5,597 research outputs found
Journeys Through Jackson 2013 Vol.23 No.01
No full textJourneys Through Jackson is the official journal of the Jackson County Genealogical Society, Inc. The journal began as a monthly publication in July 1991, was published bimonthly from 1994 to 2003, and continues today as a quarterly publication. The journal issues in this digital collection are presented as annual compilations.c
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J o u r n e y s
T h r o u g h
J a c k s o n
L ,
T h e Official Journal of t h e J a c k s o n C o u n t y G e n e a l o g i c a l S o c i e t y , Inc.
V o l . XXIII, N o . I W i n t e r 2 0 13
JACKSON COUNTY GENEALOGICAL SOCIETY, INC.
2013 Officers
U
President Kenneth E. Nicholson
Vice Presidents Timothy Osment, William L. Crawford
Secretary .*. Karen C. Nicholson
Treasurer E. Lawrence Morton
Librarian. DorrisD.Beck
Office Manager Ruth C. Shuler
WebMaster. Deanne G. Roles
Computer Technician Jason N. Gregory
Chair, Publications (Editor) Sanji Talley Watson
Journeys Through Jackson is the official publication of the Jackson County Genealogical Society. Members and non-members are invited to
submit genealogical materials for publication, with the understanding that the editor reserves the right to edit these materials for genealogical
content, clarity, or taste. The Society assumes no responsibility for errors of fact that may be contained in submissions, and except where noted,
the opinions expressed are not those of the editor or of the Jackson County Genealogical Society. The Society accepts no advertising for this
publication except for notices from other non-profit groups.
From the Editor
For 17 years, Journeys Through Jackson has been produced and edited by Robert Larry Crawford.
Through hard work and perseverance, he has taken the journal from its humble beginnings to the award
winning publication that we all receive. He has informed, educated, and at times entertained us with the
information that he has collected, been gifted with, and allowed to use by members and friends of the
society alike. He has dedicated untold hours to ensuring that our journal was as good as he could make it.
He is and will continue to be a valuable resource for the society. As the new Editor, I stand in awe of the
tremendous work and effort that Larry has given the society as Editor. I have no hesitation in saying I
cannot begin to fill his shoes, only hope that I can follow in his footsteps. Thank you, Larry, for all the
work you have done and will continue to do for the society.
Larry and I graduated from Sylva-Webster High School in 1963. Our paths did not cross again until I
became principal at Smoky Mountain High School in 1994. Larry was one of the best teachers that I have
had the opportunity to observe. His history classes were filled with students who were required to take
most of his classes. Although the classes were required, they came to love history and the teacher who
made history come alive. Larry respected his students and they respected him. One of his classes that
drew my attention to his rapport and respect from students was World Religions. Although this class was
not required and was listed as an elective it was always filled with students who knew that Larry would
continue to expect their best and they would respond with their best work.
Larry is very knowledgeable of the families of Jackson county. He is able to tell you about your
cousins, uncles, aunts, grandparents, parents and most other relatives that you might have. Larry has for a
number of years been the Editor of Journeys Through Jackson. His knowledge of and research for articles
are impeccable. His work ethic is never ending and his ability to write transcends you into the past as if
you were there.
Larry, I know that "rest" is not in your vocabulary so I know that you will continue to research and
write. As one famous person stated, "Thanks for all the memories that you bring to life for us."
— Kenneth E. Nicholson, President JCGS
Journeys Through Jackson Winter 2013
C T a b l e o f C o n t e n t s
Announcements and Expression of Sympathy 1
JCGS Photo Album 2 - 6
Prepublication Announcement 7-8
Financial Statement for 2012 9
Scott Foundation Scholarship Announcement 10
Of Mountains, Mountain People, and Mountain Waters That Call
Their Children Home 11 - 14
1927 Jackson County Death Certificates of Persons Born 1900 - 1 9 3 0 15 - 18
James Brown F a m i l y - Who are They? 19 - 24
A New JCGS Member's Ties to Jackson County 25 - 28
Franklin Descendants 29 - 32
A Native Son 33 - 36
Building the Glenville Dam 37 - 39
Continuation of Death Certificates and Library Acquisitions 40
Shepherd Photographs 41 - 46
Index 47-48
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We offer our sincere sympathy to the family of JCGS member, Franlde Jean Shelton Stewart. Our
condolences to members: Naomi Beck Seago, R. O. Wilson, Rachel Brown Phillips, Edith Jamison
Cabe, Jim Wheatley, and Pearl Brown Smith on the passing of their family members.
A good friend to the society, who allowed us to interview her and put her life on paper, passed away on 2
Jan 2013. Mrs. Nancy Jane Shook' Chastain passed away after a long and eventful life. She enjoyed
being independent, having her own garden, canning and making quilts for people in need. She was born
on 23 Oct 1909 to James Marion and Clercy Jane Hooper Shook, She will be missed by many.
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Q u e r y
We received two queries from Mrs. Linda McGuire of Durant, Oklahoma. She is a great-granddaughter of
James and Elizabeth Parker Moore. Hopefully, some of the members may be able to help Mrs. McGuire.
First Inquiry: Would anyone have information about:
Elizabeth J. Parker; b. 25 Aug 1840 in North Carolina, d. 12 Jan 1904, Indian Territory,
Oklahoma. She married James A. Moore; b 5 Apr 1830 in North Carolina, d. 10 Mar 1910. They came
to Indian Territory about 1890. Their daughter, Ella Wike remained in East La Porte. North Carolina.
My grandmother, Lula Caro Wells, lived in Indian Territory.
Second Inquiry: Does anyone know where the Masonic Lodge was located in East La Porte? James A.
Moore, a carpenter, is supposed to have carved the door to this lodge, and I would like a picture of it.
If you can help, contact Mrs. McGuire at: [email protected]
Journeys Through Jackson Winter 2013
J C G S P h o t o A l b u m u
S o c i e t y P r e s e n t s A w a r d s a t D e c e m b e r a n n u a l m e e t i n g .
From left to right: B. B. "Bud" Cantrell, James Monteith accepting for Kay Keefer Monteith, Ben H.
Battle, Jr, and Jane Gibson Nardy. Picture used with permission of the Sylva Herald.
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The Jackson County Genealogical Society presented its yearly awards as is customary at the annual
meeting. Three persons - Sue Kilby Fouts, Ben H. Battle, Jr. and Kay Keefer Monteith received the
JCGS Patron Award for their benevolent support of the Society.
The Daniel Washington Deitz Memorial Award was presented to longtime JCGS Vice-President B. B.
"Bud" Cantrell. Bud has served the Society in numerous ways, most notably as one of the program
chairmen, and always with his trademark grin.
Winner of the Robert Lee and Drucilla Holden Award for Distinguished Service to Genealogy was Jane.
Gibson Nardy. A JCGS life member, Jane is the author of several books, many articles (including some
for this publication), and is one of the mainstays of the Cashiers Historical Society. Accepting her award
with her usual wit and grace, Jane gave an anecdotal story that proves the "superiority" of genealogists.
Journeys Through Jackson Winter 2013
These Photographs are two of the
many from the estate of our late
member Willa Mae Dills Scroggs.
While we are not sure of the
identities of these persons, the
pictures are interesting examples of
social history relative to style.
Journeys Through Jackson Winter 2013
Also from the Scroggs pictures, and speaking of social history, we
don't find it bizarre to add a picture of "Old Sparky," the state's
electric chair.
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Journeys Through Jackson Winter 2013
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This fabulous picture is a likeness of Mrs. Sophia Hipps (1870-1956). She was the mother-in-law of one
of the Dillsboro Hensley family. Picture submitted by JCGS member Jean Hooper Scott.
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Journeys Through Jackson Winter 2013
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This Civil War portrait above is of Stephen H. Miller, who served in the North Carolina 29th. This picture
was submitted by bis great-great-grandson Brernm Hooper.
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Journeys Through Jackson Winter 2013
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Announcing the reprinting of:
T h e H e r i t a g e o f
J a c k s o n C o u n t y , N C
V o l . O n e - 1 9 9 2
Long out of print, this could be your
last chance to obtain a copy!
Acid free, archival paper
9" x 12" coffee table size,'552 pages
Hardbound, collector's edition with rich
gold embossed arid gold foil stamped
cover, closely matching the first printing
Nearly 1250 Modern and Early family.
Genealogies stones and pictures .
Surname index; •
Topical History including.
Communities-
Churches
Clubs, Organizations
Stores
Memorials
Tributes
Business Histories
T H I S I S A P R E -
P U B L I C A T I O N S A L E
O n l y t h o s e w h o o r d e r a n d p ay
f o r a b o o k i n a d v a n c e w i l l be
c e r t a i n of o b t a i n i n g o n e ;
D e l i v e r y -: S p r i n g 2 0 *3
O R D E R F O R M:
PLEASE ENTER MY ORDER FOR:
Jackson Co. Heritage -1992 Vol. 1 reprint
Copy(ies) @ 93.50 (shipped to your
homo.or office!)
TOTAL BOOKS TO BE SHIPPED
TOTAL BOOKS TO BE PICKED UP
.TOTAL ENCLOSED
D E A D L I N E : M a r c h 1 5 , 2 0 13
Name
Address
City.
State/Zip_i_
SEND CHECK OR MONEY ORDER TO:
Jackson Co., Heritage -:1992 Vol. 1 reprint
Jackson Co. Genealogical Society.
PO.Box2108
Cullowhee, NC 28723-2108
Journeys Through Jackson Winter 2013
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F o r m o r e i n f o r m a t i o n c o n t a c t : ;
T h e J a c k s o n Co. G e n e a l o g i c a l S o c i e t y |
828-631-2646 o r 1
K e n o r K a r e n N i c h o l s o n . ;
828-586-2590 <
A n n o u n c i n g t h e R e p r i n t i n g of
T h e H e r i t a g e o f
J a c k s o n C o u n t y , N C
V o l . O n e - 1 9 9 2
i For f u r t h e r d e t a i l s c o n t a c t:
I T h e J a c k s o n C o . G e n e a l o g i c a l Society \
l Kenny and Karen Nicholson 828-586-2590
j [email protected]
! Tim Osment 828-273-761?
I • timosment(g!gmaiLcom .
| Ruth Shuler 828-293-5227:.
i rshuIer3383(g),frontier,com
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Journeys Through Jackson Winter 2013
F i n a n c i a l S t a t e m e n t
[Ed: The Financial Statement was provided by JCGS Treasurer, Larry Morton.]
^
Jackson County Genealogical Society
Net Cash Row
January 1 - December 31,2012
STARTING Balance
Regular Deposits
Book Sales
Copier
Refund-half of copier contract
Donations (incl royalties)
Fund Raiser
Grants Received
Interest Income
Family Memberships
Individual Memberships
Life Memberships
Received for Postage
Sales Tax Received
Petty cash
Total Regular Deposits
,
STARTING BALANCE + Deposits
' *•• .
Expenses ••
Advertisements'
Dues/Memberships other societies •
-., Insurance ,
Library Purchases - Cowan Fund
Miscellaneous- copier contract
Miscellaneous-Purchases for Resale -
Miscellaneous-Awards •.
. Office Supplies..
. Postofflce Box Rent
Postage i/
Prepaid postage .
Printing/Copylng/Reproducing
Program Presentation/Meals . .
Fund Raiser.
Office Rent, Storage Unit
Sales Tax Paid-
Utilities-Telephone
, Internet: DnetWebsite.Domain. A
Total Expenses
-• . ." ; ., .
Net Income
-..'.', •" v •• • •' . '•'
Ending Balance- .
Certificates of Deposit
Prepaid postage • permit 22
Total Cash Assets
YTD
9,269.20
4,079.93
224.25
133.79
826.01
10,333.00
200.00
4.80
825.00
2,180.00
750.00
160.25
318.47
(18.10)
20,017.40
29,288.60
; ..•-'•
- 100,00
140.00
604.00
9343
282.51
217.50
463.11
557.23
100.00
298.63
468.17
4,090.82 ;
50.00
1,626.48
4,536.00 !
243.96 ;
733.58
392.87
14,896429
: \ ;•
5,121.11
. " >•.
14,390.31
2,214.60
31.09
16,638.00
Journeys Through Jackson Winter 2013
S c o t t F o u n d a t i o n S c h o l a r s h i ps ^J
At the JCGS Christmas dinner and awards program in December, President Ken Nicholson
announced the endowment of a scholarship program to be administered by the Society. JCGS members
Jim and Jean Hooper Scott of Tryon provided a generous start-up fund to originate this program. A
Society committee was named and it has since met to establish the scholarship rules and parameters.
Applicants must be students at Smoky Mountain High School, Blue Ridge High School and Early
College, Jackson County Early College, or the Jackson County School of Alternatives. The applicant
must also write an essay related to family or genealogical research. The winners will then report to the
Society within one year.
In the first year, two scholarships valued at $750.00 each are to be awarded. Checks will then be
made to the college or university of the winners.
W o u l d y o u l i k e t o c o n t r i b u t e?
Make checks specifically to the Scott Foundation Scholarship Fund, and send to the Society's post office
address. This gift, of course, is tax deductible.
JCGS member Linda Hughes Collins with her great-grandson, Spencer Fitzgerald, who fished the
winning tickets in the JCGS raffle last October.
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Journeys Through Jackson Winter 2013
^
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O f M o u n t a i n s , M o u n t a i n P e o p l e , a n d M o u n t a i n W a t e r s
T h a t C a l l T h e i r C h i l d r e n H o m e
[Ed. The following article was written and submitted by JCGS member Don Casada. Its principal subject, Elizabeth Holt, is a
granddaughter of JCGS member Christine Cole Proctor.]
Close on the heels of dog days, on a warm September morning, a shuttle boat carried a gathering of folks
across Fontana Lake. Shortly after leaving the launch area at Cable Branch, the boat passed over the
streambed of what was once a fine mountain river.
From way back in the mountains, hundreds of feeder streams laughed, jumped, played, and sang along
their descending way. Boisterous waters showered diamond sprays of life onto the stream banks where
ramps, sarvis, squirrel corn, bluets and yellow root reaped the blessings of their contagious joy. They
were living, life giving waters.
Trickles became branches, branches became forks, and forks became creeks. The accumulated
collections fed the Oconaluftee, Tuckaseigee, Nantahala and Little Tennessee Rivers, waters eons older
than the Cherokee names which predated the arrival of white men. The Tuckasegee, a man among men
flowing on an east-west course, met the south-to-north flowing lady of the Little Tennessee. It was love
at first sight, and the couple was married near the place that would become the little town of Bushnell.
Tuck, the gentleman, defied human convention and took on the name of his bride. Although they called
themselves the Little Tennessee, it was Tuck's east-west course that they followed from that point on, in
deference to his better judgment. For Tuck, unlike the sweet Little T, drew much of his life blood from
the Great Smoky Mountains which they would skirt along the rest of their way. Of all those who traveled
these mountains, no one knew every holler like Old Tuck.
Now more mature in demeanor than in their earlier rambunctious ways, the two that were now one
inclined to a gentler course, as if on a front porch swing of a Sunday afternoon. But they could still kick
up their heels every now and then. Like all couples, they'd occasionally have their issues, separating to
the left and the right around Calhoun Island near Wayside. Differences resolved, they rejoined hands
downstream, and the family continued to grow along the way.
Damned by progress and dammed by the TVA, laughter and family ties along this section of the Little
Tennessee have been silenced and broken for seven decades. The life-giving energy from North Carolina
Counties of Jackson, Macon (Macon's part includes a charitable donation from Rabun County, Georgia),
Graham and Swain is deadened by the dam, harvested by turbines, and sent by wires without payment
into Tennessee. The formerly vibrant river lies buried beneath 370 feet of stagnant water and silt
accumulation at the point where our boat passed over.
Our destination was Hazel Creek, a place where unhindered waters still flow and echoes of laughter yet
linger, unreachable by the roads of an uncivilized world. There are those who despair the lack of road
access to this land, including some of our little company. A sense of betrayal by the same federal
government - which took the land that many called home - underlies the despair. But were there now a
road to this place, I fear that the song it sings softly in minor mountain key would be lost in the discordant
strife and the noise. That has certainly been the case for Cades Cove, located just across the spine of the.
Smokies, where an armada of automobiles daily assault what was once a place of perspicacious people
imbued with both the spirit and ability to make do.
There are reasons aplenty to go to this place and others like it. I routinely find myself seeking the refuge
of walking and crawling, sometimes tumbling and sliding through these mountains, most often alone.
Whisperings of advice and signs of parental affection — as well as stern admonitions - from these
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Journeys Through Jackson Winter 2013
mountains (which are indeed our parents) are most readily perceived by the wonderfully lonesome, if .
somewhat prodigal, child. ^—^
But on this day, I was glad to be in the company of some like-minded companions. Though seeking a
place, ours was not a search for solitude. We were intent on congregating, cornmitting, honoring, and
remembering.
Proctor
The particular place on Hazel Creek to which we were headed has been known since the late 1800s as
Proctor. Sometime before 1830, Moses and Patience Proctor settled here and began raising a family.
Their home place was on what is now known as Shehan Branch in Possum Holler. It empties into Hazel
Creek - or directly into the lake itself when it is full - almost four miles from where Hazel Creek once
emptied into the Little Tennessee River.
The Proctors had come over the main spine of the Smokies from Cades Cove. If it was solitude and
elbow room they sought, they found it. Based on the sequence of names in the 1830 Macon County
census (this area is now in Swain County, but Swain wasn't formed until 1871) and knowledge of where
other families located, it was likely well over a half-dozen miles to their closest neighbors. Something
just felt right about this particular place, so they carved out a home and a life for themselves and their
children here. Bradshaws, Cables and others were soon to come to the area, but it remained sparsely
populated for decades.
In 1848, Joseph Brackett composed the Shaker Hymn, "Simple Gifts". Though penned a thousand miles
away near the northeastern end of the Appalachian Mountain range, the words could well have applied to
the lives of Patience, Moses, and their children in the Hazel Creek valley: v /
'Tis the gift to be simple, 'tis the gift to be free,
'tis the gift to come down where you ought to be.
And when we find ourselves in the place just right,
It will be in the valley of love and delight.
Times and seasons pass; lives and circumstances change. The Civil War took away two of their sons,
Moses, Jr. and Mansfield. Moses, Sr. died, perhaps of a broken heart, in 1864. Patience lived to see the
end of the war and the return of two sons and a son-in-law, but according to family tradition described by
Duane Oliver in Remembered Lives, she was never the same. She died in 1870, and is buried beside
Moses on the ridge near their home.
Over time, their children and their children's children drifted to and fro, ranging up the river and across
the mountains back into Tennessee. Ritter Lumber Company arrived and set up a massive operation in
the early 1900s, providing hundreds of jobs - for a time. But by the late 1920s, the raw materials of the
entire Hazel Creek basin had been sawn, kiln dried, cut to dimension, and shipped away to become floors,
furniture, books and toilet paper, so Ritter Lumber closed shop. While there were still several dozen
farnilies who owned land and lived in the area, including some descendants of Moses and Patience, the
vast majority of the Hazel Creek drainage was now owned by land speculators such as Jack Coburn and
George Stikeleather (to whom Ritter had sold its vast holdings). Private fishing waters were established ,
with uninvited natives unwelcome.
Physical connections to vestiges of life as it had once been were completely severed by the construction
of Fontana Dam in the early 1940s. Exercising powers of what might be called pre-eminent domain with
a will, TVA acquired all lands on the north shore of Fontana, removed the people and turned the land over ^ j
to the Department of Interior for inclusion in the Great Smoky Mountains National Park. It is worth
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Journeys Through Jackson Winter 2013
/ noting here that the entire area along the north shore of the Little Tennessee had been coveted for the Park
^ ^ since the 1920's; in fact, it had been included in the original park outline, drawn in 1926.
hi the course of a century, Hazel Creek witnessed the coming of the first white settlers, an era of slow
increase in families on subsistence farms, followed by a period of rapid industrial and job growth, an
equally rapid loss of resources - an thus industry and its jobs. By the time the 1930 census was taken,
there were but two dozen individuals on the entire north shore who listed saw mill or logging as their
trade, and most of these were well to the east of Hazel Creek.
Just over a decade later, there was to be no more permanent human presence.
And yet .... even now, there is something about this place which seems to want people around, and it
Wavelength tunable 10-GHz 3-ps pulse source using a dispersion decreasing fiber-based nonlinear optical loop mirror
No full textWe experimentally demonstrate the use of a dispersion decreasing fiber (DDF)-based nonlinear optical loop mirror (NOLM) for the generation of wavelength tunable soliton-like pulses at a repetition rate of 10 GHz. We compress ~12 ps Gaussian pulses from an electro-absorption modulator (EAM) (followed by 125 m of DCF for preliminary linear dispersion compensation) into 3 ps pedestal-free pulses using both high-order soliton compression and nonlinear switching effects within an 8.5 km DDF-based loop mirror. The output pulses from the DDF-based NOLM show considerable pedestal reduction compared to those obtained by directly compressing the EAM seed pulses via a single passage through the DDF. Wavelength tuning of the compressed pulses over a ~15 nm bandwidth (from 1541 to 1556 nm) is demonstrated without a significant increase in pulse duration or degradation in pulse quality
Bank, Wis
No full textPhotograph of a First National Bank in Wisconsin taken from the large parking lot of a strip mall. A sign points to the Auto Bank or ATM. A cop car sits in front of the bank. In front of the entrance is a large, leafless tree. The sun is out creating shadows of the lamp posts on the pavement of the parking lot in the foreground of the image. Handwritten caption by J.B. Jackson reads: "Bank, Wis" and "[river falls, i think] PS
Fall River
No full textPhotograph of a large, public, institutional building made of stone, columns and walls of reflective glass showing the blue sky. The building appears to be in a sprawling urban section of town, like a financial district. Part of the yellow traffic lights are visible on the side of the image. Handwritten caption by J.B. Jackson reads: "Bank" and "Fall River" on the front and back. Then, another caption on the sleeve of the slide reads: "[No! this is the City Hall] PS]"
Plantar pressures in rheumatoid arthritis using prefabricated metatarsal padding
No full textWe sought to determine whether one of two prefabricated insole designs could better manage high forefoot plantar pressures in patients with rheumatoid arthritis. Ten subjects with rheumatoid arthritis who experienced pain with shod weight bearing were studied by using a plantar pressure measurement system. Two insole designs and a shoe-only control condition were randomly tested in repeated trials. Dome- and bar-shaped metatarsal pads made of latex foam were incorporated into full-length insoles made of urethane. Significant reductions in mean peak plantar pressures over the central metatarsals were noted when using the insole and dome pad design (12% [33 kPa]) and the insole and bar pad design (21% [58 kPa]) compared with the shoe-only condition. A prefabricated insole design incorporating a bar metatarsal pad is recommended to manage high forefoot plantar pressures in patients with rheumatoid arthritis
Player agency in interactive narrative: audience, actor & author
No full textThe question motivating this review paper is, how can
computer-based interactive narrative be used as a constructivist learn-
ing activity? The paper proposes that player agency can be used to
link interactive narrative to learner agency in constructivist theory,
and to classify approaches to interactive narrative. The traditional
question driving research in interactive narrative is, ‘how can an in-
teractive narrative deal with a high degree of player agency, while
maintaining a coherent and well-formed narrative?’ This question
derives from an Aristotelian approach to interactive narrative that,
as the question shows, is inherently antagonistic to player agency.
Within this approach, player agency must be restricted and manip-
ulated to maintain the narrative. Two alternative approaches based
on Brecht’s Epic Theatre and Boal’s Theatre of the Oppressed are
reviewed. If a Boalian approach to interactive narrative is taken the
conflict between narrative and player agency dissolves. The question
that emerges from this approach is quite different from the traditional
question above, and presents a more useful approach to applying in-
teractive narrative as a constructivist learning activity
Activation parameters for the reaction of phenylchloro carbene with pyridine, tri- n -butyltin hydride, and triethylsilane; evidence against the need to invoke reversibly formed complexes in the reaction of this carbene with olefins
No full textPT: J; CR: CALDIN EF, 1964, FAST REACTIONS SOLUT, CH1 DOYLE MP, UNPUB TETRAHEDRON LE GIESE B, 1978, ANGEW CHEM INT EDIT, V17, P595 GIESE B, 1980, ANGEW CHEM INT EDIT, V19, P835 GIESE B, 1980, LIEBIGS ANN CHEM, P725 GIESE B, 1981, CHEM BER, V114, P3306 GIESE B, 1982, ANGEW CHEM INT EDIT, V21, P310 GOULD IR, 1985, TETRAHEDRON, V41, P1587 HOUK KN, 1984, J AM CHEM SOC, V106, P4291 HOUK KN, 1984, J AM CHEM SOC, V106, P4293 HOUK KN, 1985, TETRAHEDRON, V41, P1555 JACKSON JE, 1988, IN PRESS J AM CHEM S, V110 MOSS RA, 1986, J AM CHEM SOC, V108, P7028 PLATZ MS, 1983, TETRAHEDRON LETT, V24, P4763 SCAIANO JC, 1988, CHEM KINETICS SMALL, P73 SKELL PS, 1969, J AM CHEM SOC, V91, P7131 SOUNDARARAJAN N, 1988, IN PRESS J AM CHEM S, V110 TURRO NJ, 1987, J AM CHEM SOC, V109, P4973 WEAST RC, 1970, HDB CHEM PHYSICS, F42 ZUGRAVESCU I, 1976, N YLID CHEM; NR: 20; TC: 36; J9: TETRAHEDRON LETT; PG: 4; GA: T9526Source type: Electronic(1
Charisma and Spirituality in the Early Church: A Study of Messalianism and Pseudo-Macarius
No full textThe thesis is an investigation into the concept of Charisma and Spirituality in the Early Church with particular emphasis upon the writings of Ps-Macarius, and of a group of ascetics known as the Messalians, evident in the late fourth / early fifth centuries. The Macarian writings are
examined to see what they reveal about the experiential pneumatic theology of the Early Church, the relationship between Syrian and Hellenic traditions of Christian Rhetoric, and the relationship between Ps-Macarius and the Cappadocian Circle. The Macarian corpus as a whole is examined to assess its rhetorical influences and style. The rhetoric of the Macarian corpus is seen to illustrate a high degree of sophistication. This study also gives definition to two terms that have become imprecise and diverse in their use: 'enkrateia' (self-control), and
`Syrian Christianity'. By isolating the characteristics of enkratefa the definitive stages of an encratic lifestyle are identified. The breaking down of the term into enkrateia, radical enkrateta and exclusive enkrateta enables a much clearer discussion to take place as to the
nature of the encratic theology of a group or individual. The final element of this study is a consideration of the distinct Macarian imagery that is evident within the corpus. Two images are considered in detail, the 'flight of the soul' and 'sober intoxication'. Overall this study
shows the variety of influences upon Ps-Macarius, and the uniqueness of his expression. The influences upon Ps-Macarius include a context of endemic Syrian spirituality, a radical encratic lifestyle, a Hellenic rhetorical training, and a distinct interpretation of Platonic and Neo-
Platonic images, coupled to the wider Judaic / Mesopotamian influences of his Church. It is shown that Ps-Macarius represents an individual voice that is distinct and recognisable amongst the Fathers of the Church
Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity
No full textL1-CAM (L1 cell-adhesion molecule), or more simply L1, plays an important role in the progression of human carcinoma. Overexpression promotes tumour-cell invasion and motility, growth in nude mice and tumour metastasis. It is feasible that L1-dependent signalling contributes to these effects. However, little is known about its mechanism in tumour cells. We reported previously that L1 is cleaved by ADAM (a disintegrin and metalloprotease) and that the cytoplasmic part is essential for L1 function. Here we analysed more closely the role of proteolytic cleavage in L1-mediated nuclear signalling. Using OVMz carcinoma cells and L1-transfected cells as a model, we found that ADAM10-mediated cleavage of L1 proceeds in lipid raft and non-raft domains. The cleavage product, L1-32, is further processed by PS (presenilin)/gamma-secretase to release L1-ICD, an L1 intracellular domain of 28 kDa. Overexpression of dominantnegative PS1 or use of a specific gamma-secretase inhibitor leads to an accumulation of L1-32. Fluorescence and biochemical analysis revealed a nuclear localization for L1-ICD. Moreover, inhibition of ADAM10 and/or gamma-secretase blocks nuclear translocation of L1-ICD and L1-dependent gene regulation. Overexpression of recombinant L1-ICD mediates gene regulation in a similar manner to full-length L1. Our results establish for the first time that regulated proteolytic processing by ADAM10 and PS/gamma-secretase is essential for the nuclear signalling of L1 in human carcinoma cell lines. Key words: a disintegrin and metalloprotease 10 (ADAM10), L1 cell-adhesion molecule (L1-CAM), nuclear translocation, presenilin (PS)/gamma-secretase activity, raft, signalling
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