3 research outputs found
Evaluation of anti-hyperglycemic activity and side effects of Erythraea centaurium (L.) Pers. in rats
No full textIn folk medicine, several plants, among which the small centaury, are recommended for the treatment of diabetes type 2 in humans. An experimental study to evaluate anti hyperglycemic effect of Erythraea centaurium (L.) Pers. was performed on wistar rats. Normoglycemic rats and rats subjected to oral glucose tolerance test overload “OGTT” were used. Administration to these animals by gavage of 20% aqueous extracts (at a dose of 0.66 ml/100 g body weight) and butanolic extract (at a dose of 0.015 ml/100 g body weight) of E. centaurium allowed to note, after the kinetic study of glucose between t0 and t180 min, a significant reduction in blood glucose levels. The anti hyperglycemic action of butanolic and aqueous extracts was compared to that obtained by the administration of Glibenclamide “Daonil® 5mg (ND)” at a dose of 0.25 mg/100 g weight body as a reference drug. This study showed the anti hyperglycemic property of the small centaury. But in the medium term, the administration of this plant in rats showed adverse effects on the liver and kidney.Keywords: Erythraea centaurium, aqueous extract, butanolic extract, anti-hyperglycemic effect, rats Afr. J. Biotechnol. Vol. 12 No. 5
Effect Of Virgin Fatty Oil Of Pistacia Lentiscus On Experimental Burn Wound&Apos;S Healing In Rabbits
No full textThis study aimed to assess the efficiency of the virgin fatty oil of
Pistacia lentiscus (PLVFO) for burn wounds healing. It was carried out
on 6 adult male New Zealand rabbits. Four burn wounds of deep third
degree were made on the back of each animal. The first was not treated
and served as control (CRL group); the others were covered immediately
after burning procedure by 0.5g of one of the following products:
Vaseline gel (VAS group), Madecassol® cream 1% (MAD group) or 1ml
of PLVFO (PLVFO group). The treatments were repeated once daily until
complete healing. For four days post burns, the percentage of wound
contraction was assessed. Also, the different healing times were noted.
The results showed that both PLVFO and Madecassol® significantly
accelerated wound healing activity compared to wounds dressed with
Vaseline and the untreated wounds. However, the level of wound
contraction was significantly higher and the healing time was faster in
PLVFO group than those of the MAD group, VAS group and CRL group. The
different epithelization periods obtained in days were respectively:
30±3.94 (PLVFO group), 33.5±3.78 (MAD group), 34.66±3.88
(VAS group) and 37.16±3.54 (CRL group). We conclude that Pistacia
lentiscus virgin fatty oil promotes significantly (p< 0.05) wound
contraction and reduces epithelization period in rabbit model
Antileishmanial activity of some plants growing in Algeria: Juglans Regia, Lawsonia inermis and Salvia officinalis.
No full textThe current study was undertaken to evaluate in vitro the antileishmanial activity of three plants growing wild in Algeria : Juglans regia, Lawsonia inermis and Salvia officinalis. The hydroalcoholic extracts of these plantswere tested on the growth of the promastigotes of Leishmania major. The plant extract effects were compared with three controls : CRL1 composed of 1 ml RPMI inoculated with 106 of promastigotes, CRL2 composed of 1 ml RPMI inoculated with 106 of promastigotes and 100 ìl of hydroalcoholic solvent, CRL3 composed of 1 ml RPMI inoculated with 106 of promastigotes and 100 ìl of Glucantim as a reference drug in the management of leishmaniasis. The results showed that both J. regia and L. inermis extracts reduced the promastigotes number significantly (P<0.01). however, S. officinalis showed a total inhibition of the Leishmania major growth.Key words : anti-leishmanial activity ; Leishmania major ; Juglans regia ; Lawsonia inermis ; Salvia officinalis
