257 research outputs found
La culture du virus de la fièvre aphteuse sur épithélium lingual de bovin en survie. Nouvelle technique permettant une augmentation du rendement en virus : technique de multiculture
No full textDubouclard C., Roumiantzeff M., Fontaine J., Mackowiak Czesław, Brocco J., Dupasquier M. La culture du virus de la fièvre aphteuse sur épithélium lingual de bovin en survie. Nouvelle technique permettant une augmentation du rendement en virus : technique de multiculture. In: Bulletin de l'Académie Vétérinaire de France tome 121 n°6, 1968. pp. 251-258
The selective D3 receptor antagonist, S33084, improves parkinsonian-like motor dysfunction but does not affect L-DOPA-induced dyskinesia in 6-hydroxydopamine hemi-lesioned rats
No full textDespite evidence linking dopamine D3 receptors to the etiology of Parkinson’s disease and L-DOPAinduced
dyskinesia, the potential therapeutic utility of D3 receptor ligands remains unclear. In the
present study, we investigated whether the selective D3 receptor antagonist, S33084, affects development
and expression of abnormal involuntary movements (AIMs), a behavioural correlate of dyskinesia,
in rats hemi-lesioned with 6-hydroxydopamine and chronically treated with L-DOPA. The ability of
S33084, alone or in combination with L-DOPA, to attenuate 6-hydroxydopamine induced motor deficits
was also investigated employing a battery of behavioural tests. Acute administration of S33084
(0.64 mg/kg, s.c.) did not attenuate the induction of AIMs in dyskinetic rats upon challenge with L-DOPA
(6 mg/kg, s.c.). Moreover, S33084 (0.64 mg/kg) did not prevent the development of AIMs affecting axial,
limb and orolingual muscles when chronically administered together with L-DOPA (6 mg/kg for 21 days).
However, both acute and chronic administration of S33084 enhanced L-DOPA-induced contralateral
turning, suggesting potential antiparkinsonian properties. Furthermore, S33084 (0.01–0.64 mg/kg) dosedependently
attenuated parkinsonian disabilities, including bradykinesia, in drag and rotarod tests,
although, in these procedures, the combination of S33084 with L-DOPA did not produce synergistic
effect. It is concluded that sustained D3 receptor blockade does not blunt L-DOPA-induced dyskinesia in
hemiparkinsonian rats. However, D3 receptor antagonism may be associated with antiparkinsonian
properties. The clinical relevance of these observations will be of interest to explore further
The community organization process in the development of the Montgomery neighborhood center, Rochester, New York 1913-1951
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Impact of experimental hypercalcemia on routine haemostasis testing.
No full textBACKGROUND:The blood to anticoagulant ratio is standardized according to the physiological calcium concentration in blood samples conventionally used for hemostasis testing. Specifically, one fixed volume of 0.109 mmol/L sodium citrate is added to 9 volumes of blood. Since little is known about the impact of hypercalcemia on the calcium-binding capacity of citrate, this study was planned to investigate the effect of experimental hypercalcemia on routine hemostasis testing. METHODS:Fifteen pooled citrated plasmas with matching lithium-heparin pooled plasma from patients with different values of prothrombin time (PT) were divided in three aliquots of 0.6mL each. The first paired aliquots of both citrate and lithium-heparin plasma were supplemented with 60μL of saline, the second paired aliquots with 30μL of saline and 30μL of calcium chloride and the third paired aliquots with 60μL of calcium chloride. Total and ionized calcium was measured in all aliquots of citrate and lithium-heparin plasma, whereas PT, activated partial thromboplastin time (APTT) and fibrinogen were measured in citrate plasma aliquots. RESULTS:Total calcium concentration gradually increased in both lithium-heparin and citrate plasma aliquots 2 and 3 compared to baseline aliquot 1. The concentration of ionized calcium also gradually increased in lithium-heparin plasma aliquots 2 and 3, whereas it remained immeasurable (i.e., <0.10 mmol/L) in all citrate plasma aliquots. No significant differences were observed for values of PT, APTT and fibrinogen in citrate plasma aliquots 2 and 3 compared to the baseline aliquot 1, with a mean bias was always comprised within the desirable quality specifications derived from biological variability data. CONCLUSION:Hypercalcemia, up to severe hypercalcemia does not generate significant bias in results of first-line coagulations tests, so that hypothetical consideration of adjusting citrate-blood ratio is unjustified in hypercalcemic patients
Renal structural changes in non insulin dependent diabetes. Am J Hypertension, 10: 184S-188S, 1997.
No full textIF 3.38
The Ursinus Weekly, November 20, 1922
No full textGroups convene in regular monthly sessions Tuesday • Faculty ladies speak on Honor and honors • Varsity eleven bows before overwhelming F. and M. force • Reverend George M. Smith, Sem. \u2706, to conduct evangelistic services • W. Harry Snyder selected for Rhodes competition • Shaffer \u2723, and Brocco, \u2725 elected to Weekly staff • Trackmen elect Markley manager • YM-YW social • Radio Club to be organized • Plays in Reading • Former student author of book on education • Reifsneider resigns • Student council dancehttps://digitalcommons.ursinus.edu/weekly/2364/thumbnail.jp
Evaluation of ChromaticTM OXA-48 medium for direct detection of OXA-48 producing Enterobacteriaceae from rectal swabs.
No full textSerum concentration of growth differentiation factor-15 is independently associated with global platelet function and higher fibrinogen values in adult healthy subjects
No full textSerum Concentration of Growth Differentiation Factor-15 Is Independently Associated with Global Platelet Function and Higher Fibrinogen Values in Adult Healthy Subjects
Pontencial of heartwood extractives from teak as a natural preservative and its influence on color of light woods
No full textThis study aimed to evaluate the preservative potential of the heartwood extractives from teak (Tectona grandis) and the capacity of the same in the color change of light woods. For both, the waste generated in mechanical processing of the teak heartwood with 20 years old were collected and used for performing extractions. To evaluate the influence of teak heartwood extractives in the color and natural resistance of timber, were used the sapwood of teak wood with 10 years and the wood of Pinus sp., due to being a light colored wood and with low natural resistance to wood-destroying organisms. Extractions were performed in hot water and absolute ethanol. To determine the concentration of treatment solutions, a toxicity test to fungus Postia placenta was performed. After set the concentration, the extracted solutions were prepared for impregnation. Furthermore, it was used a third solution, composed by mixing of extracted solutions in hot water and absolute ethanol. The treatment by the method of cell-full (Bethell) was performed for each treatment solution. To test the efficiency of the solutions prepared with teak heartwood extractives, colorimetric analyses and biological assays with fungi and termites were carried out. The combination of the tested extractives promoted a darkening and reduced the disparity of color, making the treated wood closer to the heartwood color than the untreated samples of the respective species. The extractive solution obtained in absolute ethanol and the combination of the extractives obtained in hot water and absolute ethanol provided the best results in the resistance of treated wood against fungi and ermites,significantly changing the biological resistance class of the respective treated species.Este estudo teve como objetivo avaliar o potencial preservativo dos extrativos do cerne da madeira de teca (Tectona grandis) e a capacidade dos mesmos na mudança de coloração de madeiras claras. Para tanto, os resíduos gerados no processamento
mecânico do cerne da madeira de teca com 20 anos de idade foram coletados e utilizados para realização de extrações. Para avaliar a influência dos extrativos de teca na cor e resistência natural da madeira foi utilizado o alburno da madeira de teca com 10 anos, além da madeira de Pinus sp., em função de ser uma madeira de coloração
clara e baixa resistência natural. Foram realizadas extrações em água quente e etanol absoluto. Para determinação da concentração das soluções de tratamento foi realizado um ensaio de toxidez ao fungo Postia placenta. Após definida a concentração, as soluções extraídas foram preparadas para a impregnação. Além
disto, foi utilizada uma terceira solução, composta pela combinação das soluções extraídas em água quente e etanol absoluto. Para cada solução testada foi realizado o tratamento pelo método de célula-cheia (Bethell). Para testar a eficiência das soluções preparadas com extrativos de teca, foram realizados leituras colorimétricas
e ensaios biológicos com fungos e térmitas xilófagos. A combinação dos extrativos testados promoveu um escurecimento e reduziu a desuniformidade da cor, fazendo com que as madeiras tratadas se aproximassem mais da cor da madeira de cerne do que das amostras sem tratamento das respectivas espécies. A solução de extrativos
obtida em etanol absoluto e a combinação dos extrativos obtidos em água quente e etanol absoluto promoveram os melhores resultados na resistência da madeira tratada contra fungos e térmitas xilófagos, alterando significativamente a classe de resistência das respectivas espécies tratadas
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