230 research outputs found
<b>Supplemental Material - EDP-514 in healthy subjects and nucleos(t)ide reverse transcriptase inhibitor-suppressed patients with chronic hepatitis B</b>
No full textSupplementary Material for EDP-514 in healthy subjects and nucleos(t)ide reverse transcriptase inhibitor-suppressed patients with chronic hepatitis B by Jordan J Feld, Eric Lawitz, Tuan Nguyen, Jacob Lalezari, Tarek Hassanein, Paul Martin, Steven-Huy Han, Douglas Dieterich, Jeanne-Marie Giard, Guy De La Rosa, Alaa Ahmad, Ed Luo, Annie L Conery, and Nathalie Adda in Antiviral Therapy.</p
sj-docx-1-tah-10.1177_20406207231166779 – Supplemental material for Efficacy and safety of damoctocog alfa pegol prophylaxis in patients ≽40 years with severe haemophilia A and comorbidities: post hoc analysis from the PROTECT VIII study
No full textSupplemental material, sj-docx-1-tah-10.1177_20406207231166779 for Efficacy and safety of damoctocog alfa pegol prophylaxis in patients ≽40 years with severe haemophilia A and comorbidities: post hoc analysis from the PROTECT VIII study by Mark T. Reding, Ingrid Pabinger, Pål Andrè Holme, Monika Maas Enriquez, Maria Elisa Mancuso, Shadan Lalezari, Wolfgang Miesbach, Giovanni Di Minno, Robert Klamroth and Cedric Hermans in Therapeutic Advances in Hematology</p
Week 48 safety and efficacy of the HIV-1 attachment inhibitor prodrug fostemsavir in heavily treatment-experienced participants (BRIGHTE study)
No full textNon-Thermal Radio Frequency and Static Magnetic Fields Increase Rate of Hemoglobin Deoxygenation in a Cell-free Preparation
No full textNon-Thermal Radio Frequency and Static Magnetic Fields Increase Rate of Hemoglobin Deoxygenation in a Cell-Free Preparation
No full textThe growing body of clinical and experimental data regarding electromagnetic field (EMF) bioeffects and their therapeutic
applications has contributed to a better understanding of the underlying mechanisms of action. This study reports that two
EMF modalities currently in clinical use, a pulse-modulated radiofrequency (PRF) signal, and a static magnetic field (SMF),
applied independently, increased the rate of deoxygenation of human hemoglobin (Hb) in a cell-free assay. Deoxygenation
of Hb was initiated using the reducing agent dithiothreitol (DTT) in an assay that allowed the time for deoxygenation to be
controlled (from several min to several hours) by adjusting the relative concentrations of DTT and Hb. The time course of Hb
deoxygenation was observed using visible light spectroscopy. Exposure for 10–30 min to either PRF or SMF increased the
rate of deoxygenation occurring several min to several hours after the end of EMF exposure. The sensitivity and biochemical
simplicity of the assay developed here suggest a new research tool that may help to further the understanding of basic
biophysical EMF transduction mechanisms. If the results of this study were to be shown to occur at the cellular and tissue
level, EMF-enhanced oxygen availability would be one of the mechanisms by which clinically relevant EMF-mediated
enhancement of growth and repair processes could occur
Gastrointestinal pH profile in subjects with irritable bowel syndrome. Ann Gastroenterol 2012;25:333–7
No full textAbstract Aim To investigate the small bowel pH profile and small intestine transit time (SITT) in healthy controls and patients with irritable bowel syndrome (IBS). Methods Nine IBS patients (3 males, mean age 35 yr) and 10 healthy subjects (6 males, mean age 33 yr) were studied. Intestinal pH profile and SITT were assessed by a wireless motility pH and pressure capsule (Smart Pill). Mean pH values were measured in the small intestine (SI) and compared both within and between groups. Data presented as mean or median, ANOVA, P <0.05 for significance. Results We found the pH for the first (Q1), second (Q2), third (Q3), and fourth quartile (Q4) of the SI in healthy versus IBS patients was 5.608 ± 0.491 vs. 5.667 ± 0.297, 6.200 ± 0.328 vs. 6.168 ± 0.288, 6.679 ± 0.316 vs. 6.741 ± 0.322, and 6.884 ± 0.200 vs. 6.899 ± 0.303, respectively. We found no significant group difference in pH per quartile (P=0.7979). The proximal SI was significantly more acidic, compared to distal segments, in both healthy subjects and IBS patients (P<0.0001). We found no significant difference in the measured SITT between IBS and control groups with a mean SITT of 218.56 ± 59.60 min and 199.20 ± 82.31 min, respectively (P=0.55). Conclusion This study shows the presence of a gradient of pH along the SI, in both IBS and healthy subjects, the distal being less acidic. These finding may be of importance in small bowel homeostasis
- …
