375 research outputs found
Importance of Glutamate Dehydrogenase (GDH) in Clostridium difficile Colonization In Vivo
No full textCitation: Girinathan, B. P., Braun, S., Sirigireddy, A. R., Lopez, J. E., & Govind, R. (2016). Importance of Glutamate Dehydrogenase (GDH) in Clostridium difficile Colonization In Vivo. Plos One, 11(7), 18. doi:10.1371/journal.pone.0160107Clostridium difficile is the principal cause of antibiotic-associated diarrhea. Major metabolic requirements for colonization and expansion of C. difficile after microbiota disturbance have not been fully determined. In this study, we show that glutamate utilization is important for C. difficile to establish itself in the animal gut. When the gluD gene, which codes for glutamate dehydrogenase (GDH), was disrupted, the mutant C. difficile was unable to colonize and cause disease in a hamster model. Further, from the complementation experiment it appears that extracellular GDH may be playing a role in promoting C. difficile colonization and disease progression. Quantification of free amino acids in the hamster gut during C. difficile infection showed that glutamate is among preferred amino acids utilized by C. difficile during its expansion. This study provides evidence of the importance of glutamate metabolism for C. difficile pathogenesis
Two-fluid Physical Modeling of Superconducting Resonators in the ARTEMIS Framework
No full textInput files, data files and scripts to replicate results in "Two-fluid Physical Modeling of Superconducting Resonators in the ARTEMIS Framework" (Jambunathan et el.)
Please direct any questions to the corresponding author, Revathi Jambunathan (rjambunathan [at] lbl.gov)
Artemis simulations were run using the development branch of artemis https://github.com/ECP-WarpX/artemis
Some simulations in this paper were performed with different commit hashes of artemis and amrex, however, the input files should still work with the most recent development branch of artemis.
In the attached tar file, the input files, data, and scripts used to analyse simulation results shown in Figures 1, 2, 3, 4, and 6 of the paper are provided. To run the simulations on perlmutter GPUs, the code is compiled with USE_GPU=TRUE and USE_LLG=FALS
Cloud-Assisted Privacy-Preserving Method for Healthcare Using Adaptive Fractional Brain Storm Integrated Whale Optimization Algorithm
No full textRETRACTED: Feasibility Studies on Compressive Strength of Ground Coal Ash Geopolymer Mortar
No full textPAPER RETRACTED May 10, 2016, by the general editor of Periodica Polytechnica, because of plagiarism. Plagiarized paper: V Revathi, R Saravanakumar and J Thaarrini, Effect of Molar Ratio of SiO2/Na2O, Na2SiO3/NaOH Ratio and Curing Mode on the Compressive Strength of Ground Bottom Ash Geopolymer Mortar. International Journal of Earth Science and Engineering, August 2014, pp. 1511-1516
Disruptive Technology: Do Robots Want Your Job?
No full textKeynote talk with Martin Ford, author of Rise of the Robots. Part of the “Deep Humanities,” One-Day Symposium: FrankenSTEM? Technology Ethics in Silicon Valley, organized by Dr. Revathi Krishnaswamy & Dr. Katherine D. Harris, Department of English and Comparative Literature, San Jose State University.
May 1, 2018, 7pm, The Tech Museum of Innovation, San Jose.https://scholarworks.sjsu.edu/frankenstein200_flyers/1003/thumbnail.jp
Urban Asymmetries Ciudad Juarez, Mexico: Designing A Transferium ...... A point of Exchange
No full textThe MSc. graduation project dealt with understanding the implications of Neo liberal policies on the city of Juarez which lies on the US - Mexico border. In 2009 Ciudad Juarez was rated as “the most violent zone in the world outside of declared war zones” due to high crime rates, femisides, homicides, corruption, drug trafficking and multiple other problems. The city is also presently facing massive exodus and the abandoning of large portions of its housing stock due to the increase in violence and a prevailing low intensity war between the state and the drug cartels. The reasons for this asymmetrical development are multiple and point towards a complex mesh of forces that transgress the scope of the built environment. They encompass entangled dimensions of political economy and socio-economic developments, which eventually affect the built environment. With this background a six month intense research was carried out and a counter proposal group strategy was proposed on a prototype site Riberas Del bravo and eventually an Urban & architectural intervention was designed. Thus as part of my graduation project I designed a collective transport system comprising of three design elements the Transferium hub, the bus stops and the routes on the prototype site. The core design idea dealt with developing a time based concept, that allowed hybridization of the programme and hence catered to both peak and anti-peak hour differently. Firstly a strong east west axis was developed to regulate and accentuate the flow of people along the canal & public promenade proposed as part of the group strategy. These east west axis were flanged by three pavilions serving the Transferium and Community center on the two edges and a multipurpose market space at the center. The central multipurpose market space manifested itself further as Hawking zone courtyard, Mobile Market courtyard and Permanent Market. During the peak hour the Transferium expanded into the central multipurpose space and during the anti-peak hour the community market/activities expanded into the multipurpose space. Thus depending on the flow of vehicles the central multipurpose space grew or condensed in size catering to different activities.Urban AsymmetriesDelft School of DesignArchitectur
Bacteriophage mediated toxin gene regulation in Clostridium difficle
No full textEmbargo status: Restricted to TTU community only. To view, login with your eRaider (top right). Others may request the author grant access exception by clicking on the PDF link to the left
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On the structural response of eukaryotic cells
No full texttextThe actin, microtubule and intermediate filament cytoskeletal polymer assemblies, along with their accessory proteins, govern the mechanical or structural
response of an eukaryotic cell to an external stress. Using statistical mechanics
tools, this dissertation investigates the molecular properties, such as mesh size, persistence length and filament length, that determine the structural strength of the in
vivo polymer networks, with an emphasis on the actin network or the cortex of cells.
Our study of actin shows how the wide range of shear moduli from 1 Pa to 1 kPa that
spans the viscous sol-like state to the elastic gel-like state witnessed in eukaryotic
cells can be achieved through transient crosslinking and the spatial distribution of
actin and actin crosslinking proteins alone. Thus, this gel-sol transition is achieved
without the action of any severing or capping proteins that depolymerize the actin
network.
In order to understand how the microscopic quantities controlling the structural properties of these in vivo polymers are related to the deformation of a cell
observed experimentally, a cell model is created by us. It starts with modeling the
actin cortex as a thick shell and increases in complexity to include microtubules
and the nucleus. Our cell model predicts that the structural response of the cell
amplifies changes in molecular properties such as the in vivo actin concentration.
Hence, the sensitivity of the structural response to cytoskeletal changes can be used
to distinguish between different cells such as normal and cancer cells and can serve
as an indicator of disease.Physic
Incorporating current research, wikis, and discussion lists in a mathematics capstone course
No full textThis article shows how current mathematical research and innovative internet technologies such as wikis and email discussion lists can enliven a senior seminar or capstone course. We give example of assignments as well as examples of how new technologies can enhance a course. This paper grew out of the author\u27s experience of teaching a senior seminar for many years at Kean University
Effectiveness of Teacher Training in Using Latest Technologies
No full textIn this chapter, the author would elaborately discuss the workshop, which she conducted for teachers (who represented various Indian states) and trained them in using the hand-held devices for teaching language skills. Further, she would throw light on the responses given by the participants, which reflected the effectiveness of the program. </jats:p
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