192 research outputs found
Goffard M. (1994). Le problème de physique et sa pédagogie. Paris, ADAPT, 80 p
No full textToussaint J. Goffard M. (1994). Le problème de physique et sa pédagogie. Paris, ADAPT, 80 p. In: Didaskalia, n°6, 1995. pp. 181-182
Jacques Chemla, Monique Goffard et Lucette Valensi, Un siècle de céramique d’art en Tunisie. Les fils de J. Chemla, Tunis, Paris : Éditions de l’Éclat ; Tunis : Éditions Demeter, 2015
No full textCet ouvrage vient combler une lacune dans la connaissance de l’artisanat de la céramique tunisienne du xxe siècle. Descendants de la dynastie des maîtres potiers Chemla, les auteurs de cette étude, Jacques Chemla, Monique Goffard et Lucette Valensi, sont également des acteurs de l’histoire familiale qui nous est racontée. Ils reconstruisent ici l’aventure de cette industrie artisanale consacrée à la céramique qui se déroule entre les années 1860 et 1960 dans les villes de Tunis et de Nabeul. ..
Gene expression in RET/PTC3 and E7 transgenic mouse thyroids: RET/PTC3 but not E7 tumors are partial and transient models of human papillary thyroid cancers.
No full textWe studied gene expression profiles in two mouse models of human thyroid carcinoma: the Tg-RET/PTC3 (RP3) and Tg-E7 mice. RP3 fusion gene is the most frequent mutation found in the first wave post-Chernobyl papillary thyroid cancers (PTCs). E7 is an oncoprotein derived from the human papillomavirus 16 responsible for most cervical carcinoma in women. Both transgenic mice develop thyroid hyperplasia followed by solid differentiated carcinoma in older animals. To understand the different steps leading to carcinoma, we analyzed thyroid gene expression in both strains at different ages by microarray technology. Important biological processes were differentially regulated in the two tumor types. In E7 thyroids, cell cycle was the most up-regulated process, an observation consistent with the huge size of these tumors. In RP3 thyroids, contrary to E7 tumors, several human PTC characteristics were observed: overexpression of many immune-related genes, regulation of human PTC markers, up-regulation of EGF-like growth factors and significant regulation of angiogenesis and extracellular matrix remodeling-related genes. However, similarities were incomplete; they did not concern the overall gene expression and were not conserved in old animals. Therefore, RP3 tumors are partial and transient models of human PTC. They constitute a good model, especially in young animals, to study the respective role of the biological processes shared with human PTC and will allow testing drugs targeting these validated variables.Journal ArticleResearch Support, Non-U.S. Gov'tinfo:eu-repo/semantics/publishe
Efficacy and safety of TMC114/ritonavir in treatment-experienced HIV patients: 24-week results of POWER 1.
No full textThe ongoing phase IIb POWER 1 (TMC114-C213) trial is designed to assess efficacy and safety of the protease inhibitor (PI) TMC114 (darunavir) in treatment-experienced HIV-1-infected patients.Clinical Trial, Phase IIJournal ArticleMulticenter StudyRandomized Controlled TrialResearch Support, Non-U.S. Gov'tSCOPUS: ar.jinfo:eu-repo/semantics/publishe
Eosinopenia in COVID-19 patients: A retrospective analysis
No full textObjectives: The aim of this study was to assess the diagnostic role of eosinophils count in COVID-19 patients. Methods: Retrospective analysis of patients admitted to our hospital with suspicion of COVID-19. Demographic, clinical and laboratory data were collected on admission. Eosinopenia was defined as eosinophils < 100 cells/mm3. The outcomes of this study were the association between eosinophils count on admission and positive real-time reverse transcription polymerase chain reaction (rRT-PCR) test and with suggestive chest computerized tomography (CT) of COVID-19 pneumonia. Results: A total of 174 patients was studied. Of those, 54% had positive rRT-PCR for SARS-CoV-2. A chest CT-scan was performed in 145 patients; 71% showed suggestive findings of COVID-19. Eosinophils on admission had a high predictive accuracy for positive rRT-PCR and suggestive chest CT-scan (area under the receiver operating characteristic—ROC curve, 0.84 (95% CIs 0.78–0.90) and 0.84 (95% CIs 0.77–0.91), respectively). Eosinopenia and high LDH were independent predictors of positive rRT-PCR, whereas eosinopenia, high body mass index and hypertension were predictors for suggestive CT-scan findings. Conclusions: Eosinopenia on admission could predict positive rRT-PCR test or suggestive chest CT-scan for COVID-19. This laboratory finding could help to identify patients at high-risk of COVID-19 in the setting where gold standard diagnostic methods are not available
Recommended from our members
Irradiation effects on Zircaloy-2-uranium bonds
No full textThe failure mechanics of high exposure, in-reactor coextruded fuel rods are quite different from those of defected unirradiated rods. The appearance and corrosion behavior of the high-exposure in-reactor failures suggests that the strength of the coextruded Zircaloy-2 to uranium bond has deteriorated. Notch-fracture tests, in which the strength of the Zircaloy-2 clad to uranium bond is evaluated in a qualitative manner, suggests that the bond strength has not deteriorated to the degree indicated by the failure behavior. It is believed that the irradiation induced property changes of the uranium fuel and not a deterioration of the character of the bond are responsible for the difference in irradiated and unirradiated failure behavior
Recommended from our members
Swelling behavior of co-product driver elements: KER test K-3-19
No full textThis interim report details the irradiation testing of co-product fuel-target assemblies in KER loops 3 and 4 which was authorized by PT-IP-645-D. The purpose was to demonstrate and characterize the simultaneous generation of plutonium and tritium during the irradiation of simulated N-Reactor co-product assemblies. Thirteen assemblies, each consisting of a 1.25% enriched outer fuel or driver tube and an inner, coaxial, lithium bearing target rod, were loaded in KER-3 and irradiated to approximately to approximately 1300 MWD/T tube average at N-Reactor conditions. One of the important aspects of the test was the fuel swelling performance in the large, tubular, enriched driver elements. This report describes the fuel swelling behavior of the driver elements
Recommended from our members
Swelling behavior of KSE-5 fuel elements: KER test K-2-21, Interim report
No full textThis report discusses the irradiation testing of thick-walled single-tube, 1.6% enriched test elements (KSE-5`s) in KER loops 1 and 2 to evaluate swelling behavior of uranium at high temperatures. Test charge K-2-21 consisted of four KSE-5`s containing uranium with 400 ppm iron and 800 ppm aluminum. The object of the test irradiation was to establish the swelling performance of the fuel containing the iron-aluminum additions using the N-fuel composition as a reference fuel. This latter fuel has shown good high temperature performance in the British high-temperature gas-cooled reactors, but has not previously been evaluated at ``high`` specific powers in a high-temperature pressurized-water reactor environment
Recommended from our members
Hanford Works Report HW-62875
No full textA preliminary evaluation of the autoclave corrosion behavior of a series of U-low C alloys and a series of U-low Zr alloys prepared by Fuels Fabrication Development Operation has been made. The corrosion testing was conducted by Coatings and Corrosion Operation by the experimental methods and procedure outlined in HW-61378
Recommended from our members
Swelling behavior of KSE-5 fuel elements; KER Test K-1-22: Interim report
No full textProduction Test IP-544-A authorized the irradiation testing of coextruded Zr-2 jacketed, single tube, thick walled, 1.6 percent enriched tubular elements (KSE-5`s) in KER loops 1 and 2 to evaluate swelling behavior at high uranium temperatures. This PT was intended to permit the evaluation of uranium swelling at N-reactor environmental conditions but at considerably higher uranium temperatures than those occurring in N-reactor fuel. Evaluation of the fuel performances at the authorized maximum fuel temperatures in the 550--600 C temperature range is essential in the design and analysis of single tube fuel elements for use in N-reactor. The test was subsequently supplemented to authorize the irradiation of uranium fuel containing up to 3000 ppm alloying agents for the evaluation of swelling behavior at the high uranium temperatures. This report describes the swelling behavior of a charge of 8 KSE-5 fuel elements irradiated in KER loop 1 to appproximately 2500 MWD/T as Test K-1-22. KER Test K-1-22 is similar (except for exposure level) to KER Test K-2-21 in which a charge of 8 KSE-5 fuel elements were irradiated to 1500 MWD/T. In both tests the charges consisted of 4 KSE-5`s containing uranium with low iron and silicon additions (N-reactor fuel composition) and 4 KSE-5`s containing uranium with 400 ppm iron and 800 ppm aluminum. The objective of both tests was to obtain comparative swelling performance data for the two fuel compositions under identical irradiation conditions
- …
