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sj-docx-2-jet-10.1177_15266028211058686 – Supplemental material for Comparison of Early and Mid-Term Outcomes After Fenestrated-Branched Endovascular Aortic Repair in Patients With or Without Prior Infrarenal Repair
No full textSupplemental material, sj-docx-2-jet-10.1177_15266028211058686 for Comparison of Early and Mid-Term Outcomes After Fenestrated-Branched Endovascular Aortic Repair in Patients With or Without Prior Infrarenal Repair by Mario D’Oria, Jacob Budtz-Lilly, David Lindstrom, Goran Lundberg, Magnus Jonsson, Anders Wanhainen, Kevin Mani and Jon Unosson in Journal of Endovascular Therapy</p
sj-docx-1-jet-10.1177_15266028211058686 – Supplemental material for Comparison of Early and Mid-Term Outcomes After Fenestrated-Branched Endovascular Aortic Repair in Patients With or Without Prior Infrarenal Repair
No full textSupplemental material, sj-docx-1-jet-10.1177_15266028211058686 for Comparison of Early and Mid-Term Outcomes After Fenestrated-Branched Endovascular Aortic Repair in Patients With or Without Prior Infrarenal Repair by Mario D’Oria, Jacob Budtz-Lilly, David Lindstrom, Goran Lundberg, Magnus Jonsson, Anders Wanhainen, Kevin Mani and Jon Unosson in Journal of Endovascular Therapy</p
Kaplan-Meier survival curves for patients undergoing open repair.
No full textData are stratified by number of received transfusions (0, 1–2, 2–3, 4–5 or >5) (left) or by transfused or non-transfused patients (right). Follow-up is shown for up to 10 years after aortic repair.</p
Development in transfusions and blood loss during 15-year follow-up period.
No full textUpper left: Mean blood loss (mL) per patient across time. Upper right Mean number of transfusions per patient across time. Lower: Development in transfusions and blood loss from January 1, 2000 to December 31, 2014. P value calculated with year 2000 as reference.</p
Hazard ratio (95% CI) for mortality, all transfused patients and dose-dependent subgroups compared to non-transfused patients (reference group).
No full textAbove: Forest plot based on HR in table below Forest plot. Model I: Adjusted for age and gender. Model II: Adjusted for all baseline variables and characteristics (gender, age, preoperative hemoglobin and creatinine, bleeding, BMI, smoking, diabetes, hypertension, cerebrovascular, cardiac and respiratory disease). * P value Fig 4).</p
Dose-dependent hazard ratio (95% CI) for selected postoperative in-hospital complications.
No full textDose-dependent hazard ratio (95% CI) for selected postoperative in-hospital complications.</p
Baseline characteristics, preoperative variables, and perioperative bleeding.
No full textBaseline characteristics, preoperative variables, and perioperative bleeding.</p
Flow chart of patient selection process with excluded and included patients.
No full textData were retrieved from The Danish Vascular Registry during the period of January 1, 2000 to December 31, 2014. AAA: abdominal aortic aneurysm.</p
Red blood cell transfusion associated with increased morbidity and mortality in patients undergoing elective open abdominal aortic aneurysm repair
No full textBackgroundRed blood cell (RBC) transfusions are associated with increased mortality and morbidity. The aim of this analysis was to examine the association between RBC transfusions and long-term survival for patients undergoing elective open infrarenal abdominal aortic aneurysm (AAA) repair with up to 15 years of follow-up.MethodsProspective cohort study using data from The Danish Vascular Registry from 2000–2015. Primary endpoint was all-cause mortality. Secondary endpoints were in-hospital complications. Transfused patients were divided into subgroups based on received RBC transfusions (1, 2–3, 4–5 or > 5). Using Cox regression multi-adjusted analysis, non-transfused patients were compared to transfused patients (1, 2–3, 4–5, >5 transfusions) for both primary and secondary endpoints.ResultsThere were 3 876 patients included with a mean survival of 9.1 years. There were 801 patients who did not receive transfusions. Overall 30-day mortality was 3.1% (121 patients) and 3.6% (112) for all transfused patients. For the five subgroups 30-day mortality was: No transfusions 1.1% (9 patients), 1 RBC 1.2% (4 patients), 2–3 RBC 2.2% (26 patients), 4–5 RBC 1.9% (14 patients) and > 5 RBC 7.9% (68 patients). After receiving RBCs, the hazard ratio for death was 1.54 (95% CI 1.27–1.85) compared to non-transfused patients. There was a significant increase in mortality when receiving 2–3 RBC: HR 1.32 (95% CI 1.07–1.62), 4–5 RBC: 1.64 (1.32–2.03) and >5 RBC: 1.96 (1.27–1.85) in a multi-adjusted model.ConclusionThere is a dose-dependent association between RBC transfusions received during elective AAA repair and an increase in short- and long-term mortality. Approximately 25% of included patients had preoperative anemia. These findings should raise awareness regarding potentially unnecessary and harmful RBC transfusions.</div
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