416 research outputs found
sj-pdf-1-jso-10.1177_23971983211043311 – Supplemental material for Information preferences about treatment options in diffuse cutaneous systemic sclerosis: A Delphi consensus study
No full textSupplemental material, sj-pdf-1-jso-10.1177_23971983211043311 for Information preferences about treatment options in diffuse cutaneous systemic sclerosis: A Delphi consensus study by Julia Spierings, Hilde Nienhuis, Eva van Lieshout, Jacob M van Laar and Arwen H Pieterse in Journal of Scleroderma and Related Disorders</p
sj-pdf-1-jso-10.1177_23971983231188232 – Supplemental material for Anti-thymocyte globulin exposure in patients with diffuse cutaneous systemic sclerosis undergoing autologous haematopoietic stem cell transplantation
No full textSupplemental material, sj-pdf-1-jso-10.1177_23971983231188232 for Anti-thymocyte globulin exposure in patients with diffuse cutaneous systemic sclerosis undergoing autologous haematopoietic stem cell transplantation by Yu-Hsiang Chiu, Anouk Drijver, Rick Admiraal, Anna van Rhenen, Stefan Nierkens, Jacob M van Laar and Julia Spierings in Journal of Scleroderma and Related Disorders</p
Economic value of water in agriculture: comparative analysis of a water-scarce and water-rich region in India
No full textWater productivityEconomic evaluationCrop productionIrrigated farmingWater costsWellsLivestockMilk production
The role of B cells in systemic sclerosis
No full textMarina D Kraaij, Jacob M van LaarMusculoskeletal Research Group, Institute of Cellular Medicine, School of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, United KingdomAbstract: Systemic sclerosis (SSc) is a connective disease characterized by features of autoimmunity, vasculopathy, inflammation, and fibrosis. The disease typically starts with Raynaud&rsquo;s phenomenon, followed by skin thickening in the extremities due to inflammation and fibrosis. Fibrosis results from excessive collagen production by fibroblasts, which constitutes the final common pathway of complex cellular interactions including B cells. Several studies have indicated that B cells may play a role in SSc. Lesional skin infiltrates from SSc patients consist of a variety of cells, including eosinophils, neutrophils, lymphocytes, plasma cells, and macrophages. Autoantibodies of several specificities are present in the serum of SSc patients of which antitopoisomerase 1 is the most common, and evidence has been gathered for a potential pathogenic role of some autoantibodies, eg, anti-PDGF antibodies. The blood of SSc patients contains an increased proportion of na&iuml;ve B cells but a decreased proportion of memory B cells. Furthermore, serum levels of interleukin-6, an important pro-inflammatory cytokine, have been shown to correlate with skin fibrosis. Animal models of SSc have provided more in-depth information on the role of B lymphocytes, eg, through disruption of B cell function. In this review we will discuss the evidence that B cells are involved in the pathogenesis of SSc.Keywords: B lymphocyte, systemic sclerosis, fibrosi
Research Report 1: Are breeding success in spring and dominance in winter correlated in blue tits (Cyanistes caeruleus)?
No full textDe begeleider en/of auteur heeft geen toestemming gegeven tot het openbaar maken van de scriptie.
The supervisor and/or the author did not authorize public publication of the thesis.
IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics
No full textSystemic sclerosis is an autoimmune connective tissue disease in which T cells play a prominent role. We and others have previously demonstrated a role for T cell-derived IL-13 in mediating the induction of collagen in dermal fibroblasts and that blockade with IL-13 antibodies attenuates this increase. In this study we want to probe the signalling that underpins IL-13 mediated matrix deposition. Isolated dermal fibroblasts were incubated with recombinant IL-13 and gene expression by qRT-PCR was performed for collagen1A1 and TGF-β1. Small interfering RNA (siRNA) was used to knock down STAT6 and a small molecule inhibitor was also used to block this pathway. MiR-135b was transfected into fibroblasts plus and minus IL-13 to see if this miR plays a role. miR-135b was measured in systemic sclerosis fibroblasts isolated from patients and also in serum. Results showed that IL-13 increased collagen expression and that this is independent from TGF-β1. This is dependent on STAT6 as targeting this blocked induction. MiR-135b reduces collagen induction in fibroblasts and scleroderma fibroblasts have lower constitutive levels of the miR. We further demonstrate that miR135b is repressed by methylation and may include MeCP2. In conclusion we show that STAT6 and miR-135b regulate IL-13-mediated collagen production by fibroblasts
Retraído: los autoanticuerpos anti-ribosomal-fosfoproteína penetran en las células neuronales a través de la proteína asociada al crecimiento neuronal, afectando las células neuronales in vitro
No full textThe above article from Rheumatology ‘Anti-ribosomal-phosphoprotein autoantibodies penetrate to neuronal cells via neuronal growth associated protein, affecting neuronal cells in vitro’ by Shaye Kivity, Yehuda Shoenfeld, Maria-Teresa Arango, Dolores J. Cahill, Sara Louise O`Kane, Margalit Zusev, Inna Slutsky, Michal Harel-Meir, Joab Chapman, Torsten Matthias and Miri Blank, published online on 06 May 2016 by Oxford University Press, has been retracted by agreement between the journal Editor, Dr Jacob M. van Laar, The British Society for Rheumatology and Oxford University Press. The retraction has been agreed due to the discovery of significant errors relating to methods and presentation of results
Targeting the TLR4–MD2 axis in systemic sclerosis
No full textInappropriate activation of Toll-like receptor 4 (TLR4) on resident fibroblasts, through the binding of damage-associated molecular patterns, is a potential driver of fibrosis in systemic sclerosis. New evidence suggests that targeting fibroblast-specific TLR4 or an accessory molecule MD2 could have therapeutic value
An exploration in Visual Semiotics and Phenomenology, to propose India's Entry for the Venice Biennale
No full textThe thesis aims to address the Emotional and Cultural void in architecture today. A dialogue between Deleuze’s thoughts on the logic of sensation (as equivalent to Emotion) in art, and thoughts on the interpretation of the nine primary sensations or the Navrasa in the Natyashastra, form its philosophical basis. Deleuze was a famous 20th century philosopher, widely studied today in the architectural fraternity as well and Natyashastra is an ancient Indian treatise on dramaturgy. Besides these, texts on architectural and aesthetic semiotics were important sources. The suggestions put forth are argued for in a way that combines textual, visual and physical means. Writing too becomes a dimension of research, as much as sketching, coding and modelling, which together informs the process in ways that an isolated approach does not. With the hope of achieving greater lucidity, the narration surrenders an intellectual highpoint in favour of exploring an emotionally indulgent manner. The text forms the theoretical basis for proposing India's Entry for the Venice Biennale.ExploreLabArchitectureArchitecture and The Built Environmen
Connective tissue diseases: Nucleosomes and systemic sclerosis
No full textSystemic sclerosis (SSc) is characterized by an abnormal immune response to innocuous antigens that might lead to autoantibody production. New observations suggest that nucleosomes can mediate both IgG production and B-cell proliferation, via Toll-like receptor signalling, and thereby affect the pathogenesis of SSc.
Refers to Yoshizaki, A. et al. Nucleosome in patients with systemic sclerosis: possible association with
immunological abnormalities via abnormal activation of T and B cells. Ann. Rheum. Dis. http://dx.doi.org/10.1136/
annrheumdis-2015-20740
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