373,729 research outputs found
(R ,S )-methyl 2-(2 '-methylenecyclopropyl)-hydroxyacetate
No full textThe relative configuration of the title molecule, C7H10O3, has been determined. The asymmetric C atoms are of opposite chirality (R,S or S,R), as opposed to having the same chirality (R,R or S,S). The molecule adopts an antiperiplanar conformation around the bond connecting the cyclopropyl and carbonyl groups. In the crystal structure, molecules form hydrogen-bonded chains
Generalized support vector regression: duality and tensor-kernel representation
Get PDFIn this paper, we study the variational problem associated to support vector regression in Banach function spaces. Using the Fenchel–Rockafellar duality theory, we give an explicit formulation of the dual problem as well as of the related optimality conditions. Moreover, we provide a new computational framework for solving the problem which relies on a tensor-kernel representation. This analysis overcomes the typical difficulties connected to learning in Banach spaces. We finally present a large class of tensor-kernels to which our theory fully applies: power series tensor kernels. This type of kernels describes Banach spaces of analytic functions and includes generalizations of the exponential and polynomial kernels as well as, in the complex case, generalizations of the Szegö and Bergman kernels.sponsorship: The research leading to these results has received funding from the European Research Council ERC AdG A-DATADRIVE-B (290923) and ERC AdG EDUALITY (787960) under the European Union's Horizon 2020 research and innovation programme. The first author was partly supported by SAP SE. (European Research Council ERC AdG A-DATADRIVE-B under the European Union's Horizon 2020 research and innovation programme|290923, European Research Council ERC AdG EDUALITY under the European Union's Horizon 2020 research and innovation programme|787960, SAP SE)status: Publishe
(1 ' S,2R,3S,4S)-Ethyl 2-hydroxy-4-methyl-3-)1 '- phenylethylcarbamoyl)hexanoate
No full textThe relative configuration of the title compound, C18H27NO4, was determined as being R,S,S,S. There are three crystallographically independent molecules in the asymmetric unit, which show only slight conformational differences. Molecules in the crystal structure are connected by hydrogen bonds in ribbons along the a axis
JAK-STAT Signaling in Autoimmunity and Cancer
Get PDFSana Parveen,1,2 Mariyam Fatma,1,2 Snober Shabnam Mir,1,2 Said Dermime,3,4 Shahab Uddin1,5,6 1Department of Biosciences, Faculty of Science, Integral University, Lucknow, India; 2Molecular Cell Biology Laboratory, Integral Centre of Excellence for Interdisciplinary Research-4 (ICEIR-4) Integral University, Lucknow, India; 3Translational Cancer Research Facility, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, 3050, Qatar; 4College of Health Sciences, Qatar University, Doha, Qatar; 5Translational Research Institute & Dermatology Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar; 6Laboratory Animal Research Center, Qatar University, Doha, QatarCorrespondence: Shahab Uddin, Molecular Pathophysiology Core, Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar, Tel +974 4025 3220, Email [email protected]: The JAK-STAT pathway is an essential cell survival signaling that regulates gene expressions related to inflammation, immunity and cancer. Cytokine receptors, signal transducer and activator of transcription (STAT) proteins, and Janus kinases (JAKs) are the critical component of this signaling cascade. When JAKs are stimulated by cytokines, STAT phosphorylation, dimerization, and nuclear translocation occur, which eventually impacts gene transcription. Dysregulation of JAK-STAT signaling is linked with various autoimmune diseases, including rheumatoid arthritis, psoriasis, and inflammatory bowel disease. This pathway is constitutively activated in human malignancies and leads to tumor cell survival, proliferation, and immune evasion. Oncogenic mutations in the JAK and STAT genes have been found in solid tumors, leukemia, and lymphoma. Targeting the JAK-STAT pathway is a viable and promising therapeutic strategy for the treatment of autoimmune diseases and cancers.Keywords: JAK-STAT pathway, inflammation, autoimmune diseases, cance
JAK Inhibitors in Psoriatic Disease
No full textMatteo Megna,1 Luca Potestio,1 Angelo Ruggiero,1 Sara Cacciapuoti,1 Francesco Maione,2 Marco Tasso,3 Francesco Caso,3,* Luisa Costa3,* 1Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy; 2Immunopharmalab, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy; 3Rheumatology Research Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy*These authors contributed equally to this workCorrespondence: Angelo Ruggiero, Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Via Pansini 5, Napoli, 80131, Italy, Tel +39 - 081 – 7462457, Fax +39 - 081 – 7462442, Email [email protected]: Psoriasis is now considered to be the cutaneous phenotype of a systemic inflammatory condition, recognized under the term Psoriatic Disease (PsD). PsD has several extracutaneous manifestations, such as inflammatory articular and entheseal involvement, leading to psoriatic arthritis (PsA), and the less frequent intestinal and ocular manifestations with colitis/inflammatory bowel disease and uveitis, respectively. There have also been several reports of an increased frequency of comorbidities such as hypertension, diabetes, dyslipidemia, obesity, metabolic syndrome and cardiovascular manifestations during the course of PsD. The link between psoriasis and related comorbidities is considered a long-term disease sequela, often characterized by an unhealthy lifestyle and a consequence of systemic inflammation; hence, psoriasis requires adequate and prompt treatment, with the aim of controlling not only cutaneous manifestations but also extracutaneous manifestations and systemic inflammation. Pharmacological strategies for PsD have significantly increased over recent years. Recently, the targeted synthetic DMARDs, Janus kinase (JAK) inhibitors, tofacitinib and upadacitinib, were added to the therapeutic armamentarium for treating PsA, and deucravacitinib for psoriasis. These oral agents act directly on inflammatory mechanisms underlining the disease, as antagonists of the intracellular JAK signal pathway and, by STAT phosphorylation, inhibit gene proinflammatory cytokine transcription. JAK inhibitors represent a recent additional treatment strategy for PsD management and, among these, tofacitinib and upadacitinib have recently been approved for PsA, and deucravacitinib for psoriasis. In this review we describe ongoing and recent phase II and III randomized controlled trials (RCTs) evaluating the efficacy and safety of investigational JAK inhibitors in psoriasis and PsA.Keywords: JAK inhibitors, plaque psoriasis, psoriatic arthritis, TYK2 inhibitor
Author´s book
No full textKřik ze Sodomy je autorská kniha tvořena verši 20 až 33 z 18. kapitoly knihy Genesis, kralického překladu Bible svaté, které jsem ilustrovala technikou litografie. Jak text, tak ilustrace jsou ručně tisknuty na stroji a kniha je sešita šitou vazbou.ObhájenoThe Scream of Sodom is an author´s book containing the verses 20 to 33 from the 18th chapter of Genesis, the Holy Bible, which I have illustrated by the litographic graphic technique. The text as well as the illustrations are printed on the hand press. The book was created by the sewn binding
CyclopropyI building blocks for organic synthesis, 60 Synthesis and properties of optically active dispiro[2.0.2.1]heptane derivatives as novel ferroelectric liquid crystalline compounds
No full textEnantioselective enzymatic acylation, using Lipase PS(R) (Pseudomonas sp., immobilized on Celite, Amano Pharmaceutical Co., Ltd.), of endo-dihalosubstituted and nonsubstituted dispiro[2.0.2.1]heptylmethanol and endo-4-methylene-spiropentylmethanol provided the corresponding optically active compounds in high enantiomeric excesses (> 95% ee). Difluorocarbene addition onto the optically active endo-4-methylenespiropentylmethanol yielded the first enantiomerically pure difluorodispiro[2.0.2.1]heptylmethanols. The obtained optically active dispiro[2.0.2.1]heptane derivatives were used in syntheses of phenylpyrimidine derivatives, providing novel ferroelectric liquid crystalline compounds with unique physical properties
Jak se ucit s houbami?
No full text'Jak se ucit s houbami?' [Learning with Fungi?]' is an excerpt from a guided walk booklet 'Learning Collaboration with Fungi' reprented in an educational magazine for students and teachers KRUNYR: a multi-species workbook
Methyl exo-bicyclo[3.1.0]hexane-6,6-dicarboxylate
No full textThe bicyclo[3.1.0]hexane fragment of the title molecule, C9H12O4, adopts a boat-like conformation, with its methoxycarbonyl substituent in the endo position. In the crystal structure, molecules form centrosymmetric O-H...O hydrogen-bonded dimers, which are arranged in layers
CyclopropyI building blocks for organic synthesis, 60 Synthesis and properties of optically active dispiro[2.0.2.1]heptane derivatives as novel ferroelectric liquid crystalline compounds
No full textEnantioselective enzymatic acylation, using Lipase PS(R) (Pseudomonas sp., immobilized on Celite, Amano Pharmaceutical Co., Ltd.), of endo-dihalosubstituted and nonsubstituted dispiro[2.0.2.1]heptylmethanol and endo-4-methylene-spiropentylmethanol provided the corresponding optically active compounds in high enantiomeric excesses (> 95% ee). Difluorocarbene addition onto the optically active endo-4-methylenespiropentylmethanol yielded the first enantiomerically pure difluorodispiro[2.0.2.1]heptylmethanols. The obtained optically active dispiro[2.0.2.1]heptane derivatives were used in syntheses of phenylpyrimidine derivatives, providing novel ferroelectric liquid crystalline compounds with unique physical properties
- …
