83 research outputs found
A 35-gene signature discriminates between rapidly- and slowly-progressing glioblastoma multiforme and predicts survival in known subtypes of the cancer
No full textBackground
Gene expression can be employed for the discovery of prognostic gene or multigene signatures cancer. In this study, we assessed the prognostic value of a 35-gene expression signature selected by pathway and machine learning based methods in adjuvant therapy-linked glioblastoma multiforme (GBM) patients from the Cancer Genome Atlas.
Methods
Genes with high expression variance was subjected to pathway enrichment analysis and those having roles in chemoradioresistance pathways were used in expression-based feature selection. A modified Support Vector Machine Recursive Feature Elimination algorithm was employed to select a subset of these genes that discriminated between rapidly-progressing and slowly-progressing patients.
Results
Survival analysis on TCGA samples not used in feature selection and samples from four GBM subclasses, as well as from an entirely independent study, showed that the 35-gene signature discriminated between the survival groups in all cases (p<0.05) and could accurately predict survival irrespective of the subtype. In a multivariate analysis, the signature predicted progression-free and overall survival independently of other factors considered.
Conclusion
We propose that the performance of the signature makes it an attractive candidate for further studies to assess its utility as a clinical prognostic and predictive biomarker in GBM patients. Additionally, the signature genes may also be useful therapeutic targets to improve both progression-free and overall survival in GBM patients
Investigations of the solution properties of both unmodified and modified cyclodextrins
No full textIncludes abstract.Includes bibliographical references.The major part of this focuses on investigating the anomalous solubility of β-cyclodextrin using time correlation functions as the main tool for analysis. The primary focus is on the conformational metrics which govern the internal motions of the three main, unmodified cyclodextrins (namely a, β and y). The conformational space and dynamics of the interglycosidic dihedral angles, individual glucose tilting and verticallibrations of each glucose unit is investigated. Also the hydrogen bonding across the glycosidic linkage is examined. We then investigate the solution properties of cyclodextrin solutions using both ultrasonic interferometry and molecular dynamics
Parameterization of the Gay-Berne coarse-grained potential from atomistically detailed anisotropic free energy volumes
No full textIncludes bibliographical references.Simulating a system of 300,000+ atoms, such as an explicitly solvated protein using all atom molecular dynamics on the microsecond time-scale, would require an enormous amount of computing power and specialized software, even with which would still require months of computing time. However, if the atomic degrees of freedom of the system can be reduced (or averaged) in some physically intuitive manner, while still retaining a connection with the underlying atomistic detail, microsecond simulations could be achieved within weeks or days. Coarse-graining, a sub-class of mesoscale modelling, is used to represent molecules in a reduced form as either regular spheroids (ellipsoids) or as continuum models, using specialized interaction potentials. The Gay-Berne is a one such coarse-grain potential, which has been particularly successful in that it has been used in modelling of liquid crystals, protein dynamics and lipid membrane and micelle formation..
Evolution of HIV-1 subtype C immune responses during acute and chronic HIV infection
No full textThe aim of this study was to compare the magnitude and breadth of HIV-specific T cell responses to HIV Gag and Nef mounted during acute HIV infection with those that emerged during chronic infection and to investigate the association of these responses with subsequent HIV disease progression (CD4 counts and plasma viral loads)
SASOP Biological Psychiatry Congress 2013 Abstracts
No full textList of abstracts and authors:
1. Bipolar disorder not otherwise specified -overdiagnosed or underdiagnosed?
E Allers
2. The prognosis of major depression untreated and treated: Does the data reflect the true picture of the prognosis of this very common disorder?
E Allers
3. Can we prolong our patients' life expectancy? Providing a better quality of life for patients with severe mental illness
O A Betencourt
4. The scope of ECT practice in South Africa
J Benson-Martin, P Milligan
5. Biomarkers for schizophrenia: Can we evolve like cancer therapeutics?
P Buckley
6. Relapse in schizophrenis: Major challenges in prediction and prevention
P Buckley
7. Informed consent in biological treatments: The right to know the duty to inform
I Chetty
8. Effectiveness of a long-acting injectable antipsychotic plus an assertive monitoring programme in first-episode schizophrenia
B Chiliza, L Asmal, O Esan, A Ojagbemi, O Gureje, R Emsley
9. Name, shame, fame
P Cilliers
10. Can we manage the increasing incidence of violent raging children? We have to!
H Clark
11. Serotonin, depression and antidepressant action
P Cowen
12. Prevalence and correlates of comorbid psychiatris illness in patients with heroin use disorder admitted to Stikland Opioid Detoxification Unit
L Dannatt, K J Cloete, M Kidd, L Weich
13. Investigating the association between diabetes mellitus, depression and psychological distress in a cohort of South African teachers
A K Domingo, S Seedat, T M Esterhuizen, C Laurence, J Volmink, L Asmal
14. Neuropeptide S -emerging evidence for a role in anxiety
K Domschke
15. Pathogenetics of anxiety
K Domschke
16. The effects of HIV on the fronto-striatal system
S du Plessis, M Vink, J Joska, E Koutsilieri, C Scheller, B Spottiswoode, D Stein, R Emsley
17. Effects of acute antipsychotic treatment on brain morphology in schizophrenia
R Emsley, L Asmal, B Chiliza, S du Plessis, J Carr, A Goosen, M Kidd, M Vink, R Kahn
18. Development of a genetic database resource for monitoring of breast cancer patients at risk of physical and psychological complications
K Grant, F J Cronje, K Botha, J P Apffelstaedt, M J Kotze
19. Unipolar mania reconsidered: Evidence from a South African study
C Grobler
20. Antipsychotic-induced movement disorders: Occurence and management
P Haddad
21. The place of observational studies in assessing the effectiveness of long-acting injectable antipsychotics
P Haddad
22. Molecular mechanisms of d-cycloserine in fear extinction: Insights from RNS sequencing
S Hemmings, S Malan-Muller, L Fairbairn, M Jalali, E J Oakeley, J Gamieldien, M Kidd, S Seedat
23. Schizophrenia: The role of inflammation
DC Henderson
24. Addictions: Emergent trends and innovations
V Hitzeroth
25. The socio-cultural-religious context of biological psychiatric practice
B Janse van Rensburg
26. Biochemical markers for identifying risk factors for disability progression in multiple sclerosis
S Janse van Rensburg, M J Kotze, F J Cronje, W Davis, K Moremi, M Jalali Sefid Dashti, J Gamieldien, D Geiger, M Rensburg, R van Toorn, M J de Klerk, G M Hon, T Matsha, S Hassan, R T Erasmus
27. Alcohol-induced psychotic disorder: Brain perfusion and psychopathology - before and after antipsychotic treatment
G Jordaan, J M Warwick, D G Nel, R Hewlett, R Emsley
28.'Pump and dump': Harm reduction strategies for breastfeeding while using substances
L Kramer
29. Adolescent neuropsychiatry - an emerging field in South African adolescent psychiatric services
A Lachman
30. Recovery versus remission, or what it means to be healthy for a psychiatric patient?
B Latecki
31. Holistic methods utilised to normalise behaviours in youth diagnosed with neuro-biochemical disorders
P Macqueen
32. Candidate genes and novel polymorphisms for anxiety disorder in a South African cohort
N McGregor, J Dimatelis, S M J Hemmings, C J Kinnear, D Stein, V Russel, C Lochner
33. Higher visual functioning
A Moodley
34. The effects of prenatal methylmercury exposure on trace element and antioxidant levels in rat offspring following 6-hydroxydopamine-induced neuronal insult
Z M Moosa, W M U Daniels, M V Mabandla
35. Paediatric neuropsychiatric movement disorders
L Mubaiwa
36. The South African national female offenders study
M Nagdee, L Artz, C de Clercq, P de Wet, H Erlacher, S Kaliski, C Kotze, L Kowalski, J Naidoo, S Naidoo, J Pretorius, M Roffey, F Sokudela, U Subramaney
37. Neurobiological consequences of child abuse
C Nemeroff
38. What do Stellenbosch Unviversity medical students think about psychiatry - and why should we care?
G Nortje, S Suliman, K Seed, G Lydall, S Seedat
39. Neurological soft skins in Nigerian Africans with first episode schizophrenia: Factor structure and clinical correlates
A Ojagbemi, O Esan, O Gureje, R Emsley
40. Should psychiatric patients know their MTHFR status?
E Peter
41. Clinical and functional outcome of treatment refractory first-episode schizophrenia
L Phahladira, R Emsley, L Asmal, B Chiliza
42. Bioethics by case discussion
W Pienaar
43. Reviewing our social contract pertaining to psychiatric research in children, research in developing countries and distributive justice in pharmacy
W Pienaar
44. The performance of the MMSE in a heterogenous elderly South African population
S Ramlall, J Chipps, A I Bhigjee, B J Pillay
45. Biological basis addiction (alocohol and drug addiction)
S Rataemane
46. Volumetric brain changes in prenatal methamphetamine-exposed children compared with healthy unexposed controls
A Roos, K Donald, G Jones, D J Stein
47. Single voxel proton magnetic resonance spectroscopy of the amygdala in social anxiety disorder in the context of early developmental trauma
D Rosenstein, A Hess, S Seedat, E Meintjies
48. Discussion of HDAC inhibitors, with specific reference to supliride and its use during breastfeeding
J Roux
49. Prevalence and clinical correlates of police contact prior to a first diagnosis of schizophrenia
C Schumann, L Asmal, K Cloete, B Chiliza, R Emsley
50. Are dreams meaningless?
M Solms
51. The conscious id
M Solms
52. Depression and resilience in HIV-infected women with early life stress: Does trauma play a mediating role?
G Spies, S Seedat
53. State of affairs analysis for forensic psychiatry in SA
U Subramaney
54. Escitalopram in the prevention of post-traumatic stress disorder: A pilot randomised controlled trial
S Suliman, S Seedat, J Pingo, T Sutherland, J Zohar, D J Stein
55. Epigenetic consequences of adverse early social experiences in primates
S Suomi
56. Risk, resilience, and gene x environment interactions in primates
S Suomi
57. Biological aspects of anorexia nervosa
C Szabo
58. Agents used and profiles of non-fatal suicidal behaviour in East London
H Uys
59. The contributions of G-protein coupled receptor signalling to opioid dependence
J van Tonder
60. Emerging trend and innovation in PTSD and OCD
J Zohar
61. Making the SASOP treatment guidelines operational
E Allers
Poster Presentations
62. Neuropsychological deficits in social anxiety disorder in the context of early developmental trauma
S Bakelaar, D Rosenstein, S Seedat
63.Social anxiety disorder in patients with or without early childhood trauma: Relationship to behavioral inhibition and activation and quality of life
S Bakelaar, C Bruijnen, A Sambeth, S Seedat
64. Exploring altered affective processing in obssessive compulsive disorder symptom subtypes
E Breet, J Ipser, D Stein, C Lochner
65. To investigate the bias toward recognising the facial expression of disgust in obsessive compulsive disorder as well as the effect of escitalopram
E Breet, J Ipser, D Stein, C Lochner
66. A fatal-case of nevirapine-induced Stevens-Johnson's syndrome in HIV mania
A Bronkhorst, Z Zingela, W M Qwesha, B P Magigaba
67. Association of the COMT G472A (met/met) genotype with lower disability in people diagnosed with multiple sclerosis
W Davis, S J van Rensburg, L Fisher, F J Cronje, D Geiger, M J Kotze
68. Homocycsteine levels are associated with the fat mass and obesity associated gene FTO(intron 1 T>A) polymorphism in MS patients
W Davis, S J Van Rensburg, M J Kotze, L Fisher, M Jalali, F J Cronje, K Moremi, J Gamieldien, D Geiger, M Rensburg, R van Toorn, M J de Klerk, G M Hon, T Matsha, S Hassan, R T Erasmus
69. Analysis of the COMT 472 G>A (rs4680) polymorphism in relation to environmental influences as contributing factors in patients with schizophrenia
D de Klerk, S J van Rensburg, R A Emsley, D Geiger, M Rensburg, R T Erasmus, M J Kotze
70. Dietary folate intake, homocysteine levels and MTHFR mutation detection in South African patients with depression: Test development for clinical application
D Delport, N vand der Merwe, R Schoeman, M J Kotze
71. The use ofexome sequencing for antipsychotic pharmacogenomic applications in South African schizophrenia patients
B Drogmoller, D Niehaus, G Wright, B Chiliza, L Asmal, R Emsley, L Warnich
72. The effects of HIV on the ventral-striatal reward system
S du Plessis, M Vink, J Joska, E Koutsilieri, C Scheller, B Spottiswoode, D Stein, R Emsley
73. Xenomelia relates to asymmetrical insular activity: A case study of fMRI
S du Plessis, M Vink, L Asmal
74. Maternal mental helath: A prospective naturalistic study of the outcome of pregancy in women with major psychiatric disorders in an African country
E du Toit, L Koen, D Niehaus, B Vythilingum, E Jordaan, J Leppanen
75. Prefrontal cortical thinning and subcortical volume decrease in HIV-positive children with encephalopathy
J P Fouche, B Spottiswoode, K Donald, D Stein, J Hoare
76. H-magnetic resonance spectroscopy metabolites in schizophrenia
F Howells, J Hsieh, H Temmingh, D J Stein
77. Hypothesis for the development of persistent methamphetamine-induced psychosis
J Hsieh, D J Stein, F M Howells
78. Culture, religion, spirituality and psychiatric practice: The SASOP Spirituality and Psychiatry Special Interest Group Action Plan for 2012-2014
B Janse van Rensburg
79. Cocaine reduces the efficiency of dopamine uptake in a rodent model of attention-deficit/hyperactivity disorder: An in vivo electrochemical study
L Kellaway, J S Womersley, D J Stein, G A Gerhardt, V A Russell
80. Kleine-Levin syndrome: Case in an adolescent psychiatric unit
A Lachman
81. Increased inflammatory stress specific clinical, lifestyle and therapeutic variables in patients receiving treatment for stress, anxiety or depressive symptoms
H Luckhoff, M Kotze, S Janse van Rensburg, D Geiger
82. Catatonia: An eight-case series report
M Mabenge, Z Zingela, S van Wyk
83. Relationship between anxiety sensitivity and childhood trauma in a random sample of adolescents from secondary schools in Cape Town
L Martin, M Viljoen, S Seedat
84. 'Making ethics real'. An overview of an ethics course presented by Fraser Health Ethics Services, BC, Canada
JJ McCallaghan
85. Clozapine discontinuation rates in a public healthcare setting
M Moolman, W Esterhuysen, R Joubert, J C Lamprecht, M S Lubbe
86. Retrospective review of clozapine monitoring in a publica sector psychiatric hospital and associated clinics
M Moolman, W Esterhuysen, R Joubert, J C Lamprecht, M S Lubbe
87. Association of an iron-related TMPRSS6 genetic variant c.2007 C>7 (rs855791) with functional iron deficiency and its effect on multiple sclerosis risk in the South African population
K Moremi, S J van Rensburg, L R Fisher, W Davis, F J Cronje, M Jalali Sefid Dashti, J Gamieldien, D Geiger, M Rensburg, R van Toorn, M J de Klerk, G M Hon, T Matsha, S Hassan, R T Erasmus, M Kidd, M J Kotze
88. Identifying molecular mechanisms of apormophine-induced addictive behaviours
Z Ndlazi, W Daniels, M Mabandla
89. Effects of lifestyle factors and biochemistry on the major neck blood vessels in patients with mutiple sclerosis
M Nelson, S J van Rensburg, M J Kotze, F Isaacs, S Hassan
90. Nicotine protects against dopamine neurodegenration and improves motor deficits in a Parkinsonian rat model
N Ngema, P Ngema, M Mabandla, W Daniels
91. Cognition: Probing anatomical substrates
H Nowbath
92. Chronic exposure to light reverses the effects of maternal separation on the rat prefrontal cortex
V Russel, J Dimatelis
93. Evaluating a new drug to combat Alzheimer's disease
S Sibiya, W M U Daniels, M V Mabandla
94. Structural brain changes in HIV-infected women with and without childhood trauma
G Spies, F Ahmed, C Fennema-Notestine, S Archibald, S Seedat
95. Nicotine-stimulated release of hippocampal norepinephrine is reduced in an animal model of attention-deficit/ hyperactivity disorder: the spontaneously hypertensive rat
T Sterley
96. Brain-derive neurotrophic factor (BDNF) protein levels in anxiety disorders: Systematic review and meta-regression analysis
S Suliman, S M J Hemmings, S Seedat
97. A 12-month retrospective audit of the demographic and clinical profile of mental healthcare users admitted to a district level hospital in the Western Cape, South Africa
E Thomas, K J Cloete, M Kidd, H Lategan
98. Magnesium recurarization: A comparison between reversal of neuromuscular block with sugammadex v. neostigmine/ glycopyrrolate in an in vivo rat model
M van den Berg, M F M James, L A Kellaway
99. Identification of breast cancer patients at increased risk of 'chemobrain': Case study and review of the literature
N van der Merwe, R Pienaar, S J van Rensburg, J Bezuidenhout, M J Kotze
100. The protective role of HAART and NAZA in HIV Tat protein-induced hippocampal cell death
S Zulu, W M U Daniels, M V Mabandl
RNA-Seq reveals strain-specific immune gene expression by epithelial cells infected with Mycobacterium tuberculosis strains of varying pathogenicity
No full textBiological Psychiatry Congress 2015
No full textList of Abstract Titles and authors:
1. Psychosis: A matter of mental effort?
M Borg, Y Y van der Zee, J H Hsieh, H Temmingh, D J Stein, F M Howells
2.In search of an affordable, effective post-discharge intervention: A randomised control trial assessing the influence of a telephone-based intervention on readmissions for patients with severe mental illness in a developing country
U A Botha, L Koen, M Mazinu, E Jordaan, D J H Niehaus
3. The effect of early abstinence from long-term methamphetamine use on brain metabolism using 1H-magnetic resonance spectro-scopy (1H-MRS)
A Burger, S Brooks, D J Stein, F M Howells
4. The effect of in utero exposure to methamphetamine on brain metabolism in childhood using 1H-magnetic resonance spectroscopy (1H-MRS)
A Burger, A Roos, M Kwiatkowski, D J Stein, K A Donald, F M Howells
5. A prospective study of clinical, biological and functional aspects of outcome in first-episode psychosis: The EONKCS Study
B Chiliza, L Asmal, R Emsley
6. Stimulants as cognitive enhancers - perceptions v. evidence in a very real world
H M Clark
7. Pharmacogenomics in antipsychotic drugs
Ilse du Plessis
8. Serotonin in anxiety disorders and beyond
Ilse du Plessis
9. HIV infection results in ventral-striatal reward system hypo-activation during cue processing
S du Plessis, M Vink, J A Joska, E Koutsilieri, A Bagadia, D J Stein, R Emsley
10. Disease progression in schizophrenia: Is the illness or the treatment to blame?
R Emsley, M J Sian
11. Serotonin transporter variants play a role in anxiety sensitivity in South African adolescents
S M J Hemmings, L I Martin, L van der Merwe, R Benecke, K Domschke, S Seedat
12. Iron deficiency in two children diagnosed with multiple sclerosis: Report on whole exom sequencing
S Janse van Rensburg, R van Toorn, J F Schoeman, A Peeters, L R Fisher, K Moremi, M J Kotze
13. Benzodiazepines: Practical pharmacokinetics
P Joubert
14. What to consider when prescribing psychotropic medications
G Lippi
15. Current prescribing practices for obsessive-compulsive disorder in South Africa: Controversies and consensus
C Lochner, L Taljaard, D J Stein
16. Correlates of emotional and behavioural problems in children with preinatally acquired HIV in Cape Town, South Africa
K-A Louw, N Phillips, JIpser, J Hoare
17. The role of non-coding RNAs in fear extinction
S Malan-Muller, L Fairbairn, W M U Daniels, M J S Dashti, E J Oakleley, M Altorfer, J Harvey, S Seedat, J Gamieldien, S M J Hemmings
18. An analysis of the management og HIV-mental illness comorbidity at the psychiatric unit of the Dr George Mukhari Academic Hospital
M L Maodi, S T Rataemane, T Kyaw
19. The identification of novel genes in anxiety disorders: A gene X environment correlation and interaction study
N W McGregor, J Dimatelis, S M J Hemmings, C J Kinnear, D J Stein, V Russel, C Lochner
20. Collaborations between conventional medicine and traditional healers: Obstacles and possibilities
G Nortje, S Seedat, O Gureje
21. Thought disorder and form perception: Relationships with symptoms and cognitive function in first-episode schizophrenia
M R Olivier, R Emsley
22. Investigating the functional significance of genome-wide variants associated with antipsychotic treatment response
E Ovenden, B Drogemoller, L van der Merwe, R Emsley, L Warnich
23. The moral and bioethical determinants of "futility" in psychiatry
W P Pienaar
24. Single voxel proton magnetic resonance spectroscopy (1H-MRS) and volumetry of the amylgdala in social anxiety disorder in the context of early developmental trauma
D Rosenstein, A T Hess, J Zwart, F Ahmed-Leitao, E Meintjies, S Seedat
25. Schizoaffective disorder in an acute psychiatric unit: Profile of users and agreement with Operational Criteria (OPCRIT)
R R Singh, U Subramaney
26. The right to privacy and confidentiality: The ethics of expert diagnosis in the public media and the Oscar Pistorius trial
C Smith
27. A birth cohort study in South Africa: A psychiatric perspective
D J Stein
28. 'Womb Raiders': Women referred for observation in terms of the Criminal Procedures Act (CPA) charged with fetal abduction and murder
U Subramaney
29. Psycho-pharmacology of sleep wake disorders: An update
R Sykes
30. Refugee post-settlement in South Africa: Role of adjustment challenges and family in mental health outcomes
L Thela, A Tomita, V Maharaj, M Mhlongo, K Jonathan
31. Dstinguishing ADHD symptoms in psychotic disorders: A new insight in the adult ADHD questionnaire
Y van der Zee, M Borg, J H Hsieh, H Temmingh, D J Stein, F M Howells
32. Oscar Pistorius ethical dilemmas in a trial by media: Does this include psychiatric evaluation by media?
M Vorster
33. Genetic investigation of apetite aggression in South African former young offenders: The involvement of serotonin transporter gene
K Xulu, J Somer, M Hinsberger, R Weierstall, T Elbert, S Seedat, S Hemmings
34. Effects of HIV and childhood trauma on brain morphemtry and neurocognitive function
G Spies, F Ahmed-Leitao, C Fennema-Notestine, M Cherner, S Seedat
35. Measuring intentional behaviour normative data of a newly developed motor task battery
S Bakelaar, J Blampain, S Seedat, J van Hoof, Y Delevoye-Turrel
36. Resilience in social anxiety disorder and post-traumatic stress disorder in the context of childhood trauma
M Bship, S Bakelaar, D Rosenstein, S Seedat
37. The ethical dilemma of seclusion practices in psychiatry
G Chiba, U Subramaney
38. Physical activity and neurological soft signs in patients with schizophrenia
O Esan, C Osunbote, I Oladele, S Fakunle, C Ehindero
39. A retrospective study of completed suicides in the Nelson Mandela Bay Metropolitan Area from 2008 to 2013 - preliminary results
C Grobler, J Strumpher, R Jacobs
40. Serotonin transporter variants play a role in anxiety sensitivity in South African adolescents
S M J Hemmings, L I Martin, L van der Merwe, R Benecke, K Domschke, S Seedat
41. Investigation of variants within antipsychotic candidate pharmacogenes associated with treatment outcome
F Higgins, B Drogmoller, G Wright, L van der Merwe, N McGregor, B Chiliza, L Asmal, L Koen, D Niehaus, R Emsley, L Warnich
42. Effects of diet, smoking and alcohol consumption on disability (EDSS) in people diagnosed with multiple sclerosis
S Janse van Rensburg, W Davis, D Geiger, F J Cronje, L Whati, M Kidd, M J Kotze
43. The clinical utility of neuroimaging in an acute adolescnet psychiatric inpatient population
Z Khan, A Lachman, J Harvey
44. Relationships between childhood trauma (CT) and premorbid adjustment (PA) in a highly traumatised sample of patients with first-episode schizophrenia (FES)
S Kilian, J Burns, S Seedat, L Asmal, B Chiliza, S du Plessis, R Olivier, R Emsley
45. Functional and cognitive outcomes using an mTOR inhibitor in an adolescent with TSC
A Lachman, C van der Merwe, P Boyes, P de Vries
46. Perceptions about adolescent body image and eating behaviour
K Laxton, A B R Janse van Rensburg
47. Clinical relevance of FTO rs9939609 as a determinant of cardio-metabolic risk in South African patients with major depressive disorder
H K Luckhoff, M J Kotze
48. Childhood abuse and neglect as predictors of deficits in verbal auditory memory in non-clinical adolescents with low anxiety proneness
L Martin, K Martin, S Seedat
49. The changes of pro-inflammatory cytokines in a prenatally stressed febrile seizure animal model and whether Rhus chirindensis may attenuate these changes
A Mohamed, M V Mabandla, L Qulu
50. Influence of TMPRSS6 A736v and HFE C282y on serum iron parameters and age of onset in patients with multiple sclerosis
K E Moremi, M J Kotze, H K Luckhoff, L R Fisher, M Kidd, R van Toorn, S Janse van Rensburg
51. Polypharmacy in pregnant women with serious mental illness
E Thomas, E du Toit, L Koen, D Niehaus
52. Infant attachment and maternal depression as predictors of neurodevelopmental and behavioural outcomes at follow-up
J Nothling, B Laughton, S Seedat
53. Differences in abuse, neglect and exposure to community violence in adolescents with and without PTSD
J Nothling, S Suliman, L Martin, C Simmons, S Seedat
54. Assessment of oxidative stress markers in children with autistic spectrum disorders in Lagos, Nigeria
Y Oshodi, O Ojewunmi, T A Oshodi, T Ijarogbe, O F Aina, J Okpuzor, O C F E A Lesi
55. Change in diagnosis and management of 'gender identity disorder' in pre-adolescent children
S Pickstone-Taylor
56. Brain network connectivity in women exposed to intimate partner violence
A Roos, J-P Fouche, B Vythilingum, D J Stein
57. Prolonged exposure treatment for PTSD in a Third-World, task-shifting, community-based environment
J Rossouw, E Yadin, I Mbanga, T Jacobs, W Rossouw, D Alexander, S Seedat
58. Contrasting effects of early0life stress on mitochondrial energy-related proteins in striatum and hippocampus of a rat model of attention-deficit/ hyperactivity disorder
V Russell, J Dimatelis, J Womersley, T-L Sterley
59. Attention-deficit hyperactivity disorder in adults: A South African perspective
R Schoeman, M de Klerk, M Kidd
60. Cognitive function in women with HIV infection and early-life stress
G Spies, C Fennema-Notestine, M Cherner, S Seedat
61. Changes in functional connectivity networks in bipolar disorder patients after mindfulness-based cognitic therapy
J A Starke, C F Beckmann, N Horn
62. Post-traumatic stress disorder, overweight and obesity: A systematic review and meta-analysis
S Suliman, L Anthonissen, J Carr, S du Plessis, R Emsley, S M J Hemmings, C Lochner, N McGregor L van den Heuvel, S Seedat
63. The brain and behaviour in a third-trimester equivalent animal model of fetal alcohol spectrum disorders
P C Swart, C B Currin, J J Dimatelis, V A Russell
64. Irritability Assessment Model (IAM) to monitor irritability in child and adolescent psychiatric disorders.
D van der Westhuizen
65. Outcome of parent-adolescent training in chilhood victimisation: Adaptive functioning, psychosocial and physiological variables
D van der Westhuizen
66. The effect of ketamine in the Wistar-Kyoto and Sprague Dawley rat models of depression
P J van Zyl, J J Dimatelis, V A Russell
67. Investigating COMT variants in anxiety sensitivity in South African adolescents
L J Zass, L Martin, S Seedat, S M J Hemming
Hydration-determined orientational preferences in aromatic association from benzene dimer free energy volumes
No full textIn this study of the thermodynamics of benzene association in water, we show that although the potential energy and enthalpy play an important role in the association of benzene dimers, they do not determine the relative orientation of these molecules on close contact in solution. We observe a large variation in the configurations that contribute to the vacuum (i.e., solvent-free) minimum free energy wells of the benzene contact pair. In water, fewer and smaller minimum free energy wells are observed. On examination, we find that fewer close contact configurations of benzene dimers populate these wells and that they are more energetically distinct from each other (compared with the vacuum case). The edge-over-edge configuration is most likely in solution and appears to evolve from the entropically favored side-by-side solvent shared configuration. Therefore, the relative orientation of the benzene molecules (i.e., parallel displaced, T-shaped, etc.) on association is a result of maximizing the contribution of the benzene benzene entropy of association, to the solution free energy
Identification of novel prognostic markers of survival time in high-risk neuroblastoma using gene expression profiles
No full textNeuroblastoma is the most common extracranial solid tumor in childhood. Patients in high-risk group often have poor outcomes with low survival rates despite several treatment options. This study aimed to identify a genetic signature from gene expression profiles that can serve as prognostic indicators of survival time in patients of high-risk neuroblastoma, and that could be potential therapeutic targets. RNA-seq count data was downloaded from UCSC Xena browser and samples grouped into Short Survival (SS) and Long Survival (LS) groups.
Differential gene expression (DGE) analysis, enrichment analyses, regulatory network analysis and machine learning (ML) prediction of survival group were performed. Forty differentially expressed genes (DEGs) were identified including genes involved in molecular function activities essential for tumor proliferation. DEGs used as features for prediction of survival groups included EVX2, NHLH2, PRSS12, POU6F2, HOXD10, MAPK15, RTL1, LGR5, CYP17A1, OR10AB1P, MYH14, LRRTM3, GRIN3A, HS3ST5, CRYAB and NXPH3. An accuracy score of 82% was obtained by the ML classification models. SMIM28 was revealed to possibly have a role in tumor proliferation and aggressiveness. Our results indicate that these DEGs can serve as prognostic indicators of survival in high-risk neuroblastoma patients and will assist clinicians in making better therapeutic and patient management decisions.The work reported herein was made possible through funding by the South African Medical Research Council through its Division of Research Capacity Development under the Mid-Career Scientist Programme from funding received from the South African National Treasury
Semantic interrogation of a multi knowledge domain ontological model of tendinopathy identifies four strong candidate risk genes
No full textTendinopathy is a multifactorial syndrome characterised by tendon pain and thickening, and impaired
performance during activity. Candidate gene association studies have identified genetic factors
that contribute to intrinsic risk of developing tendinopathy upon exposure to extrinsic factors.
Bioinformatics approaches that data-mine existing knowledge for biological relationships may assist
with the identification of candidate genes. The aim of this study was to data-mine functional annotation
of human genes and identify candidate genes by ontology-seeded queries capturing the features of
tendinopathy. Our BioOntological Relationship Graph database (BORG) integrates multiple sources of
genomic and biomedical knowledge into an on-disk semantic network where human genes and their
orthologs in mouse and rat are central concepts mapped to ontology terms. The BORG was used to
screen all human genes for potential links to tendinopathy. Following further prioritisation, four strong
candidate genes (COL11A2, ELN, ITGB3, LOX) were identified. These genes are differentially expressed
in tendinopathy, functionally linked to features of tendinopathy and previously implicated in other
connective tissue diseases. In conclusion, cross-domain semantic integration of multiple sources of
biomedical knowledge, and interrogation of phenotypes and gene functions associated with disease,
may significantly increase the probability of identifying strong and unobvious candidate genes in
genetic association studies
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