7 research outputs found
Exploring community midwives\u27 perceptions of their work experience after deployment in the rural areas of Chitral, Pakistan.
No full textAims:
To explore the perceptions of community midwives about their work experiences after deployment in the rural settings of Chitral, Khyber Pakhtunkhwa, Pakistan.
Methods:
A qualitative descriptive approach was used, conducting in-depth semi-structured interviews with 13 community midwives.
Findings:
The three major themes that emerged from the analysis of the data were: (1) rural community midwives\u27 perceptions of their role and competencies, (2) factors facilitating and hindering the rural community midwives\u27 ability to function, and (3) continuation of community midwives\u27 services in the future.
Conclusions:
The study findings highlighted the factors that empower and obstruct community midwives in providing services in rural areas. The majority of the community midwives felt empowered because of their increased earning capacity and enhanced competencies in performing their roles. However, some of them shared challenges in terms of socio-cultural and financial constraints. These findings have important implications for midwives working in rural areas
Can CMWs sustain quality services and high coverage as private providers in Chitral? A three-year prospective qualitative study
No full textBackground: The maternal and neonatal mortality ratesof Chitral district of Pakistan are among the highest in the country. One of the factors that found to havepositive impact on maternal and newborn health indicators is the availability ofquality skill birth attendance because the majority of the poor women cannot access facility-based maternity care. Therefore, in 2006, the Government of Pakistan (GOP) has initiated a program to train and deploy Community Midwives (CMWs) to support safe pregnancies and births. The Aga Khan Health Service’ Pakistan, initiated the Chitral Child Survival Program (CCSP) in partnership with the National Maternal Neonatal and Child Health program. The CCSP was an intervention package deploying 28 CMWs in remote villages of the district and supported by several strategies to ensure successful transition of these CMWs in remote settings.
Aim: This study aims to assess the effectiveness of CCSP’s package of interventions and to identify the push (facilitating) and pull (hindering) factors that may have an impact on the CMW’s service utilization.
Methods: A three-year longitudinal prospective qualitative design, using individual in-depth CMWs and focus group interviews of key informants conducted in Chitral district of Khyber Pakhtunkhwa province, Pakistan in localities where the CMWs were deployed. Using purposive sampling, 27 CMWs (all part of CCSP), key informants and other stakeholders were recruited. Data analysis was done concurrently with data collection by the researcher, using Creswell’s six steps.
Findings: The major themes emerging from this study are: Safe and competent care in isolated villages, community’s support and satisfaction from the CMW work, Supportive supervision, dynamics of CMWs with other healthcare professionals, CMW’s referral systems and its challenges, CMW remuneration and fee for service , and Sustainability of the CMW services
Recommendations: Continued support, ongoing in-service education of CMWs and constant engagement of the community, certainly plays a crucial role. TheGoP could consider incorporating CMWs in the service structure with a salary based on their scope of practice. This may ensure the sustainability of the CMW model and would allowcommunity to access the MNCH services provided by them
Pediatric appendicitis score for identifying acute appendicitis in children presenting with acute abdominal pain to the emergency department
No full textObjective: To determine the diagnostic accuracy of Pediatric Appendicitis Score (PAS) in predicting appendicitis in children presenting with acute abdominal pain to the Emergency Department (ED) of a private hospital in Pakistan. Methods: This validation study was through retrospective chart review of children between 4-18 years of age with clinical suspicion of acute appendicitis, presenting to the pediatric ED. Diagnostic accuracy was determined using sensitivity, specificity, predictive values, and area under the curve (AUC). Results: 104 children (76% boys) with mean (SD) age of 10.9 (3.5) years met the eligibility criteria. 91% (n=95) patients had moderate to high PAS (score ³4), and 95% (n=99) had biopsy-proven appendicitis. The likelihood ratio calculated for low, equivocal and high-risk PAS was 0.10, 2.17 and 2.53, respectively. An equivocal PAS (score 4-6) showed a sensitivity of 96.8%, specificity of 80%, positive predictive value of 98.9% and AUC of 0.84 for predicting acute appendicitis. Conclusion: PAS showed good diagnostic accuracy in predicting acute appendicitis in children presenting to the E
Incorporating patient safety and quality course into the nursing curriculum: An assessment of student gains
No full textBackground: Training nursing students on quality and patient safety (PS) is crucial to ensuring safe healthcare practices given the key role nurses play on the healthcare team. The aim of this study was to evaluate the impact of quality and PS course on the knowledge, and system thinking of students at different stages of the undergraduate nursing course.Methods: A 4.5-day quality improvement and PS course was conducted at the Aga Khan University School of Nursing and Midwifery for 146 second- and 139 fourth-year students. Students\u27 knowledge, self-assessment of knowledge and skills, and system thinking were assessed using pretest and posttest.Results: Of the total of 20 points, the course significantly improved students\u27 knowledge by a mean of 4.91 points for second-year students (95% confidence interval [CI], 4.32-5.51) and 3.46 points for fourth-year students (95% CI, 2.90-4.02) between pretest and posttest. For systems thinking, the Systems Thinking Scale scores increased by 0.41 points (95% CI, 0.29-0.52) for second-year students and 0.33 points (95% CI, 0.22-0.44) for fourth-year students out of the total of 5 points. The self-assessment scores significantly increased on postcourse assessment for second (P \u3c 0.05) and fourth-year students (P \u3c 0.001). Positive experience reported by students in the narrative reflections complemented these results.Conclusions: There was a significant increase in nursing students\u27 knowledge, self-efficacy, and system thinking after participating in this short PS course. Replication at a national level may improve safety knowledge and skills among nursing students with subsequent gains in the safety of healthcare delivery in Pakistan
Assessing the Efficacy and Impact of Using a Simulation-Based Approach for Rapid Critical Care Capacity Development at Scale
No full textIn response to the increased COVID-19 cases and staff limitations, the need to enhance critical care capacity was identified by the Aga Khan University Hospital (AKUH). We designed and delivered a series of in-person simulation-based workshops to rapidly upskill healthcare workers in Pakistan. The primary objective of our workshops was to train healthcare workers across various medical fields to serve as supplemental intensive care unit staff if needed. A total of 19 in-person workshops were organized, targeting physicians, nurses, and allied health workers from across Pakistan. Using high-fidelity medical simulation technology, these workshops provided hands-on exposure and addressed specific learning objectives such as diagnosis and management of COVID-19 patients, shock, arrythmias, respiratory failure, oxygen titration and noninvasive ventilation, mechanical ventilation, critical care pharmacy, interpretation of arterial blood gases, code simulation, prone positioning, central line placement, and video laryngoscopy
Magrath Store News (February 21, 1963)
No full textAn archive of the Magrath Trading Store News.The University of Lethbridge Library received permission from the Wes Balderson to digitize and display this content.Thursday, February 21st, 1963
PHONES: OFFICE 21 GROCERIES 364 DRY GOODS 124 HARDWARE 34
STORE HOURS:
Wednesday......................8 A.M, to 1 P.M.................. Saturday 8 A.M. to 7
Ifegrath Alberta«
£
ABRICADABRA
SIZES 12 to 18
z
=e
E
g
c
s=
attractively styléd witjjr
patterned in Pink, Blue,
Drip Dry Cotton Baby Dresses in
styles that are sure to please
Mother, Dainty trimming in lace,
eyelet, applique, and embroidery.
COIDRS; Pink, Blue, White and
Yellow’ 298
uiiiiiihinimiiitiiiiiHiiiiimiitiiiuimttiiiiiiiniiiiiiiiiuiihtui'iiiuiiuiiiiHiiiiiiiuiUKHtniiiiHiiii
The giveable COTTON BRA that fits
like a second skin. Soft as a
handkerchief, -
REGULAR - LONG LINE-0
Upstairs
LADIES NEW SPRING DRESSES IN BECOMING STYLES. SEE THE
NEW "Koret of California” ONE AND TWO PIECE DRESSES OF
WASHABLE COTTON KNIT, New one and two piece frocks
have just arrived — LINENS, HUNTED SILKSa COTTON KNIT,
Crinkle Crepe Cotton Dusters,
ribbon and lace trim. Floral
Yellow, Turquoise and Green
SIZES 32 to 44
LONDON LASSIE BLOUSES:
and figured including the smart
"Barber Shop" blouse with plain
round neck
STRETCHY DENIM SLIMS - for
ladies. Fit superbly. In
Tan, Blue, Grey
951
THE ’>T BASKETBALL NIGHT OF . J YEAR
The Ifegrath Zeniths defeated the surprisingly zippy "All Stars” 62-44 in one of the most hard-fought games of the season* Thewe "All Stars" being out of shape and having had very little practise, justified themselves in using their ability and experience to give the younger boys a good game. Following is the scoring statistics for the "All Stars”» James (Brush) Blumell -0; George (Pots) Hamilton -Oj Walter (Pussh) Pashuk —0; Blair (Cross Foot) Sabey -7; Wes (Dutch) Rice -12; Tyler (Tex) Alston —9; Bob (Mehtab) Bourne -2; Bob (ifessey) HandLton — 5; Dean (Fritz) Harker -1; Elden Coleman —0; Dick Sabey -6; Manley-Bourne 2* For the Ifegrath Zeniths, John Taylor with 14 and Ron Hansen with 11 were high scorers» Everyone on the team hit for five or more points. The referees for this game were dashing’ young Jim Cook and somewhat - slow - but popular "Cud" Rolfson, who took a fall in the game«
At half time the foul—shotting event pulled out Lloyd Sabey as the winner with Alf Ririe shooting a close second. The other finalists in this contest of luck and'skill (I say "luck and skill" because many times the ball would twirl around and go in, and many other times it would twirl around and fall out) were Doctor Low and Lee Harker. Also included in this time period was a cheerleading contest with participants from Grades'8,9,10 and 20* The Grade 9 Girls — Linda Godionton, Helen Jean Hillmer, Bonnie Brewerton, Rose Rarick, Donna Johnson, Leota Strate, Dorothy Ann Robinson and Gloria Harris - dressed like "little girls" and displaying a might Panda Bear mascot, were awarded first price. The Grade 10 girls, looking very pretty in their costumes, took 2nd and the youngest but very promising group of Grade 8 cheerleaders grabbed 3rd. The more mature cheerleaders - Alice Stevensen, Maureen Tanner^ Betty Tanner and Lbreen Brewerton - added glamor (and humor) as they snatched the Consolation prize* Our own MiH.S. Cheerleaders with their persision and ability were delightful to watch* Ndrihg one of the time-outs, Loreen Brewerton and daughter Bonnie captivated the audience with an authentic Hawaiian hula dance which they had learned first hand in Hawaii. Emcee Juniot* Turner should be commended on his performance as program director* His resonant voice could be heard clearly fi*om all walls; The Magiath High School thanks all those who came to watch this game and thereby making it a Success; We hope thht everyone will come to the future games as well and support the Magrath Zeniths one of the finest high school teams that Magrath has ever produced and certainly one of the best teams of its class in Canada today. You may never see such high caliber high school basketball in Magrath again.
This Friday, Feb. 22nd Magrath Zeniths and Cardston Cougars will tangle in a league play-off game in the Big Gym. A good crowd will be appreciated* ’
Reporter - Sherwin Mbriyama*
"BASKETBALL AT IT’S BEST”
The Big Gym was packed. The biggest crowdever. The Magrath High School Zeniths versus "The Honored Stars". The Stars are like the "Old Grey Jfere", they are not what they used to be. The score might have been different had the referees not been so impartial??
"Once in a life time" basketball was right down our alley. The Zeniths — we have never seen their equal. They won in Regina, Sask. They couldn’t lose*
What a world this would be, we thought, if those same boys could be trained to the degree of perfection in the class room as in the gymnasium.
WHAT WAS SEEN AND HEARD • '
The"Store News" will welcome an interesting or amusing incident, an unusual story,' interview, or what have yo.u. Liberal payments will be paid for readers’ contributions, if accepted. Mrs. Norma Owens will be the judge.
Jim Blumell presented us with the book "English Lieterature". "I think you will like this book", he said. We studied English Literature for two terms at Logan, UtahJ under a professor who had few equals. We turned the pages "to some of our favorite poems, among them was Grey’s Elegry ’In A Country Church Yard". The preview to the poem stated that Grey was 9 years in composing the poem. We had read it many times but this time more carefully. The author mentioned that Wolf was reciting the poem at the Battle of Abriam Heighta Wolf says "I would rather be the author of that poem than take Quebec". He defeated the French, captured Quebec, but lost his life.
FOR SAIEj Baled straw. Also 250 gallon propane tank. Robert Matson.
FOR SALE:18 month Gurnsey heifer,
Gilbert Sheridan.
NOTICE: F.U.A. meeting this Friday evening, Feb. 22nd in the United Church Hall at 8 P.M. Guest speakers and also farewell social for Mrs, M.B. Pharis. W. Wbcknitz.
LOST - OR LEFT AT SOMEONE’S HOME - a pair of ladies black kid pumps with brown stacked heels. Also a pair of cream colored chamoislike gloves. Please phone 221.
CARD OF THANKS: We with to thank all those who helped make Sheldon and Nichole’s wedding reception such a memorable occasion* Earl and Lorelle Gurney.
CARD OF THANKS: We wish to express our thanks to all who supported us in the basketball game and other qctivities last Saturday ' night. Magrath High School, R.E. Blumell^ Principal, farm truck and X plates at my home this year be-
NOTICE: The 17th of March Social is coming up. All ladies be thinking of a cotton or print dress. Watch for further announcement, 1st & 2nd Ward R, S.
NOTICE: I will be selling passenger car, ginning March 1st. Emma Coleman,PICNIC HAMS - boneless .... lb. 69 Cl
[LIVER SAUSAGE _8oz, Chubs...... .....350
5... «».«oom .................................................................................................................................... . ............................................................................................................................
ittuunutiHihHuunitHHin
I per quart
mum HUIllI 1 IIIIUIllUhHlUUHiliinn
(Headcheese Mock Chicken .........................69C|
...................................... ..
A very pretty wedding took place in the banquet room of the Magrath Assembly Hall Friday
Feb, Sth when Bishop Nyal Fletcher united in marriage Miss Nicole'Heninger, daughter of Mr,
and Mrs, Willard D, Heninger of Foremost and Ralph Sheldon Gurney, son of Mp, and Mrs, Earl
Gurney, Attending the bride were Mrs, Vonda Gurney of Warner and Mrs, Myrna law of Ifegrathj
flower girls were Janice Gurney and Joanne Heninger and Martin Gurney wax best man for his
brother. Ushers were Bob and Arthur Heninger, Miss Linda Toomer played the Wedding March
and during the signing of the register Mr. Darwin Johnson sang "Sweet Mystery of Life",
Friday evening the bride and groom were honored at a cal ling reception. Welcoming the guests
were Mr, and Mrs, Emery Gurney and Mr, and Mrs, E, T, Law of Magrath and Mr* and Mrs, El 1_ys
Peipgrass of Raymond, Mrs, Gladys Williams of Foremost attended the guest book while Mrs,
Alice Stevensen took charge of gift arranging assisted by Miss Leora Gurney and Mrs Pearl
Nilsson and Mrs, Marie Wright of Raymond, Mrs, Laureen Brewerton was hostess for the occasion
and refreshments were served by Misses Linda Toomer, Beryl Hindley, Lenadean Smith,
Joan Christensen, Iferina Blumell and Miss Ifeureen Peipgrass of Raymond, Kitchen arrange^-
ments were in charge of Mrs. Jill Harker assisted by Mesdames Norma Zobell, Zelma Strong,
Arlene Meldrum, Ruth Johnson and Fern Cook, During the evening Mrs, Freda Fletcher was
in charge of organ music. The beautiful decorations were done by Mesdames Avilda Harker
Lois Blumell and Mary Ifergaret Blumell, The occasion marked the 74th wedding anniversary
of the groom’s grandparents, Mr. and Mrs. George A. Gurney.
The happy couple are making their home in Magrath.
The annual meeting of the Magrath Community Savings and Credit Union was held in the
Lions Club Rooms on Wednesday, Feb. 13th following a Pot Luck Supper, 'Mr, James Lynn of
Lethbridge accompanied by Mr. Drost, an executive of Credit Union Work, was guest speaker
and gave a very educational and inspirational address, Mr, Hall Poulsen, president, was
re-elected, also Mrs. Ireta Matkin on Board of Directors, Don Johnson was returned to the
Credit Committee and Carl Baxter chairman of Supervisory Committee, George Minor was elected
to take the place of Mrs, Audrey Brown who moved to Saskatchewan, An Education Committee
was elected including Mrs, Eva Thomson, Mr, ^ans Pfeffel and Mr, Wayne Smith, The year 1962
was very satisfactory for a small Credit Union; Organized May 10th, I960 membership has in—
creased to members. Shares amount 9033, both accounts doubling during
the last year, 4i10,00, Fh, R1204 or write Box 190
Magrath,
NOTICE: A very nice Border-Collie dog has
been at Spring Coulee for about a month. He
is so gentle, everybody feeds him so we ,
think someone must be looking for him, En-
^uire of Mrs. Robt, First Charger «f- Mrs.
.S, Lane, Spring Coulee
3oys Pants
SATEEN CHECK BOXERS: Slim trim
Drip - D!ry Cottons,
Flannelettes
SIZES 6-14.
fit, color fast, pre-shrunk
Elastic back. or
SIZES 2-6X.
CASUAL SATEEN SPORT CHECKS:
Styled for comfort. Fast
color, pre-shrunk. Smart
appearance. Olive or Brown
SIZES: 6-10. 3^ & 450
SIZES 11-18. 5^ & 5^
Corduroys,
t0 298
Mrs. Eva Godfrey passed away in the '
Magrath Municipal Hospital Monday evening.
She was 84 years of age. Survivors include
one daughter Mrs. Lottie Harker, Magrathand
sons Joe of Picture Btitte; Floyd,
Cardstonj Mervin and Bert, Provo, Utah*
and Douglas, San Raefel, California,
Funeral services were held this Thursday
afternoon at 2 P.M. in the Magrath Firs'»
Ward Church with Bishop Nyal Fletcher ;
officiating
COWBOY KINGS;
ular
NAVY
NAVY
NAVY
The dhoice of Champions. Pop-for
school. Pre shrunk.
DENIM, sizes 2 to 5»»-»
DENIM, sizes 6 jjo 10 .,
295
425
DENIM, sizes 11 to 18*1
TAN DENIM, sizes 11 to 18 Ü 595
Plain shades.
DUPONT NYLON STRETCH
SOCKS4 100% dupont
nylon, guaranteed
5 years .wear.
<50 I pr»
PENMANS 5 STAR 100% NYIDN Work Sock: Long
wearing, comfortable
red or blue trim.
to wear.
98C
Grey with
FRINTED BY SPECIAL REQUEST: Some Facts You
Should know About Old Age Security Pensions:
Location of Old Age Security Officers: Pensions
under the old Age Security Act are paid wholly .. EEl
by the Federal Government through its Depart- Dlen^ of wool and nylon. Endless wear, good
ment of National Health and Welfare. This looks, superb value. | AC) I 7 A
department has a Regional Office in the capital
city of each province which looks after Old
Age Security for all pensioners who live in
that province. In the case of the Yukon and
Northwest Territories only, the Regional
Office is located in Ottawa.
pr.
British -de, miracle
150 md
GREBE
MEN'S
OPEN ROAD: Popular
with the Westerner.
Grey, Tan, Blue-grey,
1195 41295
ROYAL STETSON - centredent.
Latest style
creation. |
(NEW STOCK OF GREHB WORK SHCHS ON THE
WAY) .
See the KODIAK WORK SHOE on di splay.
Styled by Grebb, it is ankle length,'
has genuine leather sole, steel arch,
plain toe.
SIZES 6 to 10.
Mr.' and Mrs. Douglas Nelson of Great
Falls, Mont, announce'the birth of d
daughter Lamie Lenore, bom Tuesday,
February 19th. A sister for Bruce,
Calen and Terry.
SEE THE NARROW BRIMS
JN "Crispin11 & Retriever,
THE MAGRATH TRADING COMPANY LTD
A Good PJace to Trade
hardware
Mr. and Mrs. Ihul Taylor had as
their weekend guests Mr, and Mrs,
Robert Allen, Provo, Utah. Mr, ’
Allen is a nephew of Mr. Taylor.
He and his bride who had just
arrived from France were married
in the Cardston Temple Saturday,
GAS RANGE.- 1963 MODEL MOFFAT GAS
RANGE - with the latest features:
1« Custom backdresting with full width fluorescent
light,
2. Therm-O-Guard Burner,
3, Centre Simmer Speed Burners
4. Simplimatic Clock with Min*te Minder
5. Fully Automatic Oven Ignition with
100% safety shutoff.
6, Silent-glide Broiler
7, Super King size oven with picture
window door.
The annual meeting of the Magrath
Irrigation Dist.'will be held in the
Town Hall Friday, Feb. 22nd at 2 P.M,
Election of officers at the close of
the meeting for one place on the Board
of Trustees. C.C. Spencer and Cyrus ’
Card seeking a position on the Board,
Polls will close at 6 PiM.
-|oovervacuum
NEW HOOVER PORTABLE VACUUM CLEANER
8,
9.
Lift-off dorr for easier oven cleaning. the latest in cleaning devices*
Comes in handsome case fitted with
PER MONTH FOR
PAYMENT PLAN ..........
2 4
DOWN.
MONTHS.
all the latest attachments, neatly
placed for easy use. When not being
used, folds up like a suit case.
Glides ’on wheels. Has verjr powerful
suction, 'Use for »leaning, demoth-ing,
spraying and blowing.
GAS DRYER : MOFFAT AUTOMATIC DRYER
FEATURING: 2 drying selections. 120 minute timer
and safety door latch.
LOW PRICE ..................
Gleaming white finish.
TIME PAYMENT PLAN .......... PER tyDNTH,
LIONS PANCaKE SUPPER Tuesday, Feb. 26th in the
Lions Club Rooms from 5 to 8 P.M. Come and enjoy
a "home cooked" meal served by the "Lions Beauties’*.
All you can eat for 1,79............... I29
IH11H II 11 HI UHI Mil 111
iliiiiilif tllumi i H11 11
Jig. h i iiiiitiiniii i itiintutiiiii’iiiniHiiiiiiiniii iiiiiiiiuiim 111111 i< i i lililí Kill l’l II Illi 111M III III
“ Oí 111 nitiiiuim iiittiiiiiiiuntiuiiiiiiKiiiiiiiitiniiiiiiiihitHiitt 1 111 ■
Available in INTERIOR LATEX and SEMI GLOSS ENAMEL. 18
colors including: Almond Pink.....Antique Pink.•...Bridal
Wreath.... Chalk Beige,...Crystal Blue .... Doeskin ....
Du»kling (yellow)....Georgia Pink...,Lemon Chiffon....Pearl
Grey..... link Lemonade..... Pink Mist.......... Rainbow Haze (grey)
Ripple (turquoise) Seafoam (it, turquoise) Stratosphere (m,
blue) Sunset Pink and Tallow (off white). -,r
PER GALLON.......... 25 PER QUART I '
OXFORD CLOTH; Available in "mix and match"
plain shades or stripes. Tan or Olive. 1 gQ
45" wide .;....*;*»..**............................ |^^ ■
Patients in the Magrath Municipal
Hospital during the past
week included Mrs, Audrey Ririe,
Mrs. Vinessa Tanner, Mrs. Ruth
Sindlinger, Mrs. Minnie Wolsey,
Baby Kormas, Mr, Dick Toomer,
Mr, Rynald Jorgensen, Mrs. Deana
Sabey and son, Mrs. June Anderson
and sAn and Mrs* Pat Sheridan,
yd.
DAN RIVER GINGHAMS: giant i» checks in
Redj Yellow, Turquoise, Black, Green and Rose all
with white* 36" wide*............................................| 2D
g" and CHECKED GINGHAMS by Dan River, Green,
yellow, orange, tan* 36" wide ,,,,,*. 1 O
CRINKLE STRIPE: 100% Drip Dry Cotton in
ractive two tone stripe. Pink and White; Tan and White.
36" wide ,i .................................. *....* f^Q
yd.
Red, ‘
yd.
att-
Tuesday evening Const,
Jake Willis, R, C. M» P*
was guest speaker at the regular
meeting of CUBS held in
the United Church Recreation
Hall, Const, Wil lis spoke on
"Safety" to 21 Cubs, Cub Master
Myrtle Matkin and Assistants
Len Whitt, Noris Tomlinson and
Jim Minor
yd.
SAILCLOTH : Sport fabric ideal for slims,
suits, kiddies jeans, etc. Black oi4 Olive.
36" in width ..................... . * | £|Q
✓
skirts,
yd.
EROADCLOTH: Gay new colors in wonderfully
washable Broadcloth, A good selection of colors in
various weights......................................................AQA OGA ’ PRINTS toDO^yd.
r n I IN ID. See the new arrivals in gay cotton prints
New Spring colors in a variety of designs." Make up
into Ladies and Children’s Dresses, Aprons, etc, Sev—
eral pieces in designs for Children, no A
590 toDcO
Weekend visitors at the home of Mr, and Mrs. E. T. Law
included their daughter Lorna, student at the Lethbridge
Junior College, also Mr. and Mrs. Collingridge and Mr,
Harry Halley of Calgary, Mrs. Collingridge is the fohmer
Nadene Smith, daughter of Mr, and Mrs. Franklin Smith,
formerly of Magrath,
Mr. and Mrs, C. C, Spencer'had as their weekend guests
their son-in-law and daughter, Mr. and Mrs, Dale Davies
and family of Calgary.
_S_T_A__N__F_I_E_L_D__'S : New arr_i_v__a_l_s in
Stanfield's Panties for little
Girls. Exquisitely made, plain
or dainty trimming in net, lace
and eyelet. Pink, Blue, White,
sizes, 2 up. 59cto79c
RIGHT RON
Then there was the party returning to his
seat at a recent show, remarking to the man
at the end of the row: "I beg your pardon,
but did I happen to step on your ioe as I
walked out at the opening of intermission?"
"You certainly did," the man replied
rather bitterly,
"Oh good," said the first party, "Then
this is the right row".
ea.
BATH TOWELS
New arrivals in
luxurious Bath
Towels. Plain or
attractively check—
69 •
KITCHEN, TPJg<g
Multi stripes on '
natural background,
large size,
PER PAIR -
THE MAGRATH TRADING COMPANY LTD
MEN’S
patterned.
LINGERIE
NYLON HALF SLIPS: Pleated nylon sheer ovei*-
skirts. lace trim. White, Turquoise or
Pink. ■ ' 19Q
REGULAR 2.98 ,1**.***.;i*»;. i,*u. u, 198
COMBINATION PANTY SLIP; floral printed arnel
in tones of turquoise and gold. Scalloped
along bottom^ p. 0
REGULAR 2*98 I.....................................................
PANTIES: Plastic pack contqining 3 pair of
Laides Panties. Applique design, assorted
colors. Q0
PACK OF 3 ..........................................J
SLIP & PANTY SETS: Half Slip and Panty Sets
in white, blue, rose, green, turquoise.
Dainty applique design. QO
GIFT BOXED....................................... I
(Dry Goods Department)
NOTIONS n
TONI HOME PERMANENTS; with hidden body. |98
Regular, Super, Gentle ..
BOBBI — the pin curl wave ¡98
powder
|98
I
POWDER COMPACTS Gold compacts in heart shape
round or square shape. With puff. |
MANICURE. SETS: Plastic zippered cases of
scissors, nail file, cuticle tools, etc.
Ideal gift items ............................. .. 198
(Dry Goods Department)
KIDDIES WEAR
INFANT'S JODHHES: Girls and Beys, figured
corduroy. 18-24 months. REG. 2.25 |QC
ROMPER SETS; Terylene 2 piece. Assorted
coiers. 6 to^ngnt^.^.^. j gg
PONDS "DATE" CASES: Angel face pressed
with puff in attractive case,
for
MENS NEEDS
STRETCHY SOCKS: all nylon. Plain and
2 Pair for 1^8 ,
MEN’S WHITE HANDKERCHIEF'S; Wide hems; soft,
already laundered. Quality packages, cello
2 packages |98
MEN’S WORK GLOVES: Kangaroo tan leather,
gore back, roper thumb. .
REGULAR 2.10......................................... ..
MEN’S SPORT SHIRTS; Blended fabric in two
tone plaids. Greys, Tans, Greens,
(Men*s Wear Department)
HOUSEHOLD NEEDS
OUTDOOR WINDOW OR WALL THERMOMETERS: Smartly
styled. .............. iQo
REGULAR 2.25
THEKM9S BOTTLES : Lunch
lids* «................................
......... |98
open spout. ’ ^gg
size, plastic cup
........ . |98
REFRIGERATOR SET; 3 piece Plastic.Food
storage containers. } |9Q
MIXING BOWL SETS: Graduated sizes, set
of 3 bowls,............... .....................j 98
(Hardware Dept.) •
LADIES-CHILDREN
LADIES WINTER HATS;■ fashionable styles in
wool felts, velours, velvets^’ ' ,QO
YOUR CHOICE................ pO
GIRLS SLIMS; Assorted styles in plain and
printed corduroys. Sizes 8 to-14* • • IQQ
YOUR CHOICE .......
BOYS FLANNELETTE PYJAMAS; Assorted patterns
and colors. Sizes 3 to 6X. | gg
BOYS T SHIRTS: Long sleeves in multi stripe
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Revisión sistemática: inhibidores de la Lipasa pancreática como alternativa de tratamiento frente a la obesidad
No full textLa obesidad es una enfermedad crónica con gran prevalencia en el mundo, la cual es
característica por un aumento de la grasa corporal, lo que puede llegar a ser un factor de
riesgo para varias enfermedades asociadas como la diabetes mellitus, enfermedades
cardiovasculares y diversos tipos de cánceres; en adultos ésta se clasifica de acuerdo al
Índice de masa corporal (IMC). Actualmente una de las estrategias para la lucha contra la
obesidad es la creación de medicamentos que tengan como objetivo la inhibición de la
lipasa pancreática (LP) o también llamada glicerol-éster hidrolasa, debida a que, se ha
llegado a comprobar que su inhibición es de gran ayuda para dar solución a este problema,
ya que, ésta es una enzima que cataliza los enlaces de ésteres de los triglicéridos; al
inactivar esta enzima los triglicéridos no van a ser catalizados y el epitelio intestinal no
podrá absorber las grasas para su posterior almacenamiento en el organismo.
El Orlistat es el único medicamento contra la obesidad avalado por la Food and Drug
Administration (FDA) que inhibe la LP, pero causa graves efectos secundarios a nivel
gastrointestinal. Se realizó una revisión sistemática teniendo en cuenta artículos de la base
de datos Pubmed Central (PMC) y se logró evidenciar algunas alternativas de posibles
tratamientos para la obesidad que inhiban la LP y que generan menos efectos adversos
que los medicamentos actualmente utilizados.Obesity is a chronic disease with great prevalence in the world, which can become a risk
factor for several diseases associated with diabetes mellitus, cardiovascular diseases and
other types of cancers; in adults it is classified according to the Body Mass Index (BMI).
Currently, one of the strategies for the fight against obesity is the creation of drugs that aim
to inhibit the pancreatic (LP) or also called glycerol-ester hydrolase, due to which, it has
been reached a test that inhibition of great help to solve this problem, since this is an
enzyme that catalyzes the triglyceride ester bonds; When this enzyme is inactivated, the
triglycerides will not be catalyzed and the intestinal epithelium will not be able to absorb fats
for later storage in the body.
Orlistat is the only anti-obesity medication endorsed by the Food and Drug Administration
(FDA) that inhibits LP, but causes gastrointestinal side effects. A systematic review was
carried out taking into account articles from the Pubmed Central database (PMC) and it was
possible to demonstrate some alternatives of possible treatments for obesity that inhibit LP
and that generate fewer adverse effects than the drugs currently used.RESUMEN 10
INTRODUCCIÓN 12
OBJETIVOS 15
1. ANTECEDENTES 16
2. MARCO TEÓRICO 23
2.1 DEFINICIÓN Y CLASIFICACIÓN DE LA OBESIDAD 23
2.2 CAUSAS DE LA OBESIDAD 25
2.2.1 DISMINUCIÓN DE LA ACTIVIDAD FÍSICA 26
2.2.2 MALOS HÁBITOS DE ALIMENTACIÓN 26
2.2.3 GENÉTICA 27
2.2.4 CONDICIONES SOCIALES Y ECONÓMICAS 28
2.2.5 MEDICAMENTOS 29
2.2.6 MALOS HÁBITOS DE SUEÑO 31
2.2.7 DISRUPTORES ENDOCRINOS 32
2.2.8 DAÑOS PSICOLÓGICOS 33
2.3. CONSECUENCIAS DE LA OBESIDAD 34
2.3.1 ENFERMEDADES CARDIOVASCULARES 35
2.3.2 DIABETES MELLITUS (DM 37
2.3.3 RESISTENCIA A LA INSULINA 38
2.3.4 CÁNCERES 39
2.3.5 DISLIPIDEMIAS 40
2.4 EPIDEMIOLOGÍA 42
2.5 LEY DE LA OBESIDAD 43
2.6 TRATAMIENTO FARMACOLÓGICO DE LA OBESIDAD 44
2.7 TRATAMIENTO QUIRÚRGICO DE LA OBESIDAD 46
2.8 LIPASA PANCREÁTICA 47
2.9 LA LIPASA PANCREÁTICA COMO DIANA TERAPÉUTICA 49
2.10 INHIBIDORES DE LA LIPASA PANCREÁTICA 50
2.10.1 Extractos de plantas, árboles y frutas (flavonoides) 50
2.10.1.1 Las proteínas hidrofóbicas en los tilacoides 51
2.10.1.2 El gel de Aloe vera: 52
2.10.1.3 Plantas usadas en la medicina tradicional tailandesa 53
2.10.1.4 Cuadrania Tricuspidata: 55
2.10.1.5 Flavonoides: 57
2.10.1.6 El Pinhão 58
2.10.1.7 El aceite esencial de Rhaponticum acaule 59
2.10.1.8 El té (Camellia sinensis 59
2.10.1.9 Cosmos caudatus 59
2.10.1.10 Citrolive 60
2.10.1.11 Diospyros kaki fruit y Citrus unshiu peel (PCM) 60
2.10.1.12 El tratamiento de arroz integral germinado (GBR) 61
2.10.2 Bacterias 62
2.10.2.1 Lactobacillus gasseri (LG2055) 62
2.10.2.2 El factor adipocito inducido por ayuno o la proteína angiopoyetina tipo 4
(Fiaf/ANGPTL4) 63
2.10.2.3 Microbiota intestinal 64
2.10.3 Endófitos en plantas 64
2.10.3.1 Viola odorata 64
2.10.4 HERRAMIENTAS COMPUTACIONALES PARA EL DISEÑO DE FÁRMACOS
INHIBIDORES DE LIPASA PANCREÁTICA 66
3. DISEÑO METODOLÓGICO 67
3.1 Tipo de estudio 67
3.2 Universo 67
3.3 Población 67
3.4 Muestra 67
3.5 Criterios de inclusión 68
3.6 Criterio de exclusión 68
4. RESULTADOS 70
5. DISCUSIÓN 74
6. CONCLUSIONES 79
REFERENCIAS BIBLIOGRÁFICAS 80INTRODUCCIÓN 17
1 ANTECEDENTES 19
2 MARCO TEÓRICO 22
2.1 Leptospirosis 22
2.1.1 Características generales de Leptospira spp. 22
2.1.2 Taxonomía 27
2.1.3 RESERVORIOS 28
2.1.4 Epidemiología 30
2.1.5 Factores de Virulencia 32
2.1.6 Patogénesis 33
2.1.7 La respuesta inmune en el control de la infección 37
2.1.8 Manifestaciones clínicas 37
2.1.9 Complicaciones 40
2.1.10 Diagnóstico 41
2.1.11 Control y prevención 43
2.1.12 Tratamiento 44
2.2 Estado actual de la Leptospirosis 45
2.2.1 Contexto mundial 45
2.2.2 Contexto en Latinoamérica 46
2.2.3 Contexto en Colombia 46
3 OBJETIVOS 48
3.1 Objetivo general 48
3.2 Objetivos específicos 48
4 DISEÑO METODOLÓGICO 49
4.1 Tipo de investigación 49
4.2 Universo, población y muestra 49
4.2.1 Universo 49
4.2.2 Población 49
4.2.3 Muestra 49
4.3 Criterios de selección 50
4.3.1 Criterios de inclusión 50
4.3.2 Criterios de exclusión 50
4.4 Variables 51
4.5 Instrumentos 52
4.6 Técnicas y procedimientos 52
4.6.1 Identificación de anticuerpos por MAT 53
5 RESULTADOS Y ANÁLISIS 59
5.1 Descripción de la población 59
5.2 Resultados obtenidos en la prueba MAT 67
5.2.1 Resultado positivo 69
5.2.2 RESULTADO NEGATIVO 69
5.3 Caracterización serológica de Leptospira spp 70
6 DISCUSIÓN 77
7 CONCLUSIONES 84
8 RECOMENDACIONES 85
9 REFERENCIAS 86PregradoBacteriólogo(a) y Laboratorista Clínic
