiont densities during maternal transmission to prevent long-term, negative fitness effects. Because little is known about evolutionary forces that underpin the regulation of maternally transmitted symbionts, a forward genetic screen was conducted to find a gene responsible for regulating a 80-fold difference in Wolbachia titers between N. vitripennis and N. giraulti. A quantitative trait loci analysis, the introgression of N. vitripennis genomic regions into a N. giraulti background, and RNAi gene knockdown validation identified the maternal effect Wds gene that suppresses Wolbachia titers in N. vitripennis.
To study the ecological and evolutionary processes by which Nasonia wasps interact with their gut microbiota, phylosymbiosis was tested and validated as an eco-evolutionary pattern by which the host evolutionary history is paralleled by the similarity in the composition of their gut microbiota. To reveal the importance of phylosymbiosis in Nasonia evolutionary relationships, microbiota transplantation assays were performed with an optimized Nasonia germ-free rearing system. Transplantations of gut microbiota from different Nasonia spp. into a germ-free recipient resulted in reductions in traits related to host fitness, supporting that Nasonia-gut microbiota interactions can drive adaptation and speciation. We conclude that the described interactions between Nasonia and their associated microbes influence Nasonia function and play a role in Nasonia evolutionary processes
Performance on the standard and hearing‐impaired Montreal Cognitive Assessment in cochlear implant users
No full textOBJECTIVES: Commonly used cognitive screening tools were not originally developed for patients with hearing loss (HL) and rely heavily on the ability to hear the instructions and test stimuli. Recently, the Montreal Cognitive Assessment (MoCA) was modified for use with hearing-impaired populations (ie, HI-MoCA). In order to investigate the clinical utility of the HI-MoCA, we assessed performance between the standard MoCA and HI-MoCA among postlingually deafened cochlear implant (CI) users.
METHODS: We administered the standard MoCA and HI-MoCA to 21 CI users and compared their performance. We assessed differences in pass/fail status when items from the attention and language sections and the delayed recall task were removed.
RESULTS: There was no significant difference in performance between the standard MoCA and HI-MoCA. Participants scored higher on both test versions when the delayed recall task was removed. Participants also performed better on the delayed recall task on the HI-MoCA than on the standard MoCA.
CONCLUSIONS: While our findings suggest that the modality of presentation for the MoCA does not influence overall performance for postlingually deafened CI users, visual presentation of stimuli impacted performance on delayed recall. Furthermore, irrespective of presentation modality, our participants scored higher on both MoCA versions when the delayed recall task was removed. Clinically, modifications to the presentation of the MoCA might not be necessary for CI users; however, clinicians should be aware that the delayed recall task is inherently harder for these patients
Synthesis of (2-amino-4,5-dimethylthiophen-3-yl)(4-chlorophenyl)methanone (S2): A Precursor to Selective Bromodomain Inhibitor, (+)-JQ1
No full textS2 [(2-amino-4,5-dimethylthiophen-3-yl)(4-chloropheyl)methanone)] is an organic precursor to the (+)-enantiomer of JQ1, a break-through molecule in cancer research. The purpose of this research was to sufficiently synthesize enough of the S2 intermediate to continue the synthetic pathway of (+)-JQ1. The synthesis of S2 is similar to the Gewald reaction, where 2-butanone (ketone) condenses 4-chlorobenzoylacetonitrile (α-cyanoester) in the presence of elemental sulfur and morpholine (base) to yield the poly-substituted thiophene product, though the mechanism for the cyclization is still unknown. The resulting residue was characterized by thin-layer chromatography and purified using column chromatography. The greatest yield of S2 resulted from recrystallization with ethanol/water. Proton NMR of the product was compared to that of theoretical research done by fellow Linfield student Kevin Romero. Now that S2 has successfully been synthesized, we will begin the next step in the synthesis of (+)-JQ1
Prescribing by mental health nurses: the UK perspective
No full textPURPOSE. This article aims to discuss the growth of mental health nurse (MHN) prescribing in the United Kingdom as an exemplar for readers to compare progress in their own countries and context. This study also aims to provide a historical overview of this process in the United Kingdom where MHNs prescribe safely and competently.
CONCLUSIONS. Finally, evidence has shown that MHNs with prescriptive authority are competent when prescribing when compared to psychiatrists.
PRACTICE IMPLICATIONS. Despite organizational barriers and educational concerns, MHN prescribing is becoming embedded in the healthcare context in the United Kingdo
What are the best practices for curating eDNA custom barcode reference libraries? A case study using Australian subterranean fauna
No full textIdentification of species for environmental assessment and monitoring is essential for understanding anthropogenic impacts on biodiversity, but for subterranean fauna this task is frequently difficult and time consuming. The implementation of environmental DNA (eDNA) metabarcoding for biodiversity discovery and assessment offers considerable promise for improving the speed, accuracy, and efficiency of species detection in ecosystems both above and below the ground. Importantly, for a better understanding of the biodiversity and ecology of organisms detected using eDNA, a custom library of known reference sequences with associated correct taxonomic metadata—i.e. a barcode reference library (BRL)—is required. Yet, minimal guidance is currently available on how an effective (i.e. shareable, multisequence, that permits metadata, and has a unified nomenclature) and accurate (i.e. verified) custom BRL can be achieved. Here, we present a detailed roadmap for curation of a BRL for subterranean fauna. To do this, we curated a custom sequence database of subterranean fauna at an environmentally sensitive location, for four gene loci useful for eDNA metabarcoding, worked toward addressing the disparate nomenclature of subterranean fauna, and summarized a best practice workflow for curation of a custom BRL that is broadly applicable.Michelle T. Guzik, Danielle N. Stringer, Jake Thornhill, Peterson J. Coates, Mieke van der Heyde, Mia J. Hillyer, Nicole E. White, Mattia Saccò, Perry G. Beasley-Hall, William F. Humphreys, Mark S. Harvey, Joel A. Huey, Nerida G. Wilson, Jason Alexander, Garth Humphreys, Rachael A. King, Steven J.B. Cooper, Adrian Pinder, Giulia Perina, Andrew M. Hosie, Lisa Kirkendale, Paul Nevill, Andrew D. Austi
