25,709 research outputs found
Children\u27s Friend Articles on Louie B. Felt
No full textText document pages 148-149,169 of the April 1940 children\u27s friend. pages 409,408,410,411,421 possibly from The Children\u27s Friend, 1910 Vol.9: Organ of the Primary Associations of the Church of Jesus Christ of Latter-Day Saint
Marvin\u27s friend, P. Knute Peterson
No full textBlack and white photograph of P. Knute Peterson, a friend of Marvin J. Bertoch, probably also serving in the Navy during World War II
J. Gaggi, friend of Elis Gangl Leonard
No full textPhoto of a friend of Leo Leonard\u27s second wife, Elisabeth Josefine Gangl Leonard, identified as "J. Gaggi
Report : Petition of J. Friend
No full text44-1ClaimsReport : Petition of J. Friend. [1667] Comanche depredations of 1867-1868 in Texas.1876-4
Report : Petition of J. Friend
No full textReport : Petition of J. Friend. [1667] Comanche depredations of 1867-1868 in Texas
DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire
No full textThe majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must therefore be cautiously circumvented to generate cytotoxic T cell responses against these targets. Our strategy uses DNA fusion vaccines to activate high levels of peptide-specific CTL. Key foreign sequences from tetanus toxin activate tolerance-breaking CD4+ T cell help. Candidate MHC class Ibinding tumor peptide sequences are fused to the C terminus for optimal processing and presentation. To model performance against a leukemia-associated antigen in a tolerized setting, we constructed a fusion vaccine encoding an immunodominant CTL epitopederived from Friend murine leukemia virus gag protein (FMuLVgag) and vaccinated tolerant FMuLVgag-transgenic (gag-Tg) mice. Vaccination with the construct induced epitopespecificIFN-c-producing CD8+ T cells in normal and gag-Tg mice. The frequency and avidity of activated cells were reduced in gag-Tg mice, and no autoimmune injury resulted. However, these CD8+ T cells did exhibit gag-specific cytotoxicity in vitro and in vivo. Also, epitope-specific CTL killed FBL-3 leukemia cells expressing endogenous FMuLVgag antigen and protected against leukemia challenge in vivo. These results demonstrate a simple strategy to engage anti-microbial T cell help to activate epitope-specific polyclonal CD8+ T cell responses from a residual tolerized repertoire
Honey bunch [music] /
No full textCaption title.; Portrait of singer Elsie Prince on cover.; "Introduced in Sir Benjamin & John Fuller's Xmas ... pantomime Jack and the Beanstalk."; "This song includes special ukulele accompaniment."; Also available online http://nla.gov.au/nla.mus-an6001715; MUS: N, MUSM 114023/1905 ; A, MUS/E89/115 ; NL, MUSM142235.Jack and the beanstalk (Pantomime
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[Letter from a friend to Pedro J. Gonzalez]
No full textLetter from a friend to Pedro J. Gonzalez. A paper clip sits at the page' stop edge, above a printed date and small block of text. A wider, paragraphed column of text fills the rest of the page and ends above handwritten words
Letter from the Business Editor to J. W. Story
No full textLetter from the Business Editor of Our Florida Friend to J. W. Story. The one-page typewritten note is dated 21 November 1912
Letter from the Business Editor to J. O. Barnes
No full textLetter from the Business Editor of Our Florida Friend to J. O. Barnes in Lake City, Florida. The one-page typewritten note is dated 7 December 1912
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