45,447 research outputs found
PCB congener 126-induced ultrastructural alterations in the rat liver: a stereological study
No full textHepatocyte cytoplasmic alterations were morphometrically determined in male and female Sprague-Dawley rats fed PCB congener 126 (3,3',4,4',5-pentachlorobiphenyl) in concentrations of 0.1, 1.0, 10, 100 ppb or corn oil in diets for 13 weeks. A dose-dependent increase (P < 0.05) in the volume fraction of smooth endoplasmic reticulum (SER) and mitochondria was measured in the hepatocytes of the females. However, these cells of the male rats contained a significantly greater baseline volume fraction of SER compared to that in the females. Statistical differences were not detected in the volume fractions of rough endoplasmic reticulum, peroxisomes or lipid droplets of the hepatocytes in either the males or females. We conclude the increase in mitochondrial volume was a necessary cellular adaptation to meet the heightened energy demands by the SER to produce the necessary enzymes to detoxify the PCB. Morphometric analysis rather than a descriptive methodology allowed for a more accurate determination of the liver pathology induced by PCB 126. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.PT: J; CR: AHLBORG UG, 1994, CHEMOSPHERE, V28, P1049 BANDIERA S, 1982, CHEM-BIOL INTERACT, V39, P259 CHU I, 1994, FUND APPL TOXICOL, V22, P457 CLARKE DW, 1984, CAN J PHYSIOL PHARM, V62, P1253 DEVITO MJ, 1993, FUND APPL TOXICOL, V20, P125 GHADIALLY FN, 1988, ULTRASTRUCT PATHOL, V2, P767 GILLETTE DM, 1987, FUND APPL TOXICOL, V8, P4 GILROY C, 1998, TOXICOLOGY, V127, P179 HANSELL MM, 1974, TOXICOL APPL PHARM, V28, P418 HARRIS C, 1984, ARCH ENVIRON CON TOX, V13, P715 HONG CS, 1992, ECOTOX ENVIRON SAFE, V23, P118 KANNAN N, 1989, ARCH ENVIRON CON TOX, V18, P850 KASZA L, 1978, J ENVIRON PATHOL TOX, V1, P241 KIMBROUGH RD, 1972, ARCH ENVIRON HEALTH, V25, P354 LEECE B, 1985, J TOXICOL ENV HEALTH, V16, P379 LIN FS, 1979, ARCH ENV CONTAM TOXI, V88, P321 MACLELLAN K, 1994, HISTOL HISTOPATHOL, V9, P453 MACLELLAN K, 1994, HISTOL HISTOPATHOL, V9, P461 MACLELLAN K, 1994, J SUBMICR CYTOL PATH, V26, P279 MARTUCCI CP, 1993, PHARMACOL THERAPEUT, V57, P237 OKEY AB, 1990, PHARMACOL THERAPEUT, V45, P241 PARKINSON A, 1980, CHEM-BIOL INTERACT, V30, P217 PATTERSON DG, 1994, ENVIRON HEALTH PERSP, V102, P195 PENG J, 1997, TOXICOLOGY, V120, P171 POLAND A, 1977, MOL PHARMACOL, V13, P924 SAFE S, 1990, CRIT REV TOXICOL, V21, P51 SAFE SH, 1994, CRIT REV TOXICOL, V24, P87 SATO T, 1968, J ELECTRON MICROSC, V17, P158 SCHECTER A, 1984, BANBURY REPORT, V18, P177 SHAPIRO BH, 1995, INT J BIOCHEM CELL B, V27, P9 SINGH A, 1981, PATHOLOGY, V13, P487 SINGH A, 1996, ULTRASTRUCT PATHOL, V20, P275 SINGH A, 1997, ULTRASTRUCT PATHOL, V21, P143 SMITH LM, 1990, CHEMOSPHERE, V21, P1063 TANABE S, 1987, ENVIRON POLLUT, V47, P147 TEHSEEN WM, 1992, B ENVIRON CONTAM TOX, V48, P101 VANBIRGELEN APJM, 1994, TOXICOL APPL PHARM, V127, P209 VOS JG, 1972, TOXICOL APPL PHARM, V23, P563 WASSERMANN D, 1979, TOXICOL EUR RES, V1, P159 WEIBEL ER, 1969, J CELL BIOL, V42, P68 WEISS L, 1988, CELL TISSUE BIOL TXB, P1; NR: 41; TC: 4; J9: TOXICOLOGY; PG: 9; GA: 240XASource type: Electronic(1
Comments on the paper "COINCIDENCE THEOREMS FOR SOME MULTIVALUED MAPPINGS" by B. E. RHOADES, S. L. SINGH AND CHITRA KULSHRESTHA
No full textThe aim of this note is to point out an error in the proof of Theorem 1 in the paper entitled “Coincidence theorems for some multivalued mappings” by B. E. Rhoades, S. L. Singh and Chitra Kulshrestha [Internat. J. Math. & Math. Sci., 7 (1984), 429-434], and to indicate a way to repair it
PCB congener 77-induced ultrastructural alterations in the rat liver: a quantitative study
No full textLiver alterations were estimated morphometrically in male and female Sprague-Dawley rats that were fed PCB congener 77 (3,3',4,4'-tetrachlorobiphenyl) in concentrations of 0.01, 0.1, 1, 10 ppm or corn oil in diets for 13 weeks. A dose-dependent increase in the volume of smooth endoplasmic reticulum (SER) and an elevation in the volume of mitochondria following administration of the highest congener concentration (10 ppm) were estimated in the female rats. Hepatocytes of the male rats contained a significantly greater baseline volume of both SER and mitochondria compared to that in the females. A statistically significant (P < 0.05) change in the volumes of either SER or mitochondria in the PCB-fed males was not revealed. The authors concluded that the increase in mitochondrial volume was probably a necessary cellular adaptation to meet the heightened energy demands required by the SER to detoxify the PCB. The use of morphometric rather than a descriptive methodology allowed for a better determination of the hepatic alterations induced by PCB 77. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.PT: J; CR: AHLBORG UG, 1994, CHEMOSPHERE, V28, P1049 CHU I, 1995, FUND APPL TOXICOL, V26, P282 CLARKE DW, 1984, CAN J PHYSIOL PHARM, V62, P1253 DEVITO MJ, 1993, FUND APPL TOXICOL, V20, P125 DURHAM SK, 1989, TOXICOL PATHOL, V17, P782 GHADIALLY FN, 1988, ULTRASTRUCT PATHOL, V2, P767 GILLETTE DM, 1987, FUND APPL TOXICOL, V8, P5 GUNDERSEN HJG, 1985, J MICROSC-OXFORD, V138, P127 HANSELL MM, 1974, TOXICOL APPL PHARM, V28, P418 HARRIS C, 1984, ARCH ENVIRON CON TOX, V13, P715 HUFF J, 1994, ANNU REV PHARMACOL, V34, P343 KASZA L, 1978, J ENVIRON PATHOL TOX, V1, P241 KIMBROUGH RD, 1972, ARCH ENVIRON HEALTH, V25, P354 LIN FS, 1979, ARCH ENV CONTAM TOXI, V88, P321 MACLELLAN K, 1994, HISTOL HISTOPATHOL, V9, P453 MACLELLAN K, 1994, HISTOL HISTOPATHOL, V9, P461 MACLELLAN K, 1994, J SUBMICR CYTOL PATH, V26, P279 OKEY AB, 1990, PHARMACOL THERAPEUT, V45, P241 PARKINSON A, 1980, CHEM-BIOL INTERACT, V30, P217 PATTERSON DG, 1994, ENVIRON HEALTH PERSP, V102, P195 PENG J, 1997, TOXICOLOGY, V120, P171 SAFE SH, 1994, CRIT REV TOXICOL, V24, P87 SATO T, 1968, J ELECTRON MICROSC, V17, P158 SCHECTER A, 1984, BANBURY REPORT, V18, P177 SINGH A, 1981, PATHOLOGY, V13, P487 SINGH A, 1996, ULTRASTRUCT PATHOL, V20, P275 SINGH A, 1997, ULTRASTRUCT PATHOL, V21, P143 VOS JG, 1972, TOXICOL APPL PHARM, V23, P563 WASSERMANN D, 1979, TOXICOL EUR RES, V1, P159 WEIBEL ER, 1969, J CELL BIOL, V42, P68 WEISS L, 1988, CELL TISSUE BIOL TXB, P1; NR: 31; TC: 5; J9: TOXICOLOGY; PG: 7; GA: 104FDSource type: Electronic(1
Liver ultrastructure in pigs fed various oils
No full textPT: J; CR: ABDELLATIF AMM, 1970, STE ADELE QUEBE 0920, P423 ACKMAN RG, 1977, FETT SEIFEN ANSTR, V79, P15 ASTORG PO, 1977, ANN NUTR ALIMENT, V31, P43 BEAREROGERS JL, 1977, PROG CHEM FATS OTHER, V15, P29 BLOMSTRAND R, 1974, LIPIDS, V9, P771 CHRISTIANSEN RZ, 1979, BIOCHIM BIOPHYS ACTA, V573, P417 CHRISTOPHERSEN BO, 1972, BIOCHIM BIOPHYS ACTA, V280, P506 FLAKS B, 1971, J ANAT, V108, P563 GHADIALLY FN, 1975, ULTRASTRUCTURAL PATH, P160 HEIJENSKJOLD L, 1975, ACTA MED SCAND S, V585, P75 HOUTSMULLER UMT, 1970, BIOCHIM BIOPHYS ACTA, V218, P564 HSU CML, 1977, LIPIDS, V12, P486 JONES AL, 1966, J HISTOCHEM CYTOCHEM, V14, P215 KRAMER JKG, 1978, CAN J ANIM SCI, V58, P257 LAZAROW PB, 1976, P NATL ACAD SCI USA, V73, P2043 MICHALEK H, 1975, NUTR METAB, V18, P272 QUAN PC, 1974, COMPTES RENDUS HEB D, V279, P579 REMMER H, 1963, SCIENCE, V142, P1657 ROCQUELIN G, 1977, MED NUTR, V13, P269 SINGH A, 1976, P CANADIAN FEDERATIO, V19, P15 SINGH A, 1977, CAN VET J, V18, P140 SINGH A, 1977, P CANADIAN FEDERATIO, V20, P6 TREMOLIERES J, 1972, CAH NUTR DIET, V7, P155 VODOVAR N, 1973, J MICROSCOPIE PARIS, V17, A109; NR: 24; TC: 2; J9: RES VET SCI; PG: 6; GA: LS822Source type: Electronic(1
Bovine ocular squamous-cell carcinoma: ultrastructural characteristics invitro
No full textPT: J; CR: DMOCHOWSKI L, 1958, AM J PATH, V34, P602 DMOCHOWSKI L, 1967, P AM ASS CANCER RES, V8, P14 FORD JN, 1982, RES VET SCI, V32, P257 FROST JK, 1969, MONOGRAPHS CLIN CYTO, V2, P2 GHADIALLY FN, 1982, ULTRASTRUCTURAL PATH, P810 HOD I, 1973, REFUAH VET, V30, P41 HOFFMANN D, 1981, AUST VET J, V57, P159 JUN MH, 1981, KOREAN J VET PUBL HL, V5, P31 KLEINSCHUSTER SJ, 1979, VET SCI COMMUN, V3, P65 NIEBURGS HE, 1967, DIAGNOSTIC CELL PATH, P47 RUSSELL WO, 1956, CANCER, V9, P1 SINGH A, 1981, PATHOLOGY, V13, P487 SPRADBROW PB, 1980, VET B, V50, P449 SYKES JA, 1961, J NATL CANCER I, V26, P445; NR: 14; TC: 0; J9: VET RES COMMUN; PG: 9; GA: QU348Source type: Electronic(1
Topical chemotherapy for ocular surface squamous neoplasia: current status.
No full textBr J Ophthalmol. 2010 May;94(5):532-5. Epub 2009 Sep 23.
Topical chemotherapy for ocular surface squamous neoplasia: current status.
Sepulveda R, Pe'er J, Midena E, Seregard S, Dua HS, Singh AD.
SourceDepartment of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Abstract
Although there are no randomised trials directly comparing topical chemotherapeutic agents mitomycin-C, 5-fluorouracil, and interferon-alpha2b, published studies indicate equal efficacy of these agents for treatment of non-invasive ocular surface squamous neoplasia (80%-88%). 5-Fluorouracil may be preferred, given low incidence of serious side effects and low cost to the patient.
PMID: 19776089 [PubMed - indexed for MEDLINE
The Folio: F. C. C. Magazine
No full textEditorial. pp. 1-2; Chawla, S. B. Prabh Singh-Valedictory Address. pp. 3-5; Manohar Ray-Essay-Some Aspects of Applied Mathematics. pp. 5-9; Yvonne-Essay-The Highway. pp. 9-10; Amar Nath Bindal-Story-A Short Story. pp. 10-12; Article-Shadows. pp. 12-13; Yvonne-Poetry-If Life were Endless Pleasures. pp. 13; Co-Ed's Corner. pp. 13-14; Salim J. Din-Jokes-Laugh and Grow Fit. pp. 14; Satyindra Singh-Sports. pp. 15-17; Satyindra Singh-News and Notes. pp. 17-20; Malhotra, I. C.-Senior Speakers' Union. pp. 20-21; The Late Mr. M. K. Tandon. pp. 21-22; News from the Outposts. pp. 22-25; Chacko, C. J.-Essay-The Juristic Conception of State Sovereignty. pp. 25-34; The Alumni Corner. pp. 34-37; [Hindi]. 13 p.; The Folio [Urdu]. 7 p.The Forman College Players. after page 12; F.C.C. Football Team: Punjab University Champions, 1937-38 and F.C.C. Athletics Team: Punjab University Champions, 1937-38. after page 14; The Board of Editors, 1937-38. after page 1
PCB 118 induces ultrastructural alterations in the rat liver
No full textPolychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants that bioaccumulate in the food chain and thus pose a health risk to humans and other animals. In this study, PCB 118 was added to the diets of Sprague Dawley rats for 13 weeks in concentrations of 2, 20, 200, 2000 p.p.b. to the females and 10, 100, 1000 and 10 000 p.p.b, to the males. The chemical was dissolved in corn oil; animals that served as the control received corn oil in the diets devoid of PCB. Use of transmission electron microscopy and stereology revealed significant (P < 0.05) elevation in the mean volume fraction of smooth reticulum profiles (20 p.p.b.), peroxisomes (200, 2600 p.p.b.) and lipid droplets (2000 p.p.b.) in the females. Hepatocytes from the males exhibited a significant increase in the mean volume fraction of lipid droplets at 10 000 p.p.b. (P < 0.05). Interactions between large quantity of estrogen and the PCB probably would account for more profound alterations in the liver of female Sprague-Dawley rats than in the males. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.PT: J; CR: BOLL M, 1998, XENOBIOTICA, V28, P479 BURSE VW, 1974, ARCH ENVIRON HEALTH, V29, P301 CASLEYSMITH JR, 1967, J R MICROSC SOC, V87, P463 CHU I, 1995, FUND APPL TOXICOL, V26, P282 CLARKE DW, 1984, CAN J PHYSIOL PHARM, V62, P1253 CONNELL BJ, 1998, J SUBMICR CYTOL PATH, V30, P157 CONNELL BJ, 1999, TOXICOLOGY, V136, P107 CULLEN JM, 1991, HEPATOTOXICOLOGY, P67 DAR E, 1992, ENVIRON RES, V59, P189 ESPEEL M, 1997, MICROSC RES TECHNIQ, V39, P453 GALLANT TL, 1999, P 165 ANN M AM ASS A, V165, A71 GHADIALLY FN, 1988, ULTRASTRUCT PATHOL, V2, P767 GILLETTE DM, 1987, FUND APPL TOXICOL, V8, P4 GILROY C, 1998, TOXICOLOGY, V127, P179 HARRIS C, 1984, ARCH ENVIRON CON TOX, V13, P715 HINTON DE, 1978, VIRCHOWS ARCH B, V27, P279 HUFF J, 1994, ANNU REV PHARMACOL, V34, P343 KEDDERIS GL, 1998, CIIT ACTIVITIES, V18, P1 KIMBROUGH RD, 1995, CRIT REV TOXICOL, V25, P133 LEMARCHAND Y, 1973, J BIOL CHEM, V248, P6862 LODISH L, 1995, MOL CELL BIOL, P170 MACLELLAN K, 1994, HISTOL HISTOPATHOL, V9, P461 MACLELLAN K, 1994, J SUBMICR CYTOL PATH, V26, P279 MARTUCCI CP, 1993, PHARMACOL THERAPEUT, V57, P237 MCFARLAND VA, 1989, ENVIRON HEALTH PERSP, V81, P225 NISHIZUMI M, 1970, ARCH ENVIRON HEALTH, V21, P620 ORCI L, 1973, NATURE, V244, P30 PARKINSON A, 1996, CASARETT DOULLS TOXI, P113 PENG J, 1995, P MICROSC MICROANAL, V1, P994 PENG J, 1997, TOXICOLOGY, V120, P171 RENDER JA, 1982, TOXICOL APPL PHARM, V62, P428 ROSS MH, 1995, HISTOLOGY TEXT ATLAS, P496 SAFA B, 1997, TOXICOL LETT, V90, P163 SAFE S, 1984, CRC CRIT R TOXICOL, V13, P319 SATO T, 1968, J ELECTRON MICROSC, V17, P158 SCHECTER A, 1984, BANBURY REPORT, V18, P177 SINGH A, 1975, EUR J CLIN INVEST, V5, P495 SINGH A, 1981, PATHOLOGY, V13, P487 SINGH A, 1996, ULTRASTRUCT PATHOL, V20, P275 SINGH A, 1997, ULTRASTRUCT PATHOL, V21, P143 SINGH A, 1999, IN PRESS J SUBMICROS UNDERWOOD EE, 1970, QUANTITATIVE STEREOL, P25 WASSERMANN D, 1979, TOXICOL EUR RES, V1, P159 WEIBEL ER, 1969, J CELL BIOL, V42, P68 ZUBAY GL, 1995, PRINCIPLES BIOCH, P412; NR: 45; TC: 2; J9: TOXICOLOGY; PG: 8; GA: 311PESource type: Electronic(1
The Folio: Forman Christian College Magazine
No full textSatyindra Singh-Editorial. pp. 1-2; John B. Weir-The Value of the Individual. pp. 2-7; Trilokinath Anand-My Visits to the Camp. pp. 8-9; Rice, C. H.-Convocation Address. pp. 10-19; Shanti Cameron-The Co-Eds' Corner. pp. 19-20; Benade, J. M.-Farewell Address to the Outgoing Clases. pp. 21-24; Satyindra Singh-Societies. pp. 25; Bhim Sain Chadha-Valedictory Address. pp. 26-28; Om Prakash Sharma-They Part. pp. 28; [Hindi]. 14 p.; Punjabi Kiyari [Punjabi]. 4 p.; Folio [Urdu]. 16 p
Dictyostelium giganteum B. N. Singh, J. Gen. Microbiol.
No full textDictyostelium giganteum B.N. Singh, J. Gen. Microbiol. 1: 11–21 (1947). Cultures examined. HMJAU MR060. Strain 0445 isolated from grass land soil in the forest of Jingyue, Changchun City, Jilin Province, China. Known distribution. U.S.A., England, France, Netherlands, New Zealand, Germany, Japan, and China.Published as part of Liu, Pu & Li, Yu, 2014, Dictyostelids from Jilin Province, China. I, pp. 279-283 in Phytotaxa 183 (4) on page 281, DOI: 10.11646/phytotaxa.183.4.7, http://zenodo.org/record/514953
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