2,289 research outputs found
Corrigendum to Skitmore M and Pemberton J (1994). A multivariate approach to construction contract bidding mark-up strategies. The Journal of the Operational Research Society, Vol. 45, No. 11 (Nov., 1994), pp. 1263-1272
No full textA multivariate approach to contract bidding strategies in the construction industry is presented. This represents a radical departure from previous work in the field by using all available data on competing bidders. 'Optimal', 'no loss' and 'break even' mark up strategies are derived and methods of parameter estimation proposed. A case study shows how the three strategic mark up values are calculated against known competitors
Genetic variation in the Alpine chamois, with special reference to the subspecies Rupicapra rupicapra cartusiana Couturier, 1938
No full textGenetic Variation in 53 individuals representing 6 Alpine chamois (Rupicapra rupicapra) populations was investigated by starch gel electrophoresis, in order to determine the extent to which the endangered subspecies R. r. cartusiana differs from R. r. rupicapra and merits protection. Across all populations studied 10 of 55 loci screened were polymorphic and average heterozygosity was typical for a mammal but high for a large mammal. As measured by Nei genetic distances, the cartusiana population was the most distinct, but no loci diplaying fixed differences between populations were detected. It is concluded that the decision to protect the cartusiana population must depend on the cost of the protection
The works /
No full textv.2 reads: The works ... revis'd by the last Paris edition. To which is added a supplement by the author now first made English.V.2 has imprint: London : Edmund Curll, K. Sanger, John Pemberton, 1713.Each of the author's works has special t.p.v.1 A defense of M. de la Bruyere, and of his book, intitl'd, The characters or manners of the present age, &c.--The moral characters of Theophrastus ... / Theophrastus ; from the French of Mons. de la Bruyere.--Mons. de la Bruyere's speech upon his admission into the French academy, June the 15th, 1693.--Of the manner of living with great men ... / N. Rowe.--v.2. The characters, or, the manners of the present age / Jean de la Bruyere.Mode of access: Internet.Isaac Myer Collection
When groups are more competitive than individuals: The domain of the discontinuity effect
No full textThe related goals of the research were to delineate the domain of discontinuity, 1st by demonstrating its occurrence in a nonmatrix situation and, 2nd, by establishing the antecedent outcome conditions necessary for producing a discontinuity effect. The 1st goal was met by designing a mixed motive situation involving the production of origami products. Under these conditions, the magnitude of the discontinuity effect did not significantly differ from that in a matrix-only condition. The 2nd goal was met by a separate experiment that used H. H. Kelley and J. W. Thibaut's (1978) analysis of degree of noncorrespondence of outcomes. This experiment demonstrated that as noncorrespondence increased, so did the rate of competitive responding by groups but not by individuals. This pattern was qualified by an interaction with gender such that competitiveness was more markedly affected by noncorrespondence for groups of women than for groups of men
Natural and sexual selection on MHC genes in Soay sheep
No full textThe major histocompatibility complex (MHC) is one of the most variable gene
families in vertebrates. MHC molecules can recognize antigens from pathogens and
signal immune cells to invoke an adaptive immune response. Pathogen-mediated
selection is believed to be the main force maintaining diversity at MHC genes and
three main hypothesis have been proposed including heterozygote advantage,
negative frequency-dependent selection and fluctuating selection. However, it has
proven hard to demonstrate the exact selection regime that maintains variation in
natural populations. An effective method to examine contemporary selection on MHC
genes is to test for association between MHC genetic variation and fitness. However,
many previous studies suffer from poor genetic tools, low sample size, short time
scale and inappropriate statistical approaches. Also, a critical question, which is
rarely studied, is whether the associations between MHC variation and fitness are
consistent with associations between MHC variation and phenotypic traits that
predict fitness.
Besides the paradigm of pathogen-mediated selection, sexual selection may also
contribute to the maintenance of MHC diversity. MHC-dependent sexual selection
could also occur via three mechanisms including selection for specific alleles or
haplotypes, selection for heterozygosity and selection for compatibility. However, at
present there is no consensus as to which of these mechanisms are involved and
their importance. Previous studies have often suffered from limited genetic and
behavioural data and small sample size, and were rarely able to examine all the
mechanisms together, determine whether signatures of MHC-based non-random
mating are independent of genomic effects or distinguish whether MHC-dependent
sexual selection takes place at the pre- or post-copulatory stage.
For more than three decades, Soay sheep living in the island of Hirta, St Kilda
archipelago have been followed from birth, through all breeding attempts, to death.
With a genetically-inferred multigenerational pedigree, individual fitness of Soay
sheep can be measured directly. In addition, genomic pairwise relatedness and a
genomic measure of individual inbreeding is available for most individuals. Recently,
using genotyping-by-sequencing, a total of eight MHC class IIa haplotypes have
been identified in the study population and 5349 sheep alive between 1985 and 2012
have been diplotyped. This data, together with accurate fitness measurements and a
large number of phenotypic observations makes the Soay sheep a good system to
study selection on MHC class IIa genes. In addition, the availability of a large
number of consort and parentage records enabled us to test for MHC-dependent
sexual selection in Soay sheep more thoroughly than previous studies. Therefore, in
this thesis, taking advantage of this high quality dataset, I study natural and sexual
selection on MHC genes in Soay sheep.
In chapter 2, I investigate natural selection on MHC genes by examining
associations between MHC class IIa variation and fitness measurements including
total fitness and five fitness components using data for from 1080 to 3400 Soay
sheep depending on the measurement. I found haplotypes C and D were associated
with decreased and increased male total fitness respectively. In terms of fitness
components, juvenile survival was positively associated with haplotype divergence
while the above haplotype C and F were associated with adult male breeding
success and adult female lifespan respectively. Consistent with the increased male
total fitness, the rarest haplotype D has increased in frequency throughout the study
period more than expected under neutral expectations. My results suggest that
contemporary selection is acting on MHC class II genes in Soay sheep and that
fitness components may show a different mode of selection to total fitness.
In chapter 3, I test associations between MHC class IIa variation and five
representative phenotypic traits that are associated with fitness: weight, strongyle
faecal egg count, and IgA, IgE and IgG immunoglobulin titres against the
gastrointestinal nematode parasite Teladorsagia circumcincta all collected in Soay
sheep caught in August. I found no association between MHC class IIa genes and
August weight or strongyle faecal egg count. I did, however, find age-, isotype- and
sex-dependent associations between MHC class II genes and immunoglobulin
levels. These results suggest associations between MHC variation and phenotypic
traits are more likely to be found for traits more closely associated with parasite
defence than integrative traits such as body weight and highlight the association
between MHC variation and antibodies in wild populations.
In chapter 4, I use Monte Carlo simulation to investigate evidence for non-random
MHC-dependent mating patterns by all three mechanisms in a free-living population
of Soay sheep. Using 1710 sheep diplotyped at the MHC class IIa region and
genome-wide single-nucleotide polymorphisms (SNPs), together with field
observations of consorts, I found sexual selection against haplotype C in males at
the pre-copulatory stage and sexual selection against female MHC heterozygosity
during the rut. I also found MHC-dependent disassortative mating at the post-copulatory stage, along with strong evidence of inbreeding avoidance at both stages.
Results from generalized linear mixed models suggest that the pattern of MHC-dependent disassortative mating could be a by-product of inbreeding avoidance. My
results therefore suggest that while multiple apparent mechanisms of non-random
mating with respect to the MHC may occur, some of them have alternative
explanations.
In chapter 5, I use 2459 parent-offspring trios to examine whether there was within-trio post-copulatory selection on MHC class IIa genes at both the haplotype and
diplotype levels. I found there was transmission ratio distortion of one of the eight
MHC class II haplotypes (E) which was transmitted less than expected by fathers,
and transmission ratio distortion of another haplotype (A) which was transmitted
more than expected by chance to male offspring. However, in both cases, these
deviations were not significant after correction for multiple tests. In addition, I did not
find any evidence of post-copulatory selection at the diplotype level. These results
imply that, given known parents, there is no strong within-trio post-copulatory
selection on MHC class II genes in this population
Bulletin MA 1/90 - Manjimup/Pemberton vegetable variety planting guide 1990
No full textAGDEX NO: 250/30
Manjimup Regional Office
Manjimup and Pemberton vegetable planting guide 1990
792271suppmat – Supplemental material for Performance and predictors of recruitment success in National Heart, Lung, and Blood Institute’s cardiovascular clinical trials
No full textSupplemental material, 792271suppmat for Performance and predictors of recruitment success in National Heart, Lung, and Blood Institute’s cardiovascular clinical trials by Victoria L Pemberton, Frank Evans, Jamie Gulin, Ellen Rosenberg, Ebyan Addou, Kristin M Burns, David J Gordon, Gail D Pearson and Jonathan R Kaltman in Clinical Trials</p
Oxford and Oxford life /
No full textOxford in the past, by Rev. H.H. Henson.--Oxford in the present, by J. Wells.--Expenses of Oxford life, by J. Wells.--The intellectual life, by F. G. Brabant.--The social life, by J. S. G. Pemberton.--The religious life, by Rev. G. W. Gent.--Aids to supply at Oxford: the Bodleian, the University galleries, &c., by C. W. C. Oman.--Women's education at Oxford, by Miss K. M. Gent.--University extension, by M. E. Sadler.Mode of access: Internet
Learner centred development of cross platform language learning support system
No full textInteractive television (iTV) is a new media technology that has great potential for supporting second language learning, particularly for independent adult learners. It has many characteristics demanded by modern second language (L2) learning theories and is technologically quite sophisticated. However, in order for it to succeed it needs to fit in with these learners’ approaches to media use in language learning. While there is an extensive literature on many other aspects of language learning and teaching, particularly in classroom settings, we know surprisingly little about the independent adult language learner's attitudes and approaches to learning and to technologies for supporting it. In this paper, we describe a project to develop language learning via interactive television (iTV) where a focus group study has been used to elicit the attitudes of potential users in order to direct the design process using a use-case scenario. We present the design implications that emerged from the focus group, broadly suggesting the use of mobile phone in conjunction with iTV to facilitate informal language learning from up-to-date authentic materials broadcast on televisio
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