102 research outputs found
Fortissat Science Alliance podcast: Aryanne Finnie
No full textAryanne Finnie was an EPSRC/MRC OPTIMA CDT PhD student studying optical medical imaging alongside an integrated Masters in healthcare innovation and entrepreneurship at the University of Strathclyde. She took part in the Fortissat Science Alliance podcast recordings in December 2021.What is the Fortissat Science Alliance?The Fortissat Science Alliance was a Wellcome Trust & Children In Need "Curiosity" project. This scheme provided informal STEM learning opportunities for young people who attended the community centre Getting Better Together Shotts (GBT Shotts) between 2019 and 2023. Due to the COVID-19 pandemic, deliveries had to pivot online so the podcast was founded. These recordings were made via Zoom with warm-up STEM activities sent to every young person in advance, along with a profile page for each researcher, so that they were relaxed and able to ask excellent questions.Link to episode on Spotify.Depending on the broadcast date, podcast deliveries were co-sponsored by Glasgow Science Festival, EXPLORATHON 2021, or EXPLORATHON 2022/23.For the duration of the project, it was supported jointly by Children in Need and the Wellcome Trust. In 2021, EXPLORATHON episodes were supported by the European Commission [grant agreement ID 101036101]. In 2022-23, EXPLORATHON episodes were supported by the Engineering & Physical Sciences Research Council [grant number EP/X020894/1]. Layla was supported by the EPSRC/MRC Centre for Doctoral Training in Optical Medical Imaging (OPTIMA).Author contributions to contentAryanne Finnie was the guest featured on this episode. Rebecca Hay was the youth worker coordinating the young people who conducted the interviews as well as co-editing and broadcasting the recordings. Iain Hamilton co-edited the episodes. Kirsty Ross was the STEM consultant for the project and uploaded completed episodes to Figshare.</p
Neurological diseases of ruminant livestock in Australia. III: bacterial and protozoal infections
No full textBacteria (including chlamydia) and protozoa can produce neurological disease in Australian ruminant livestock and the nature of the inflammatory and neuroparenchymal response is often suggestive of a particular aetiological agent. An overview of the clinicopathological features of infectious disease affecting the central nervous system (CNS) is followed by a discussion of important bacterial and protozoal infections in Australia. Each infectious disease is discussed in terms of classification and pathogenesis linked to clinical signs and gross and microscopic findings. The literature review is restricted to infectious conditions causing CNS disease in Australia. Sources include the Australian Veterinary Journal (over 50 years of articles), the quarterly newsletter of the National Animal Health Surveillance System and the Animal Health Surveillance Quarterly.AE Kessell, JW Finnie and PA Windso
Alzheimer type II astrocytes in the brains of pigs with salt poisoning (water deprivation/intoxication)
No full textThe finding of Alzheimer type II astrocytes, in addition to the pathognomonic combination of laminar cerebrocortical necrosis and eosinophil infiltration, in the brains of pigs is reported for the first time in cases of indirect salt poisoning following water deprivation.J.W. Finnie, P.C. Blumbergs and M.M. Williamso
Neurological diseases of ruminant livestock in Australia. II: toxic disorders and nutritional deficiencies
No full textThe second in this series of clinical reviews on neurological diseases in ruminant livestock in Australia examines toxic disorders associated with plant and microbial toxins as well as the neurological effects of vitamin and mineral deficiencies. The aim of these reviews is to assist in the surveillance of neurological diseases, especially the transmissible spongiform encephalopathies.J. W. Finnie, P. A. Windsor and A. E. Kessel
Congenital dyserythropoietic anaemia and dyskeratosis in Australian Poll Hereford calves
No full textCongenital dyserythropoietic anaemia (CDA) is a heterogeneous group of rare genetic disorders that in humans is characterised by ineffective haematopoiesis with morphological abnormalities in erythroid precursor cells and secondary iron overload. In the 1990s, a syndrome of CDA with dyskeratosis and progressive alopecia was reported in Poll Hereford calves in Canada and the USA. We report the clinical and pathological findings in two Poll Hereford calves with this syndrome from separate properties in South Australia. The animals had a variably severe anaemia, associated with abnormal nucleated red blood cells in peripheral blood, and large numbers of rubricytes and metarubricytes with a characteristic nuclear ultrastructure in the bone marrow. Both calves were born with a wiry hair coat and a progressively ‘dirty-faced’ appearance associated with hyperkeratosis and dyskeratosis (apoptosis).AE Kessell, DM Hanshaw, JW Finnie and P Nosworth
Neurological diseases of ruminant livestock in Australia. I: general neurological examination, necropsy procedures and neurological manifestations of systemic disease, trauma and neoplasia
No full textDisease surveillance is an integral part of most veterinary practices in Australia. The aim of this series of invited reviews is to facilitate the differential and ultimately definitive diagnosis of some of the previously known, as well as the novel and emerging, neurological disorders of ruminant livestock, which is of particular importance in the surveillance for transmissible spongiform encephalopathies. General principles of a systematic neurological examination, necropsy procedures and the neurological manifestations of systemic disease, trauma and neoplasia are described here.J.W Finnie, P.A Windsor and A.E Kessel
Neuroaxonal dystrophy in Merino-Border Leicester x Polled Dorset lambs
No full textArticle first published online: 13 AUG 2014Case report: The clinicopathological features of neuroaxonal dystrophy (NAD) in 2 lambs are described. Of 40 Merino-Border Leicester × Polled Dorset lambs on a property in north-eastern Victoria, 4 presented with marked ataxia and listlessness, and 2 affected animals (2 days and 2 weeks of age, respectively) of both sexes were necropsied. Numerous axonal swellings (spheroids) were found in the central nervous system, particularly in brainstem nuclei and spinal cord grey matter, and there was severe spinal cord demyelination. Conclusions: This is the first report of NAD in such crossbred lambs; the affected animals were much younger than in previously described cases of ovine NAD and myelin loss was of much greater magnitude than previously reported.JW Finnie, IV Jerrett, J Manavis and J Cav
Neurological diseases of ruminant livestock in Australia. V: congenital neurogenetic disorders of cattle
No full textAs part of a series on neurological disorders in ruminant livestock in Australia, this review focuses on the congenital neurogenic disorders of cattle. The genetic pressures that contribute to the emergence of congenital neurogenic disorders, as well as the methods of diagnosis, are discussed. Disorders reviewed are ordered by breed and include arthrogryposis multiplex, fawn calf syndrome, inherited congenital myoclonus and maple syrup urine disease.PA Windsor, AE Kessell and JW Finni
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2I Negotiating Author Agreements
No full textThis fall, ACRL New England’s Scholarly Communication Interest Group is offering both a one- or two-day copyright workshop, in two different locations, taught by the New England Copyright Crew (NECC)! NECC includes Laura Quilter (Copyright and Information Policy Librarian, UMass Amherst), who spearheaded this approach last year at UMass, Kyle Courtney (Copyright Advisor, Harvard University), Ellen Finnie Duranceau (Program Manager, Scholarly Publishing, Copyright & Licensing, MIT Libraries), and Joan Emmet (Licensing & Copyright Librarian, Yale University).Advanced Topics : Licensing, Negotiation, and Scholarly Communication (Dec. 2 Boston, Dec. 16 Amherst) Laura Quilter, UMass - Authors & Scholarly Communication. Includes an overview of copyright in relation to author contracts, a hands-on exercise reviewing an author publication agreement, and pointers about talking with authors about their publication agreements
Selective Vulnerability of Peripheral Nerves in Avian Riboflavin Deficiency Demyelinating Polyneuropathy
No full textRiboflavin (vitamin B2) deficiency in young chickens produces a demyelinating peripheral neuropathy. In this study, day-old broiler meat chickens were fed a riboflavin-deficient diet (1.8 mg/kg) and killed on posthatch days 6, 11, 16, 21, and 31, while control chickens were given a conventional diet containing 5.0 mg/kg riboflavin. Pathologic changes were found in sciatic, cervical, and lumbar spinal nerves of riboflavin-deficient chickens from day 11 onwards, characterized by endoneurial oedema, hypertrophic Schwann cells, tomacula (redundant myelin swellings), demyelination/remyelination, lipid deposition, and fibroblastic onion bulb formation. Similar changes were also found in large and medium intramuscular nerves, although they were less severe in the latter. However, by contrast, ventral and dorsal spinal nerve roots, distal intramuscular nerves, and subcutaneous nerves were normal at all time points examined. These findings demonstrate, for the first time, that riboflavin deficiency in young, rapidly growing chickens produces selective injury to peripheral nerve trunks, with relative sparing of spinal nerve roots and distal nerve branches to muscle and skin. These novel findings suggest that the response of Schwann cells in peripheral nerves with riboflavin deficiency differs because either there are subsets of these cells in, or there is variability in access of nutrients to, different sites within the nerves.Cai Z, Blumbergs PC, Finnie JW, Manavis J and Thompson PD
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