496 research outputs found
The presence and absence of god in the Jacob narrative
No full textThis thesis explores the theological complexity of the Jacob narrative. In particular this is centred upon the paradox of divine presence and absence, and the contrast of the human and the divine. In the first part, an investigation is made of three key episodes which contain an encounter with the divine: the opening oracle (25:19ff), Bethel (28:10-22) and Peniel (32:23-33). It is concluded that the first passage is constructed as an introduction, making explicit the theme of the presence of God in the Jacob story, but also introducing the human side of the paradox. Bethel and Peniel are based on older pre-Yahwistic traditions, now shaped and incorporated into the story of Jacob to throw a theological perspective over the wider plot. The second part consists of a reading of the wider Jacob story, with particular attention to the theme of divine presence and absence and the interaction of the human and the divine. It is argued that even the most human of stories betray a theological interest and contribute to the overall paradox, but also that there are several indications of the presence of God. In the conclusion, it is noted that behind the present unity of the Jacob story there is evidence of earlier traditions, a growing together of material, and supplements offering new perspectives. It is also concluded that a close reading of the final text and a historical-critical appreciation need not be mutually exclusive, and that a cautious use of critical insights has thrown light upon the final form. Finally, it is argued that the theme of the presence and absence of God offers a way of reading the Jacob story in a theological way, that does most justice to its historical depth, final form, and canonical status
Supplemental Material, sj-docx-1-ptd-10.1177_08968608231198984 - Systemic and local complement activation in peritoneal dialysis patients via conceivably distinct pathways
No full textSupplemental Material, sj-docx-1-ptd-10.1177_08968608231198984 for Systemic and local complement activation in peritoneal dialysis patients via conceivably distinct pathways by Bernardo Faria, Mariana Gaya da Costa, Anita H Meter-Arkema, Stefan P Berger, Carla Lima, Catia Pêgo, Jacob van den Born, Casper FM Franssen, Mohamed R Daha, Manuel Pestana, Marc A Seelen and Felix Poppelaars in Peritoneal Dialysis International</p
The dynamics of production in advance: three essays in how pre-made decisions on inventory can influence revenue-maximization and the nature of competition.
No full textProduktie van ammoniak-synthesegas met oude en nieuwe HTS-katalysator
No full textDocument(en) uit de collectie Chemische ProcestechnologieDelftChemTechApplied Science
Fragmenten van twee onbekende prognosticaties in het archief van de Abdij van Averbode
No full textThe archives of the abbey of Averbode hold an item that turns out to be a combination of fragments of two published prognostications in Dutch, for the years 1512 and 1513, now folded together. The reason why the two editions where combined is unclear.
The prognostication for 1512, only half of which has survived, was printed in Antwerp by Henrick Eckert van Homberch, who is known from a counterfeit edition of a prognostication by Laet, but not from any other editions of similar works by others. The anonymous author of the 1512 prognostication uses a lunar calendar and refers to dates by the relevant saint’s feasts. Soon after, the latter feature was adopted also by others, including Laet.
The second prognostication, for 1513, which has also been incompletely preserved, is authored by the Antwerp municipal surgeon Hendrik (or Heijnrick) van den Eynde van Lier, also known as Afineus, Afinius or Henry de Fine. He was born ca.1470 in Lier and studied medicine at Leuven as a mature student. As municipal surgeon it was his duty to inspect the Antwerp leprosery. In 1517 he graduated with a doctoral degree in medicine, astronomy and metaphysics. He was acquainted with Erasmus, who urged him to continue with the study of Greek, but he died relatively young in 1519. Apart from the newly discovered prognostication for 1513 written in Dutch, there is also a surviving copy of a prognostication for 1517 in French.
Van den Eynde must have published several more and have built up a reputation for his prognostications, because even after his death more prognostications attributed to him were published in French, including one for the year 1524 that has until now been overlooked in the bibliographical catalogues
Landscape 1:1, a study of designs for leisure in the Dutch countryside
No full textBrinkhuijsen onderzoekt in haar dissertatie hoe recreatie in de loop van de twintigste eeuw een plek kreeg in het landschap en het landschapsontwerp, van de pioniersperiode (voor W.O. II), de massacrecreatie (jaren zestig), het recreatief medegebruik (rond 1980) to de huidige periode, die Brinkhuijsen kenmerkt met "verbreding". Ze analyseert ontwerpen die invloed hebben uitgeoefend op de manier waarop we recreatielandschappen nu zien, zoals het Amsterdamse Bos uit 1934, kleinschalige recreatielandschappen en een netwerk van fietspaden en wandelpaden in de landinrichting Oukoop-Kortrijk uit 1966, natuurontwikkelingsprojecten in het rivierengebied uit de jaren tachtig en negentig en de landschapsvisie voor de Drentsche Aa uit 2005. De achteraf wat schokkende conclusie luidt dat recreatie nauwelijks van belang is geweest in het landschapsontwer
Fragmenten van twee onbekende prognosticaties in het archief van de Abdij van Averbode [Fragments of two unknown prognostications preserved in the Archvies of Averbode Abbey]
No full textThe archives of the abbey of Averbode hold an item that turns out to be a combination of fragments of two published prognostications in Dutch, for the years 1512 and 1513, now folded together. The reason why the two editions where combined is unclear.
The prognostication for 1512, only half of which has survived, was printed in Antwerp by Henrick Eckert van Homberch, who is known from a counterfeit edition of a prognostication by Laet, but not from any other editions of similar works by others. The anonymous author of the 1512 prognostication uses a lunar calendar and refers to dates by the relvant saint’s feasts. Soon after the latter feature was picked up by others, including Laet.
The second prognostication, for 1513, which has also been incompletely preserved, is authored by the Antwerp municipal surgeon Hendrik (or Heijnrick) van den Eynde van Lier, also known as Afineus, Afinius or Henry de Fine. He was born c. 1470 in Lier and studied medicine at Leuven as a mature student. As municipal surgeon it was his duty to inspect the Antwerp leprosery. In 1517 he graduated with a doctoral degree in medicine, astronomy and metaphysics. He was acquainted with Erasmus, who urged him to continue with the study of Greek, but he died relatively young in 1519. Apart from the newly discovered prognostication for 1513 written in Dutch, there is also a surviving copy of a prognostication for 1517 in French.
Van den Eynde must have published several more and have built up a reputation for his prognostications, because even after his death more prognostications attributed to him were published in French, including one for the year 1524 that has until now been overlooked in the bibliographical catalogues
Econometric analysis of the performance of cooperatives and investor owned firms in the European dairy industry
No full textKeywords: Cooperatives, IOFs, European dairy industry, logistic regression, stochastic frontier analysis, inter- and intra-firm efficiency, catch-up component, data envelopment analysis, hyperbolic technical efficiency, overall efficiency, scale efficiency, bootstrapping. In this study we measure the performance of cooperatives and investor-owned firms in the European dairy processing industry. Comparing the performance between cooperatives and investor-owned firms requires accounting for differences in their mission and objectives. Traditionally, cooperatives were established by farmers to gain access to markets, balance market powers and have a secured and sustainable income. Generally, there is a consensus in the economic literature that a cooperative can be defined as a (members)user-owned and (members)user-controlled organization that aims to benefit its (members)user. Cooperatives are transaction oriented, the members provide themselves with services they could not secure otherwise. In addition member are owners and determine the mission and strategy of cooperatives equally as the owners of the cooperative enterprise. Our study takes into account the consequences of members’ strategies for the cooperatives’ organizational structure and subsequently the significance of structure on (technical and economical) efficiencies. Although the theoretical literature emphasizes the difference in economic behavior between cooperatives and IOFs, the empirical studies have failed to follow up with theoretical approaches. The failure of the empirical studies to apply the models proposed by the theoretical literature seems to be due to either the inaccessibility of data, the inability to take into account the interests of all the various types of members and stakeholders of the cooperative, or the difficulty in testing the various hypotheses in practice. An empirical analysis of differences in financial indicators between IOFs and cooperatives in six European countries shows that cooperatives are less profitable but operationally more efficient, they have higher material costs and lower debts than IOFs. Furthermore, cooperatives display a substantially greater variation in financial indicators than IOFs. Stochastic Frontier Analysis is used to measure and compare the efficiency and production technology of cooperatives and IOFs. Cooperatives are found to have a more productive technology than IOFs, but they use their production potential less efficiently. A further empirical analysis of technical efficiency using Data Envelopment Analysis shows that explicit accounting for the objectives of cooperatives generates different outcomes compared with treating cooperatives as if they were IOFs. The results of the empirical analyses in this study promote the conclusion that measuring the performance of cooperatives as if they were IOFs produces misleading insights about the cooperatives’ performance suggesting performance suggesting that cooperatives’ performance is influenced by their organizational characteristics and members objectives. <br/
Potential applications of the cell-penetrating peptide crotamine
No full textThe use of the snake-derived cell penetrating peptide (CPP) named crotamine was investigated as a potential therapeutic agent for cancer and in metabolic conditions and as non-viral delivery vector for renal targeting.Previous studies from Prof Hayashi´s group have demonstrated the selective specificity of crotamine for actively proliferating cells, including tumor cells. In this work, we showed that the administration of crotamine by oral route, daily, for 21 consecutive days, in mouse animal models engrafted subcutaneously with melanoma cells, allowed the observation of a significant inhibition of tumor growth with increased animal survival compared with a control group.The same treatment regimen but in healthy mice (without implanted tumours), showed a reduction in the animal body weight gain, with improved glucose clearance and insulin sensitivity and alterations in adipose tissue suggesting an important change in the animal metabolism.As crotamine is considered a cell-penetrating peptide that works as a non-viral nanocarrier targeting specific cells, the conjugation of crotamine with molecules including gold nanoparticles and therapeutic genes, such as siRNA, is also described here.Furthermore, as previous studies indicated that crotamine mainly accumulates in the kidney after ip administration, we also investigated the renal accumulation, safety and specific cellular localization of crotamine in proximal tubule cells. And finally, we demonstrated for the first time the potential use of crotamine as a non-viral delivery vector complexed with siRNA, targeting proximal tubules cells, confirming the possible therapeutic use of this polypeptide to downregulate overexpressed proteins during renal conditions
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