496 research outputs found
The Randstad conurbation: a floating metropolis in the Dutch delta (co-author Paul van der Laar)
No full textThe Randstad conurbation: a floating metropolis in the Dutch delta (co-author Paul van der Laar)
The Randstad conurbation: a floating metropolis in the Dutch delta (co-author Paul van der Laar)
Some milestones in the life and work of the mathematical chemist J.J. Van laar (1860-1938): Calphad XIX (1990)
No full textThis lecture: 'Some Milestones in the Life and Work of Mathematical Chemist J.J. van Laar (1860-1938)' discusses his life and three important examples of his work. Insufficient schooling meant that Van Laar was not permitted to take academic examinations and this lack of recognized qualifications led to problems in establishing his scientific career. These difficulties brought him close to mental collapse in 1896 and 1911. At the University of Amsterdam he was opposed by J.D. Van der Waals (1837-1923) but was highly appreciated by H.W. Bakhuis Roozeboom (1854-1907). This lecture focuses on some of his achievements and describes his recognition as a scientist. H.A. Lorentz (1853-1928) played an important part in Van Laar's development as a mathematical chemist. Van Laar is said to have endowed him with 'the father role' and it is certain that Lorentz encouraged and supported him. The study of mathematical chemistry as Van Laar practiced it no longer exists. Together with Bakhuis Roozeboom, Van Laar is the founder of phase theory. Examples of his work are discussed in the sections of the melting point line of tin amalgam (1902), the spinodal (1905) and retrograde solubility (1908). The lecture concludes with a description of the final years of his life and includes the kind letter of condolence by L.S. Ornstein (1880-1941). Throughout the lecture reference is made to fragments of letters and to photographs.Applied Science
sj-pdf-1-jso-10.1177_23971983211043311 – Supplemental material for Information preferences about treatment options in diffuse cutaneous systemic sclerosis: A Delphi consensus study
No full textSupplemental material, sj-pdf-1-jso-10.1177_23971983211043311 for Information preferences about treatment options in diffuse cutaneous systemic sclerosis: A Delphi consensus study by Julia Spierings, Hilde Nienhuis, Eva van Lieshout, Jacob M van Laar and Arwen H Pieterse in Journal of Scleroderma and Related Disorders</p
sj-pdf-1-jso-10.1177_23971983231188232 – Supplemental material for Anti-thymocyte globulin exposure in patients with diffuse cutaneous systemic sclerosis undergoing autologous haematopoietic stem cell transplantation
No full textSupplemental material, sj-pdf-1-jso-10.1177_23971983231188232 for Anti-thymocyte globulin exposure in patients with diffuse cutaneous systemic sclerosis undergoing autologous haematopoietic stem cell transplantation by Yu-Hsiang Chiu, Anouk Drijver, Rick Admiraal, Anna van Rhenen, Stefan Nierkens, Jacob M van Laar and Julia Spierings in Journal of Scleroderma and Related Disorders</p
Economic value of water in agriculture: comparative analysis of a water-scarce and water-rich region in India
No full textWater productivityEconomic evaluationCrop productionIrrigated farmingWater costsWellsLivestockMilk production
De hedendaagse traditionele boerderij: Het vinden van architectonische middelen voor het ontwerp van een hedendaagse traditionele boerderij
No full textDe bereiding van kaliumpermanganaat
No full textDocument(en) uit de collectie Chemische ProcestechnologieDelftChemTechApplied Science
De oneindige ruimte
No full textOneindigheid komt in verschillende disciplines voor: zoals in de filosofie, natuurwetenschappen, theologie en kunst. Elke discipline heeft een eigen kijk op oneindigheid. Oneindigheid heeft hierdoor geen vaste definitie, het begrip kan op meerdere manieren worden geïnterpreteerd. In dit onderzoek is de definitie van oneindigheid in architectuur: De ongrijpbaarheid van een grens. Om deze definitie uit te kunnen leggen moeten we kijken naar het fundament van de architectuur (het ontwerpen van grenzen) en naar de ervaring die de mens in een ruimte heeft.Explore LabArchitectureArchitectur
The role of B cells in systemic sclerosis
No full textMarina D Kraaij, Jacob M van LaarMusculoskeletal Research Group, Institute of Cellular Medicine, School of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, United KingdomAbstract: Systemic sclerosis (SSc) is a connective disease characterized by features of autoimmunity, vasculopathy, inflammation, and fibrosis. The disease typically starts with Raynaud&rsquo;s phenomenon, followed by skin thickening in the extremities due to inflammation and fibrosis. Fibrosis results from excessive collagen production by fibroblasts, which constitutes the final common pathway of complex cellular interactions including B cells. Several studies have indicated that B cells may play a role in SSc. Lesional skin infiltrates from SSc patients consist of a variety of cells, including eosinophils, neutrophils, lymphocytes, plasma cells, and macrophages. Autoantibodies of several specificities are present in the serum of SSc patients of which antitopoisomerase 1 is the most common, and evidence has been gathered for a potential pathogenic role of some autoantibodies, eg, anti-PDGF antibodies. The blood of SSc patients contains an increased proportion of na&iuml;ve B cells but a decreased proportion of memory B cells. Furthermore, serum levels of interleukin-6, an important pro-inflammatory cytokine, have been shown to correlate with skin fibrosis. Animal models of SSc have provided more in-depth information on the role of B lymphocytes, eg, through disruption of B cell function. In this review we will discuss the evidence that B cells are involved in the pathogenesis of SSc.Keywords: B lymphocyte, systemic sclerosis, fibrosi
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