1,604,084 research outputs found
Graduate Recital: Kenneth Long, composition
No full textMr. Long is a student of Paul Cooper.Pesemá, Kenneth Long -- Vigil, Kenneth Long -- Winter Music, Kenneth Long -- Four Haiku, Kenneth Long -- There is an Empty House, Kenneth Lon
JACOBSON RADICAL ALGEBRAS WITH QUADRATIC GROWTH
No full textWe show that over every countable algebraically closed field K there exists a finitely generated K-algebra that is Jacobson radical, infinite-dimensional, generated by two elements, graded and has quadratic growth. We also propose a way of constructing examples of algebras with quadratic growth that satisfy special types of relations.</p
A. O. Jacobson
No full textThis house was originally built by Michael Mauss in 1910. It is located at 365 Vine Street. Alfred O. Jacobson moved his family into the house in 1923. More information included with photo. Courtesy of Venda Jacobso
Tecniques: recent developments in computer aided engineering of GPCR ligands using the human A3 adenosine receptor as an example.
No full textG-protein-coupled receptors (GPCRs) represent the largest known family of signal-transducing molecules, and convey signals for light and many extracellular regulatory molecules. GPCRs are dysfunctional or dysregulated in several human diseases and are estimated to be the targets of O40% of the drugs used in clinical medicine today. The crystal structure of rhodopsin provides the first information on the three-dimensional structure of GPCRs, which now supports homology modeling studies and structure-based drug-design approaches
New business creation : internal ventures or spinoffs?
No full textThesis (S.M.M.O.T.)--Massachusetts Institute of Technology, Sloan School of Management, Management of Technology Program, 1998.Includes bibliographical references (leaves 86-89).by Kenneth P. Jacobson and Charles A. Myers.S.M.M.O.T
Recommended from our members
A letter from Eric Jacobson to Dr. Hector P. Garcia.
No full textA letter from Eric Jacobson, for the University of North Texas History Department, to Dr. Hector P. Garcia, thanking him for a recent meeting
Novel fluorescent hA3 adenosine receptor antagonists.
No full textActivation of the Gi protein-coupled A3 adenosine receptor (AR) is associated with anticancer, antiischemic and anti-inflammatory effects. hA3 AR antagonists are being examined as promising agents for the treatment of glaucoma.1
Fluorescent probes are useful tools to investigate specific subcellular components in cells, tissues and organisms. In high throughput screening, fluorescent ligands represents a safer, more powerful and more versatile alternative to radioligands.2
We have recently reported a series of pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine (PTP) based fluorophore-conjugated hA3 AR antagonists.3 Unfortunately, none of them reached affinities in the nM range. Here we report a novel series of PTP based fluorophore-conjugated hA3 AR antagonist with an additional pharmacophoric group at the 5-position, in order to obtain more potent hA3 AR antagonists.
References
1. Müller, C.E.; Jacobson, K.A. Recent developments in adenosine receptor ligands and their potential as novel drugs. Biochim. Biophys. Acta 2011, 1808, 1290-1308.
2. Kuder,K.; Kiec-Kononowicz, K. Fluorescent GPCR ligands as new tools in pharmacology. Curr. Med. Chem. 2008, 15, 2132–2143.
3. Kozma, E.; Kumar, T.S.; Federico, S.; Phan, K.; Balasubramanian, R.; Gao, Z.G.; Paoletta, S.; Moro, S.; Spalluto, G.; Jacobson, K.A. Novel fluorescent antagonist as a molecular probe in A3 adenosine receptor binding assays using flow cytometry. Biochem. Pharmacol. 2012, 83, 1552-1561
Goat rancher, Texas.
No full textStereograph of a herd of goats on a ranch.Attributed to: Doerr & Jacobson. Verso: [handwritten] Goat rancher. Texas. No - 18 -
[Young Girl Smiling]
No full textVerso: [imprinted] Doerr & Jacobson, 63 Commerce St., San Antonio, Tex
- …
