7,051 research outputs found
The MERLIN Simulation Program: New Features used in Studies of the LHC Collimation System using MERLIN
No full textWe present recent developments in the MERLIN particle
tracking simulation code, originally developed at DESY.
We have implemented differential scattering cross-sections
based on a pomeron exchange model interpolated over experimental
measurement data, and show that this model is
important at the small scattering angles generated in the
LHC collimators. Preliminary comparisons with previous
simulations are presented
Personal Papers (MS 80-0002)
No full textLetter from Isaac H. Kempner to Merlin J. McGivney informing that the bill is correct
When King Arthur met the Venus : Romantic Antiquarianism and the Illustration of Anne Bannerman’s “The Prophecy of Merlin”
No full textThe first edition of Bannerman’s Tales of Superstition and Chivalry (1802) contained an erotic engraving of a naked Venus figure, which was declared ‘offensive to decency’ by Scottish audiences in the poet’s native Edinburgh. Garner’s account investigates the controversy surrounding the engraving and the puzzling disparity between it and the ballad it illustrated: the Arthurian-themed ‘Prophecy of Merlin’. Using evidence from Bannerman’s correspondence with noted Scottish male publishers and antiquarians, this essay argues that decision to include the dangerous engraving was symptomatic of current anxieties surrounding a female-authored text which threatened to encroach on antiquarian and Arthurian enquiry.Peer reviewe
A study of the behaviour and interactions of the novel FERM protein Willin
No full textWillin is a novel member of the Four-point-one Ezrin Radixin Moesin
(FERM) protein superfamily, containing an N-terminal FERM domain most like the
Ezrin-Radixin-Moesin (ERM) family but also the closely related protein Merlin.
Willin was initially discovered as a yeast two-hybrid binding partner of
neurofascin155, and this interaction has now been confirmed by both co-localisation
studies and the use of two different biochemical methods. Like neurofascin155,
Willin also localises to detergent resistant membranes, and like the ERM family, it is
able to bind to phospholipids. The expression of Willin appears to be toxic as the
production of cell-lines stably expressing Willin proved to be not possible and this
appears to be because it induces apoptosis in cultured cells. This is a proliferation
control function consistent with the suggestion that Willin is the human homologue of the Drosophila tumour suppressor ‘Expanded’. Three antibodies to Willin were also characterised and a novel splice variant, Willin2, subcloned into a GFP-tagged
plasmid for comparison with the original form
Union académique internationale. Corpus vasorum antiquorum. — Italia, Regio museo archeologico di Firenze, par Doro Levi, fasc. 1, 1931 Great Britain, Oxford, Ashmolean Museum, par J. D. Beazley, H. G. G. Payne et E. R. Price, fasc. 2, 1931 France, Paris, Bibliothèque nationale (Cabinet des Médailles), par Mme S. Lambrino (Marcelle Flot), fasc. 2, 1931 Pays-Bas, Musée Scheurleer (La Haye), par C.W. Lunsingh Scheurleer, fasc. 2, 1931
No full textMerlin Alfred. Union académique internationale. Corpus vasorum antiquorum. — Italia, Regio museo archeologico di Firenze, par Doro Levi, fasc. 1, 1931 Great Britain, Oxford, Ashmolean Museum, par J. D. Beazley, H. G. G. Payne et E. R. Price, fasc. 2, 1931 France, Paris, Bibliothèque nationale (Cabinet des Médailles), par Mme S. Lambrino (Marcelle Flot), fasc. 2, 1931 Pays-Bas, Musée Scheurleer (La Haye), par C.W. Lunsingh Scheurleer, fasc. 2, 1931. In: Journal des savants, Mars 1932. pp. 133-137
Inhibition of the hyaluronan-CD44 interaction by merlin contributes to the tumor-suppressor activity of merlin
No full textMutation or loss of expression of merlin is responsible for neurofibromatosis type 2 (NF2), which is characterized by the development of schwannomas and other tumors of the nervous system. Like the ERM (ezrin-radixin-moesin) proteins, merlin interacts with CD44, a cell-surface receptor for hyaluronan (HA) that promotes tumorigenesis. However, the relationship between merlin and CD44 and the mechanism by which merlin exerts its tumor-suppressor function have not been elucidated. In the present study, we show that increased expression of wild-type merlin in Tr6BC1 schwannoma cells inhibits HA binding to CD44. Furthermore, we demonstrate that the residues required for this inhibitory effect and the interaction between CD44 and merlin lie within the first 50 amino acids of merlin. Overexpression of merlin inhibited subcutaneous growth of Tr6BC1 cells in immunocompromised Rag1 mice. In contrast, knocking down expression of endogenous merlin promoted tumor cell growth, as did overexpression of a merlin deletion mutant (merlinDel-1) that lacks the first 50 amino acids but not of other NH(2)-terminal deletion mutants. Together, our results demonstrate that inhibition of the CD44-HA interaction contributes to the tumor-suppressor function of merlin, and they suggest that merlin inhibits tumor growth, at least in part, by negatively regulating CD44 functio
[Jeu de cartes belge à enseignes françaises] : [estampe]
No full textAncien possesseur : Merlin, Romain (1793-1871). Ancien possesseurAppartient à l’ensemble documentaire : JeuCartCarte à joue
Merlin im Spiegel der Moderne
No full textMerlin, der Magier und Seher, betrat die Bühne der Weltliteratur im Jahre 1136. Geoffrey of Monmouth legte bereits einen Teil der Tradition fest, in der wir Merlin heute sehen: er machte ihn zum Zauberer und Ratgeber König Arthurs, gleichzeitig teilte er ihm die Rolle des Propheten und Sehers zu, der abseits der Menschen im Wald hauste und in Frömmigkeit dahinlebte. Ergänzungen und Ausschmückungen, die sein Bild bei Robert de Boron und anderen erfahren hat, greifen auf Quellen zurück, die für uns heute verloren sind. Moderne Autoren haben dem Charakter Merlins, der allein durch die Fähigkeit, die Realität manipulieren zu können, fasziniert, zum Teil eine Tiefe verliehen, die bei Geoffrey und seinen Nachfolgern nicht vorhanden ist. Die drei hier eher willkürlich gewählten und sicher einem breiteren Publikum nicht unbedingt vertrauten Autoren machen Merlin zur zentralen Gestalt in der Auseinandersetzung mit der Welt: bei T. H. White erscheint ein eher zerstreuter älterer Mann, der die Zeit rückwärts durchlebt, in der Funktion des Lehrers und Erziehers, bei J. C. Powys ist Merlin die 'life-force', der Wille zum Leben schlechthin, und bei C. S. Lewis ist Merlin ein Instrument in dem kosmischen Kampf zwischen Gut und Böse.Apart from King Arthur himself Merlin is probably the medieval figure most portrayed in modern art. And no wonder: he is after all the one who can manipulate reality and place himself within it at whichever position he chooses. He makes his first literary appearance in the writings of that great mythopoetic story-teller Geoffrey of Monmouth, who defined his role as magician and counsellor to the great King Arthur and as the seer and prophet who lived the life of a recluse in the deep of the woods. Later accretions to his character in Robert de Boron and others go back to sources forever lost to us. The following essay proposes to investigate the role Merlin plays in three notable modern novels, all three certainly off the mainstream of modern literary tradition. T. H. White in his retellings of Malory's Le Morte Darthur uses Merlin as the (almost traditional) schoolmaster and educator of the young Wart, who is later to become Arthur; John Cowper Powys in his Porius makes him the bearer of the world's wisdom, and for C. S. Lewis in That Hideous Strength Merlin is an instrument “good enough and not to good" in his cosmic struggle between good and evil
Talk: Biographical, part of a Civil War song about Euchre; Account of baby found on Wilson's Creek Battlefield, and Mansfield Cyclone
No full textCollected by Merlin Mitchell
For Mary C. Parler
Mrs. J. T. Davidson
Elkins, Missouri
July 20, 1950
Reel 57, Item 1
There is about two minutes of blank tape at the
beginning of the reel. Then Mitchell begins to tell of
his visit to the old lady:
Mitchells On July 20, 1950, we interviewed an old lady,
Mrs. J. T. Davidson, 74 years old, near
Elkins, Mo. She told us a little bit about
her experiences as postmistress, and some things
that she remembered about the old days ....
July 7, 1959:
I was with Mitch on this visit. Mrs. Davidson was very
interesting but so exceedingly shy that it was impossible
to get a satisfactory recording. This should some day
be transcribed for some tales her parents told her about
the Civil War and the Battle of Wilson's Creek.
Mary Celestia ParlerFunding for digitization provided by the Arkansas Humanities Council and the Happy Hollow Foundation
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