569 research outputs found
Klaus Matthaei with the Equity and Diversity Medal
No full textANU Reporter Photos - Equity & Diversity Medal, Conferring Ceremonies, Excellence in Teaching Awards, General Staff Medal, etc. - Klaus Matthaei, Nelson Mandela, Natalie Buckmaster, Dr. Michael A. Martin, Dr. Paul J. Francis, Christina Dunn, Joshua Dunn, Tony Wynack, Dairi M. Vele, Terry Murphy, Pieta Carroli, Matthew Absalom & other
Tailoring Treatment to the Individual in Type 2 Diabetes Practical Guidance from the Global Partnership for Effective Diabetes Management
No full textGood glycaemic control continues to be the most effective therapeutic manoeuvre to reduce the risk of development and/or progression of microvascular disease, and therefore remains the cornerstone of diabetes management despite recent scepticism about tight glucose control strategies. The impact on macrovascular complications is still a matter of debate, and so glycaemic control strategies should be placed in the context of multifactorial intervention to address all cardiovascular risk factors. Approaches to achieve glycaemic targets should always ensure patient safety, and results from recent landmark outcome studies support the need for appropriate individualisation of glycaemic targets and of the means to achieve these targets, with the ultimate aim to optimise outcomes and minimise adverse events, such as hypoglycaemia and marked weight gain. The primary goal of the Global Partnership for Effective Diabetes Management is the provision of practical guidance to improve patient outcomes and, in this article, we aim to support healthcare professionals in appropriately tailoring type 2 diabetes treatment to the individual. Patient groups requiring special consideration are identified, including newly diagnosed individuals with type 2 diabetes but no complications, individuals with a history of inadequate glycaemic control, those with a history of cardiovascular disease, children and individuals at risk of hypoglycaemia. Practical guidance specific to each group is provided
Isobutyrylcarnitine as a Biomarker of OCT1 Activity and Interspecies Differences in its Membrane Transport
No full textGenome-wide association studies have identified an association between isobutyrylcarnitine (IBC) and organic cation transporter 1 (OCT1) genotypes. Higher IBC blood concentrations in humans with active OCT1 genotypes and experimental studies with mouse OCT1 suggested an OCT1-mediated efflux of IBC. In this study, we wanted to confirm the suggested use of IBC as an endogenous biomarker of OCT1 activity and contribute to a better understanding of the mechanisms behind the association between blood concentrations of carnitine derivatives and OCT1 genotype. Blood and urine IBC concentrations were quantified in healthy volunteers regarding intra- and interindividual variation and correlation with OCT1 genotype and with pharmacokinetics of known OCT1 substrates. Furthermore, IBC formation and transport were studied in cell lines overexpressing OCT1 and its naturally occurring variants. Carriers of high-activity OCT1 genotypes had about 3-fold higher IBC blood concentrations and 2-fold higher amounts of IBC excreted in urine compared to deficient OCT1. This was likely due to OCT1 function, as indicated by the fact that IBC correlated with the pharmacokinetics of known OCT1 substrates, like fenoterol, and blood IBC concentrations declined with a 1 h time delay following peak concentrations of the OCT1 substrate sumatriptan. Thus, IBC is a suitable endogenous biomarker reflecting both, human OCT1 (hOCT1) genotype and activity. While murine OCT1 (mOCT1) was an efflux transporter of IBC, hOCT1 exhibited no IBC efflux activity. Inhibition experiments confirmed this data showing that IBC and other acylcarnitines, like butyrylcarnitine, 2-methylbutyrylcarnitine, and hexanoylcarnitine, showed reduced efflux upon inhibition of mOCT1 but not of hOCT1. IBC and other carnitine derivatives are endogenous biomarkers of hOCT1 genotype and phenotype. However, in contrast to mice, the mechanisms underlying the IBC-OCT1 correlation in humans is apparently not directly the OCT1-mediated efflux of IBC. A plausible explanation could be that hOCT1 mediates cellular concentrations of specific regulators or co-substrates in lipid and energy metabolism, which is supported by our in vitro finding that at baseline intracellular IBC concentration is about 6-fold lower alone by OCT1 overexpression
Individualized glycaemic targets and pharmacotherapy in type 2 diabetes.
No full textThe Global Partnership for Effective Diabetes Management, established to provide practical guidance to improve patient outcomes in diabetes, has developed and modified recommendations to improve glycaemic control in type 2 diabetes. The Global Partnership advocates an individualized therapeutic approach and, as part of the process to customize therapy, has previously identified specific type 2 diabetes patient subgroups that require special consideration. This article builds on earlier publications, expanding the scope of practical guidance to include newly diagnosed individuals with complications and women with diabetes in pregnancy. Good glycaemic control remains the cornerstone of managing type 2 diabetes, and plays a vital role in preventing or delaying the onset and progression of diabetic complications. Individualizing therapeutic goals and treatments to meet glycaemic targets safely and without delay remains paramount, in addition to a wider programme of care to reduce cardiovascular risk factors and improve patient outcomes
Heritability of Caffeine Metabolism: Environmental Effects Masking Genetic Effects on CYP1A2 Activity but Not on NAT2
No full textHeritability of caffeine pharmacokinetics and cytochrome P450 1A2 (CYP1A2) activity is controversial. Here, we analyzed the pharmacokinetics of caffeine, an in vivo probe drug for CYP1A2 and arylamine N-acetyltransferase 2 (NAT2) activity, in monozygotic (MZ) and dizygotic (DZ) twins. In the entire group, common and unique environmental effects explained most variation in caffeine area under the curve (AUC). Apparently, smoking and hormonal contraceptives masked the genetic effects on CYP1A2 activity. However, when excluding smokers and users of hormonal contraceptives, 89% of caffeine AUC variation was due to genetic effects and, even in the entire group, 8% of caffeine AUC variation could be explained by a CYP1A1/1A2 promotor polymorphism (rs2470893). In contrast, nearly all of the variations (99%) of NAT2 activity were explained by genetic effects. This study illustrates two very different situations in pharmacogenetics from an almost exclusively genetic determination of NAT2 activity with no environmental modulation to only moderate genetic effects on CYP1A2 activity with strong environmental modulation
Matthaei Parker Cantuariensis archiepiscopi De antiquitate Britannicae ecclesiae et privilegiis ecclesiae Cantuariensis : cum archiepiscopis ejusdem LXX e XXI exemplarium 1572 excusorum, sibique mutuo sorte plane singulari discrepantium, collatione, integra nunc primum numerisque absoluta omnibus historia /
No full textIncludes index.Engraved portrait of Parker by George Vertue; engraved head- and tail-pieces, pictorial initials.Signatures: pi² *⁴ A⁸ chi²(-chi2) ²A² B-L²,²chi²(-²chi2) M-Q²,²B-Q² R-8L².Mode of access: Internet.Bookplate of Revd. George Williams. Signature of Wm. H. Ink, 1879. Signature of Peter Karney, Cambridge, July 1939. Signature on t.p. of Schaefer Williams, Bay Settlement, Wis., 8 July 1976.Binding: 19th-century marbled paper, quarter goatskin. Author & title on spine in gilt. Edges sprinkled red & tan
IL-5-overexpressing mice exhibit eosinophilia and altered wound healing through mechanisms involving prolonged inflammation
No full textLeucocytes are essential in healing wounds and are predominantly involved in the inflammatory and granulation stages of wound repair. Eosinophils are granulocytic leucocytes and are specifically regulated by interleukin-5 (IL-5), a cytokine produced by T helper 2 (Th2) cells. To characterize more clearly the role of the IL-5 and eosinophils in the wound healing process, IL-5-overexpressing and IL-5-deficient mice were used as models of eosinophilia and eosinophil depletion, respectively. Our results reveal a significantly altered inflammatory response between IL-5-overexpressing and IL-5 knockout mice post-wounding. Healing was significantly delayed in IL-5-overexpressing mice with wounds gaping wider and exhibiting impaired re-epithelialization. A delay in collagen deposition was observed suggesting a direct effect on matrix synthesis. A significant increase in inflammatory cell infiltration, particularly eosinophils and CD4+ cells, one of the main cell types which secrete IL-5, was observed in IL-5-overexpressing mice wounds suggesting that one of the main roles of IL-5 in wound repair may be to promote the infiltration of eosinophils into healing wounds. Healing is delayed in IL-5-overexpressing mice and this corresponds to significantly increased levels of eosinophils and CD4+ cells within the wound site that may contribute to and exacerbate the inflammatory response, resulting in detrimental wound repair.Victoria D Leitch. Xanthe L Strudwick, Klaus I Matthaei, Lindsay A Dent and Allison J Cowin
Mallevs Calvinistarvm, hoc est: diuus Ioannes Chrysostomus, solus sufficienter scriptis suis retundens vniuersos errores, quos Ioannes Caluinus, eiusq[ue] præcessores aut asseclæ de ter venerabili Eucharistiæ sacramento commenti vel secuti sunt /
No full textColofon: Typis Matthaei de RischeBib. Belgica (1964-1970 ed.) ; V 279Cockx-Indestege, E. Belgica typographica ; 7147Machiels, J. Catalogus van de boeken gedrukt vóór 1600 ; V 408Europeana-GoogleBook
Die twaelf boecken van Aeneas, ghenaemt int Latijn AEneidos, /
No full textColofon: Typis Matthaei de RischeHerkomst: Ex libris Jacobi Janssens, Vignet Bibliotheek Snellaert.Herkomst: Joseph de la Cour 1814Bib. Belgica (1964-1970 éd.) G16Cockx-Indestege, E. Belgica typographica ; 4707Machiels, J. Catalogus van de boeken gedrukt vóór 1600 ; V 175Europeana-GoogleBook
Psalterivm Davidicvm paraphrasibus breuibus illustratum, seruata vbique ad verbum Hieronymi translatione. Autore Reynerio Snoy Goudano. Accessit Magni Athanasii opusculum ad Marcellinum in librum Psalmorum Capnione interprete.
No full textHerkomst: Sum Martini Matthaei Hulstensis pastoris S. Gevigerici ; Servaius Willem de Monte Bruxellensis en sum servati Wilhelmi Anderlacenatis 1616. Vignet Biblioth. eccles. cathed. Torn.Cockx-Indestege, E. Belgica typographica ; 9104Machiels, J. Catalogus van de boeken gedrukt vóór 1600 ; B 484Europeana-GoogleBook
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