470 research outputs found
The PKC, HOG and Ca2+ signalling pathways co-ordinately regulate chitin synthesis in Candida albicans
Get PDFOpen Access via PMC2649417Peer reviewe
sj-pdf-1-ajs-10.1177_03635465211049219 – Supplemental material for Obesity Impairs Enthesis Healing After Rotator Cuff Repair in a Rat Model
No full textSupplemental material, sj-pdf-1-ajs-10.1177_03635465211049219 for Obesity Impairs Enthesis Healing After Rotator Cuff Repair in a Rat Model by Scott M. Bolam, Young-Eun Park, Subhajit Konar, Karen E. Callon, Josh Workman, A. Paul Monk, Brendan Coleman, Jillian Cornish, Mark H. Vickers, Jacob T. Munro and David S. Musson in The American Journal of Sports Medicine</p
sj-pdf-1-ajs-10.1177_03635465211072557 – Supplemental material for Novel Growth Factor Combination for Improving Rotator Cuff Repair: A Rat In Vivo Study
No full textSupplemental material, sj-pdf-1-ajs-10.1177_03635465211072557 for Novel Growth Factor Combination for Improving Rotator Cuff Repair: A Rat In Vivo Study by Mark Zhu, Mei Lin Tay, Khoon S. Lim, Scott M. Bolam, Donna Tuari, Karen Callon, Michael Dray, Jillian Cornish, Tim B.F. Woodfield, Jacob T. Munro, Brendan Coleman and David S. Musson in The American Journal of Sports Medicine</p
Alice Munro\u27s Short Fiction against the Slovene Literary and Cultural Background
Get PDFKanadska pisateljica Alice Munro, mojstrica sodobne kratke proze in prejemnica Nobelove nagrade za književnost leta 2013, je pozornost literarnih kritikov v svoji domovini pritegnila že leta 1968 z objavo svoje prve zbirke kratkih zgodb. V dolgoletni pisateljski karieri je izdala štirinajst zbirk kratkih zgodb, za katere je prejela številne pomembne književne nagrade, med drugim leta 2009 mednarodno nagrado man booker za življenjsko delo. Številne njene zbirke so postale mednarodne prodajne uspešnice, v Sloveniji pa je bila popolnoma spregledana vse do leta 2003, ko je bila v slovenščino prevedena ena izmed njenih zgodb, šele leta 2010 pa sta bili v slovenščino v celoti prevedeni dve njeni zbirki. Potem ko je avtorica leta 2013 prejela Nobelovo nagrado, smo poslovenili še dve njeni zbirki. Osrednje vprašanje, na katerega želi odgovoriti disertacija, je, zakaj je bila Alice Munro v Sloveniji tako dolgo spregledana. Naša predpostavka je, da se razlogi za to skrivajo tako v specifikah njene pisave kot v posebnostih slovenskega kulturnega in literarnega prostora. Pisavo Alice Munro odlikujejo dovršen literarni slog, zapletene pripovedne tehnike, »regionalizem« in osveščenost glede ženskega vprašanja. Zaradi omenjenega je prenos njenih del v slovenski kulturni in literarni prostor problematičen, še posebej zaradi drugačnega razvoja zvrsti kratke zgodbe pri nas, drugačne tradicije ženske književnosti, ki je povezana z družbenopolitično preteklostjo tega prostora, ter zaradi posebnosti slovenske prevajalske in založniške politike, ki igrata pomembno vlogo pri odločanju o tem, kateri tuji avtorji bodo prevedeni v slovenščino.The Canadian author Alice Munro, master of the contemporary short story and winner of the 2013 Nobel Prize in Literature, received the attention of literary critics in her home country already in 1968, with the publication of her first short-story collection. In her longstanding career, she has published fourteen short story collections, among which many received important literary awards, including Man Booker International in 2009, and several became international best-sellers. However, she was completely overlooked in Slovenia until 2003, when one of her stories was translated into Slovene. It was not until 2010 that two of her collections finally appeared in Slovene, followed by two other by 2015. The issue that this thesis addresses is why Alice Munro was neglected in Slovenia for so long. Our main assumption is that the reasons for the neglect of her work lie in the specifics of her writing, as well as in the specifics of the Slovene cultural and literary space. Munro’s writing, which is characterized by complex writing aesthetics and narrative art, as well as by regionalism and the predilection for women’s issues, cannot be easily transferred into the Slovene environment, where the short-story genre as well as women’s writing have a different tradition, the latter being related to this area’s specific socio-political past. Another particularity of the Slovene literary and cultural space is its translation industry and publishing policy, which play a crucial role in deciding which foreign authors will be translated into Slovene
Retroacetabular stress-shielding in THA
No full textRocco P. Pitto, Akanksha Bhargava, Salil Pandit, Jacob T. Munr
Musculoskeletal Modelling and the Physiome Project
No full textThis chapter presents developments as part of the International Union of Physiological Sciences (IUPS) Physiome Project. Models are multiscale, multispatial and multiphysics, hence, suitable numerical tools and platforms have been developed to address these challenges for the musculoskeletal system. Firstly, we present modelling ontologies including several markup languages used to facilitate storage, sharing and exchange of numerical models. Secondly, custom software tools, CMISS and CMGUI, are then presented in the development of anatomically based geometrical models. Customisation methods are also presented to morph generic models into subject-specific representations. Thirdly, population based modelling and statistical shape analysis methods are presented as efficient techniques that harness the power of big data and imaging databases. These allow prediction of human anatomy from minimal geometric information. Fourthly, a specific example of our framework is presented in the context of a validated orthopaedic clinical tool used for assessing osteolytic defects around implants. Finally, EMG-informed muscle modelling is presented combined with medical imaging to better understand musculoskeletal injury. The problem of NaF PET CT is used to highlight the problem of patellofemoral pain
Quantitative CT-assisted osteodensitometry of femoral adaptive bone remodelling after uncemented total hip arthroplasty
No full textRocco P. Pitto, Aknaksha Bhargava, Salil Pandit, Cameron Walker, Jacob T. Munr
South German Silver, European Textiles, and Venetian Trade with the Levant and Ottoman Empire, c. 1370 to c. 1720: A non-mercantilist approach
Get PDFA recurrent and indeed persistent problem in European economic history – a veritable deus ex machina -- from medieval to modern times, is Europe’s supposed ‘balance of payments’ problem in trade with the ‘East’. This supposed problem has often been couched in Mercantilist overtones: namely, that export of supposedly large volumes of precious metals, especially, silver to conduct trade with, first the Levant, and then with the rest of Asia meant a serious drainage of wealth from western Europe. This seems to be particularly true in the debate about the late-medieval ‘Great Depression’ in which some contend that this balance of payments ‘deficit’ led to monetary contraction, deflation, and then economic depression. This paper, while not denying periodic problems of monetary contraction and indeed deflation, provides a non-Mercantilist perspective on not just European but global trade from the fourteenth to early eighteenth centuries. It offers the following related theses: (1) That late-medieval monetary contraction was far more related to falling outputs of mined silver and to reductions in the income-velocity of coined money and the related problem of hoarding, the roots of which were the growth of international warfare from the 1290s, significantly financed by coinage debasements; and together they provided serious barriers to the international flow of specie and bullion, and indeed to the emergence of bullionist philosophies, which are the very core of Mercantilism. (2) That, insofar as such monetary contractions did lead to deflation, that deflation, in augmenting the purchasing power of silver (gram for gram), provided the profit motive for the technological solutions to this very same problem: namely, innovations in both mechanical and chemical engineering that produced the South German silver-copper mining boom, which quintupled Europe’s silver supplies from the 1460s to the 1540s, when even cheaper supplies of silver were arriving from the Spanish Americas. (3) That South German silver-copper mining boom, controlled by German merchant bankers who also controlled the now thriving fustian-textile (linen-cotton) industry, had two related consequences: (a) it was a major factor in the revival and expansion of the European economy in general and the growth of the Antwerp market in particular, via new transcontinental trading routes from Venice through Germany to the Brabant Fairs, based on a tripod of English woollens, South German metals, and Portuguese spices. (b) at the same time, it promoted a great expansion in Venetian trade with the Levant, to acquire not only Asian spices but also large quantities of Syrian cotton to feed the booming German fustians industry. (4) While the 15th-century Venetian trade with the Levant did indeed require large amounts of silver, perhaps enough to pay for two thirds of goods acquired in the Levant, the 16th century commerce with not just the Levant but the far larger Ottoman Empire benefited from a very new trade: the exports of fine quality Venetian woollens. This paper examines the reasons for both the rise and fall of the Venetian cloth industry (5) While traditional explanations for the rapid decline of the Venetian cloth industry in the 17th century have focused on Venice’s own ‘internal faults’, this paper offers an alternative explanation: how England’s new Levant Company and the English cloth industries so successfully gained a major share of Ottoman and Persian markets, at the direct expense of Venice: through a combination of diplomacy and superior naval technology. Their success meant that even less silver was required to conduct this trade with the Ottoman Empire, than had been true for Venice. (6) A further major factor in the decline of Venice in the 17th century was the final loss of the Asian spice trades, which had involved close Venetian ties with the Ottomans, to the Dutch and the English, who succeeded where the Portugese had failed. That story in turn allows us, with much more ample data, to examine the nature of vastly larger ‘balance of payments deficits’, so that as much as 80 percent of Asian goods had to be acquired with silver. That silver came not from Europe but principally from the Spanish Americas. Thus the major thesis of the paper is that first the South German and then the Spanish American silver mining booms greatly benefited Europe by promoting a vast increase in truly global trade.Venice, Levant, Ottoman Empire, South Germany, Antwerp, Portugal, England, Asia, East Indies, balance of payments, gold, silver, international trade,
ImPACT™ Performance of High School Student Athletes with ADHD
Get PDFBACKGROUND: To date, two studies demonstrate that adolescents with ADHD tend to perform poorer on the Immediate Post-Concussion Assessment and Cognitive Test (ImPACT; Lovell, 2013) at baseline than do adolescents without ADHD at baseline (Elbin et al., 2013; Zuckerman, Lee, Odom, Solomon, & Sills, 2013). In an effort to replicate and extend these studies, the baseline and immediate post-concussion performance of high school athletes with and without ADHD were evaluated to identify potential differences between groups on the ImPACT’s domains.
SUBJECTS: Student athletes were recruited from a private high school. Baseline testing was conducted biannually to establish pre-injury/baseline levels of individual participants. Thirty-eight students with ADHD and a matched control group of thirty-eight students without ADHD were used to test the first hypothesis. Twenty-three students with ADHD and a matched control group of twenty-three students without ADHD who sustained a concussion were used to test the second and third hypotheses. Additional analyses were performed on data from four student athletes with ADHD who sustained a concussion.
METHOD: Data were used from a larger study conducted by a large public metropolitan university. Variables included demographic information and the ImPACT. All data were stored on an encrypted computer or in a locked file cabinet.
RESULTS: Independent samples t-tests revealed significant differences between athletes with ADHD and non-ADHD athletes at baseline on the Impulse Control (t (74) = 2.73, p < .01) and the Total Symptoms (t(74)= 2.63, p < .05) scores of the ImPACT. A multivariate analysis of variance (MANOVA) was conducted on data from two time periods. A statistically significant difference (F(6, 39) = 2.86, p = .02; Wilks’ ? = 0.694; ?2 = .31) in ImPACT performance was found between non-concussed athletes with ADHD tested at baseline and concussed athletes without ADHD tested within 72 hours of injury (M = 1.83 days). Further analysis using independent samples t-tests found that athletes with ADHD at baseline performed significantly better than concussed athletes without ADHD tested within 72 hours of injury, on the following composites: Verbal Memory (t(44)= 2.25, p < .05), Visual Motor Speed (t(44)= 2.33, p < .05), Reaction Time (t(44)= -3.42, p < .01), and Total Symptoms (t(44)= -3.52, p < .01). No significant between-group differences were found on the Visual Memory or Impulse Control composites of the ImPACT.
DISCUSSION: These findings indicate that administration of the ImPACT to individuals with ADHD is appropriate. At baseline, both groups performed similarly on Verbal Memory, Visual Memory, Visual Motor Speed and Reaction Time. However, the overlap in ADHD and concussion profiles on Impulse Control and Visual Memory warrant caution in the clinical interpretation of the ImPACT profiles of individuals with ADHD. Nevertheless, these findings suggest that the overall use of normative data within an ADHD population is appropriate, and baseline testing has values for athletes with ADHD
Periprosthetic femoral fractures after total hip arthroplasty
No full textBACKGROUND: The management of periprosthetic fracture following a total hip arthroplasty is difficult, requiring expertise in both trauma and revision surgery. With rising numbers of patients in the population living with hip prostheses in situ, the frequency of these fractures is increasing, and controversy remains over their ideal management. The objective of this study was to review all periprosthetic fractures at a single institution to identify injury and treatment patterns and their associated clinical outcomes. METHODS: Fifty-four periprosthetic fractures in 50 patients were reviewed to determine the relative frequency of fracture types, their complication rates and the clinical outcomes. Patient data were obtained through review of the clinical notes and individual patient follow up. Clinical outcomes were evaluated using the Oxford Hip Score and Harris Hip Score. RESULTS: The 54 fractures were classified using the Vancouver system, most of which were type B1 (20) or type B2 (10). The mean time to union for all fracture types was 4.6 months. A high non-union rate was seen among fractures fixed operatively. Fifteen per cent of fractures went on to develop loosening following treatment, suggesting an underrecognition at the time of injury. The average Harris Hip Score was 73.1 and Oxford Hip Score 30.3 for all fracture types at a mean follow up of 3.3 years. In the 15 patients treated with revision surgery, the most common complication was dislocation (27%). CONCLUSION: Treatment of patients with periprosthetic fractures requires recognition of the challenging nature of these injuries, the associated poor prognosis and the high complication rate.Simon W. Young, Salil Pandit, Jacob T. Munro and Rocco P. Pitt
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