28 research outputs found
Pair-epitopes vaccination: enabling offspring vaccination in the presence of maternal antibodies
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The Influence of Variation among Replicates on Repeatability
No full textThis chapter first illustrates how a large number of observations can inform the design of a particular experiment intended to test rigorously the causes of the observed associations. It does so through the discussion and analysis of two case studies drawn from experimental immunology: (i) the efficacy of vaccines for Newcastle disease virus in poultry, and (ii) cancer immunotherapy. It then shows that it is important when repeating experiments to reproduce not only the expected result (i.e., the estimated mean value) but also to reduce the variability in estimates of the mean. Reduction in overall variance can be accomplished both with more precise measurements and by accounting for additional sources of error (covariates or “nuisance” variables). When potentially important covariates are recorded during an experiment, they can be included in the analysis of the data and help to isolate the true “signal” of the experimental treatment from the “noise” of the experimental environment.</p
Abstract 3633: Combination of innate immune activators stimulates leukocyte populations in the tumor microenvironment
No full textTargeted microbeads for attraction and induction of specific innate immune response in the tumor microenvironment
No full textGene Expression Associated With Virus Resistance in Chickens
No full textWe used the powerful contemporary genetic technologies of micrarray and Q-PCR to test global gene expression in a unique population of birds after challenge with infectious bursal disease virus (IBDV). Identification of genes that have differential expression between resistant and susceptible birds helps to determine the mechanisms of host resistance to this virus and may be used to select breeding stock for greater innate resistance to viral infection.</p
Abstract LB-327: Targeted microbeads for attraction and induction of specific innate immune response in the tumor microenvironment
No full textAbstract
Anti-tumor activity of molecules and cells of the innate immune system has been reported. Here we propose a method for targeting preferred innate immune cells and magnifying their tumoricidal effect at the tumor microenvironment, by modular multiple-component complexes. As a model, micro-complexes carried monoclonal anti-HER2 antibodies, lipopolysaccharide and mannose. The complexes showed high binding capacity to HER2-positive cancer cells in vitro, high induction of interleukin-1 RNA transcription by the activated monocytes and ability to mediate monocytes’ attachment to HER2-positive cells. We thus present a new vision of targeting a desired innate immune response to the tumor microenvironment.
Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-327.</jats:p
Modulating the innate immune activity in murine tumor microenvironment by a combination of inducer molecules attached to microparticles
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