12 research outputs found
Antibacterial activity of Rhynocoris marginatus (Fab.) and Catamirus brevipennis (Servile) (Hemiptera: reduviidae) venomS against human pathogens
No full textThe reduviid predators Rhynocoris marginatus (Fab.) and Catamirus brevipennis (Servile) use their venoms to paralyze their preys. We detected the antibacterial activity of R. marginatus and C. brevipennis venoms against seven Gram-negative and four Gram-positive bacteria by using the disc diffusion method. Rhynocoris marginatus venom exhibited antibacterial activity against four Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris, Salmonella typhimurium) and one Gram-positive (Streptococcus pyogenes). Catamirus brevipennis venom showed antibacterial activity against six Gram-negative (Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus vulgaris, and Salmonella typhimurium) and three Gram-positive (Bacillus subtilis, Staphylococcus aureus, and Bacillus sphaericus) bacteria. Both C. brevipennis (90.91%) and R. marginatus (45.45%) venoms were more effective against Gram-negative bacteria (80% and 70% for R. marginatus and C. brevipennis, respectively). The venoms of both reduviid predators are composed of low molecular weight proteins (7-33 kD)
Microprocessor fault-tolerance via on-the-fly partial reconfiguration
No full textThis paper presents a novel approach to exploit FPGA dynamic partial reconfiguration to improve the fault tolerance of complex microprocessor-based systems, with no need to statically reserve area to host redundant components. The proposed method not only improves the survivability of the system by allowing the online replacement of defective key parts of the processor, but also provides performance graceful degradation by executing in software the tasks that were executed in hardware before a fault and the subsequent reconfiguration happened. The advantage of the proposed approach is that thanks to a hardware hypervisor, the CPU is totally unaware of the reconfiguration happening in real-time, and there's no dependency on the CPU to perform it. As proof of concept a design using this idea has been developed, using the LEON3 open-source processor, synthesized on a Virtex 4 FPG
BIOCONTROL POTENTIAL OF ENTOMOPATHOGENIC FUNGUS BEAUVERIA BASSIANA (BALSAMO) AGAINST PERICALLIA RICINI (FAB.) (LEPIDOPTERA: ARCTIIDAE) LARVAE
No full textABSTRACT
In the recent study, the entomopathogenic fungus, Beauveria bassiana (Balsamo) used to evaluate its pathogenecity against Pericallia ricini Fab. (Lepidoptera: Arctiidae) third, fourth and fifth instars larvae. B. bassiana found effective at all concentrations i.e., 2x04, 2x105 and 2x106 spores ml-1 on the P. ricini, but the uppermost concentration (2.0 x106 spores ml-1) provided maximum control within short period of time (P<0.002) than the other spore concentrations. Mortality of P. ricini was observed maximum on highest concentration of 2.0x106 spores ml-1. The value of LC50 lies between 2.32x102 and 13.89x107 spores ml-1. P.ricini body weight was increased at 2.0x105 (452.7±7.8 mg) spores ml-1 followed by 2.0x106 (450.9±18.9) and 2.0x104 spores ml-1 (443.8±6.2) by testing the field efficacy of B. bassiana against P. ricini, this insect pathogenic fungus can be used as potential biocontrol agent for the management of P. ricini. Results revealed that B. bassiana caused infection and caused death.
Key words : Beauveria bassiana, Pericallia ricini, insecticidal activity, biological control potential.
REFERENCES
Preliminary studies on the use Beauveria bassiana to control Sitophilus zeamais (Coleoptera: Curculionidae) in the laboratory. Journal of Stored Products Research, 32: 105-113.
Akmal, M., Freed, S., Malik, M.N. and Gul, H.T. 2013. Efficacy of beauveria bassiana (Deuteromycetes: Hypomycetes) against different aphid species under laboratory conditions. Journal of Zoology, 45(1):71-78.
Arcas, J.A., Diaz, B.M. and Lecuona, R.E. 1999. Bioinsecticidal activity of conidia and dry mycelium preparations of two isolates of Beauveria bassiana against the sugarcane borer Diatraea saccharalis. Journal of Biotechnology, 67: 151-158.
Asafali, K., Perumal, R.S. and Subramanian, T.R. 1972. Journal of Madras Agricultural, 59: 566-570.
Bradley, K., Sterk, G., Sels, B. and Stepman, W. 1992. Role of production technology in mycoinsectide development. In frontiers in industrial development.in frontiers in industrial mycology.(Lathum G.Led.)160-173. Chapman and Hall Ne York.
Butani, D.K. and Jotwani, M.G. 1984. Periodical Expert Book Agency, Delhi, India. Insects in vegetables, 356pp.
Butt, T.M., Ibrahim, L., Bail, B.V. and Clark, S.J.1994. Pathogenicity of the entomogenous fungi Metarhizium anisopliae and Beauveria bassiana against crucifer pests and the honey bee. Biocontrol Science Technology, 4 : 207-214.
Castrillo, L. A., Vandenverg, J. D. and Wraight, S. P. 2003. Strain specific detection of introduced Beauveria bassiana in agricultural fields by use of sequence characterized amplified region markers. Journal of Invertebrate Pathology, 82: 75-83.
Copping, L.G. 2004. Fungi, man and his environment. Longman, London.
Cooke,R.C. 1977. The manual of biocontrol agents. British Crop Protection Council, UK.
Chandrasekharan, K. and Nataraju, B. 2008. Screening of bivoltine tolerance to the white muscardine fungus, Beauveria bassiana (Bals.) Vuill. Entomology 33(4): 259-266.
Atluri, B., Samantha, M., Bhupathi Raualu, D., Sandhya Deepika, C. and Subba Reddi, J. 2010. Journal of Research Lepidopteran, 42:13-20.
Asafali, K., Perumal, R.S. and Subramanian, T.R. 1972. Journal of Madras Agricultural, 59: 566-570.
Butani, D.K. and Jotwani, M.G. 1984. Periodical Expert Book Agency, Delhi, India. Insects in vegetables, 356pp.
David, B.V. 2001. Popular Book Depot. Chennai. Elements of economic entomology, 562 pp
David, B.V. and Ananthakrishnan, T.N.2004. General and Applied Entomology. Tata McGraw-Hill Publishing Company Limited, New Delhi, India.
Derakhshan, A., Rabindra, R. J. and Ramanujam, B. 2007. Efficacy of different isolates of entomopathogenic fungi against Brevicoryne brassicae (Linnaeus) at different temperatures and humidities. Journal of Biological Control, 21(1): 65-72.
Dubey, N.K., Srivastava, B. and Kumar, A. 2008. Current status of plant products as botanical pesticides in storage pest management. Journal of Biopesticides, 1(2): 182-186.
Feng, M.G., Poprawski, T.J. and Khachatourians, G.G. 1994. Production, formulation and application of the entomopathogenic fungus, Beauveria bassiana for insect contol: current status. Biological Science Technology, 4: 3-34.
Finney, D. J. 1971. Probit Analysis, 3rd ed. Cambridge University Press, Cambridge.
Franzen, H. 1993. Need for development of new strategies for locust control. In: New strategies for locust control. (Rembold, H. ed.) ATSAF. Bonn. 89: 9 - 13 PP.
Freed, S., Jin, F.L. and Ren, S.X. 2011a. Determination of genetic variability among the isolates of Metarhizium anisopliae var. anisopliae from different geographical origins. World Journal of Microbiology Biotechnology, 27:359-370.
Freed, S., Jin, F.L. and Ren, S.X. 2011b. phylogenetics of entomopathogenic fungi isolated from the soils of different ecosystems. Pakistan Journal of Zoology, 43:417-425.
Goettel, M.S. and Inglis, D.G. 1997. Fungi: Hypomycetes. In : manual of techniques in insect pathology, (L. Lacey, Ed.), Academic Press, London UK. 213-249 pp.
Hajek, A.E. and St. Leger, R.J. 1994. Interactions between fungal pathogens and insect hosts. Annual Review Entomology, 39: 293-322.
Hazarika, L.K. and Puzari, K.C.1990. Beauveria bassiana (Bals.) Vuill. for biological control of rice hispa (RH) in Assam, India. International Rice Research Newsletter, 15:31.
Hazarika, L.K. and Puzari, K.C.1997. Field fficacy of white muscardine fungus (Beauveria bassiana) on rice hispa (Dicladispa armigera). Indian Journal of Agricultural Science, 67: 463-465.
Howard, A.F.V.,Koenraadt, C.I.M., Farenhorst,M., Knols, B.G.J. and Takken, W. 2010. Pyrethroid resistance in Anopheles gambiae leads to increased susceptibility to the entomopathogenic fungi Metarhizium anisopliae and Beauveria bassiana. Journal of Malar, 9:168.
Jaramillo, J. and Borgemeister, C. 2006. New bioassay method to assess the pathogenicity of Colombian strains of Metarhizium anisopliae (Metsch.) Sorokin and Paecilomyces sp. (Deuteromycotina: Hyphomycetes) against the subterranean burrower bug Cyrtomenus bergi Froeschner (Hemiptera: Cydnidae). Journal of Invertebrates Pathology, 91: 57-60.
Jhansi Lakshmi, V.V.N.S., Kaiser Jami, I ., Venkaiah, K., Bharathi, D. and Satya Kumar, D.V.R. 2005. Differential susceptibility of silkworm, Bombyx mori L. races to white muscardine disease caused by Beauveria bassiana (Bals.) Vuill. Entomology, 30(1): 13-18.
Li, Y.W. and Yang, J.H. 1988. Prospects for the use of entomogenous fungus against forests pests, In: Study and application of entomogenous fungus in China, (Y.W.Li, Z.Li, Z.Q.Liang,u, J.W.Wu, Z. K. Wu and. Q. F. Xu ed.). Periodical Press, Beijing, 10-14.
Mburu, D.M., Maniania, N.K. and Hassanali, A. 2013. Comparison of volatile blends and nucleotide sequences of two Beauveria bassiana isolates of different virulence and repellency towards the termite Macrotermes michealseni. Journal of Chemical Entomology,39:101-108.
Malarvannan, S., Murali, P.D., Shanthakumar, S.P., Prabavathy, V.R. and Sudha Nair. 2010. Laboratory evaluation of the entomopathogenic fungi, Beauveria bassiana against the tobacco caterpillar, Spodoptera litura Fabricius (Noctuidae: Lepidoptera). Journal of Biopesticides, 3(1): 126-131.
Meyling, N.V. and Eilenberg, J., 2006. Occurrence and distribution of soil borne entomopathogenic fungi within a single organic agroecosystem. Agriculture Ecosystems and Environment, 113, 336–341.
Mohi-UD- Din, S., Zaki, A.F., Munshi, A.N., Jan, A. and Sultan, P. 2006. Evaluation of some entomopathogenic fungal isolates from Kashmir for the biocontrol of white grubs infesting turfgrass in golfcourse. Journal of Biological Control, 20(1): 45-50.
Moorthi, P.V., Balasubramanian, C. and Kubendran, T. 2011. Efficacy of local isolates of Beauveria bassiana against Spodoptera litura (F.) (Lepidoptera: Noctuidae). Journal of Biological Control, 25(1): 22-25.
Nair, M.R.G.K. 1970. Insects and mites of crops in India. New Jack Printing Works Private Limited, Bombay. 404pp.
Panda, S.S, Sahoo, K, Muduli,S.D, Sahoo,G , Ahemad, M.D.J, Nayak, B.B and Dhal, N.K Chromium tolerant indigenous fungal strains from industrial effluents of Anugul district, odisha, india. Biolife. 2(2):634-640.
Prakash, A. and Rao, J. 1997. Botanical pesticides in agriculture. CRC Lewis Publications. Boca Raton, USA.481 PP.
Purwar, J.P. and G.C. Sachan, 2006. Synergistic effect of entomogenous fungi on some insecticides against Bihar hairy caterpillar Spilarctia obliqua (Lepidoptera: Arctiidae). Microbiology Research, 161: 38-42.
Puzari, K. C., Bhuyan, R. P., Pranab, D. and Nath, H. K. D. 2010. Distribution of Mikania and its economic impact on tea ecosystem of Assam. Indian Journal of Forestry 33: 71-76 pp. Puzari, K.C. and Hazarika, L.K. 1991. Efficacy of Beauveria bassiana combined with various stickers or spreaders against rice hispa. . IRRI Newsletter 16 (6): 21
Puzari, K.C. and Hazarika, L.K. 1991. Efficacy of Beauveria bassiana combined with various stickers or spreaders against rice hispa. . IRRI Newsletter 16 (6): 21
Puzari, K.C. and Hazarika, L.K. 1992. Entomogenous fungi from North East India. Indian Phytopathology, 45 (1) : 35-35
Raja, N., Janarthanan, S. and Ignacimuthu, S. 2000. Changes of haemolymph protein profile in the larva of Pericallia ricini (Fabricius) parasitised by the braconid wasp, Apanteles taragamae Viereck (Hymenoptera: Braconidae). Indian Journal of Experimental Biology, 38(4): 393-395.
Rausell, C., Martinez-Ramirez, A.C., GarciaRoblens, I. and Real, M.D. 2000. A binding site for Bacillus thuringiensis Cry Lab toxin is lost during larval development in two forest pests. Applied Environmental Microbiology, 66: 1553-1538.
Reithinger, R., Davies, C.R., Cadena, H. and Alexander, B. 1997. Evaluation of the fungus Beauveria bassiana as a potential biological control agent against Phlebotom Ne sand flies in colombian plantations. Journal Invertebrate Pathology, 70: 131-135.
Sabbour, M.M. and Sahab, A.F. 2005. Efficacy of some microbial control agents against cabbage pests in Egypt. Pakistan Journal of Biological Sciences, 8(10): 1351-1356.
Sahayaraj, K. and Borgio, J.F., 2009. Plant protection, 42(5): 424-435.
Sahayaraj, K. and Borgio, J.F., 2010. Virulence of entomopathogenic fungus Metarhizium anisopliae (Metsch.) Sorokin on seven insect pests. Indian Journal of Agricultural Research, 44(3): 195-200.
Sahayaraj, K. and Namasivayam, K. R. S. 2007. Bioefficacy of entomopathogenic fungi against Aphis craceivora in groundnut. Indian Journal of Plant Protection, 35(2): 352-353.
Sandhu, S.S., Unkles, S.E., Rajak, R.C. and Kingdom, J.R. 2001. Generation of binomial resistant Beauveria bassiana strains and their infectivity against Helicoverpa armigera. Biocontrol Science Technology, 11: 245-256.
Sasidharan, K. R. and Varma, R. V. 2005. Laboratory evaluation of Beauveria bassiana (Balsamo) Vuillemin against Indarbela quadrinotata Walker (Lepidoptera: Metarbelidae) – a key pest of Casuarina equisetifolia L. in Tamil Nadu. Journal of Biological Control, 19(2): 197-200.
Scholte, E.J., Knols, B.C.J. and Takken, W. 2006. Infection of the malaria mosquito Anopheles gambiae with the entomopathogenic fungus Metarhizium anisopliae reduces blood feeding and fecundity. Journal of Invertebrate Pathology, 91: 43-49.
Selvaraj, K., Kaushik, H. D. and Gulati, R. 2012. Evaluation of Beauveria bassiana (Balsamo) Vuillemin against Coriander Aphid, Hyadaphis coriandri (Das) (Aphididae: Homoptera). Journal of Biological Control, 26(1) : 55-58.
Tanada, Y. and Kaya, H.K. 1993. Insect Pathology, San Diego: Academic Press. 666p.
Tasida, J. and Gobena, T. 2013. Evaluation of chemical, botanical and cultural managements of termites control. Journal of World Applied Sciences, 22 (4): 583-588.
Tsay, JG., Lee, MJ. and Chen, R.S. 2001. Evaluation of Beauveria bassiana for controlling Casuarina Tussock Moth (Lymantria xylina Swinhoe) in casuarina Plantations. Taiwan Journal for Science, 16(4): 201-207.
Vanitha, K., Karuppuchamy, P. and Sivasubramanian, P. 2011. Pest of vanilla (Vanilla planifolia Andrews) and their natural enemies in Tamil Nadu, India. International Journal of Biodiversity and Conservation, 3(4): 116-120.
Varela, A. and Morales, E. 1996. Characterization of some Beauveria bassiana isolates and their virulence toward the coffee berry borer Hypothenemus hampei. Journal of Invertebrate Pathology, 67: 147-152.
Veenakumari, K., Rabindra, R.J., Srinivasa Palk, C.D. and Shuba, M. R. 2006. First report of Quesada-Moraga, E., Landa, B.B., Munoz-Ledesma, J., jimenz-Diaz, R.M. and Santiago Alvarez, C. 2006. Endophytic colonization of opium poppy, Papaver somnifrum, by an entomopathogenic Beauveria bassiana strain. Mycopathology, 161:323-329.
Vijayavani, S., Reddy, K. R. K. and Murthy, G.B.V.N. 2009. Pathogenicity of Beauveria bassiana (Deuteromycotina: Euteromycotina: Hypomycetes) strains on Spodoptera litura (Fab.). Journal of Biopesticides, 2(2): 205-207.
Wagner, B.L. and Lewis, L.C. 2000. Colonization of corn Zea mays by the Beauveria bassiana. Applied Environmental Microbiology, 66-68.
Wraight, S.P., Carruthers, R.I, Jaronski, S.T., Bradley, C.A.,Garza, C.J. and Galaini-Wraight, S. 2000. Evaluation of the entomopathogenic fungi Beauveria bassiana and Paecilomyces fumosoroseus for microbial control of the Silverleaf Whitefly, Bemisia argentifolli. Biological Control, 17:203-217.
Zimmermann,G. 2007. Review on safety of the entomopathogenic fungi Beauveria bassiana and Beauveria brongniartii. Biocontrol Science Technology, 17:553-596
Genomic Landscape of Multidrug Resistance and Virulence in Enterococcus faecalis IRMC827A from a Long-Term Patient
No full textWe report on a highly virulent, multidrug-resistant strain of Enterococcus faecalis IRMC827A that was found colonizing a long-term male patient at a tertiary hospital in Khobar, Saudi Arabia. The E. faecalis IRMC827A strain carries several antimicrobial drug resistance genes and harbours mobile genetic elements such as Tn6009, which is an integrative conjugative element that can transfer resistance genes between bacteria and ISS1N via an insertion sequence. Whole-genome-sequencing-based antimicrobial susceptibility testing on strains from faecal samples revealed that the isolate E. faecalis IRMC827A is highly resistant to a variety of antibiotics, including tetracycline, doxycycline, minocycline, dalfopristin, virginiamycin, pristinamycin, chloramphenicol, streptomycin, clindamycin, lincomycin, trimethoprim, nalidixic acid and ciprofloxacin. The isolate IRMC827A carries several virulence factors that are significantly associated with adherence, biofilm formation, sortase-assembled pili, manganese uptake, antiphagocytosis, and spreading factor of multidrug resistance. The isolate also encompasses two mutations (G2576T and G2505A) in the 23S rRNA gene associated with linezolid resistance and three more mutations (gyrA p.S83Y, gyrA p.D759N and parC p.S80I) of the antimicrobial resistance phenotype. The findings through next-generation sequencing on the resistome, mobilome and virulome of the isolate in the study highlight the significance of monitoring multidrug-resistant E. faecalis colonization and infection in hospitalized patients. As multidrug-resistant E. faecalis is a serious pathogen, it is particularly difficult to treat and can cause fatal infections. It is important to have quick and accurate diagnostic tests for multidrug-resistant E. faecalis, to track the spread of multidrug-resistant E. faecalis in healthcare settings, and to improve targeted interventions to stop its spread. Further research is necessary to develop novel antibiotics and treatment strategies for multidrug-resistant E. faecalis infections
The Potential of Dutasteride for Treating Multidrug-Resistant <i>Candida auris</i> Infection
No full textNovel antifungal drugs are urgently needed to treat candidiasis caused by the emerging fungal multidrug-resistant pathogen Candida auris. In this study, the most cost-effective drug repurposing technology was adopted to identify an appropriate option among the 1615 clinically approved drugs with anti-C. auris activity. High-throughput virtual screening of 1,3-beta-glucanosyltransferase inhibitors was conducted, followed by an analysis of the stability of 1,3-beta-glucanosyltransferase drug complexes and 1,3-beta-glucanosyltransferase–dutasteride metabolite interactions and the confirmation of their activity in biofilm formation and planktonic growth. The analysis identified dutasteride, a drug with no prior antifungal indications, as a potential medication for anti-auris activity in seven clinical C. auris isolates from Saudi Arabian patients. Dutasteride was effective at inhibiting biofilm formation by C. auris while also causing a significant reduction in planktonic growth. Dutasteride treatment resulted in disruption of the cell membrane, the lysis of cells, and crushed surfaces on C. auris, and significant (p-value = 0.0057) shrinkage in the length of C. auris was noted at 100,000×. In conclusion, the use of repurposed dutasteride with anti-C. auris potential can enable rapid recovery in patients with difficult-to-treat candidiasis caused by C. auris and reduce the transmission of nosocomial infection
Mining the nanotube-forming Bacillus amyloliquefaciens MR14M3 genome for determining anti-Candida auris and anti-Candida albicans potential by pathogenicity and comparative genomics analysis
No full textThere is a global health concern associated with the emergence of the multidrug-resistant (MDR) fungus Candida auris, which has significant mortality rates. Finding innovative and distinctive anti-Candida compounds is essential for treating infections caused by MDR C. auris. A bacterial strain with anti-Candida activity was isolated and identified using 16 S rRNA gene sequencing. The whole genome was sequenced to identify biosynthesis-related gene clusters. The pathogenicity and cytotoxicity of the isolate were analyzed in Candida and HFF-1 cell lines, respectively. This study set out to show that whole-genome sequencing, cytotoxicity testing, and pathogenicity analysis combined with genome mining and comparative genomics can successfully identify biosynthesis-related gene clusters in native bacterial isolates that encode antifungal natural compounds active against Candida albicans and C. auris. The native isolate MR14M3 has the ability to inhibit C. auris (zone of inhibition 25 mm) and C. albicans (zone of inhibition 25 mm). The 16 S rRNA gene sequence of MR14M3 aligned with Bacillus amyloliquefaciens with similarity (100%). Bacillus amyloliquefaciens MR14M3 establishes bridges of intercellular nanotubes (L 258.56 ± 35.83 nm; W 25.32 ± 6.09 nm) connecting neighboring cells. Candida cell size was reduced significantly, and crushed phenotypes were observed upon treatment with the defused metabolites of B. amyloliquefaciens MR14M3. Furthermore, the pathogenicity of B. amyloliquefaciens MR14M3 on Candida cells was observed through cell membrane disruption and lysed yeast cells. The whole-genome alignment of the MR14M3 genome (3981,643 bp) using 100 genes confirmed its affiliation with Bacillus amyloliquefaciens. Genome mining analysis revealed that MR14M3-coded secondary metabolites are involved in the biosynthesis of polyketides (PKs) and nonribosomal peptide synthases (NRPSs), including 11 biosynthesis-related gene clusters with one hundred percent similarity. Highly conserved biosynthesis-related gene clusters with anti-C. albicans and anti-C. auris potentials and cytotoxic-free activity of B. amyloliquefaciens MR14M3 proposes the utilization of Bacillus amyloliquefaciens MR14M3 as a biofactory for an anti-Candida auris and anti-C. albicans compound synthesizer
Genome-Guided Identification of Surfactin-Producing Bacillus halotolerans AQ11M9 with Anti-Candida auris Potential
No full textThe emergence of multidrug-resistant fungi Candida auris is a worldwide health crisis connected with high rates of mortality. There is a critical need to find novel and unique antifungal compounds for treating infections of multidrug-resistant fungi such as C. auris. This study aimed to illustrate that biosynthetic gene clusters in native bacterial isolates are able to produce antifungal compounds against the multidrug-resistant fungus C. auris. It was successfully achieved using large-scale antifungal activity screening, cytotoxicity analysis, and whole genome sequencing integrated with genome mining-guided analysis and liquid chromatography–mass spectrometry (LC/MS). A list of possible gene candidates was initially identified with genome mining methods to predict secondary metabolite gene clusters of antifungal-compound-producing bacteria. Then, gene clusters present in the antifungal-compound-producing bacteria were identified and aligned with the reference genome using comparative genomic approaches. Bacillus halotolerans AQ11M9 was identified through large-scale antifungal activity screening as a natural compound-producer against multidrug-resistant C. auris, while it was nontoxic to normal human skin fibroblast cells (confirmed using a cell viability assay). The genome (4,197,347 bp) of B. halotolerans AQ11M9 with 2931 predicted genes was first mined for detecting and characterizing biosynthetic gene clusters, which revealed 10 candidate regions with antifungal activity. Clusters of AQ11M9 encoded non-ribosomal peptide synthase (NRPS) (bacilysin, bacillibactin, paenibactin, surfactin, plipastin, and fengycin) and polyketide (macrobrevin). The presence of gene clusters with anti-C. auris activity, and surfactin identified through LC/MS, from AQ11M9 suggests the potential of utilizing it as a source for a novel and powerful anti-C. auris compound
Chthonius ischnocheles
No full textChthonius ischnocheles (Hermann, 1804) (Figs 237–265, 407) Chelifer ischnochelus Hermann, 1804: 118, pl. 5 fig. p, pl. 6 fig. 14. Obisium megachelum Amary, 1840: 78, tab. IV, figs 1b–d, 3a–b (n. syn.). Chthonius rayi dalmatinus Hadži, 1930: 72, figs 10a–e, 11a–e, 12a–b, 13a–d, 14, 15a–b, 16a–c (n. syn.). Chthonius (C.) litoralis Hadži, 1933: 130, figs 2a–c (n. syn.). Chthonius (C.) rhodochelatus Hadži, 1933: 133, figs 3c, 4a–b, 5a–c, 6b–e, 7 (res. syn.). Chthonius (C.) ischnocheles ischnocheles: Callaini 1979a: 131 (in part: see C. densedentatus). Type locality: not stated, presumably near Strasbourg (France) (Harvey 2013). Distribution. Species widespread throughout Europe, Macaronesia and Anatolia, introduced to the U.S.A. and St. Helena (Harvey 2013). Diagnosis (♂ ♀). An eyed epigean Chthonius that differs from other species of the ischnocheles group in the following combination of characters: anterior margin of carapace with 2 (rarely 1) preocular microsetae; posterior margin of carapace with 4 macrosetae, lateral setae as long as or slightly shorter than the median setae; chelicerae with 3 (rarely 2 or 4) lateral microsetae; spinneret wide and semicircular; chela length 0.885–1.70 mm; movable finger length 0.56–1.08 mm; chelal fingers with reclined, pointed and widely spaced teeth; fixed chelal finger with 31–49 teeth; ratio of pedipalpal femur/carapace 1.25–1.6. Type material of Chthonius rayi examined. ITALY — Alto Adige: Bolzano Prov. — 1 ♀, (lectotype of Chthonius Rayi L. Koch, 1873, present designation), “Hauenstein” [Castelvecchio near Siusi allo Sciliar, com. Castelrotto, 1273 m a.s.l., 46°32’10”N, 11°34’06”E] “ Chthonius Rayi L. Koch ” “13.9.1.810–959” “ Chthonius rayi L. Koch / syntypes / M. Judson det. 1993” (NHM); 82 ♂ 57 ♀ (paralectotypes of Chthonius Rayi, present designation), same data as lectotype (together with 6 ♂ 27 ♀ of C. carinthiacus) (NHM). Type material of Chthonius tamaninii examined. ITALY — Apulia: Brindisi Prov. — 2 ♂ 1 ♀ 1 T (syntypes of C. tamaninii), Ostuni, Grotta di Agnano 342 Pu / BR, 11.III.1941, L. Tamanini leg. Other material examined. CROATIA — Istria — 1 ♂, Limski kanal, 10 m a.s.l., 20.VI.2016, P. Hlaváč leg., coastal forest. Split -Dalmatia — 1 ♂ 1 ♀, Split, Meje, 10.IX.2019, R. Ozimec leg. FRANCE — Ain — 2 ♂ 2 ♀, Artemare, 320 m a.s.l., 18.IX.2020, G. Gardini, P. Gardini & C. Giusto leg. Alpes- Maritimes — 1 ♀, Ponçon, Lac Serre, 21.VII.2000, E. Bernabò leg. Ardèche — 3 ♂ 1 ♀ 5 T, Berrias –et– Casteljau, Montchamp, 21.IV.2009, J. Rollet leg. Aveyron — 1 ♀, Pradines, La Bastide, 450 m a.s.l., 4. VIII.1990, G. Gardini leg. Côtes-d’Armor — 1 ♂ 1 ♀ 2 T 1 D, Hanvec, Forêt du Cranou, Mt. Arrée, 14.IX.1988, G. Gardini & R. Rizzerio leg.; 6 ♂ 7 T 4 D, Forêt de Quénécan, 15.IX.1988, G. Gardini & R. Rizzerio leg. Corse — 2 ♀, Bastia, near Brando, 16.IV.1992, S. Zoia leg.; 6 ♂ 7 ♀ 1 T, Bastia, near Erbalunga, 22. V.1982, A. Torchia & S. Zoia leg., Quercus ilex wood on limestone; 3 ♀ 1 T, Bastia, S. Maria di Loto, Miamo, 22. V.1982, A. Torchia & S. Zoia leg.; 5 ♂ 2 ♀, near Rogliano, 23. V.1982, A. Torchia & S. Zoia leg. Haute-Garonne — 1 ♀, near Arbas, 25.VII.1985, S. Zoia leg. Haute- Savoie — 5 ♂ 10 ♀, Monnetier-Mornex, Mornex ss. Salève, 600 m a.s.l., 20.III.1996, S. Vit leg. (together with 1 ♂ 1 ♀ of C. densedentatus), leaf litter and rotten stump. Hérault — 1 ♂, Mireval, Forêt Gardiole, 1.XII.1992, L. Fancello leg.; 6 ♂ 8 ♀ 4 T, Montpellier, Castelnau, alluvial debris of Lez River, 3.XII.1984, M. Bodon leg.; 1 ♂ 6 ♀ 8 T 1 D 1 P, Montpellier, 94 m a.s.l., 3.IV.2015, G. Gardini leg., under Quercus ilex on limestone; 1 T, Prades-le- Lez, 5.I.1992, M. Bodon leg. Var — 1 ♂ 2 ♀, Draguignan, Figanière, 29.IV.1975, S. Zoia leg., sieved under Quercus ilex; 4 ♂ 6 ♀ 2 T 3 D, Cabasse, La Plaine, 8.XII.1992, G. Gardini & S. Zoia leg.; 1 ♂ 2 ♀ 3 T, Toulon, Chartreuse de Montrieux, 8.XII.1992, G. Gardini & S. Zoia leg., oak wood; 1 ♂ 1 ♀ 1 T, Hyéres, Île de Porquerolles, 10–50 m a.s.l., 19. V.2013, G. Gardini, C. Giusto & S. Zoia leg. GERMANY — Rheinland-Pfalz — 5 ♂ 4 ♀, Soonwald: Guldenbachtal bei Seibersbach, 22. V.1979, W. Schawaller leg., unter Quartzstein, Bucherfe Bremerrel (SMNS). Saarland — 1 ♂, Stollen am Zollbahnhof, 1.VII.2006, D. Weber (MHNG); 1 ♀, Limbergkeller 2, 15. VIII.2004, D. Weber leg. (MHNG); 1 ♀ (det. V. Mahnert), Völklinger Bahntunnel, 26. V.2006, D. Weber leg. (MHNG); 1 ♂ 1 ♀, Alsbach Stollen, 11. VI.2004, D. Weber leg. (MHNG); Südbaden — 1 ♂ 2 ♀, Rheinwald bei Weinstetten, 29.III.1983, W. Pankow leg. (SMNS). ITALY — Venezia Giulia: Trieste Prov. — 1 ♀, Duino–Aurisina, Duino, 20 m a.s.l., 14.III.1991, F. Gasparo leg.; 1 ♂, id., 9.IV.1993, F. Gasparo leg. Friuli: Udine Prov. — 1 ♂ 1 ♀, Trasaghis, 250 m a.s.l., 5. V.1992, F. Gasparo leg.; 3 ♀, Venzone, Pioverno, 250 m a.s.l., 14.VII.1992, F. Gasparo leg. (together with 1 ♂ 1 ♀ of C. densedentatus), pitfall traps under Ostrya carpinifolia. Veneto: Belluno Prov. — 1 ♂, Agordo, La Muda, 550 m a.s.l., 2.VII.1985, G. Gardini leg. (together with 1 ♂ of C. densedentatus). Veneto: Padua Prov. — 1 ♀ (det. M. Beier), Battaglia Terme, 24.III.1974, P. Dioli leg. Veneto: Treviso Prov. — 25 ex. (C. rayi, det. G. Canestrini), Trevisano, 1873 (MZUP); 34 ex. (C. rayi, det. G. Canestrini), Treviso, 1873 (MZUP); 1 ♂ 1 ♀ (det. M. Beier), Cison di Valmarino, 17.IV.1974, A. Minelli leg. Veneto: Verona Prov. — 5 ♂ 3 ♀ (det. G. Lazzeroni, together with 6 ♂ 10 ♀ of C. densedentatus), Cologna Veneta, 11.IX.1968, G. Lazzeroni & A. Montolli leg. (MSNV); 1 ♀ (det. G. Lazzeroni, together with 5 ♂ of C. densedentatus), between Garda and Punta San Vigilio, 4. VI.1968, G. Lazzeroni & A. Montolli leg. (MSNV); 1 ♂ 6 ♀ 1 T 3 D (det. G. Lazzeroni), Grezzana, S slope of Vajo del Paradiso, 28.III.1968, G. Lazzeroni leg., xerothermic oasis; 1 ♀ (det. M. Beier), Pescantina, Settimo di Pescantina, 15.IX.1964, C. Baroni leg. (MSNV); 14 ♂ 16 ♀ (det. G. Lazzeroni), between Punta San Vigilio and Torri, 4. VI.1968, G. Lazzeroni, A. Montolli & R. Gioco leg. (MSNV); 2 ♀ (det. G. Lazzeroni), Sant’Ambrogio di Valpolicella, fort near Monte, 28. V.1968, G. Lazzeroni & A. Montolli leg. (MSNV); 8 ♂ 14 ♀ (det. G. Lazzeroni), between Sant’Ambrogio di Valpolicella and Monte, 28. V.1968, G. Lazzeroni, R. Gioco & A. Montolli leg. (MSNV); Veneto: Vicenza Prov. — 2 ♀, Arcugnano, Lago di Fimon, 31. VIII.1987, G. Gardini & R. Rizzerio leg.; 2 ♂ 1 ♀ (C. rayi, det. G. Canestrini), Bassano [del Grappa], 1883 (MZUP); 3 ♂ 1 ♀, near Lumignano, 9.VII.2019, N. Massimo leg. (NMM); 1 ♀, Sossano, Madonna della Croce, 13.III.1997,A. Tagliapietra & A. Zanetti leg., dry meadows; 2 ♀, Valstagna, Oliero, 150 m a.s.l., 31.VII.1989, F. Gasparo leg. (together with 2 ♂ of C. densedentatus); 1 ♂ 2 ♀ 1 T, Zovencedo, 8.III.1982, M. Seriani leg. Trentino: Trento Prov. — 1 ♀, Riva del Garda, 150 m a.s.l., 24. V.1990, F. Gasparo leg.; 2 ♂ 2 ♀, Trento, Povo, Colle Sant’Agata, 23. V.2019, N. Massimo leg. (NMM); 2 ♀, id., 3.IX.2019, N. Massimo leg. (NMM); 2 ♂, id., 8.X.2019, N. Massimo leg. (NMM); 1 ♀, Vallarsa, Pian delle Fugazze, 1140 m a.s.l., 15.IX.2004, D. Bianco leg. Lombardy: Bergamo Prov. — 1 ♀, Caprino, Torre de’ Busi, 29.XI.1998, R. Monguzzi leg. (RMM); 1 ♀, Nembro, Buco del Monte Podona, 1100 m a.s.l., 31. VIII.1980, G. Comotti leg.; 1 ♀, Oltre il Colle, Zambla Bassa, 1100 m a.s.l., 25. IV.1998, R. Monguzzi leg. (RMM). Lombardy: Brescia Prov. — 2 ♂ 4 ♀, Brescia, Monte Maddalena, Büsa dei Darnèi n. cat. Lo/BS, 23.IX.1973, D. Vailati leg.; 1 ♂, Odolo, Monte Corvino, Pozzetto alle Ere di Odolo 419 Lo/ BS, 18. VIII.1973, D. Vailati leg.; 3 ♀, Villanuova sul Clisi, Bus de la Lena, 30. VI.2007, L. Bodei leg.; 1 ♀ 2 T, Villanuova sul Clisi, Mt. Covolo, Bus del Bò, 20.IV.2007, L. Bodei leg.; 1 ♀, id., V.2013, L. Bodei leg.; 1 ♀, Villanuova sul Clisi, small cave on Monte Covolo, 21.IV.2007, L. Bodei leg.; 1 ♂, Zone, Mt. Guglielmo, Quèl Camarèle 166 Lo/BS, 27.IV.1975, D. Vailati leg. Lombardy: Mantova Prov. — 2 ♂ 5 ♀ 2 T, Castiglione delle Stiviere, 107 m a.s.l., 29. VI.2009, G. Ruzzante leg. (together with 2 ♀ 1 T of C. densedentatus), basis of the city walls. Lombardy: Varese Prov. — 1 ♀, Varese, Campo dei Fiori, 15.VII.2006, G. Gardini leg. Piedmont: Alessandria Prov. — 1 ♀, Carrega Ligure, 9.IV.1989, G. Gardini leg.; 1 ♀, Moncestino, Cascina Ganoia, 150 m a.s.l., 24. VIII.1997, G.B. Delmastro leg. (MCCI); 1 ♂ 2 ♀, Valenza, Garzaia, 28. VIII.1987, C. Torti leg. Piedmont: Cuneo Prov. — 1 ♂ 2 ♀, Pezzolo Valle Uzzone, 321 m a.s.l., 11.IX.2004, R. Poggi leg. (MSNG); Piedmont: Torino Prov. — 1 ♀, Pralormo, Valle di Beltramo, 330 m a.s.l., 3.X.1993, G.B. Delmastro leg. (MCCI). Liguria: Genoa Prov. — 3 ♀, Arenzano, 28.III.1978, G. Gardini & S. Zoia leg., reeds near the seaside; 3 ♀, Bavari, 18. V.1983, G. Gardini & R. Rizzerio leg.; 2 ♂ 3 ♀, Camogli, Monte di Portofino, 31. V.1972, G. Bartoli leg., Quercus ilex wood; 1 ♀, id., 9.I.1977, L. Briganti, G. Gardini & S. Zoia leg.; 1 ♀, id., Pietre Strette, 13.X.1974, N. Sanfilippo leg.; 1 ♀ 2 T, Camogli, Ruta, 8. V.1972, G. Gardini leg.; 1 ♀, Genova, Grotta della Gianchetta 305 Li/GE, 120 m a.s.l., 17.VII.1977, C. Bonzano leg.; 1 ♂ 3 ♀, Genova, Lagaccio, 11.III.1985, F. Esposito leg.; 1 ♂, Genova, near Molassana, 28.III.1976, G. Gardini leg.; 1 ♀, id., 31.III.1985, G. Gardini leg.; 1 ♂, Genova, Molassana, San Gottardo, 23.II.1976, G. Gardini leg., under stone; 2 ♂ 1 ♀, Genova, Nostra Signora del Monte, 24.X.1971, G. Bartoli leg.; 2 ♀, Genova, Panigaro, Buranco de Strie 315 Li/GE, 18.III.1988, S. Zoia leg.; 2 ♂ 1 ♀, Genova, Quinto, S slope of Mt. Moro, 300 m a.s.l., 23.IV.2000, G. Gardini leg., Quercus pubescens wood; 1 ♂, id., 50 m a.s.l., 27.X.2008, G. Gardini leg., Quercus pubescens wood; 1 ♂ 1 ♀, Genova, Quinto, W slope of Mt. Moro, 150 m a.s.l., 25.I.2004, G. Gardini leg., Quercus pubescens wood; 1 ♀, Genova, Quinto, S slope of Mt. Fasce, 480 m a.s.l., 1.XII.2015, G. Gardini leg., garrigue; 1 ♀, Genova, Righi, V.2012, L. Galli leg., Quercus ilex wood; 1 ♀, Genova, Sampierdarena, Porta degli Angeli, 28.I.1975, G. Gardini leg., under stone; 1 ♀, Genova, Sestri Ponente, Monte Gazzo, Grotta dello Scrigno 951 Li/GE, 13.I.1974, L. Cassulo & F. Esposito leg.; 1 ♂, id., 30. VIII.1975, L. Briganti, S. Zoia & L. Cassulo leg.; 1 ♂, Genova, Sestri Ponente, Monte Gazzo, 23.III.2008, M.B. Invernici leg. (MSNG); 1 ♀, Genova, Villetta Di Negro, 8.X.1972, G. Bartoli leg.; 4 ♂ 1 ♀ 2 T, id., 27.IX.1979, Gruppo Entomologico Ligure leg.; 2 ♂ 1 ♀, Genova, Voltri, Vesima, 14.III.1986, S. Zoia leg., Quercus ilex wood; 1 ♀ 1 T, Portofino, 26.IX.1979, S. Vit leg., under bark died pine tree; 1 T, Rapallo, Rio Tonnego, 16.X.1971, G. Gardini leg.; 1 ♂, Sestri Levante, Villa Scorza, 100 m a.s.l., 29.VII.2008, M. Capurro leg., Quercus pubescens wood. Liguria: Imperia Prov. — 1 ♀, Cervo, 25.II.1973, G. Gardini leg., under stone; 1 ♀, Civezza, Monte Faudo, 8.I.1996, L. Galbiati leg. (RMM); 1 ♂, Mortola, Villa Hanbury, 30.III.1976, G. Gardini leg.; 1 ♂, Sanremo, 8.IV.1985, G. Gardini leg.; 1 ♂, id., 9. V.2015, A. Pastorelli leg. Liguria: La Spezia Prov. — 2 ♂ 4 ♀, Ameglia, Ca’ del Sole, Torr. Bettigna, 2. VI.2007, R. Poggi leg. (MSNG); 1 ♀, Borghetto di Vara, Fiume Vara, 9. X.1992, N. Sanfilippo leg.; 1 ♀, Cassana, Grotta del Ginepro 66 Li/ SP, 13. VIII.1978, A. Briganti, L. Briganti & S. Zoia leg.; 2 ♂ 1 ♀, near Corniglia, 1.III.1981, S. Zoia, D. Antichi & A. Torchia leg.; 1 ♂ 2 D, Corniglia, 15.III.1998, S. Zoia & F. Polese leg.; 1 ♂, Fabiano, Grotta del Tasso 70 Li/ SP, 3.XI.1976, L. Cassulo & S. Zoia leg.; 4 ♀, La Spezia, Biassa, Grotta della Taglia 79 Li/ SP, 24. V.1988, G. Gardini & S. Zoia leg.; 1 ♂ 1 ♀, La Spezia, Foce, 2. X.1980, G. Gardini, R. Rizzerio & S. Zoia leg.; 1 ♀, La Spezia, Grotta di Bocca Lupara 74 Li/ SP, VIII.1988, P. Magrini leg.; 1 ♀, Montemarcello, Grotta del Leo 1046 Li/ SP, 15.II.1976, L. Briganti & S. Zoia leg.; 6 ♂ 8 ♀ 1 T, Montemarcello, Grotta del Salotto 1048 Li/ SP, 24.IV.1978, A. Briganti, L. Briganti & S. Zoia leg., entrance of the cave; 2 ♂ 2 ♀, Montemarcello, 14.VII.1999, G. Troiano leg.; 1 ♂, Pignone, Foro di Sant’Antonio 456 Li/ SP, 22.VII.1979, A. Briganti, L. Briganti & S. Zoia leg.; 4 ♂ 4 ♀ 9 T 13 D, Portovenere, Isola Palmaria, 11. VIII.1981, L. Briganti & S. Zoia leg.; 1 ♀, id., 24. V.2014, R. Poggi leg. (MSNG); 3 ♂ 3 ♀, Quaratica, Monte Bermego, 630 m a.s.l., 21.II.1982, G. Gardini, C. Giusto & S. Zoia leg.; 1 ♀, Riccò del Golfo, Pozzo del Monte Bermego 458 Li/ SP, 29.III.1981, A. Briganti, L. Briganti & S. Zoia leg.; 1 ♂ 1 T, Rocchetta Vara, along Fiume Vara, 10.IX.1992, N. Sanfilippo leg.; 1 ♀, Sarzana, mouth of Fiume Magra, 5.III.1977, G. Parodi & A. Torchia leg.; 1 ♂ 3 ♀, Vernazza, Punta Palma, 1.III.1981, S. Zoia, D. Antichi & A. Torchia leg. Liguria: Savona Prov. — 1 ♂, Albenga, mouth of Fiume Centa, 29.IV.1977, G. Parodi leg.; 1 ♀, Borgio Verezzi, Grotta di Valdemino 160 Li/SV, 13.X.2017, M. Isaia & S. Mammola leg.; 1 ♀, water source near Borgio Verezzi, 14. V.1989, M. Bodon leg.; 3 ♂ 2 ♀, Castelbianco, 29.XII.1991, G. Gardini leg., olive grove; 4 ♂ 1 ♀, Finale Ligure, Val Ponci, 4.IV.1976, G. Gardini leg., under stone; 1 ♂ 1 ♀ 1 T, Laigueglia, Capo Mele, 6.III.1975, G. Gardini leg., under stone near shoreline; 1 ♀, Noli, Capo di Varigotti, 31. V.1975, R. Poggi leg., under stone in olive grove; 1 ♀, id., 28.IV.1994, G. Gardini leg.; 1 ♂, Sassello, Foresta della Deiva, 400 m a.s.l., 11.VII.2007, R. Poggi leg. (MSNG); 3 ♂ 7 ♀ 7 T 2 D, Spotorno, Tann-a do Mortou 102 Li/SV, 15.XII.1976, G. Gardini leg.; 1 ♂ 1 ♀, id., 16.I.1977, L. Cassulo & S. Zoia leg. Emilia: Bologna Prov. — 1 ♂ 5 ♀, Sasso Marconi, Palazzo Rossi, III.2010, L. Colacurcio leg. Emilia: Modena Prov. — 1 ♀, Sestola, Monte Cimone, 17. V.1987, R. Sciaky leg. Romagna: Forlì Prov. — 1 ♂, Meldola, Bosco di Scardavilla, 8.IV.1997, R. Fabbri leg.; 1 ♂ 1 ♀, id., 18.VII.1997, R. Fabbri leg.; 2 ♂, id., 23.IX.1997, R. Fabbri leg.; 1 ♂ 1 ♀ 1 T, id., 21. XI.1997, R. Fabbri leg.; 1 ♂, id., 13.III.1998, R. Fabbri leg.; 3 ♂ 3 ♀ 1 T, id., 15.IV.1998, R. Fabbri leg.; 2 ♂ 1 ♀, id., 12. V.1998, R. Fabbri leg.; 2 ♂ 2 ♀, id., 26. VI.1998, R. Fabbri leg.; 1 ♂ 2 ♀, id., 17.VII.1998, R. Fabbri leg.; 1 ♀, id. 20. VIII.1998, R. Fabbri leg.; 1 ♂ 2 ♀, id., 16.IX.1998, R. Fabbri leg.; 1 ♂, id., 17.X.1998, R. Fabbri leg.; 1 ♀, id., 18.XI.1998, R. Fabbri leg. Tuscany: Arezzo Prov. — 1 ♀, Alpe della Luna, Passo di Viamaggio, 830 m a.s.l., 2. V.1986, S. Zoia leg., oak wood; 2 ♂ 1 ♀, Cortona, Valecchie, 300 m a.s.l., 17.IX.2015, C. Giusto leg., bamboo reeds; 1 ♂, id., 1.XI.2017, C. Giusto leg.; 2 ♂ 1 ♀, 12.XII.2018, C. Giusto leg.; 4 ♂ 2 ♀, Foce di Scopetone, 525 m a.s.l., 3.X.1993, F. Gasparo leg., pine wood. Tuscany: Florence Prov. — 1 ♂, Barberino di Mugello, Montecarelli, 3.IV.1988, P. Magrini leg.; 1 T, id., entrance of Buca delle Fate di Prunecchio 735 To/FI, 400 m a.s.l., 27. VIII.1983, P. Magrini leg.; 1 ♂ 1 ♀ 1 T, Barberino Val d’Elsa, 5.III.1977, G. Castellini leg.; 1 ♂ 2 T, Cantagallo, IX.1976, G. Castellini leg.; 1 ♂ 1 T, near Firenze, 15.XI.1981, L. Briganti & S. Rocchi leg.; 1 ♂ 2 ♀ 1 T, Firenze, Fiesole, 22. IX.1973, G. Bartoli leg.; 3 ♂ 4 ♀ 4 T, id., 23. VIII.1975, G. Bartoli leg., sieved under Quercus ilex; 1 ♂ 1 ♀, id., 25. VIII.1976, G. Bartoli leg.; 1 ♀ 1 T, id., 29.IX.1984, C. Torti & S. Zoia leg.; 2 ♂ 3 ♀ 2 T, Firenze, near Fiesole, 9.IV.1984, G. Gardini & S. Zoia leg.; 5 ♂ 1 ♀ 3 T, Montelupo Fiorentino, 25.II.1967, A. Bordoni leg., moss and hollow in Quercus ilex; 1 ♀, Prato, Monti della Calvana, slope of Poggio Cocolla, 400 m a.s.l., 9.IV.1984, G. Gardini & S. Zoia leg., Ostrya carpinifolia wood; 2 ♂ 2 ♀ 1 D, Strada in Chianti, 5.III.1967, A. Bordoni leg., moss; 2 ♂, near Vinci, 11.III.1988, S. Zoia leg.; 1 ♀, Fucecchio, Padule di Fucecchio, 4.II.1978, S. Rocchi leg. Tuscany: Grosseto Prov. — 3 ♂, Boccheggiano, VIII.1985, G. Castellini leg.; 2 ♂ 1 ♀ 1 T, Grosseto, Roselle, 1. VI.2004, P. Magrini leg.; 1 ♀, Poggio Moscona, 5.X.1990, P. Magrini leg.; 1 ♂ 3 ♀, Roccastrada, Val di Farma, VII.1978, G. Castellini leg. Tuscany: Livorno Prov. — 4 ♂, near Livorno, 28. V.1980, S. Zoia leg., Quercus ilex wood; 1 ♂, Piombino, Promontorio di Piombino, IV.1977, G. Castellini leg. Tuscany: Lucca Prov. — 2 ♀, Altopascio, Lago di Bientina, Case Grugno, 24. V.1974, G. Gardini leg.; 1 ♀, Camaiore, VIII.1976, G. Castellini leg.; 2 ♂ 1 ♀, Corfino, Buca Tana di Maggiano 827 To/ LU, 29. V.1988, P. Magrini leg.; 1 ♀, id., 15.II.2009, P. Magrini leg.; 1 ♀, Sillano Giuncugnano, Tana Azzurra (= Buca di Tamignana) 46 To/ LU, 2. V.1988, P. Magrini leg. Tuscany: Massa–Carrara Prov. — 3 ♀, Terrarossa, gravel bed of Fiume Magra, 18.II.1973, G. Bartoli leg.; 1 ♂ 1 ♀, Zeri, near Lago Verde, 4.X.1980, A. Briganti, L. Briganti leg. (together with 1 ♀ of C. densedentatus), beech wood. Tuscany: Pisa Prov. — 3 ♂ 3 ♀, Calci, Certosa di Calci, 1.IX.1981, G. Gardini leg., under stone; 4 ♂ 2 ♀, San Miniato, Roffia, 20 m a.s.l., 7. VI.2009, G. Gardini leg.; 2 ♀, Pisa, San Rossore, Tenuta di San Rossore, 28.IV.1973, G. Gardini leg.; 4 ex., id., 10.III.1998, R. Poggi leg. (MSNG). Tuscany: Pistoia Prov. — 1 ♂ 3 ♀, San Baronto, X.1977, G. Castellini leg. Tuscany: Siena Prov. — 5 ♂ 2 ♀, Bagno Vignoni, 2. VIII.1990, P. Magrini leg.; 2 ♀, Orgia, 1. VI.1977, G. Castellini leg. Tuscany Archipelago: Grosseto Prov. — 1 ♂, Isola del Giglio, 25.III.1991, P. Magrini leg.; 1 ♂, Isola del Giglio, Promontorio del Franco, 17.IV.1974, G. Gardini leg.; 1 ♂ 1 T, id., IV.1985, A. Focarile leg., under Cistus; 7 ♂ 8 ♀, id., 18.VII.2009, G. Caoduro leg.; 8 ♂ 2 ♀ 2 T, Isola del Giglio, Valle Pertuso, IV.1985, A. Focarile leg., Quercus ilex wood; 17 ♂ 26 ♀, Isola di Giannutri, 20. V.1978, G. Gardini leg., garrigue and Quercus ilex wood; 1 ♀, id., 13. V.1979, M. Benedetti & A. Torchia leg.; 1 ♂ 2 T, Monte Argentario, Santa Liberata, 28.IV.1979, G. Gardini & S. Zoia leg. Tuscany Archipelago: Livorno Prov. — 1 ♂, Isola d’Elba, Ugliero delle Conche, 5. V.1976, leg.?; 1 ♂ 1 ♀, Isola d’Elba, E slope of Mt. Orello, 6.XII.1999, S. Zoia & F. Polese leg., sieved under seeds. Marche: Ancona Prov. — 1 ♀, Genga, near San Vittore delle Chiuse, 200 m a.s.l., 18. VI.2009, R. Poggi leg., mixed wood (MSNG). Marche: Pesaro e Urbino Prov. — 1 ♀, Cagli, 15.IX.1991, L. Latella & A.M. Tocci leg.; 1 ♂ 3 ♀, N slope of Urbino, 14.IX.1992, R. Poggi leg. (MSNG); 2 ♂, San Leo, 580 m a.s.l., 15.X.1991, F. Gasparo leg. Umbria: Perugia Prov. — 1 ♂, Foligno, Uppello, 24.IV.1974, R. Poggi leg., under stone; 1 ♂, id., 8. V.1974, R. Poggi leg.; 1 ♀, id., 15. V.1974, R. Poggi leg.; 2 ♂ 3 ♀, Scheggia, Isola Fossara, 460 m a.s.l., 21.IV.1989, S. Zoia leg.; 1 ♂ 1 ♀ 1 T, id., 18. VI.1989, G. Gardini & S. Zoia leg.; 2 ♀, Scheggia, San Emiliano in Congiuntoli, 375 m a.s.l., 18.IV.2017, G. Gardini leg.; 1 ♂ 1 ♀, Spello, Roman amphitheatre, 24.III.1974, R. Poggi leg.; 7 ♂, id., 13.IV.1974, R. Poggi leg., under stones; 3 ♀, Todi, Roccaccia, Pozzo della Piana I 56 U/PG, 260 m a.s.l., 31.III.1994, L. Latella leg.; 7 ♂ 8 ♀ 15 T, Orvieto, 300 m a.s.l., 12.X.1986, G. Gardini, R. Rizzerio & S. Zoia leg.; 1 ♂, Orvieto, Titignano, entrance of Pozzo della Piana 56 U/ TR, 260 m a.s.l., 6. VI.2004, P. Magrini leg. (together with 2 ♂ 3 ♀ of C. densedentatus). Latium: Frosinone Prov. — 1 ♂, Amaseno, Monte Fortino, 30. V.1992, L. Latella leg.; 1 ♂ 2 ♀, Arpino, 500 m a.s.l., 26. VI.1999, G. Osella leg., oak wood; 1 ♀, Cassino, Monte Cairo, III.1991, P. Magrini leg.; 2 ♀, Cassino, Monte Cairo, Grotta a quota 300 n. c. La/ FR, 300 m a.s.l., 2.IV.1988, P. Magrini leg.; 1 ♀, Ceccano, Pozzo l’Arcaro 340 La/ FR, 28. VIII.2007, M. Bastianini & P. Magrini leg.; 4 ♀, id., 18. VIII.2008, P. Magrini leg.; 4 ♂ 12 ♀, Collepardo, Certosa di Trisulti, 1.X.1982, G. Gardini & S. Zoia leg.; 1 ♀, Filettino, slope of Mt.
Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015)
No full textTable of contents
O1 Regulation of genes by telomere length over long distances
Jerry W. Shay
O2 The microtubule destabilizer KIF2A regulates the postnatal establishment of neuronal circuits in addition to prenatal cell survival, cell migration, and axon elongation, and its loss leading to malformation of cortical development and severe epilepsy
Noriko Homma, Ruyun Zhou, Muhammad Imran Naseer, Adeel G. Chaudhary, Mohammed Al-Qahtani, Nobutaka Hirokawa
O3 Integration of metagenomics and metabolomics in gut microbiome research
Maryam Goudarzi, Albert J. Fornace Jr.
O4 A unique integrated system to discern pathogenesis of central nervous system tumors
Saleh Baeesa, Deema Hussain, Mohammed Bangash, Fahad Alghamdi, Hans-Juergen Schulten, Angel Carracedo, Ishaq Khan, Hanadi Qashqari, Nawal Madkhali, Mohamad Saka, Kulvinder S. Saini, Awatif Jamal, Jaudah Al-Maghrabi, Adel Abuzenadah, Adeel Chaudhary, Mohammed Al Qahtani, Ghazi Damanhouri
O5 RPL27A is a target of miR-595 and deficiency contributes to ribosomal dysgenesis
Heba Alkhatabi
O6 Next generation DNA sequencing panels for haemostatic and platelet disorders and for Fanconi anaemia in routine diagnostic service
Anne Goodeve, Laura Crookes, Nikolas Niksic, Nicholas Beauchamp
O7 Targeted sequencing panels and their utilization in personalized medicine
Adel M. Abuzenadah
O8 International biobanking in the era of precision medicine
Jim Vaught
O9 Biobank and biodata for clinical and forensic applications
Bruce Budowle, Mourad Assidi, Abdelbaset Buhmeida
O10 Tissue microarray technique: a powerful adjunct tool for molecular profiling of solid tumors
Jaudah Al-Maghrabi
O11 The CEGMR biobanking unit: achievements, challenges and future plans
Abdelbaset Buhmeida, Mourad Assidi, Leena Merdad
O12 Phylomedicine of tumors
Sudhir Kumar, Sayaka Miura, Karen Gomez
O13 Clinical implementation of pharmacogenomics for colorectal cancer treatment
Angel Carracedo, Mahmood Rasool
O14 From association to causality: translation of GWAS findings for genomic medicine
Ahmed Rebai
O15 E-GRASP: an interactive database and web application for efficient analysis of disease-associated genetic information
Sajjad Karim, Hend F Nour Eldin, Heba Abusamra, Elham M Alhathli, Nada Salem, Mohammed H Al-Qahtani, Sudhir Kumar
O16 The supercomputer facility “AZIZ” at KAU: utility and future prospects
Hossam Faheem
O17 New research into the causes of male infertility
Ashok Agarwa
O18 The Klinefelter syndrome: recent progress in pathophysiology and management
Eberhard Nieschlag, Joachim Wistuba, Oliver S. Damm, Mohd A. Beg, Taha A. Abdel-Meguid, Hisham A. Mosli, Osama S. Bajouh, Adel M. Abuzenadah, Mohammed H. Al-Qahtani
O19 A new look to reproductive medicine in the era of genomics
Serdar Coskun
P1 Wnt signalling receptors expression in Saudi breast cancer patients
Muhammad Abu-Elmagd, Abdelbaset Buhmeida, Ashraf Dallol, Jaudah Al-Maghrabi, Sahar Hakamy, Wejdan Al-Qahtani, Asia Al-Harbi, Shireen Hussain, Mourad Assidi, Mohammed Al-Qahtani, Adel Abuzenadah
P2 Analysis of oxidative stress interactome during spermatogenesis: a systems biology approach to reproduction
Burak Ozkosem, Rick DuBois
P3 Interleukin-18 gene variants are strongly associated with idiopathic recurrent pregnancy loss.
Safia S Messaoudi, Maryam T Dandana, Touhami Mahjoub, Wassim Y Almawi
P4 Effect of environmental factors on gene-gene and gene-environment reactions: model and theoretical study applied to environmental interventions using genotype
S. Abdalla, M. Nabil Al-Aama
P5 Genomics and transcriptomic analysis of imatinib resistance in gastrointestinal stromal tumor
Asmaa Elzawahry, Tsuyoshi Takahashi, Sachiyo Mimaki, Eisaku Furukawa, Rie Nakatsuka, Isao Kurosaka, Takahiko Nishigaki, Hiromi Nakamura, Satoshi Serada, Tetsuji Naka, Seiichi Hirota, Tatsuhiro Shibata, Katsuya Tsuchihara, Toshirou Nishida, Mamoru Kato
P6 In-Silico analysis of putative HCV epitopes against Pakistani human leukocyte antigen background: an approach towards development of future vaccines for Pakistani population
Sajid Mehmood, Naeem Mahmood Ashraf, Awais Asif, Muhammad Bilal, Malik Siddique Mehmood, Aadil Hussain
P7 Inhibition of AChE and BuChE with the natural compounds of Bacopa monerri for the treatment of Alzheimer’s disease: a bioinformatics approach
Qazi Mohammad Sajid Jamal, Mughees Uddin Siddiqui, Mohammad A. Alzohairy, Mohammad A. Al Karaawi
P8 Her2 expression in urothelial cell carcinoma of the bladder in Saudi Arabia
Taoufik Nedjadi, Jaudah Al-Maghrabi, Mourad Assidi, Heba Al-Khattabi, Adel Al-Ammari, Ahmed Al-Sayyad, Abdelbaset Buhmeida, Mohammed Al-Qahtani
P9 Association of angiotensinogen single nucleotide polymorphisms with Preeclampsia in patients from North Africa
Hédia Zitouni, Nozha Raguema, Marwa Ben Ali, Wided Malah, Raja Lfalah, Wassim Almawi, Touhami Mahjoub
P10 Systems biology analysis reveals relations between normal skin, benign nevi and malignant melanoma
Mohammed Elanbari, Andrey Ptitsyn
P11 The apoptotic effect of thymoquinone in Jurkat cells
Sana Mahjoub, Rabeb El Ghali, Bechir Achour, Nidhal Ben Amor, Mourad Assidi, Brahim N'siri, Hamid Morjani
P12 Sonic hedgehog contributes in bladder cancer invasion in Saudi Arabia
Taoufik Nedjadi, Adel Al-Ammari, Ahmed Al-Sayyad, Nada Salem, Esam Azhar, Jaudah Al-Maghrabi
P13 Association of Interleukin 18 gene promoter polymorphisms - 607A/C and -137 G/C with colorectal cancer onset in a sample of Tunisian population
Vera Chayeb, Maryam Dendena, Hedia Zitouni, Khedija Zouari-Limayem, Touhami Mahjoub
P14 Pathological expression of interleukin-6, -11, leukemia inhibitory factor and their receptors in tubal gestation with and without tubal cytomegalovirus infection
Bassem Refaat, Ahmed M Ashshi, Sarah A Batwa
P15 Phenotypic and genetic profiling of avian pathogenic and human diarrhegenic Escherichia coli in Egypt
Hazem Ramadan, Amal Awad, Ahmed Ateya
P16 Cancer-targeting dual gene virotherapy as a promising therapeutic strategy for treatment of hepatocellular carcinoma
Adel Galal Ahmed El-Shemi, Ahmad Ashshi, Mohammed Basalamah, Youjin Na, Chae-Ok YUN
P17 Cancer dual gene therapy with oncolytic adenoviruses expressing TRAIL and IL-12 transgenes markedly eradicated human hepatocellular carcinoma both in vitro and in vivo
Adel Galal Ahmed El-Shemi, Ahmad Ashshi, Mohammed Basalamah, Youjin Na, Chae-Ok Yun
P18 Therapy with paricalcitol attenuates tumor growth and augments tumoricidal and anti-oncogenic effects of 5-fluorouracil on animal model of colon cancer
Adel Galal El-Shemi, Bassem Refaat, Osama Kensara, Amr Abdelfattah
P19 The effects of Rubus idaeus extract on normal human lymphocytes and cancer cell line
Batol Imran Dheeb, Mohammed M. F. Al-Halbosiy, Rghad Kadhim Al lihabi, Basim Mohammed Khashman
P20 Etanercept, a TNF-alpha inhibitor, alleviates mechanical hypersensitivity and spontaneous pain in a rat model of chemotherapy-induced neuropathic pain
Djouhri, Laiche, Chaudhary Adeel, Nedjadi, Taoufik
P21 Sleeping beauty mutagenesis system identified genes and neuronal transcription factor network involved in pediatric solid tumour (medulloblastoma)
Hani Al-Afghani, Maria Łastowska, Haya H Al-Balool, Harsh Sheth, Emma Mercer, Jonathan M Coxhead, Chris PF Redfern, Heiko Peters, Alastair D Burt, Mauro Santibanez-Koref, Chris M Bacon, Louis Chesler, Alistair G Rust, David J Adams, Daniel Williamson, Steven C Clifford, Michael S Jackson
P22 Involvement of interleukin-1 in vitiligo pathogenesis
Mala Singh, Mohmmad Shoab Mansuri, Shahnawaz D. Jadeja, Hima Patel, Yogesh S. Marfatia, Rasheedunnisa Begum
P23 Cytogenetics abnormalities in 12,884 referred population for chromosomal analysis and the role of FISH in refining the diagnosis (cytogenetic experience 2004-2013)
Amal M Mohamed, Alaa K Kamel, Nivin A Helmy, Sayda A Hammad, Hesham F Kayed, Marwa I Shehab, Assad El Gerzawy, Maha M. Ead, Ola M Ead, Mona Mekkawy, Innas Mazen, Mona El-Ruby
P24 Analysis of binding properties of angiotensin-converting enzyme 2 through in silico method
S. M. A. Shahid, Qazi Mohammad Sajid Jamal, J. M. Arif, Mohtashim Lohani
P25 Relationship of genetics markers cis and trans to the β-S globin gene with fetal hemoglobin expression in Tunisian sickle cell patients
Moumni Imen, Chaouch Leila, Ouragini Houyem, Douzi Kais, Chaouachi Dorra Mellouli Fethi, Bejaoui Mohamed, Abbes Salem
P26 Analysis of estrogen receptor alpha gene polymorphisms in breast cancer: link to genetic predisposition in Sudanese women
Areeg Faggad, Amanuel T Gebreslasie, Hani Y Zaki, Badreldin E Abdalla
P27 KCNQI gene polymorphism and its association with CVD and T2DM in the Saudi population
Maha S AlShammari, Rhaya Al-Ali, Nader Al-Balawi , Mansour Al-Enazi, Ali Al-Muraikhi, Fadi Busaleh, Ali Al-Sahwan, Francis Borgio, Abdulazeez Sayyed, Amein Al-Ali, Sadananda Acharya
P28 Clinical, neuroimaging and cytogenetic study of a patient with microcephaly capillary malformation syndrome
Maha S. Zaki, Hala T. El-Bassyouni, Marwa I. Shehab
P29 Altered expression of CD200R1 on dendritic cells of patients with inflammatory bowel diseases: in silico investigations and clinical evaluations
Mohammed F. Elshal, Kaleemuddin M., Alia M. Aldahlawi, Omar Saadah,
J. Philip McCoy
P30 Development of real time PCR diagnostic protocol specific for the Saudi Arabian H1N1 viral strains
Adel E El-Tarras, Nabil S Awad, Abdulla A Alharthi, Mohamed M M Ibrahim
P31 Identification of novel genetic variations affecting Osteoarthritis patients
Haneen S Alsehli, Ashraf Dallol, Abdullah M Gari, Mohammed M Abbas, Roaa A Kadam, Mazen M. Gari, Mohmmed H Alkaff, Adel M Abuzenadah, Mamdooh A Gari
P32 An integrated database of GWAS SNVs and their evolutionary properties
Heba Abusamra, Sajjad Karim, Hend F Nour eldin, Elham M Alhathli, Nada Salem, Sudhir Kumar, Mohammed H Al-Qahtani
P33 Familial hypercholesterolemia in Saudi Arabia: prime time for a national registry and genetic analysis
Fatima A. Moradi, Omran M. Rashidi, Zuhier A. Awan
P34 Comparative genomics and network-based analyses of early hepatocellular carcinoma
Ibrahim Hamza Kaya, Olfat Al-Harazi, Dilek Colak
P35 A TALEN-based oncolytic viral vector approach to knock out ABCB1 gene mediated chemoresistance in cancer stem cells
Nabila A Alkousi, Takis Athanasopoulos
P36 Cartilage differentiation and gene expression of synovial fluid mesenchymal stem cells derived from osteoarthritis patients
Afnan O Bahmaid, Etimad A Alhwait, Mamdooh A Gari, Haneen S Alsehli, Mohammed M Abbas, Mohammed H Alkaf, Roaa Kadam, Ashraf Dallol, Gauthaman Kalamegam
P37 E-GRASP: Adding an evolutionary component to the genome-wide repository of associations (GRASP) resource
Hend F Nour Eldin, Sajjad Karim, Heba Abusamra, Elham Alhathli, Nada Salem, Mohammed H Al-Qahtani, Sudhir Kumar
P38 Screening of AGL gene mutation in Saudi family with glycogen storage disease Type III
Salma N Alsayed, Fawziah H Aljohani, Samaher M Habeeb, Rawan A Almashali, Sulman Basit, Samia M Ahmed
P39 High throughput proteomic data suggest modulation of cAMP dependent protein kinase A and mitochondrial function in infertile patients with varicocele
Rakesh Sharma, Ashok Agarwal, Damayanthi Durairajanayagam, Luna Samanta, Muhammad Abu-Elmagd, Adel M. Abuzenadah, Edmund S. Sabanegh, Mourad Assidi, Mohammed Al-Qahtani
P40 Significant protein profile alterations in men with primary and secondary infertility
Ashok Agarwal, Rakesh Sharma, Luna Samanta, Damayanthi Durairajanayagam, Mourad Assidi, Muhammad Abu-Elmagd, Mohammed Al-Qahtani, Adel M. Abuzenadah, Edmund S. Sabanegh
P41 Spermatozoa maturation in infertile patients involves compromised expression of heat shock proteins
Luna Samanta, Ashok Agarwal, Rakesh Sharma, Zhihong Cui, Mourad Assidi, Adel M. Abuzenadah, Muhammad Abu-Elmagd, Mohammed Al-Qahtani
P42 Array comparative genomic hybridization approach to search genomic answers for spontaneous recurrent abortion in Saudi Arabia
Alaa A Alboogmi, Nuha A Alansari, Maha M Al-Quaiti, Fai T Ashgan, Afnan Bandah, Hasan S Jamal, Abdullraheem Rozi, Zeenat Mirza, Adel M Abuzenadah, Sajjad Karim, Mohammed H Al-Qahtani
P43 Global gene expression profiling of Saudi kidney cancer patients
Sajjad Karim, Hans-Juergen Schulten, Ahmad J Al Sayyad, Hasan MA Farsi, Jaudah A Al-Maghrabi, Zeenat Mirza, Reem Alotibi, Alaa Al-Ahmadi, Nuha A Alansari, Alaa A Albogmi, Maha M Al-Quaiti, Fai T Ashgan, Afnan Bandah, Mohammed H Al-Qahtani
P44 Downregulated StAR gene and male reproductive dysfunction caused by nifedipine and ethosuximide
Rasha A Ebiya, Samia M Darwish, Metwally M. Montaser
P45 Clustering based gene expression feature selection method: A computational approach to enrich the classifier efficiency of differentially expressed genes
Heba Abusamra, Vladimir B. Bajic
P46 Prognostic significance of Osteopontin expression profile in colorectal carcinoma
Jaudah Al-Maghrabi, Wafaey Gomaa, Mehenaz Hanbazazh, Mahmoud Al-Ahwal, Asia Al-Harbi, Wejdan Al-Qahtani, Saher Hakamy, Ghali Baba, Abdelbaset Buhmeida, Mohammed Al-Qahtani
P47 High Glypican-3 expression pattern predicts longer disease-specific survival in colorectal carcinoma
Jaudah Al-Maghrabi, Abdullah Al-Harbi, Mahmoud Al-Ahwal, Asia Al-Harbi, Wejdan Al-Qahtani, Sahar Hakamy, Ghalia Baba, Abdelbaset Buhmeida, Mohammed Al-Qahtani
P48 An evolutionary re-assessment of GWAS single nucleotide variants implicated in the Cholesterol traits
Elham M Alhathli, Sajjad Karim, Nada Salem, Hend Nour Eldin, Heba Abusamra, Sudhir Kumar, Mohammed H Al-Qahtani
P49 Derivation and characterization of human Wharton’s jelly stem cells (hWJSCs) in vitro for future therapeutic applications
Aisha A Alyamani, Gauthaman Kalamegam, Etimad A Alhwait, Mamdooh A Gari, Mohammed M Abbas, Mohammed H Alkaf, Haneen S Alsehli, Roaa A Kadam, Mohammed Al-Qahtani
P50 Attitudes of healthcare students toward biomedical research in the post-genomic era
Rawan Gadi, Abdelbaset Buhmeida, Mourad Assidi , Adeel Chaudhary, Leena Merdad
P51 Evaluation of the immunomodulatory effects of thymoquinone on human bone marrow mesenchymal stem cells (BM-MSCs) from osteoarthritic patients
Saadiah M Alfakeeh, Etimad A Alhwait, Mamdooh A Gari, Mohammed M Abbas, Mohammed H Alkaf, Haneen S Alsehli, Roaa Kadam, Gauthaman Kalamegam
P52 Implication of IL-10 and IL-28 polymorphism with successful anti-HCV therapy and viral clearance
Rubi Ghazala, Shilu Mathew, M.Haroon Hamed, Mourad Assidi, Mohammed Al-Qahtani, Ishtiaq Qadri
P53 Selection of flavonoids against obesity protein (FTO) using in silico and in vitro approaches
Shilu Mathew, Lobna Mira, Manal Shaabad, Shireen Hussain, Mourad Assidi, Muhammad Abu-Elmagd, Mohammed Al-Qahtani
P54 Computational selection and in vitro validation of flavonoids as new antidepressant agents
Shilu Mathew, Manal Shaabad, Lobna Mira, Shireen Hussain, Mourad Assidi, Muhammad Abu-Elmagd, Mohammed Al-Qahtani
P55 In Silico prediction and prioritization of aging candidate genes associated with
progressive telomere shortening
Ahmed Rebai, Mourad Assidi, Abdelbaset Buhmeida, Muhammad Abu-Elmagd, Ashraf Dallol, Jerry W Shay
P56 Identification of new cancer testis antigen genes in diverse types of malignant human tumour cells
Mikhlid H Almutairi
P57 More comprehensive forensic genetic marker analyses for accurate human remains identification using massively parallel sequencing (MPS)
Angie Ambers, Jennifer Churchill, Jonathan King, Monika Stoljarova, Harrell Gill-King, Mourad Assidi, Muhammad Abu-Elmagd, Abdelbaset Buhmeida, Muhammad Al-Qatani, Bruce Budowle
P58 Flow cytometry approach towards treatment men infertility in Saudi Arabia
Muhammad Abu-Elmagd, Farid Ahmed, Ashraf Dallol, Mourad Assidi, Taha Abo Almagd, Sahar Hakamy, Ashok Agarwal, Muhammad Al-Qahtani, Adel Abuzenadah
P59 Tissue microarray based validation of CyclinD1 expression in renal cell carcinoma of Saudi kidney patients
Sajjad Karim, Hans-Juergen Schulten, Ahmad J Al Sayyad, Hasan MA Farsi, Jaudah A Al-Maghrabi, Abdelbaset Buhmaida, Zeenat Mirza, Reem Alotibi, Alaa Al-Ahmadi, Nuha A Alansari, Alaa A Albogmi, Maha M Al-Quaiti, Fai T Ashgan, Afnan Bandah, Mohammed H Al-Qahtani
P60 Assessment of gold nanoparticles in molecular diagnostics and DNA damage studies
Rukhsana Satar, Mahmood Rasool, Waseem Ahmad, Nazia Nazam, Mohamad I Lone, Muhammad I Naseer, Mohammad S Jamal, Syed K Zaidi, Peter N Pushparaj, Mohammad A Jafri, Shakeel A Ansari, Mohammed H Alqahtani
P61 Surfing the biospecimen management and processing workflow at CEGMR Biobank
Hanan Bashier, Abrar Al Qahtani, Shilu Mathew, Amal M. Nour, Heba Alkhatabi, Adel M. Abu Zenadah, Abdelbaset Buhmeida, Mourad Assidi, Muhammed Al Qahtani
P62 Autism Spectrum Disorder: knowledge, attitude and awareness in Jeddah, Kingdom of Saudi Arabia
Muhammad Faheem, Shilu Mathew, Shiny Mathew, Peter Natesan Pushparaj, Mohammad H. Al-Qahtani
P63 Simultaneous genetic screening of the coagulation pathway genes using the Thromboscan targeted sequencing panel
Hani A. Alhadrami, Ashraf Dallol, Adel Abuzenadah
P64 Genome wide array comparative genomic hybridization analysis in patients with syndromic congenital heart defects
Ibtessam R. Hussein, Adeel G. Chaudhary, Rima S Bader, Randa Bassiouni, Maha Alquaiti, Fai Ashgan, Hans Schulten, Mohamed Nabil Alama, Mohammad H. Al Qahtani
P65 Toxocogenetic evaluation of 1, 2-Dichloroethane in bone marrow, blood and cells of immune system using conventional, molecular and flowcytometric approaches
Mohammad I Lone, Nazia Nizam, Waseem Ahmad, Mohammad A Jafri, Mahmood Rasool, Shakeel A Ansari, Muhammed H Al-Qahtani
P66 Molecular cytogenetic diagnosis of sexual development disorders in newborn: A case of ambiguous genitalia
Eradah Alshihri, Muhammad Abu-Elmagd, Lina Alharbi, Mourad Assidi, Mohammed Al-Qahtani
P67 Identification of disease specific gene expression clusters and pathways in hepatocellular carcinoma using In Silico methodologies
Shilu Mathew, Peter Pushparaj Natesan, Muhammed Al Qahtani
P68 Human Wharton’s Jelly stem cell conditioned medium inhibits primary ovarian cancer cells in vitro: Identification of probable targets and mechanisms using systems biology
Gauthaman Kalamegam, Peter Natesan Pushparaj, Fazal Khan, Roaa Kadam, Farid Ahmed, Mourad Assidi, Khalid Hussain Wali Sait, Nisreen Anfinan, Mohammed Al Qahtani
P69 Mutation spectrum of ASPM (Abnormal Spindle-like, Microcephaly-associated) gene in Saudi Arabian population
Muhammad I Naseer, Adeel G Chaudhary, Mohammad S Jamal, Shilu Mathew, Lobna S Mira, Peter N Pushparaj, Shakeel A Ansari, Mahmood Rasool, Mohammed H AlQahtani
P70 Identification and characterization of novel genes and mutations of primary microcephaly in Saudi Arabian population
Muhammad I Naseer, Adeel G Chaudhary, Shilu Mathew, Lobna S Mira, Mohammad S Jamal, Sameera Sogaty, Randa I Bassiouni, Mahmood Rasool, Mohammed H AlQahtani
P71 Molecular genetic analysis of hereditary nonpolyposis colorectal cancer (Lynch Syndrome) in Saudi Arabian population
Mahmood Rasool, Shakeel A Ansari, Mohammad S Jamal, Peter N Pushparaj, Abdulrahman MS Sibiani, Waseem Ahmad, Abdelbaset Buhmeida, Mohammad A Jafri, Mohiuddin K Warsi, Muhammad I Naseer, Mohammed H Al-Qahtani
P72 Function predication of hypothetical proteins from genome database of chlamydia trachomatis
Rubi, Kundan Kumar, Ahmad AT Naqvi, Faizan Ahmad, Md
Relationship between structural abnormalities in the cerebellum and dementia, posttraumatic stress disorder and bipolar disorder
No full textABSTRACT. New evidence suggests that the cerebellum has structural and functional abnormalities in psychiatric disorders. Objective: In this research, the goal was to measure the volume of the cerebellum and its subregions in individuals with psychiatric disorders and to relate these findings to their symptoms. Methods: Patients with different degrees of cognitive impairment (Epidemiology of the Elderly - UNIFESP) and patients with post-traumatic stress disorder (PTSD) from population studies were analyzed. Also, patients with bipolar disorder from an outpatient clinic (Center for the Study of Mood and Anxiety Disorders, Universidade Federal da Bahia) were recruited for this study. All subjects underwent a 1.5T structural magnetic resonance scan. Volumetric measures and symptom measurements, by psychometric scales, were performed and compared between patients and controls. Results: The cerebellum volume was reduced in patients with cognitive impairment without dementia and with dementia, in patients with PTSD, and in patients with bipolar disorder compared to controls. In dementia and PTSD, the left cerebellar hemisphere and vermis volume were reduced. In bipolar disorder, volumes of both hemispheres and the vermis were reduced. In the first two studies, these cerebellar volumetric reductions correlated with symptoms of the disease. Conclusion: The exact nature of cerebellar involvement in mental processes is still not fully understood. However, abnormalities in cerebellar structure and its functions have been reported in some of these diseases. Future studies with larger samples are needed to clarify these findings and investigate whether they are important for treatment and prognosis
