32,209 research outputs found
ALT-C 2011 Abstracts
No full textThis is a PDF of the abstracts for all the sessions at the 2011 ALT conference. It is designed to be used alongside the online version of the conference programme. It was made public on 1 September, with a "topped and tailed" made live on 2 September
Editorial
No full textThis is my last editorial before I step down from the ALT-J editorial team. Rhona Sharpe and Frances Bell, will form the new ALT-J editorial team and I wish them the best of luck in developing the direction of ALT-J in the future. I would also like to thank the rest of outgoing editorial team, the ALT-J editorial board, the reviewers and authors that I have worked with over the last six issues of ALT-J, who each in their way has contributed to furthering our knowledge and understanding of the relationship between technology and learning
ALT-C 2011 Proceedings Papers: 0136 Learning Through Online Discussion: A Framework Evidenced in Learners' Interactions.
No full textJoint response to the Royal Society’s call for views: Vision for science and mathematics education 5-19
No full textThis response has been prepared by a consortium of the leading Technology Enhanced Learning (TEL) research labs in the UK, in collaboration with the UK’s Technology Enhanced Learning research programme and the Association for Learning Technology (ALT)
Alt-A: the forgotten segment of the mortgage market
No full textThis study presents a brief overview of the Alt-A mortgage market with the goal of outlining broad trends in the different borrower and mortgage characteristics of Alt-A market originations between 2000 and 2006. The paper also documents the default patterns of Alt-A mortgages in terms of the various borrower and mortgage characteristics over this period.Mortgages ; Subprime mortgage
Association for Learning Technology Media release – 9 December 2010 The Transformational Impact of Learning Technology Special Issue of the Journal ALT-J, Research in Learning Technology (Volume 18, Number 3)
No full textEffects of BRCA2 deficiency on telomere recombination in non-ALT and ALT cells
No full textThis article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2011 Sapir et al.Background: Recent studies suggest that BRCA2 affects telomere maintenance. Interestingly, anti cancer treatments that involve BRCA2 and telomerase individually are currently being explored. In the light of the above recent studies their combinatorial targeting may be justified in the development of future treatments. In order to investigate effects of BRCA2 that can be explored for this combinatorial targeting we focused on the analysis of recombination rates at telomeres by monitoring T-SCEs (Telomere Sister Chromatid Exchanges). Results: We observed a significant increase in T-SCE frequencies in four BRCA2 defective human cell lines thus suggesting that BRCA2 suppresses recombination at telomeres. To test this hypothesis further we analyzed T-SCE frequencies in a set of Chinese hamster cell lines with or without functional BRCA2. Our results indicate that introduction of functional BRCA2 normalizes frequencies of T-SCEs thus supporting the notion that BRCA2 suppresses recombination at telomeres. Given that ALT (Alternative Lengthening of Telomeres) positive cells maintain telomeres by recombination we investigated the effect of BRCA2 depletion in these cells. Our results show that this depletion causes a dramatic reduction in T-SCE frequencies in ALT positive cells, but not in non-ALT cells. Conclusion: BRCA2 suppresses recombination at telomeres in cells that maintain them by conventional mechanisms. Furthermore, BRCA2 depletion in ALT positive cells reduces high levels of T-SCEs normally found in these cells. Our results could be potentially important for refining telomerase-based anti-cancer therapies.This work is supported in part by grants from European Commission RISC-RAD contract FI6RCT2003-508842 and British Counci
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