1,928 research outputs found
Low plasma pyridoxal-5’-phosphate levels are associated with elevation of the inflammation marker, C-reactive protein
No full text<i>In vitro</i> ubiquitylation assay of <i>Pf</i>UBA1 and <i>Pf</i>UBC.
No full text<p>(<b>A</b>) 6xHIS-tagged recombinant <i>Pf</i>UBA1 (E1) and <i>Pf</i>UBC (E2) are depicted and anti-HIS blots reveal purification. (<b>B</b>) <i>In vitro</i> ubiquitylation assays were performed with recombinant <i>Pf</i>UBC (E2), which revealed an attachment of a single ubiquitin when incubated with human UBA1 (E1) (second lane from the right) and an increased number of ubiquitylation products when both UBA1 and recombinant <i>Pf</i>HRD1(E3) was added (far right lane). (<b>C</b>) When incubated with human UBA1 (E1), recombinant <i>Pf</i>UBC (E2) (along with the other necessary reagents) attaches polymers of ubiquitin to recombinant <i>Pf</i>HRD1 (E3) (far right lane). (<b>D</b>) Recombinant <i>Pf</i>UBA1 (E1) is capable of attaching a single ubiquitin to recombinant <i>Pf</i>UBC (E2), which is depicted by the appearance of a 27 kDa band (second lane from the right). Extra banding was not detected with the addition of recombinant <i>Pf</i>HRD1 (E3) (far right lane).</p
Contextual metrical invisibility
No full textIn some languages, certain vowels are invisible to syllable-sensitive processes, but only in certain contexts. This paper argues that metrically invisible vowels are undominated by a syllable node in prosodic structure. Considering mainly Mohawk and Passamaquoddy, the behavior of these "weak vowels" is derived from pressure to avoid using weak vowels as syllable nuclei, countered by pressure to realize underlying segments in well-formed syllables. Because not only epenthetic vowels can be weak vowels, their unsuitability as syllable nuclei is derived representationally, through amount of underlying prosodic structure. Existing analyses of the data are critiqued, and the theoretical implications and potential extensions are discussed.The definitive version of this paper was published in PF: Papers at the Interface (1997) and is available at http://mitwpl.mit.edu/catalog/mwpl30/Hagstrom, P. (1997). Contextual metrical invisibility. In B. Bruening, Y. Kang, & M. McGinnis (Eds.) PF: Papers at the interface (pp. 113-181). Cambridge, MA: Department of Linguistics and Philosophy, Massachusetts Institute of Technology
The portraits of the female author: the case of Ángela Figuera Aymerich
No full textEste artículo se enmarca en el Programa Severo Ochoa (referencia PA-17-PF-BP16126) de Ayudas predoctorales para la investigación y la docencia del Gobierno del Principado de Asturias
native non-endemic flora for each abundance class. [n = total in each category; D? = probably extinct; RR = very rare; R = rare; PF = infrequent or disseminated; LOC = localised; C = common; CC = very common] in Floristic analyses of the Corsican flora: biogeographical origin and endemism
No full textnative non-endemic flora for each abundance class. [n = total in each category; D? = probably extinct; RR = very rare; R = rare; PF = infrequent or disseminated; LOC = localised; C = common; CC = very common]Published as part of Jeanmonod, Daniel, Naciri, Yamama, Schlüssel, André & Gamisans, Jacques, 2015, Floristic analyses of the Corsican flora: biogeographical origin and endemism, pp. 21-41 in Candollea 70 (1) on page 27, DOI: 10.15553/c2015v701a3, http://zenodo.org/record/572090
The prosodic structure of Serbo-Croatian function words: An argument for tied constraints
No full textThe question of the proper treatment of clitics has received considerable attention in literature on the syntax-morphology and morphology-phonology interfaces. Selkirk (1996) proposes an elegant theory of the prosodification of clitic function words crosslinguistically, demonstrating that variation in the behavior of function words both within a language (English) and across dialects of a language (Serbo-Croatian) follows straightforwardly from re-rankings of universal constraints in an Optimality Theory. In this paper I argue that, in addition to strict re-rankings of constraints, tied constraints are also needed within such a system, in order to capture the Serbo-Croatian facts. I discuss three empirical shortcomings of Selkirk¹s analysis, all involving optionality, and show how they can be remedied by appealing to a particular notion of what it means for constraints to be tied in rank. To the extent that Selkirk¹s basic insights are correct, this supports the conclusion that tied constraints play an important role in OT accounts of the ways in which dependent and independent morphemes are combined into larger prosodic units. It adds to the growing evidence for "crucial nonranking", whereby separate tableaux are computed for each ordering of the relevant constraints and the output of each is a valid possibility in the language.The definitive version of this paper was published in MITWPL 30: PF: Papers at the Interface (1997) and is available at http://mitwpl.mit.edu/catalog/mwpl30/Schütze, C.T. (1997). The Prosodic Structure of Serbo-Croatian Function Words: An Argument for Tied Constraints. In B. Bruening, Y. Kang, & M. McGinnis (Eds.) PF: Papers at the Interface. Cambridge, MA : MIT Dept. of Linguistics
La Suissesse au bord du lac - Don Mus.Ms. 2435 : V, pf; A
No full textJacques-Nicolas GouléQuelle: manuscript. - Provenienz: Fürstlich Fürstenbergische Hofbibliothek, DonaueschingenLa Suissesse au bord du lac. | Romance | Avec Accompagnement de Pianoforte | ou Harpe. | Goul
Stochastic Nodal Analysis: EnKF and PF applied to petroleum production systems
No full textA petroleum production system is generally modelled based on the concept of nodal analysis, where the entire system is broken down into discrete elements such as near-well bore, tubing, surface choke and flow line. Operating flow rates and pressures can be estimated with a nodal analysis procedure by calculation of the intersection of performance curves. Input parameters in nodal analysis of production systems are considered deterministic, however, some of these parameters are better represented as distributions. In this report, the ensemble-based data assimilation methods “ensemble Kalman filter” (EnKF) and “particle filter” (PF) are applied to steady-state models of a production system for tuning of uncertain model parameters during the test separator phase. The performance of the EnKF and the PF is tested with the use of twin experiments. The calibrated model parameters of the choke, tubing and the near-well bore elements with EnKF and PF can be used to create an ensemble of performance curves leading to an ensemble of operating flow rates and pressures. The foreseen next step is to use the posterior distributions of model parameters as inputs for soft sensing of flow rates during semi-steady-state production for a single phase oil reservoir, where the oil rate and reservoir pressure are considered as unknown parameters. In the twin experiments as used in this thesis, a total number of three steady-state pressure drop measurements was used to estimate a total of six independent parameters which constitutes an ill-posed problem, resulting in non-unique parameter estimates. It is recommended to alleviate this issue by either reducing the number of parameters or by using multiple separator tests at different flow rates.Petroleum Engineering and Geo-science
PI3K/mTOR Dual Inhibitor PF-04691502 Is a Schedule-Dependent Radiosensitizer for Gastroenteropancreatic Neuroendocrine Tumors
No full textPatients with advanced-stage gastroenteropancreatic neuroendocrine tumors (GEP-NETs) have a poor overall prognosis despite chemotherapy and radiotherapy (e.g., peptide receptor radionuclide therapy (PRRT)). Better treatment options are needed to improve disease regression and patient survival. The purpose of this study was to examine a new treatment strategy by combining PI3K/mTOR dual inhibition and radiotherapy. First, we assessed the efficacy of two PI3K/mTOR dual inhibitors, PF-04691502 and PKI-402, to inhibit pAkt and increase apoptosis in NET cell lines (BON and QGP-1) and patient-derived tumor spheroids as single agents or combined with radiotherapy (XRT). Treatment with PF-04691502 decreased pAkt (Ser473) expression for up to 72 h compared with the control; in contrast, decreased pAkt expression was noted for less than 24 h with PKI-402. Simultaneous treatment with PF-04691502 and XRT did not induce apoptosis in NET cells; however, the addition of PF-04691502 48 h after XRT significantly increased apoptosis compared to PF-04691502 or XRT treatment alone. Our results demonstrate that schedule-dependent administration of a PI3K/mTOR inhibitor, combined with XRT, can enhance cytotoxicity by promoting the radiosensitivity of NET cells. Moreover, our findings suggest that radiotherapy, in combination with timed PI3K/mTOR inhibition, may be a promising therapeutic regimen for patients with GEP-NET
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