46 research outputs found
The changing prevalence of pulmonary infection in adults with cystic fibrosis: a longitudinal analysis
No full textAbstract not availableKay A. Ramsay, Harpreet Sandhu, James B. Geake, Emma Ballard, Peter O'Rourke, Claire E. Wainwright, David W. Reid, Timothy J. Kidd, Scott C. Bel
Sudden death in a young male with a recent pneumothorax: a case report
Get PDFLetter to the EditorJames B. Geake, Donald M. Ritchey, Jo Burke, Andrew Halliday, Richard Wood-Baker, Graeme Maguir
Seventh Lunar Science Conference abstracts for special symposium on recent activity in the Moon
No full textA Symposium at the 7th Lunar Science Conference 16 March 1976.Sponsored Jointly by The Lunar Science Institute and Johnson Space Center (NASA)Organizing Committee: S. K. Runcorn; G. V. Latham; B. Middlehurst; R. R. Hodges; R. O. Pepin; L. J. SrnkaPARTIAL CONTENTS: Lunar Seismicity and Tectonics / D. R. Lammlein--Review of HFT Events (Shallow Moonquakes ?) / Y. Nakamura--Correlation Between Periodic Lunar Phenomena: An Interpretation- B. Middlehurst--Spectral Observations of LTP / N. A. Kozyrev--New Polarmetric Evidence for Lunar Activity / P. Dzhapiashvili--Manifestations, Site Distributions, Possible Causes and Correlations of LTP / W. S. Cameron--Astronaut Observations / J, E. McCoy--Possible Physical Processes Causing Transient Lunar Events / J. E. Geake and A. A. Mills--Measurements of Spatial and Temporal Variability in Lunar Radon Emission / P. Gorenstein and P. Bjorkholm--Episodic Emanation of Argon from the Moon- R. R. Hodges, Jr
Why do some primary teacher trainees hate maths? A case study
No full textStudent teachers' negative attitudes towards mathematics and the inadequacy of their mathematical backgrounds have been a concern of mathematics educators for many years. In an attempt to understand the interaction of cognitive and affective factors in mathematics learning, this paper presents a case study of one preservice early childhood/primary teacher education student's experiences of learning mathematics. The study identifies issues which are of concern to teachers and teacher educators
An international, multicentre evaluation and description of Burkholderia pseudomallei infection in cystic fibrosis
Get PDFSeveral cases of Burkholderia pseudomallei infection in CF have been previously reported. We aimed to identify all cases globally, risk factors for acquisition, clinical consequences, and optimal treatment strategies.We performed a literature search to identify all published cases of B. pseudomallei infection in CF. In addition we hand-searched respiratory journals, and contacted experts in infectious diseases and CF around the world. Supervising clinicians for identified cases were contacted and contemporaneous clinical data was requested.25 culture-confirmed cases were identified. The median age at acquisition was 21 years, mean FEV1 % predicted was 60 %, and mean BMI was 19.5 kg/m(2). The location of acquisition was northern Australia or south-east Asia for most. 19 patients (76 %) developed chronic infection, which was usually associated with clinical decline. Successful eradication strategies included a minimum of two weeks of intravenous ceftazidime, followed by a consolidation phase with trimethoprim/sulfamethoxazole, and this resulted in a higher chance of success when instituted early. Three cases of lung transplantation have been recorded in the setting of chronic B. pseudomallei infection.Chronic carriage of B. pseudomallei in patients with CF appears common after infection, in contrast to the non-CF population. This is often associated with an accelerated clinical decline. Lung transplantation has been performed in select cases of chronic B. pseudomallei infection.James B. Geake, David W. Reid, Bart J. Currie, Scott C. Bell, and MelioidCF Investigator
Within-host evolution of Burkholderia pseudomallei during chronic infection of seven Australasian cystic fibrosis patients
Get PDFCystic fibrosis (CF) is a genetic disorder characterized by progressive lung function decline. CF patients are at an increased risk of respiratory infections, including those by the environmental bacterium Burkholderia pseudomallei, the causative agent of melioidosis. Here, we compared the genomes of B. pseudomallei isolates collected between similar to 4 and 55 months apart from seven chronically infected CF patients. Overall, the B. pseudomallei strains showed evolutionary patterns similar to those of other chronic infections, including emergence of antibiotic resistance, genome reduction, and deleterious mutations in genes involved in virulence, metabolism, environmental survival, and cell wall components. We documented the first reported B. pseudomallei hypermutators, which were likely caused by defective MutS. Further, our study identified both known and novel molecular mechanisms conferring resistance to three of the five clinically important antibiotics for melioidosis treatment. Our report highlights the exquisite adaptability of microorganisms to long-term persistence in their environment and the ongoing challenges of antibiotic treatment in eradicating pathogens in the CF lung. Convergent evolution with other CF pathogens hints at a degree of predictability in bacterial evolution in the CF lung and potential targeted eradication of chronic CF infections in the future
Neural correlates of intelligence as revealed by fMRI of fluid analogies
No full textIt has been conjectured that the cognitive basis of intelligence is the ability to make fluid or creative analogical relationships between distantly related concepts or pieces of information (Hofstadter, D.R. 1995. Fluid Concepts and Creative Analogies. Basic Books, New York., Hofstadter, D.R. 2001. Analogy as the Core of Cognition. In The Analogical Mind: Perspectives from Cognitive Science (D. Gentner, K. J. Holyoak and B. N. Kokinov, Ed.). pp. 504–537. MIT Press, Cambridge, Mass.). We hypothesised that fluid analogy-making tasks would activate specific regions of frontal cortex that were common to those of previous inferential reasoning tasks. We report here a novel self-paced event-related fMRI study employed to investigate the neural correlates of intelligence associated with undertaking fluid letter string analogy tasks. Stimuli were adapted from items of the AI program Copycat (Mitchell, M. 1993. Analogy-making as Perception: A computer model. The MIT Press, Cambridge MA.). Twelve right-handed adults chose their own "best" completions from four plausible response choices to 55 fluid letter string analogies across a range of analogical depths. An analysis using covariates determined per subject by analogical depth revealed significant bilateral neural activations in the superior, inferior, and middle frontal gyri and in the anterior cingulate/paracingulate cortex. These frontal areas have been previously associated with reasoning tasks involving inductive syllogisms, syntactic hierarchies, and linguistic creativity. A higher-order analysis covarying participants' verbal intelligence measures found correlations with individual BOLD activation strengths in two ROIs within BA 9 and BA 45/46. This is a provocative result given that verbal intelligence is conceptualised as being a measure of crystallised intelligence, while analogy making is conceptualised as requiring fluid intelligence. The results therefore support the conjecture that fluid analogising could underpin general intellectual performance
A soft solid surface on Titan as revealed by the Huygens Surface Science Package
No full textThe surface of Saturn's largest satellite - Titan - is largely obscured by an optically thick atmospheric haze, and so its nature has been the subject of considerable speculation and discussion1. The Huygens probe entered Titan's atmosphere on 14 January 2005 and descended to the surface using a parachute system2. Here we report measurements made just above and on the surface of Titan by the Huygens Surface Science Package3,4. Acoustic sounding over the last 90 m above the surface reveals a relatively smooth, but not completely flat, surface surrounding the landing site. Penetrometry and accelerometry measurements during the probe impact event reveal that the surface was neither hard (like solid ice) nor very compressible (like a blanket of fluffy aerosol); rather, the Huygens probe landed on a relatively soft solid surface whose properties are analogous to wet clay, lightly packed snow and wet or dry sand. The probe settled gradually by a few millimetres after landing. © 2005 Nature Publishing Group
Language, learning and literacy in science and mathematics
Get PDFThe Secondary Literacy Inservice Package for High School Science and Mathematics was developed to assist teachers of science and mathematics to help their students become more literate in these two subject areas. We examine the meaning of literacy and its relationship to language and learning, and describe the outcomes from trialing the package
-agonist, versus twice-daily beta-agonists or placebo for chronic obstructive pulmonary disease
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