50 research outputs found
Solid waste management in Manali
No full textManali is a popular hill resort of India located in state of Himachal Pradesh in north-western Himalayan
region of the country. It attracts about a million tourists annually. As a result the town has a large number of hotels and floating population of the town touches a peak of about 35,000 against a fixed population of about 5000 residents during peak season.
Proper solid waste management has been a burning issue at Manali for sometime as the descretion of landscape
was beginning to be noticed by large number of tourist visiting the place. Collection of waste has been a major
constraint due to difficult hilly terrain. Disposal options are also limited as the land for disposal is hard to come by. Manali is a favourite summer resort for a large number of
important decision makers and prominent citizens of India, including the Prime Minister, clean Manali has therefore
been an issue for consideration at national level. Government of Himachal Pradesh under a funded scheme invited the author to study the situation and
formulate a solid waste management project strategy for Manali. The work therefore was undertaken in 1999 to
study existing situation and develop a properly formulated action plan
Solid waste management in Manali
No full textManali is a popular hill resort of India located in state of Himachal Pradesh in north-western Himalayan
region of the country. It attracts about a million tourists annually. As a result the town has a large number of hotels and floating population of the town touches a peak of about 35,000 against a fixed population of about 5000 residents during peak season.
Proper solid waste management has been a burning issue at Manali for sometime as the descretion of landscape
was beginning to be noticed by large number of tourist visiting the place. Collection of waste has been a major
constraint due to difficult hilly terrain. Disposal options are also limited as the land for disposal is hard to come by. Manali is a favourite summer resort for a large number of
important decision makers and prominent citizens of India, including the Prime Minister, clean Manali has therefore
been an issue for consideration at national level. Government of Himachal Pradesh under a funded scheme invited the author to study the situation and
formulate a solid waste management project strategy for Manali. The work therefore was undertaken in 1999 to
study existing situation and develop a properly formulated action plan
Towards a Habitable Earth: Transitional Logistics: A New Transportation Template in The Kullu Valley
No full textManali, the second largest urban settlement in The Kullu Valley, is a major tourist destination in the state of Himachal Pradesh. The town is made up of two setlements, Old Manali and New Manali. The original settlement of Old Manali is located high in the hills above New Manali and has an urban morphology whichhas been built up slowly over time around a major market street. The location and urban fabric of Old Manali makes it inherently resilient from the major natural hazards which Manali faces, mainly landslides, avalanches, and earthquakes. However, it is the heritage, alongside the recreational activities which bring tourists to Old Manali. These activities are accommodated by the local inhabitants of Manali, who mainly live in the settlements closer to the river, in New Manali, and by doing so put themselves at risk of landslides. This risk has come about through over development in New Manali. New Manali’s urban belt has expanded into the town’s nature reserve to create access to the Manali highway and The Rohtang Pass beyond. By doing this, New Manali provides and entry point for tourists traveling to Old Manali, with the linking road between the two settlements being continuously occupied with traffic which moves tourist between the two settlements. Here we see a system of Supply and Demand between these two sub regions of Manali. Therefore, the tourism industry has destabilized the resilience of New Manali, through uncontrolled over evelopment, which has led to an environment which is highly susceptible to landslides but also contains living environments which on an everyday basis are detrimental tothe health and safety of the local residents of New Manali. However, it is not tourism itself that is causing these problems, it is the way in which tourism is managed that creates this unsustainable environment. The most notable aspect of this is road traffic. From this analysis, a new station house is proposed, removing the car from the streets of Manali and replacing the link between Old and New with a cable car. It is located in an expanded nature reserve which aims to re-stabilize the ground which leads from the towns urban belt to the river,preventing landslides. The station house will be constructed from a new typological hybrid which interrelated the building methods of the vernacular Kathkhuni with the typological flexibility of the modern vernacular, allowing it to be adapted from a singular home to a large public building. By doing this, small units will interlink, enabling the construction to be completed by unskilled workers and make it a constructible typology available to all.This station house acts as a test unit for the reproduction of this typology throughout the valley, enabling the expansion of the cable car system and the hybrid construction system, to renovate unsafe concrete structures. This transportation system is then connected digitally through the introduction of a digital mobile app, connection people and transport both physically and digitally.Ryan McGaffney is a Scottish architecture graduate with a deep interest in the implementation of sustainable development and resiliency in the built environment. He is a graduate of The Mackintosh School of Architecture, The Glasgow School of Art, Glasgow, United Kingdom, holding a Bachelor of Architecture which he received in 2014. In 2018 he graduated cum laude with honourable mention from TU Delft, The Netherlands with a Master of Science in Architecture, Urbanism, & The Built Environment. He has worked in the field of architecture at Tham & Videgård Arkitekter in Stockholm, Sweden, and Denton Corker Marshall Architects in Melbourne, Australia. - August 2018Atelier for Resilient Environmental architectur
Adding audio clips functionality to TaleBlazer/
No full textThesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2016.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (pages 107-108).TaleBlazer is a platform for creating and playing mobile location-based augmented reality games. This thesis describes the design and implementation of audio clips functionality in the platform. Audio clips are recordings that can be attached to text in TaleBlazer games. This report presents results from conducting user testing of the new feature and specifies the subsequent improvements that were made. It also details the infrastructure enhancements made to improve all media support on the platform, including audio clips.by Manali A. Naik.M. Eng
State-of-the-art REDOR and TEDOR methods for elucidation of protein structure and interactions
No full textProtein structure determination is vital for elucidating their function, folding or misfolding pathways, and their interaction with other biomolecules, small molecules and membranes. In the field of neurodegenerative disorders like Parkinson’s Disease and Alzheimer’s Disease, amyloid fibrils that constitute the aggregates in the diseased brain are formed due to misfolding of proteins like a-synuclein (a-syn) and amyloid-b. Understanding the structure of these amyloid fibrils will be beneficial for probing amyloid- ligand interactions, amyloid-membrane interactions and even their misfolding pathways. This dissertation thesis introduces some state-of-the-art solid-state nuclear magnetic resonance (SSNMR) techniques to investigate protein structures and their interactions, which will facilitate the study of amyloid fibrils formed in the neurodegenerative disorders.
One of the major biophysical techniques to probe biomolecular structure and their interactions is magic angle spinning (MAS) SSNMR spectroscopy due to its ability to examine insoluble systems and with no inherent restriction on the size of the molecule. For structure determination and refinement, we employ famous and robust techniques like rotational echo double resonance (REDOR) and transferred echo double resonance (TEDOR) that recouples the dipolar couplings between two selective heteronuclear spins present in the biomolecule. The dipolar coupling is directly proportional to the gyromagnetic ratio (g) of the spins and indirectly proportional to the cube of the distance between them. Hence, fitting the dipolar dephasing curves to Bessel function of first kind provide us quantitative, precise and unambiguous distance restraints within or between molecules and these distance restraints will assist the structure calculations or docking of small molecules or other biomolecules to the proteins.
Structure or ligand binding mode determination with REDOR or TEDOR has been performed extensively on all types of biomolecules, small molecules and inorganic compounds in the past couple of decades. However, due to utilization of lower g nuclei in the spin pair and restrictions in the pulse sequence, the sensitivity, resolution, the distance detection range, and the types of sample on which REDOR and TEDOR can be applied have been limited. In my thesis, I have focused on advancing REDOR and TEDOR methodology such that we can obtain quantitative and precise distances up to 1.5-2 nm. These are the longest quantitative distances obtained by SSNMR so far. This has been made possible by utilizing high g spins, like 1H and 19F as REDOR or TEDOR spins. The novel methods are multidimensional in nature, can be applied to uniformly 13C or 2H labeled proteins, highly sensitive and will be performed in reduced experimental time due to 1H-detection.
1H-detection is feasible under fast MAS and in perdeuterated proteins. Perdeuteration of protein leads to enhanced 1H spin-spin relaxation time (T2), which is a huge advantage for performing REDOR dephasing or TEDOR build-up for longer times and hence increasing the distance detection range. The REDOR or TEDOR techniques introduced in this thesis have been mainly applied on uniformly-13C, 2H, 15N (U-CDN) labeled proteins, like GB1 crystalline protein and a-syn fibrils and their mutants, back-exchanged to 10-30% 1H. 1H-detected REDOR or TEDOR techniques developed here are unique in measuring distances between the side chain 13C atoms and backbone 1H atoms in the proteins, thereby providing accurate restraints for side chain orientations and not only backbone restraints.
Performing REDOR with 19F atom is advantageous because of the usefulness and popularity of 19F atom in the drug or diagnostic agent development industry. In our studies, we have also successfully demonstrated the incorporation of 19F atom in a-syn fibrils through mutagenesis and chemical modification. Thereafter, we performed 13C-19F REDOR to obtain distances of up to 10 Å and with our newly developed 1H-detected REDOR pulse sequence, we obtained 1H-19F unambiguous REDOR distances of up to 17 Å in a-syn fibrils. Taken together, this thesis lays a foundation towards shaping REDOR and TEDOR spectroscopy to be feasible for — (1) structure determination and refinement of uniformly 13C labeled and perdeuterated proteins, and (2) binding mode determination of fluorinated imaging agents or drugs, and lipid membranes to amyloid fibrils like a-syn, or non-fluorinated small molecules to 19F- labeled proteins.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2021-08-01The student, Manali Ghosh, accepted the attached license on 2019-06-17 at 19:31.The student, Manali Ghosh, submitted this Dissertation for approval on 2019-06-17 at 19:41.This Dissertation was approved for publication on 2019-06-18 at 12:41.DSpace SAF Submission Ingestion Package generated from Vireo submission #14051 on 2019-11-26 at 13:03:32Made available in DSpace on 2019-11-26T20:49:14Z (GMT). No. of bitstreams: 2
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Effect of First Premolar Extraction on Point A, Point B, and Pharyngeal Airway Dimension in Patients with Bimaxillary Protrusion
No full textEvaluation of Surface Runoff Estimation in Ungauged Watersheds Using SWAT and GIUH
No full textAbstractSoil and Water Assessment Tool (SWAT) is a physically based distributed model that can estimate runoff, sediment and soil erosion from agricultural watersheds under different management conditions. The new SWAT has provision to simulate watershed process using sub daily rainfall. Though the model is generally meant for continuous modelling, the provision to make use of sub daily rainfall enables the model to be used for event modelling. GIUH is a methodology which can also be used for predicting the surface runoff from ungauged basins. On assessing the performance of these models in modeling of different events in Manali watershed, it is concluded that the GIUH method are marginally better than that from the SWAT model
Fiesta: Parallelism for Data Collection and Intelligent Inference in a Distributed Heterogeneous Environment
No full textAuthor Correction: Fast inter-frame motion correction in contrast-free ultrasound quantitative microvasculature imaging using deep learning
No full textResearch project work plan for multi-modal intersections :: resolving conflicts between trains, motor vehicles, bicyclists and pedestrians
No full textReport -- Appendix A -- Appendix B -- Appendix C -- Appendix D.Title from PDF title page (viewed on December 21, 2017)."FHWA-OR-18-04"--Technical report documentation page.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references (pages 159-165).Sponsored by Oregon Department of Transportation, Research Section; Federal Highway AdministrationMode of access: Internet from the Oregon Government Publications Collection.Text in English.Final reportThis archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Covers OCLC #1016161929 and OCLC #1047612320
