4,054 research outputs found
Maternal ApoE genotype and risk of recurrent pregnancy loss: An updated systematic review and meta‐analysis
No full textBackgroundIn order to clarify the role of the maternal apolipoprotein E (ApoE) genotype and the risk of recurrent pregnancy loss (RPL), we herein performed an updated systematic review and meta-analysis to reevaluate the evidence on this association. MethodsA comprehensive literature search was performed on PubMed, Web of Knowledge and the Cochrane library up to September 2022. Methodological study quality was assessed using the Newcastle-Ottawa Scale and the credibility of significant pooled odds ratios (ORs) was estimated by the false positive report probability and the Bayesian false discovery probability. ResultsTwelve studies published from 2009 to 2022 fulfilled the inclusion criteria. In the overall analysis, the epsilon 4 allele was found to confer an increased risk of RPL compared to the epsilon 3 allele (OR 1.60, 95% CI 1.00-2.55, p = 0.049) and women carrying the ApoE epsilon 4 allele displayed a higher risk of RPL compared with those carrying the epsilon 2 and epsilon 3 alleles (OR 1.75, 95% CI 1.06-2.87, p = 0.028). Subgroup analysis based on subjects' ethnicity revealed that these associations were restricted to the Asian population (epsilon 4 allele vs. epsilon 3 allele, OR 5.93, 95% CI 1.79-19.61, p = 0.004; epsilon 4 allele carriers vs. carriers of epsilon 2 and epsilon 3 alleles, OR 8.42, 95% CI 1.47-48.12, p = 0.017). None of the associations detected were found to be noteworthy under false positive report probability or Bayesian false discovery probability at a prior probability of 0.001. ConclusionsThis updated meta-analysis highlights an association between maternal ApoE genotype and RPL risk in Asians, but not in Caucasians. Further case-control studies are warranted in women of Asian ancestry to exclude the possibility of false-positive findings
Aeroelastic characteristics of cylindrical hybrid composite panels with viscoelastic damping treatments
No full textSupersonic flutter analysis of cylindrical composite panels with structural damping treatments has been performed using the finite element method based on the zig-zag layerwise shell theory. The natural frequencies and loss factors of cylindrical viscoelastic composites are computed considering the effects of transverse shear deformation. And Kumhaar's modified piston theory is applied for the calculation of aerodynamic forces. The flutter of cylindrical composite panels is analyzed considering structural damping effect. With respect to aeroelastic stabilities, various damping characteristics of unconstrained layer, constrained layer, and symmetrically co-cured sandwich laminates are compared with those of an original base panel. (c) 2006 Elsevier Ltd. All rights reserved
Complications of nephrotic syndrome
No full textNephrotic syndrome (NS) is one of the most common glomerular diseases that affect children. Renal histology reveals the presence of minimal change nephrotic syndrome (MCNS) in more than 80% of these patients. Most patients with MCNS have favorable outcomes without complications. However, a few of these children have lesions of focal segmental glomerulosclerosis, suffer from severe and prolonged proteinuria, and are at high risk for complications. Complications of NS are divided into two categories: disease-associated and drug-related complications. Disease-associated complications include infections (e.g., peritonitis, sepsis, cellulitis, and chicken pox), thromboembolism (e.g., venous thromboembolism and pulmonary embolism), hypovolemic crisis (e.g., abdominal pain, tachycardia, and hypotension), cardiovascular problems (e.g., hyperlipidemia), acute renal failure, anemia, and others (e.g., hypothyroidism, hypocalcemia, bone disease, and intussusception). The main pathomechanism of disease-associated complications originates from the large loss of plasma proteins in the urine of nephrotic children. The majority of children with MCNS who respond to treatment with corticosteroids or cytotoxic agents have smaller and milder complications than those with steroid-resistant NS. Corticosteroids, alkylating agents, cyclosporin A, and mycophenolate mofetil have often been used to treat NS, and these drugs have treatment-related complications. Early detection and appropriate treatment of these complications will improve outcomes for patients with NS
Gate driving method for synchronous rectifiers in phase-shifted full-bridge converter
No full textIn high output current applications such as server power system, a phase-shifted full-bridge (PSFB) converter uses parallel connected power MOSFETs in synchronous rectifiers to reduce secondary conduction loss. However, it causes large gate driving loss. Therefore, this paper proposes a simple synchronous rectifiers (SRs) gate driving method for the PSFB converter. The proposed method reduces the supply voltage of SRs gate driver with a conventional input resistor and capacitor of SRs gate driver during the overlapping time of OR-gated signals in SRs. Therefore, without additional components and control techniques, the proposed method can significantly reduce the gate driving loss on SRs especially in light load conditions. The validity of the proposed method is confirmed by experimental results from a prototype with 400V input and 750W/12V output
Correction: Differential expression of MicroRNAs in Alzheimer’s disease: a systematic review and meta-analysis (Molecular Psychiatry, (2022), 10.1038/s41380-022-01476-z)
No full textIn this article the affiliation details for Author JAE IL SHIN were incorrectly given as ‘Department of Psychiatry, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea’ but should have been ‘Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea’. The original article has been corrected
Effect of renal Doppler ultrasound on the detection of nutcracker syndrome in children with hematuria
No full textTo assess the detection rate of nutcracker syndrome in children with isolated hematuria, renal Doppler ultrasound examinations were routinely performed on 216 consecutive children (176 microscopic hematuria and 40 gross hematuria). Renal Doppler ultrasound was also performed on 32 healthy normal children. The peak velocity (PV) was measured at the hilar portion of the left renal vein (LRV) and at the LRV between the aorta and the superior mesenteric artery. The PV at the aortomesenteric portion (P=0.003) and the PV ratios of the LRV (P=0.003) were significantly higher in children with hematuria than in normal children, while the PV at the hilar portion was not different. If a PV ratio of the LRV of at least 4.1 (the cut-off level set at the mean ±2 SD of the value for the normal children) was defined as abnormal, 72 cases (33.3%) in children with hematuria and no cases in normal children were diagnosed as having nutcracker syndrome. The prevalence of nutcracker syndrome is relatively high in children with isolated hematuria, and the inclusion of renal Doppler ultrasound as a screening examination has a substantial effect on the detection of nutcracker syndrome.ope
High‐Quality Stereo Depth Map Generation Using Infrared Pattern Projection
No full textIn this paper, we present a method for obtaining a high-quality 3D depth. The advantages of active pattern projection and passive stereo matching are combined and a system is established. A diffractive optical element (DOE) is developed to project the active pattern. Cross guidance (CG) and auto guidance (AG) are proposed to perform the passive stereo matching in a stereo image in which a DOE pattern is projected. When obtaining the image, the CG emits a DOE pattern periodically and consecutively receives the original and pattern images. In addition, stereo matching is performed using these images. The AG projects the DOE pattern continuously. It conducts cost aggregation, and the image is restored through the process of removing the pattern from the pattern image. The ground truth is generated to estimate the optimal parameter among various stereo matching algorithms. Using the ground truth, the optimal parameter is estimated and the cost computation and aggregation algorithm are selected. The depth is calculated and bad-pixel errors make up 4.45% of the non-occlusion area.
A digital leading phase current reduction (LPCR) technique for CCM boost PFC in light load conditions
No full textThis paper proposes a leading phase current reduction (LPCR) technique in a continuous conduction mode (CCM) boost power factor correction (PFC) for light load power factor (PF) improvement. The proposed LPCR technique provides the corrected average inductor current reference and the modified duty ratio feed-forward (MDFF) technique which can cancel the effect of the phase lead currents resulting from the EMI filter and input capacitor. Moreover, the proposed LPCR also provides the optimal dead-zone from the corrected current reference and MDFF. Therefore, the proposed LPCR can improve the power quality and efficiency not only in high AC line voltage range but also in extreme light load conditions. The principle and analysis of the proposed LPCR are presented, and the performance and feasibility are verified by experimental results from 230Vrms input and 750W–400V output laboratory prototype
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