97 research outputs found
Business Papers (MS 80-0003)
No full textDeed from A. J. Locklear to John E. Oliver conveying 100 acres of land part of the D. N. Burke
Nicotine Preference and Gene Expression: The Role of Cd81
Get PDFSmoking is a leading preventable cause of death worldwide. Variation in smoking behavior arises in large part from individual perception of nicotine’s rewarding effects, and the propensity for nicotine dependence. Attempts to elucidate molecular mechanisms underlying these factors have so far been insufficient for developing effective treatments for, or reliable predictors of dependence. Thus, identifying genetic determinants of nicotine addiction is of vital importance. This can most readily be accomplished using laboratory mice. We used two-bottle choice nicotine self-selection to assess differences in nicotine consumption between the C57BL/6J and A/J inbred strains, and in a separate experiment, C57BL/6J Cd81 knockout mouse strains. We quantified the relative motivation to seek nicotine. Our unique set of experimental design parameters allowed unprecedented success in distinguishing between the strains and sexes through voluntary nicotine consumption. The cohorts exhibited distinct nicotine consumption levels. Most showed increasing consumption with time, indicating tolerance effects. We measured signs of nicotine withdrawal in the C57BL/6J mice, and found without exception, each cohort became nicotine dependent. Our nicotine self-selection paradigm satisfies all accepted criteria for animal models of alcoholism. On this basis, we regard our design as being a valid model for nicotine dependence. During self-selection, we determined that Cd81 loss-of-function significantly increased nicotine preference. However, previous studies had indicated Cd81 loss-offunction produced a reduction in cocaine preference. Thus, we investigated further by comparing gene expression in wild-type and Cd81 knockout mice at baseline and after nicotine treatments. We measured the expression of genes for dopamine receptors (Drd1, Drd2S, Drd2L, Drd3), the dopamine transporter (DAT), phosphodiesterases (Pde4b, Pde4d), and the tetraspanin Cd81, in the mesocorticolimbic pathway. Our results indicated the following: (i) CD81 function was essential for normal transcriptional response to nicotine, (ii) baseline expression of Pde4b and DAT were each influenced by Cd81 genotype in key brain areas and (iii) the baseline expression of Pde4b and DAT correlated with nicotine consumption behaviors. Finally, we speculate that Cd81, Pde4b and DAT work in concert to modulate nicotine preference and that this Cd81-associated pathway may function in a drug-specific manner. In conclusion, our results support the use of laboratory mice in nicotine selfselection for assessing nicotine preference. We found that CD81 influences nicotine consumption and transcriptional activity of dopamine signaling-associated components. Our hypothesis that CD81, PDE4B and DAT participate in a single pathway, working in concert to modulate drug consumption will be tested in future experiments
sj-docx-2-han-10.1177_15589447221077363 – Supplemental material for On the Road Again: Return to Driving Following Minor Hand Surgery
No full textSupplemental material, sj-docx-2-han-10.1177_15589447221077363 for On the Road Again: Return to Driving Following Minor Hand Surgery by Mary C. Frazier, Darren T. Hackley, Tonja M. Locklear, Ariel E. Badger and Peter J. Apel in HAND</p
sj-docx-3-han-10.1177_15589447221077363 – Supplemental material for On the Road Again: Return to Driving Following Minor Hand Surgery
No full textSupplemental material, sj-docx-3-han-10.1177_15589447221077363 for On the Road Again: Return to Driving Following Minor Hand Surgery by Mary C. Frazier, Darren T. Hackley, Tonja M. Locklear, Ariel E. Badger and Peter J. Apel in HAND</p
sj-docx-1-han-10.1177_15589447221077363 – Supplemental material for On the Road Again: Return to Driving Following Minor Hand Surgery
No full textSupplemental material, sj-docx-1-han-10.1177_15589447221077363 for On the Road Again: Return to Driving Following Minor Hand Surgery by Mary C. Frazier, Darren T. Hackley, Tonja M. Locklear, Ariel E. Badger and Peter J. Apel in HAND</p
sj-docx-4-han-10.1177_15589447221077363 – Supplemental material for On the Road Again: Return to Driving Following Minor Hand Surgery
No full textSupplemental material, sj-docx-4-han-10.1177_15589447221077363 for On the Road Again: Return to Driving Following Minor Hand Surgery by Mary C. Frazier, Darren T. Hackley, Tonja M. Locklear, Ariel E. Badger and Peter J. Apel in HAND</p
Importance of open access to atypical antipsychotics for the treatment of schizophrenia and bipolar disorder : a European perspective
No full textOBJECTIVE: To assess European psychiatrists' prescribing behaviour and their perceived need for access to a wide range of atypical antipsychotics for patients with schizophrenia and bipolar disorder. METHODS: A blinded, internet survey of psychiatrists from the UK, Germany, Italy and the Netherlands occurred in 2007. Key inclusion criteria for psychiatrists: practising full time; practising for 5-35 years; prescribed atypical antipsychotics in prior 6 months to > or =20 patients with schizophrenia or bipolar disorder. Eligible psychiatrists selected records for four patients with schizophrenia or bipolar disorder for whom they prescribed > or =1 atypical antipsychotic since January 2004. RESULTS: Survey response rates were: UK, 14.8% (n = 107); Germany, 9.6% (n = 104); Italy, 8.9% (n = 101) and the Netherlands, 3.7% (n = 51); 363 psychiatrists reported on 1442 patients. Psychiatrists perceived a greater difference among atypical antipsychotics as a class (mean, 5.1 on a 7-point scale [7 = 'highly differentiated']) but not selective serotonin reuptake inhibitors (mean, 3.6). On average, psychiatrists used 6.8 different atypical antipsychotics across their patients with schizophrenia and 4.4 across their patients with bipolar disorder, with 2.5 and 2.4 changes required following first-line treatment to stabilise therapy, respectively. The most common reason for switching medication was lack of efficacy. Psychiatrists reported that expected consequences for patients should access to atypical antipsychotics be restricted would include illness deterioration, non-adherence and hospitalisation. CONCLUSIONS: Although this study is limited by potential selection biases, these data suggest that European psychiatrists tailor antipsychotic medications for patients with schizophrenia or bipolar disorder according to patients' needs and specific drug attribute
Business Papers (MS 80-0003)
No full textWarranty deed from L. T. Gilstrop to A. J. and Sarah H. Locklear conveying 100 acres of land part of the D. N. Burke survey
Applying Indigenous Knowledge to Innovations in Social Work Education
Get PDFGrounded in an indigenous holistic worldview and borrowing from the four Rs (values of relationships, responsibility, reciprocity, and redistribution), this article supports the inclusion of translational science and the integration of core metacompetencies into social work doctoral education as innovations in the field of social work science. The author argues that these innovations will enhance the ability of social–work–trained researchers to serve on transdisciplinary research teams, which are necessary to address complex metaproblems found in the natural world. Further, the author asserts that transdisciplinary scientific integration is helpful to social work science, as it builds awareness and appreciation of social work scholarly inquiry, promotes the inclusion of social work values in scientific research, and helps erode the scientific hierarchy that has traditionally existed between the natural and social sciences. By leveraging personal experiences in transdisciplinary education, the author offers a conceptual framework for innovations in doctoral education
Review of Dakota Flora: A Seasonal Sampler
Get PDFThere are few books on the plants of the Great Plains, and most of these are too technical to appeal to average readers, even those interested in natural history. Thankfully, this situation has changed with the arrival of David J. Ode\u27s Dakota Flora: A Seasonal Sampler
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