188 research outputs found
On the use of rational-function fitting methods for the solution of 2D Laplace boundary-value problems
No full textA computational scheme for solving 2D Laplace boundary-value problems using rational functions as the basis functions is described. The scheme belongs to the class of desingularized methods, for which the location of singularities and testing points is a major issue that is addressed by the proposed scheme, in the context he 2D Laplace equation. Well-established rational-function fitting techniques are used to set the poles, while residues are determined by enforcing the boundary conditions in the least-squares sense at the nodes of rational Gauss–Chebyshev quadrature rules. Numerical results show that errors approaching the machine epsilon can be obtained for sharp and almost sharp corners, nearly-touching boundaries, and almost-singular boundary data. We show various examples of these cases in which the method yields compact solutions, requiring fewer basis functions than the Nyström method, for the same accuracy. A scheme for solving fairly large-scale problems is also presented.Technion, Israel Institute of Technology. Advanced Circuit Research CenterSingapore-MIT Alliance Computational Engineering ProgrammeUSC Viterbi School of Engineering (Postdoctoral Fellowship
The application of artificial thermoluminescence to uranium exploration and uranium ore genesis studies / by Mark Brett McEwen Hochman
No full textTypescript (Photocopy)Includes copies of 5 published papers co-authored by the author in backBibliography: leaves 214-230xi, 230, [86] leaves : ill., maps (some col.) ; 30 cm.Thesis (Ph.D.)--University of Adelaide, Dept. of Geology and Geophysics, 199
Software Reliability Engineering: An Evolutionary Neural Network Approach
No full textAuthor: Robert Hochman Title: Software Reliability Engineering: An Evolutionary Neural Network Approach Institution: Florida Atlantic University Thesis Advisor: Dr. Taghi M. Khoshgoftaar Degree: Master of Science Year: 1997 This thesis presents the results of an empirical investigation of the applicability of genetic algorithms to a real--world problem in software reliability --- the fault--prone module identification problem. The solution developed is an effective hybrid of genetic algorithms and neural networks. This approach (ENNs) was found to be superior, in terms of time, effort, and confidence in the optimality of results, to the common practice of searching manually for the best--performing net. Comparisons were made to discriminant analysis. On fault--prone, not--fault--prone, and overall classification, the lower error proportions for ENNs were found to be statistically significant. The robustness of ENNs follows from their superior performance over many data configurations. ..
American Goat - 1991
No full textAuthors include: Jennifer Aquino, Thomas Hochman, John Jacob, Terry Jacobus, Trace Reddell, Hannah Alexander, Glen Brown, Tom Caulfield, Robert Cooperman, Carol Granato, John Dickson, Randall Foster, Bill Hennessey, Joan Payne Kincaid, Ellen Lieberman, Effie Mihopoulos, Sheryl L. Nelms, Carma Park, Haia Prosor, Gertrude Rubin, Beth Copeland Vargo, Constance Vogel, Jeffery L. Watershttps://neiudc.neiu.edu/goat/1000/thumbnail.jp
Organizing meeting of Labor and Peoples' ORT, Advertising Club
No full textUnder the chairmanship of B.C. Vladeck, the founding meeting of Labor and Peoples' ORT includes: Louis Hollander, Dr. Mendl Sudarsky, Julius Hochman, Dr. David Lvovitch, Adolph Held, Baruch Charney Vladeck, Mrs. Emma Dubinsky, (elected President), Benjamin Tabachinsky, David Pinsky, Henry Greenfield, Dr. S. Silverberg, Joseph Weinberg, Isidore Nagler and Jacob Heller, March 22, 1938.Digital ImageDigital finding aid available
Dalí would love the confusion surrounding art
No full textAn artcile about the supposed Dali works annonymously donated to a Salvation Army in Houston Texas. The author notes that Bruce Hochman of the Salvador Dali Gallery and Joseph Nuzzolo of the Salvador Dali society have differing views. The work ""Don Quichott""(article's spelling) is mentioned
Human sporadic breast carcinoma histotypes driven by the Human Betaretrovirus homologous to Mouse Mammary Tumor Virus
No full textThe viral hypothesis for human sporadic breast carcinoma is based on the murine model of Mouse Mammary Tumor Virus (MMTV)-induced mammary tumors. Known risk factors like estrogens, obesity, and alcohol do not play a direct causal role. The Human Betaretrovirus (HBRV), also called Human Mammary Tumor Virus (HMTV), is the human homolog of MMTV, implicated in sporadic breast carcinoma (80% of ductal carcinoma in situ and 40% of invasive tumors). In contrast, hereditary breast carcinomas lack viral sequences. Murine mammary tumor histotypes are determined by specific viral strains activating definite molecular pathways via insertional mutagenesis. Similarly, the diverse histotypes observed in human invasive breast carcinoma may be influenced by a viral etiology. A study of 253 invasive breast carcinoma cases, representing 15 histotypes, detected HBRV/MMTV-ENV sequences in 20%, consistent with international literature. All histotypes tested positive except those linked to hereditary syndromes, such as medullary, apocrine, and metaplastic carcinoma. This distinction reinforces the reported lack of association between HBRV/HMTV and hereditary breast cancer, while supporting a viral etiology for sporadic carcinoma. Relevant characteristics of sporadic histotypes align with the “hit and run” hypothesis of viral carcinogenesis. Histotype differences may result from molecular pathways activated by Int genes, though mechanism beyond insertional mutagenesis and the possibility of specific HBRV strains cannot be ruled out. The potential for detected viral sequences to originate in human tumors from endogenous MMTV or contamination with murine material is critically examined
The Empty Center: Fictions, Documents, and the Self
No full texthttps://rdc.reed.edu/v1/resources/a0cf52fc-5feb-43b1-9aab-1f3fc590ff30/thumb/128.jpgThis thesis proposes a reading of a trope of the document in three French-language works from the latter half of the 20th century, in light of the proliferation of scientific discourses, specifically social-scientific ones. The subjects of each chapter are respectively the novel Solibo Magnifique by Patrick Chamoiseau, the film Chronique d’un été – Paris 1960, directed by Jean Rouch & Edgar Morin, and the novella Un Cabinet d’amateur by Georges Perec. A definition of the document is proposed as a referential text that is identified with reality and is authorized to act upon it. As fiction is by definition non-referential, it is asked how the operations of a document change when cited in a fictional text. The trope of the document is a means of answering this question, by investigating the aesthetic function of the document. Fiction separates the author and the narrator whereas the document takes as its premise a unified author-narrator. The first chapter uses J. L. Austin’s theory of speech acts to demonstrate the function of the document in the narrative, and it is argued that this is part of an ethnographic metatext. The second chapter draws upon film theorist David Bordwell’s conception of narration in film as encompassing of all elements to consider the structure of a narrative film that is also documentary/ethnographic and the explicit and implicit claims to truth therein. The third chapter reads Perec’s novella, a text which confuses document, referent, and fiction, and contrasts verisimilitude to the logic by which the document describes reality
Life after Cleavage: The Story of a β-Retroviral (MMTV) Signal Peptide—From Murine Lymphoma to Human Breast Cancer
No full textAn increasing body of evidence in recent years supports an association of the betaretrovirus mouse mammary tumor virus (MMTV) with human breast cancer. This is an issue that still raises heated controversy. We have come to address this association using the signal peptide p14 of the MMTV envelope precursor protein as a key element of our strategy. In addition to its signal peptide function, p14 has some significant post endoplasmic reticulum (ER)-targeting characteristics: (1) it localizes to nucleoli where it binds key proteins (RPL5 and B23) involved (among other activities) in the regulation of nucleolar stress response, ribosome biogenesis and p53 stabilization; (2) p14 is a nuclear export factor; (3) it is expressed on the cell surface of infected cells, and as such, is amenable to, and successfully used, in preventive vaccination against experimental tumors that harbor MMTV; (4) the growth of such tumors is impaired in vivo using a combination of monoclonal anti-p14 antibodies or adoptive T-cell transfer treatments; (5) p14 is a phospho-protein endogenously phosphorylated by two different serine kinases. The phosphorylation status of the two sites determines whether p14 will function in an oncogenic or tumor-suppressing capacity; (6) transcriptional activation of genes (RPL5, ErbB4) correlates with the oncogenic potential of MMTV; (7) finally, polyclonal anti-p14 antibodies have been applied in immune histochemistry analyses of breast cancer cases using formalin fixed paraffin-embedded sections, supporting the associations of MMTV with the disease. Taken together, the above findings constitute a road map towards the diagnosis and possible prevention and treatment of MMTV-associated breast cancer
Acute Cardiovascular Care Association position statement for the diagnosis and treatment of patients with acute myocardial infarction complicated by cardiogenic shock: A document of the Acute Cardiovascular Care Association of the European Society of Cardiology
No full textMost of the guideline-recommended treatment strategies for patients with acute coronary syndromes have been tested in large randomised clinical trials. Still, a major challenge is represented by patients with acute myocardial infarction admitted with impending or established cardiogenic shock. Despite early revascularization the mortality of cardiogenic shock remains high and roughly half of patients do not survive until hospital discharge or 30-day follow-up. However, there is only limited evidence-based scientific knowledge in the cardiogenic shock setting. Therefore, recommendations and actual treatments are often based on retrospective or prospective registry data and extrapolations from randomised clinical trials in acute myocardial infarction patients without cardiogenic shock. This position statement will summarise the current consensus of the diagnosis and treatment of patients with acute myocardial infarction complicated by cardiogenic shock based on current evidence and will provide advice for clinical practice.Funding
The authors received no financial support for the research, authorship and/or publication of this article.
Acknowledgements
Reviewer coordinator: Sigrun Halvorsen, Department of Cardiology, Oslo University Hospital Ulleval, and University of Oslo, Oslo, Norway. Reviewers: Christian Hassager, Department of Cardiology, Rigshospitalet and Department of Clinical
Medicine, University of Copenhagen, Copenhagen, Denmark; Gilles Montalescot, Sorbonne Université, ACTION Study Group, Institut de Cardiologie, Pitié-Salpêtrière Hospital (AP-HP), Paris, France; Karl Werdan, Department of Medicine III, University
Hospital Halle (Saale), Germany; Sean van Diepen, Department of Critical Care Medicine and Division of Cardiology, Department of Medicine, University of Albert; Alessandro Sionis, Cardiology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona.Thiele, H (reprint author), Univ Leipzig, Heart Ctr Leipzig, Strumpellstr 39, D-04289 Leipzig, Germany.
Zeymer, U (reprint author), Klinikum Ludwigshafen, Inst Herzinfarktforsch, Bremser Str 79, D-67063 Ludwigshafen, Germany.
[email protected]; [email protected]
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