197 research outputs found
Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk.
No full textBACKGROUND: Somatic mutations in phosphoinositide-3-kinase catalytic subunit alpha (PIK3CA) are frequent in breast tumours and have been associated with oestrogen receptor (ER) expression, human epidermal growth factor receptor-2 overexpression, lymph node metastasis and poor survival. The goal of this study was to evaluate the association between inherited variation in this oncogene and risk of breast cancer. METHODS: A single-nucleotide polymorphism from the PIK3CA locus that was associated with breast cancer in a study of Caucasian breast cancer cases and controls from the Mayo Clinic (MCBCS) was genotyped in 5436 cases and 5280 controls from the Cancer Genetic Markers of Susceptibility (CGEMS) study and in 30 949 cases and 29 788 controls from the Breast Cancer Association Consortium (BCAC). RESULTS: Rs1607237 was significantly associated with a decreased risk of breast cancer in MCBCS, CGEMS and all studies of white Europeans combined (odds ratio (OR)=0.97, 95% confidence interval (CI) 0.95-0.99, P=4.6 × 10(-3)), but did not reach significance in the BCAC replication study alone (OR=0.98, 95% CI 0.96-1.01, P=0.139). CONCLUSION: Common germline variation in PIK3CA does not have a strong influence on the risk of breast cancer
J. G. Collee, Angewandte medizinische Mikrobiologie. 224 S., 55 Abb., 21 Tab., Berlin 1980. Akademie-Verlag. M 12,50
No full textRecommended from our members
The impact of sampling frequency on ground reaction force variables
No full textNew portable and low-cost technologies for assessing limb loading may be useful in non-laboratory environments, but have relatively low sampling frequencies. The lowest recommended sampling frequency for impact kinetics has not been investigated. The purpose of this study was to determine the effect of sampling frequency on metrics of impact kinetics during landing, walking, and running. This was a retrospective analysis of bilateral drop vertical jumps, unilateral drop landings, treadmill running, and flat, inclined, and declined treadmill walking. Landing data were collected at 1920 Hz while walking and running data were collected at 1440 Hz. Impact kinetics were computed at the highest possible sampling frequency, and then data were continuously down-sampled to determine the impact on the following computed metrics: peak impact force, average LR, and impulse. The minimum sampling frequency to compute each outcome with 90%, 95%, and 99.5% accuracy when compared to the original sampling frequency were determined. To achieve 90% of the true value of impact force, a sampling frequency of 180 Hz was needed for running, 62 Hz for bilateral landing, and 48 Hz for remaining tasks. For average LR, a sampling frequency of 1440 Hz was need for running, 63 Hz for inclined walking, 192 Hz for bilateral landing, and 48 Hz for the remaining tasks. For impulse, 48 Hz was required for all tasks. The results of this study provide future researchers with a guide for selecting the sampling frequency required to accurately assess impact kinetics during walking, landing, or running.12 month embargo; available online: 09 March 2022This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
Effect of single-dose anthelmintic treatment during pregnancy on an infant's response to immunisation and on susceptibility to infectious diseases in infancy: a randomised, double-blind, placebo-controlled trial.
No full textBACKGROUND: Helminth infections affect the human immune response. We investigated whether prenatal exposure to and treatment of maternal helminth infections affects development of an infant's immune response to immunisations and unrelated infections. METHODS: In this randomised, double-blind, placebo-controlled trial, we enrolled 2507 women in the second or third trimester of pregnancy who were planning to deliver in Entebbe General Hospital, Entebbe, Uganda. With a computer-generated random number sequence in blocks of 100, we assigned patients to 440 mg albendazole and 40 mg/kg praziquantel (n=628), 440 mg albendazole and a praziquantel-matching placebo (n=625), 40 mg/kg praziquantel and an albendazole-matching placebo (n=626), or an albendazole-matching placebo and praziquantel-matching placebo (n=628). All participants and hospital staff were masked to allocation. Primary outcomes were immune response at age 1 year to BCG, tetanus, and measles immunisation; incidence of infectious diseases during infancy; and vertical HIV transmission. Analysis was by intention-to-treat. This trial is registered, number ISRCTN32849447. FINDINGS: Data were available at delivery for 2356 women, with 2345 livebirths; 2115 (90%) of liveborn infants remained in follow-up at 1 year of age. Neither albendazole nor praziquantel treatments affected infant response to BCG, tetanus, or measles immunisation. However, in infants of mothers with hookworm infection, albendazole treatment reduced interleukin-5 (geometric mean ratio 0·50, 95% CI 0·30-0·81, interaction p=0·02) and interleukin-13 (0·52, 0·34-0·82, 0·0005) response to tetanus toxoid. The rate per 100 person-years of malaria was 40·9 (95% CI 38·3-43·7), of diarrhoea was 134·1 (129·2-139·2), and of pneumonia was 22·3 (20·4-24·4). We noted no effect on infectious disease incidence for albendazole treatment (malaria [hazard ratio 0·95, 95% CI 0·79-1.14], diarrhoea [1·06, 0·96-1·16], pneumonia [1·11, 0·90-1·38]) or praziquantel treatment (malaria [1·00, 0·84-1·20], diarrhoea [1·07, 0·98-1·18], pneumonia [1·00, 0·80-1·24]). In HIV-exposed infants, 39 (18%) were infected at 6 weeks; vertical transmission was not associated with albendazole (odds ratio 0·70, 95% CI 0·35-1·42) or praziquantel (0·60, 0·29-1·23) treatment. INTERPRETATION: These results do not accord with the recently advocated policy of routine antenatal anthelmintic treatment, and the value of such a policy may need to be reviewed. FUNDING: Wellcome Trust
A case-only study to identify genetic modifiers of breast cancer risk for <em>BRCA1/BRCA2</em> mutation carriers
No full text\ua9 2021, The Author(s).Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population BC cases and 13,007 cases with BRCA1 or BRCA2 mutations. We identify robust novel associations for 2 variants with BC for BRCA1 and 3 for BRCA2 mutation carriers, P < 10−8, at 5 loci, which are not associated with risk in the general population. They include rs60882887 at 11p11.2 where MADD, SP11 and EIF1, genes previously implicated in BC biology, are predicted as potential targets. These findings will contribute towards customising BC polygenic risk scores for BRCA1 and BRCA2 mutation carriers
Poverty, life events and the risk for depression in Uganda.
No full textBACKGROUND: Understanding the determinants of major depression in sub-Saharan Africa is important for planning effective intervention strategies. OBJECTIVE: To investigate the social and life-event determinants of major depressive disorder in the African sociocultural context of rural Uganda. METHODS: A cross-section survey was carried out in 14 districts in Uganda from 1 June 2003 to 30 October 2004. 4,660 randomly selected respondents (15 years and above) were interviewed. The primary outcome was the presence of 'probable major depressive disorder' (PMDD) as assessed by the Hopkins symptom checklist. RESULTS: The prevalence of PMDD was 29.3% (95% confidence interval, 28.0-30.6%). Factors independently associated with depression in both genders included: the ecological factor, district; age (increase with each age category after 35 years); indices of poverty and deprivation (no formal education, having no employment, broken family, and socioeconomic classes III-V). Only a few adverse life events, notably those suggestive of a disrupted family background (death of a father in females and death of a mother in males) were associated with increased risk. CONCLUSION: Socioeconomic and sociodemographic factors, operating at both ecological and the individual level are the strongest independent determinants of depression. Adverse life events were less strongly associated with depression in this sample
The effect of anthelmintic treatment during pregnancy on HIV plasma viral load: results from a randomized, double-blind, placebo-controlled trial in Uganda.
No full textBACKGROUND: To investigate the effect of helminth infections and their treatment during pregnancy on HIV load, we conducted a 2 × 2 factorial randomized controlled trial of albendazole versus placebo and praziquantel versus placebo in pregnant women in Entebbe, Uganda. METHODS: Two hundred sixty-four HIV-infected pregnant women from the Entebbe Mother and Baby Study (ISRCTN 32849447) were included in this analysis. Women were tested for helminth infections at enrollment, and mean HIV load was compared between infected and uninfected groups. The effect of anthelmintic treatment on HIV load was evaluated at 6 weeks after treatment and at delivery using linear regression and adjusting for enrollment viral load. RESULTS: Hookworm and Trichuris infections were associated with higher mean viral load at enrollment [adjusted mean difference 0.24 log10 copies/mL, 95% confidence interval (CI): 0.01 to 0.47, P = 0.03, and 0.37 log(10) copies/mL, 95% CI: 0.00 to 0.74, P = 0.05, respectively]. There were no associations between viral load and other helminth species. There was some evidence that albendazole reduced viral load at 6 weeks after treatment (adjusted mean difference -0.17, 95% CI: -0.36 to 0.01, P = 0.07); however, this effect did not differ according to mother's hookworm infection status and had diminished at delivery (adjusted mean difference -0.11, 95% CI: -0.28 to 0.07, P = 0.23). There was no effect of praziquantel treatment on HIV load at any time point. CONCLUSIONS: Infection with some soil-transmitted helminth species is associated with increased HIV load in pregnancy. Treatment with albendazole causes a small decrease in HIV load; however, this may not represent a direct effect of worm removal
To return or to discard? Randomised trial on gastric residual volume management
No full textBackground: The control of gastric residual volume (GRV) is a common nursing intervention in intensive care; however the literature shows a wide variation in clinical practice regarding the management of GRV, potentially affecting patients" clinical outcomes. The aim of this study is to determine the effect of returning or discarding GRV, on gastric emptying delays and feeding, electrolyte and comfort outcomes in critically ill patients. Method: A randomised, prospective, clinical trial design was used to study 125 critically ill patients, assigned to the return or the discard group. Main outcome measure was delayed gastric emptying. Feeding outcomes were determined measuring intolerance indicators, feeding delays and feeding potential complications. Fluid and electrolyte measures included serum potassium, glycaemia control and fluid balance. Discomfort was identified by significant changes in vital signs. Results: Patients in both groups presented similar mean GRV with no significant differences found (p=0.111), but participants in the intervention arm showed a lower incidence and severity of delayed gastric emptying episodes (p=0.001). No significant differences were found for the rest of outcome measurements, except for hyperglycaemia. Conclusions: The results of this study support the recommendation to reintroduce gastric content aspirated to improve GRV management without increasing the risk for potential complications
Washington State Association of U.A Plumbers and Pipefitters (WSA) Minutes of the Regular Meetings of Local #40, 1955-1956
No full textMinutes of Regular Meetings of Local # 40-
June 7, 1955 thru June 19, 1956
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Meeting of June -9,1955 called to order at 7:30 P M hy Pres
Ed Mc Allister.
Minutes of previous meeting read and approved.
Committees
Frank Jansen read the Financial report for the month of May 1955.
M/s/c/ To accept the Financial report for the Month fi of May 1955#
George Stearns gave the report on the Metal Trades meeting
held in Seattle pestaining to their new Contract.
Pres Ed Mc Allister reported on the State Convention•
M/s/c/ To accept all clearance cards*
Jessie Adcock Card # 423950
J G Allen Card # 744751
Rob»t Barbour Card # 699304
W S Barr Card # 311474
George Brisco Card # 343187
Wm J Dill Card # 512813
Frank L Doremus Card # 693728
John Frichtner Card # 329600
Alfred Gilmore Card # 583120
B H Jenkins Card # 621347
Arthur W Jones Card # 420745
Wm D Kirkland Card # 381149
H R Ledbetter Card # 693382
Claude Lummus Card # 515917
B J Mattoon Card # 663872
Cicero Neal Card # 709749
Edwin W Newberry Card # 363065
H C Nolen Card # 635745
Fred 0 Ousley Card # 541524
Robert L Peters Card # 701779
G H Phillips Card # 616619
David Simmons Card # 744634
Ernest C Swenson Card # 726736
Sam jef/ P Vann Card # 468570
A M Verner Card # 751342
Frank Webley Card # 394419
G A Wells Card # 354540
William R Wilson Card # 706220
A E Yates Card # 636263
F P Ackley Card # 365178
Hugh Adcock Card # 743412
J F Allen Card # 300910
Arnold Armagast Card # 440980
H V Armstead Card # 547137
JL Bert Andres Card # 777246
S B Bailley Card # 352730
Ben L Bellas Card # 494670
John Berth Card # 394500
S Besch Card # 384975
C H Blackwell Card # 681969
J C Badgett Card # 701546
Jack A Branden Card # 338756
Fernand Broussard Card # 593860
Joseph A Bufkin Card # 707092
0 K Buster Card # 324025
Geo. M Byerly Card # 416013
W W Collee Card # 683319
Henry Callanan Card # 480301
Clearance Cards of June 7, 1955 Cont-
J B Cannon Card # 591076
John A Carlson Card # 734836
Pinkey M Carlton Card # 470552
Phillip S Casteel Card # 717388
J A Cates Card # 404904
Hershel L Citty Card # 687557
W V Clark Card § 635943
Albert E Cleveland Card # 694370
Ralph W Coffing Card # 440974
Chas B Coleman Card # 389669
Joseph J Collins CArd # 401165
Durwaro Copeland Card # 400149
Glen E Crooks Card # 541512
James E Culligan Card # 531897
Wm. D Culver Card # 650432
Homer W Cupit Card # 730810
G E Dailey Card # 667709
John T Dailey Card # 44729 2
L L Davis Card // 358901
George J Deal Card # 531903
Eu~ene K Dobler C^rd # 418198
Hugh R Dunn Card § 311957
\'I J Durham Card # 407367
Milas Lee Downey Card # 635697
Ray T English Card // 434796
Leroy "V Ehgquist Card # 446541
Ray Erckenbrack Card # 370521
V L Evans Card # 489659
Earle W Farabow Card # 748821
Irwin A Foster Care # 356061
Aaron A Gerken Card f 418737
Jester Gibson Card # 744426
S H Gilkey Card # 337310
Salvatore S Greco Card # 722607
D L Haines Card # 433387
James D Hallomor Card # 623749
L Wayne Hanson Card # 708482
J L Harris Card # 747314
M S Harrist Card # 714788
Kitchell C Hayden Card # 484388
James L' Heyser Card •// 667654
Leanord M Holum Card # 290730
S S Horton Car.d # 545310
L A Houston C rd # 360241
Joe K Humphrey Card # 432678
Homer C^Hunt Card # 658406
Walter C Ingram Card # 416223
Milton Dale Johnson Card # 710539
Clarence V Jones C~rd°# 535990
T H Jones Card # 580143
Leland M Kaps Card # 701554
J B Keener Card # 745848
0 J Kessler Card # 591017
Charles S Kline Ctird # 499556
H S Kribbs Card # 419138
Samuel M Lawlis Card # 207625
Gerald R Leggett Card # 282831
A A Letz Card # 488799
John P Lewis CArd # 417055
Norman T Liggett Card # 668359
R G Linebarger Card # 564150
Jeff R Luce Card # 748379
f
Clearance Cards of June 7,1955 cont. #
Tom R Luke Card # 422169
Bert H Lynn Card # 358653
Wm R Mc Adoo Card # 704029
#\ B T Mc Cormick Card % 468597
SiM'C Guire Card # 153885
Fred Mc Leod Card # 370918
Charlie Miller Card # 706548
J A Miller Card # 434940
Geo. S Moore Card # 566461
Gould Moss Card # 714772
H H Moss Card # 589880
Claud R Mullin Card # 370602
Clayton W Mowery Card # 556969
Geo. A Nugent Card # 359414
Chas E Palmore Card # 742036
Ray E Paul Card # 454467
Clifford Peterson Card # 284802
W 0 Phillips Card # 574695
S E Philmon Card # 764832
Raymond C Philpott Card # 562496
"Walter I Pirtle Card # 471776
Bert C Poe Card # 642031
James H Posey Card # 745938
C W Rhaten Card # 745229
Rob't D Richards Card # 517119
Raymond A Rivera Card # 434608
Lewis N Robison Card # 607241
Harvey A Roper Card # 581485
rLe Roy Ross Card # 591049
D E Rust Card # 329634
Floyd Saltz Card # 714327
Harvy Saxton Card # 468557
S AScheide Card# 398380
A C Shock Card # 649717
A MSimmers C-^rd # 484929
Chas E Smith C~rd# 645644
Leo B Smith Card # 452168
J C Shell Card # 663911
James R Stamey Card # 597453
James H Stedman Card# 467695
Phiney Steinfelt Card# 657405
Wm G Steward Card # 701625
Roland P Stringer Card # 748588
Wm Talbert Card # 415870
Paul Terentieff Card # 335384
C A Tillison Card# 761556
Allen W Toby Card # 401675
John C Tyra C^rd # 616709
L C Vermillion Card # 761557
Raymond Ward Card # 386112
H L Walker Card # 391740
Chas E Warford Card # 600312
P VWarren Card # 715720
James H Watley Card # 724488
#&n Loban V Watley Card # 724496
t A V Welch Card # 406836
H C Whisemant Card # 639084
Leland HWilesC**rd# 699290
John C Willard / Card # 397594 ^moM^illis, Card# 323406
v
/$p\
.rf Clearance Cards of June 7, 1955 Cont
Kenneth E Wenn Card # 531904
Lewis J Witt Card # 748728
Eugene W Zager Card # 746061
Bert Anderson C^rd # 664322
Executive Board's Report By Jack Chandler. It Was recommended by
the E Board that Local # 4u have one meeting per month thru the je
summer months,with the E Board meeting every other Monday nite as
usual, m/s/ 6/ To reject the aforementioned recommendation
Those voting to reject the Recommendation -34
Those accepting the recommendation 6
Business Agen'ts Report by Walt Dvo&aeek, Walt asks to please
quit calling in or writing your friends and relations to come up
to Anacortes. as the job is at it's peak right now most jobs
are starting to peter out in the area. M/vS/ C/ To accept the
Business Agen'ts report.
Shop Steward E Priee or Jhe North Side Yard reports no lay-offs
and conditions pretty much 0. K. Johnny Enghoifcm reports conditions
at the Ferndale Refinery job good. '
J Coffman reports that his refigeration job is going along allright.
The Pic Sweet job is rnnning smooth. Earl Pratt of the Anacortes
Shell job reports 900 Plus men on the job—most gripes are small,
a lot of trouble is in our own ranks, there willsoon be a reduction
in force which nobody can prevent.
Good and Welfare none
New Business
Delegates for the Building Trades Construction Section of the Con
vention which will be held July 9and 10, 1955 ///
Nominees are
Walt D. 44votes
Ed McAllister 26
Earl Pratt 15
Red Martin.4-Pres Ed closed the nominations.
Your delegates are Walt D. an d Ed McAllister, and the Alternates
are Earl Pratt and Red Martin.
M/s/c/ That the afore-elected delegates and al ternates follow thru
to represent us aft theWash. State Federation of Labor Convention
July ll-12-13~14th,1955.
Receipts of themeeting $ 420..00
Pres. Ed adjourned the meeting at 8.55 P M.
Rec 'y Sec 'y
Occy Swanson.
\
Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk
No full textIn breast cancer, high levels of homeobox protein Hox-B13 (HOXB13) have been associated with disease progression of ER-positive breast cancer patients and resistance to tamoxifen treatment. Since HOXB13 p.G84E is a prostate cancer risk allele, we evaluated the association between HOXB13 germline mutations and breast cancer risk in a previous study consisting of 3,270 familial non-BRCA1/2 breast cancer cases and 2,327 controls from the Netherlands. Although both recurrent HOXB13 mutations p.G84E and p.R217C were not associated with breast cancer risk, the risk estimation for p.R217C was not very precise. To provide more conclusive evidence regarding the role of HOXB13 in breast cancer susceptibility, we here evaluated the association between HOXB13 mutations and increased breast cancer risk within 81 studies of the international Breast Cancer Association Consortium containing 68,521 invasive breast cancer patients and 54,865 controls. Both HOXB13 p.G84E and p.R217C did not associate with the development of breast cancer in European women, neither in the overall analysis (OR = 1.035, 95% CI = 0.859-1.246, P = 0.718 and OR = 0.798, 95% CI = 0.482-1.322, P = 0.381 respectively), nor in specific high-risk subgroups or breast cancer subtypes. Thus, although involved in breast cancer progression, HOXB13 is not a material breast cancer susceptibility gene
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