45 research outputs found
β-Arrestin-1 is required for adaptive β-cell mass expansion during obesity
Get PDFDuring insulin-resistance, the compensatory expansion of beta-cell mass is able to delay or the onset of overt type 2 diabetes. Here, the authors report that beta-arrestin-1, an intracellular protein known to regulate signalling through G protein-coupled receptors, is essential for beta-cell replication and function in insulin-resistant mice
Purinergic GPCR transmembrane residues involved in ligand recognition and dimerization
No full textWe compare the GPCR-ligand interactions and highlight important residues for recognition in purinergic receptors—from both X-ray crystallographic and cryo-EM structures. These include A(1) and A(2A) adenosine receptors, and P2Y(1) and P2Y(12) receptors that respond to ADP and other nucleotides. These receptors are important drug discovery targets for immune, metabolic and nervous system disorders. In most cases, orthosteric ligands are represented, except for one allosteric P2Y(1) antagonist. This review catalogs the residues and regions that engage in contacts with ligands or with other GPCR protomers in dimeric forms. Residues that are in proximity to bound ligands within purinergic GPCR families are correlated. There is extensive conservation of recognition motifs between adenosine receptors, but the P2Y(1) and P2Y(12) receptors are each structurally distinct in their ligand recognition. Identifying common interaction features for ligand recognition within a receptor class that has multiple structures available can aid in the drug discovery process
Remote working and its facilitative nuances: visualizing the intellectual structure and setting future research agenda
No full textPurpose
In the wake of the COVID-19 pandemic, remote working (RW) has emerged as a viable alternative to working employees in general and knowledge workers in particular. However, previous researchers have worked on the concept, development and facilitation of RW since the 1970s. Therefore, this study aims to review the existing literature on RW to ascertain the evolution of the concept in the business and management domain and provide for requisite arguments to extend the settings for future research agendas.
Design/methodology/approach
The authors based this study on a bibliometric analysis of articles (n = 349) retrieved from the Web of Science database published between January 1990 and October 2021. The authors have used a bibliometric toolbox comprising performance analysis, science mapping and network analysis in various software namely, VOSviewer, Gephi and Biblioshiny package in R.
Findings
The study’s results accentuated important themes like work–life balance, strengthening digital infrastructure, performance and productivity, hybrid work models and well-being and clustered them under four heads with proposed future research questions.
Research limitations/implications
The study is based on a single database; the authors have used an extensive but not exhaustive list of keywords to retrieve the articles. The analysis employs certain threshold limits while using the science mapping technique.
Practical implications
This study would enable managers and academics to comprehensively understand remote work and offer logical implications to appreciate its nuances.
Originality/value
This study is unique as it recognizes the intellectual structure in the existing literature on RW and traces the advancements and exponential growth post-COVID-19. The authors recapitulated the literature as network analysis of the RW facilitation model comprising the antecedents, outcomes, mediators and moderator
Details of additional 29 miRNAs identified after 1 mismatch data analysis in <i>Aedes albopictus</i>.
No full text<p>Details of additional 29 miRNAs identified after 1 mismatch data analysis in <i>Aedes albopictus</i>.</p
miRNA-targets KOBAS analysis and interaction network of miR-2944b-5p of <i>Ae. aegypti</i> and <i>An. stephensi</i>.
No full text<p>(<b>A</b>) Graph represents significant pathways of aal-miR-2944b-5p and ast-miR-2944b-5p after KOBAS analysis. (<b>B</b>) miRNA-target interaction network of miR-2944b-5p of both the insects showing the shared common targets.</p
The figure represents details of LogFold change ratios of miRNAs identified in SL and iSL libraries.
No full text<p>The figure represents details of LogFold change ratios of miRNAs identified in SL and iSL libraries.</p
miRNA-target KOBAS analysis and interaction network of significantly up-regulated and down-regulated miRNAs of <i>Ae. aegypti</i>.
No full text<p>(<b>A</b>) Graph represents significant pathways of up-regulated miRNAs after KOBAS analysis. (<b>B</b>) Graph represents significant pathways of down-regulated miRNAs after KOBAS analysis. (<b>C</b>) The targets common among the miRNAs are represented by red color star. Up-regulated miRNAs are shown by red colour rectangle and green color rectangles represent down-regulated miRNAs. Names of all miRNAs and targets are shown in figures.</p
Real Time PCR data analysis of miR-281-5p and miR-7-3p.
No full text<p>Fold change value obtained from RNA-Seq analysis are also represented in the figure.</p
