1,004 research outputs found

    Deep-brain stimulation for Parkinson's disease

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    Comment on N Engl J Med. 2010 Jun 3;362(22):2077-91 author reply 988.Ye

    Female directors and firm performance in Italian and Spanish listed firms. Does masculinity matter?

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    Purpose The purpose of this paper is to examine the relationship between women on the board of directors and firm performance in a comparative analysis between Italy and Spain. Design/methodology/approach The generalized method of moment is employed to examine this relationship in a sample of 1,393 firm-year observations. Findings The results show that the presence of women on the board has a positive impact on the performance of Italian and Spanish firms. However, when the whole sample is divided into Italy and Spain, some results are remarkable. For Spain, the presence of women on the board has a positive influence on firm performance, whereas for Italy the authors find a negative and significant effect on firm performance. This study also finds that the “masculinity” dimension has a negative impact on firm performance. Practical implications The results of this study have several practical implications. First, masculinity differences within the countries can have a large impact on firm performance and can explain some differences between similar countries. Second, the legal system of countries might not explain adequately some differences in the decision-making process. Third, cultural values and thinking styles, in terms of masculinity, might better explain why the results on the relationship between female directors and firm performance are mixed. Fourth, the findings suggest that it is very important to promote gender equality, not only by passing laws but also taking action about the educational system. Originality/value To the best of the authors’ knowledge, this is the first study that investigates the relationship between female directors and firm performance between Italy and Spain considering the cultural differences in term of “masculinity.

    Is the tourism perspective envisaged in climate change adaptation planning? Evaluating the road map of political, social and environmental dimension in Spanish destinations

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    Climate change is one of the main challenges for today’s society due to the increase of extreme event frequency and severity, demanding policy actions and coordination to mitigate their impacts. This contribution analyzes to what extent tourism activity is considered in the Spanish National Plan for Adaptation to Climate Change 2021–2030 (PNACC) and the local strategies, which measures are considered to reinforce the tourism industry adaptive capacity, and how coherent tourist cities’ plans for climate change adaptation are. To this end, the following research questions are posed: (1) What actions are promoted, and how do they aim to face climate change? (2) Is the type of tourist destination a driving factor conditioning actions design? (3) What is the balance between public and private responsibilities and actions when reducing the tourism industry’s vulnerability? We evaluate the top-ten Spanish tourist cities by applying the triple-loop approach to delve into the political, social, and environmental dimensions of climate change adaptation together with testing policy coherence standards. The findings reported that most plans are framed in a multi-focal adaptation strategy, in which the focus on the tourism industry can be explicit or implicit while distinguishing between actions carried out by tourist cities and cities with tourists. Interestingly, bottom-up approaches are promoted to collect citizens’ perspectives regarding climate change, sometimes including tourists as end-users. Furthermore, the policy coherence test pointed out the need to strengthen the attention to tourism-related measures and a more pro-active engagement of the tourism industry to motivate accurate and robust actions in the medium and long terms

    Arylchlorocarbenes in the synthesis of heterocycles containing two nitrogen atoms

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    Substituted pyrazoles and pyrrolo[1,2-c]pyrimidines were prepared from the reaction of arylchlorocarbenes with 1,2-diazabuta-1,3-dienes and 4-vinylpyrimidines, respectively.PT: J; CR: ATTANASI A, 1998, J ORG CHEM, V63, P9880 ATTANASI OA, 1977, SYNLETT, P1128 ATTANASI OA, 1999, TETRAHEDRON LETT, V40, P3891 BONINI BF, 1981, J CHEM SOC P1, P2322 BONNEAU R, 1999, J PHOTOCH PHOTOBIO A, V126, P31 GRAHAM WH, 1965, J AM CHEM SOC, V87, P4396 KUEHNE ME, 1964, J ORG CHEM, V29, P1582 LIU MTH, 1994, INT J CHEM KINET, V26, P1179 MAIBORODA DA, 1997, J ORG CHEM, V62, P7100 MINGUEZ JM, 1996, J ORG CHEM, V61, P4655 MOYANO EL, 1998, J ORG CHEM, V63, P8188 OVERBERGER CG, 1954, J AM CHEM SOC, V76, P1879 PERKAMPUS HH, 1972, TETRAHEDRON, V28, P2099 ROMASHIN YN, 1999, CHEM COMMUN 0307, P447 ROMASHIN YN, 1999, TETRAHEDRON LETT, V40, P7163 WONG JL, 1965, J ORG CHEM, V30, P2398; NR: 16; TC: 6; J9: CHEM COMMUN; PG: 2; GA: 324XFSource type: Electronic(1

    Effect of simplification from protease inhibitors to boosted atazanavir-based regimens in real-life conditions

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    Rubio, R., Serrano, O., Carmena, J., Asensi, V., Echevarría, S., Flores, J., Ribera, E., Zarraga, M., Ocampo, A., de la Fuente, B., Sepúlveda, M.A., Mariño, A.I., Minguez, C., Vicent, R., Cartón, J.A., Moyano, B., Esteban, H., Mahillo, B., Serrano, L., González-García, J

    Pre-operative assessment of intra-abdominal disease spread in epithelial ovarian cancer: A comparative study between ultrasound and computed tomography

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    Objective To compare the diagnostic performance of ultrasound and computed tomography (CT) for detecting pelvic and abdominal tumor spread in women with epithelial ovarian cancer. Methods An observational cohort study of 93 patients (mean age 57.6 years) with an ultrasound diagnosis of adnexal mass suspected of malignancy and confirmed histologically as epithelial ovarian cancer was undertaken. In all cases, transvaginal and transabdominal ultrasound as well as CT scans were performed to assess the extent of the disease within the pelvis and abdomen prior to surgery. The exploration was systematic, analyzing 12 anatomical areas. All patients underwent surgical staging and/or cytoreductive surgery with an initial laparoscopy for assessing resectability. The surgical and pathological findings were considered as the 'reference standard'. Sensitivity and specificity of ultrasound and CT scanning were calculated for the different anatomical areas and compared using the McNemar test. Agreement between ultrasound and CT staging and the surgical stage was estimated using the weighted kappa index. Results The tumorous stage was International Federation of Gynecology and Obstetrics (FIGO) stage I in 26 cases, stage II in 11 cases, stage III in 47 cases, and stage IV in nine cases. Excluding stages I and IIA cases (n=30), R0 (no macroscopic residual disease) was achieved in 36 women (62.2%), R1 (macroscopic residual disease <1 cm) was achieved in 13 women (25.0%), and R2 (macroscopic residual disease >1 cm) debulking surgery occurred in three women (5.8%). Eleven patients (11.8%) were considered not suitable for optimal debulking surgery during laparoscopic assessment. Overall sensitivity of ultrasound and CT for detecting disease was 70.3% and 60.1%, respectively, and specificity was 97.8% and 93.7%, respectively. The agreement between radiological stage and surgical stage for ultrasound (kappa index 0.69) and CT (kappa index 0.70) was good for both techniques. Overall accuracy to determine tumor stage was 71% for ultrasound and 75% for CT. Conclusion Detailed ultrasound examination renders a similar diagnostic performance to CT for assessing pelvic/abdominal tumor spread in women with epithelial ovarian cancer

    Modeling regional economic dynamics: spatial dependence, spatial heterogeneity and nonlinearities

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    Spatial modeling of economic phenomena requires the adoption of complex econometric tools, which allow us to deal with important methodological issues, such as spatial dependence, spatial unobserved heterogeneity and nonlinearities. In this paper we describe some recently developed econometric approaches (i.e. Spatial Autoregressive Semiparametric Geoadditive Models), which address the three issues simultaneously. We also illustrate the relative performance of these methods with an application to the case of house prices in the Lucas County

    The Glen Affric radar project: forest mapping using polarimetric interferometry

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    In this paper we describe the Glen Affric radar project, a multi-disciplinary program addressing the ability of polarimetric radar interferometry to provide quantitative vegetation structural information of importance in forest mapping and ecology studies
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