298 research outputs found
Solution NMR views of dynamical ordering of biomacromolecules.
No full textTo understand the mechanisms related to the 'dynamical ordering' of macromolecules and biological systems, it is crucial to monitor, in detail, molecular interactions and their dynamics across multiple timescales. Solution nuclear magnetic resonance (NMR) spectroscopy is an ideal tool that can investigate biophysical events at the atomic level, in near-physiological buffer solutions, or even inside cells. Scope of Review In the past several decades, progress in solution NMR has significantly contributed to the elucidation of three-dimensional structures, the understanding of conformational motions, and the underlying thermodynamic and kinetic properties of biomacromolecules. This review discusses recent methodological development of NMR, their applications and some of the remaining challenges. Major Conclusions Although a major drawback of NMR is its difficulty in studying the dynamical ordering of larger biomolecular systems, current technologies have achieved considerable success in the structural analysis of substantially large proteins and biomolecular complexes over 1 MDa and have characterised a wide range of timescales across which biomolecular motion exists. While NMR is well suited to obtain local structure information in detail, it contributes valuable and unique information within hybrid approaches that combine complementary methodologies, including solution scattering and microscopic techniques. General Significance For living systems, the dynamic assembly and disassembly of macromolecular complexes is of utmost importance for cellular homeostasis and, if dysregulated, implied in human disease. It is thus instructive for the advancement of the study of the dynamical ordering to discuss the potential possibilities of solution NMR spectroscopy and its applications. This article is part of a Special Issue entitled "Biophysical Exploration of Dynamical Ordering of Biomolecular Systems" edited by Dr. Koichi Kato
Shinzato_T_Suppl_mat_v04 – Supplemental material for Uric acid distribution volume calculated by kinetic modeling and extracellular volume predicted by bioimpedance method
No full textSupplemental material, Shinzato_T_Suppl_mat_v04 for Uric acid distribution volume calculated by kinetic modeling and extracellular volume predicted by bioimpedance method by Toru Shinzato, Shigeru Nakai, Takahito Ito, Kazuhiko Shibata, Teppei Matsuoka, Shinya Kato, Takeshi Aoki, Ikuto Masakane, Hiroki Hayashi, Naotake Tsuboi, Midori Hasegawa, Daijo Inaguma, Yukio Yuzawa and Susumu Ookawara in The International Journal of Artificial Organs</p
Making it Just in Time: Author-Creator Matsumoto Taiyō
No full textTranslated by Jon Holt and Teppei Fukuda
The first time I can remember encountering Matsumoto Taiyō’s work was probably when he released his short story collection, Blue Spring (Aoi haru - Matsumoto Taiyō tanpenshū [stories published from 1990 to 1993; Shōgakukan, 1993]). All of the stories concern a bunch of young dudes -- full of desires, frustrations, and violent tendencies -- and no chance they can ever get past those things. I thought to myself at that time, “Ah, I bet this stuff means a lot to readers in their teens, but they don’t really do anything for me.” After all, I was a man in my forties, so this stuff wasn’t on my radar as I was busy becoming a grown-up. Keep in mind that Taiyō himself was just in his early twenties. So, it really wasn’t that unnatural for him to write about life like that
Tacrolimus for Remission Induction and Maintenance Therapy in Patients with Ulcerative Colitis: A Retrospective Evaluation Study
No full text博士(医学) 乙第2945号(主論文の要旨、要約、審査結果の要旨、本文)，著者名:Ayumi ITO・ Bunei IIZUKA・Teppei OMORI・Shinichi NAKAMURA・Katsutoshi TOKUSHIGE，タイトル:Tacrolimus for Remission Induction and Maintenance Therapy in Patients with Ulcerative Colitis: A Retrospective Evaluation Study，掲載誌:Gastroenterology Research and Practice(1687-6121)，頁・年: p.5956316(2016)，著作権関連情報: Copyright © 2016 Ayumi Ito et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited., DOI:10.1155/2016/595631
Tacrolimus for Remission Induction and Maintenance Therapy in Patients with Ulcerative Colitis: A Retrospective Evaluation Study
No full text東京女子医科大学博士(医学)博士(医学) 乙第2945号(主論文の要旨、要約、審査結果の要旨、本文)，著者名:Ayumi ITO・ Bunei IIZUKA・Teppei OMORI・Shinichi NAKAMURA・Katsutoshi TOKUSHIGE，タイトル:Tacrolimus for Remission Induction and Maintenance Therapy in Patients with Ulcerative Colitis: A Retrospective Evaluation Study，掲載誌:Gastroenterology Research and Practice(1687-6121)，頁・年: p.5956316(2016)，著作権関連情報: Copyright © 2016 Ayumi Ito et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited., DOI:10.1155/2016/5956316doctoral thesi
The efficacy of medium-to long-term anti-TNF-α antibody-based maintenance therapy in Behçet's disease patients with intestinal lesions
No full text博士(医学) 乙第3099号(主論文の要旨、要約、審査結果の要旨、本文)，著者名:Harutaka KAMBAYASHI, Teppei OMORI, Satomi SAITO, Shun MURASUGI, Hiroyuki KASHIWAGI, Ayumi ITO, Maria YONEZAWA, Shinichi NAKAMURA, Katsutoshi TOKUSHIGE，タイトル:The Efficacy of Medium- to Long-term Anti-TNF-α Antibody-based Maintenance Therapy in Behçet's Disease Patients with Intestinal Lesions，掲載誌:Internal Medicine(0918-2918)，巻・頁・年:59巻19号 p.2343～2351(2020)，著作権関連情報:© 2020 by The Japanese Society of Internal Medicine.，DOI:10.2169/internalmedicine.5000-2
On the Shafarevich conjecture (Algebraic Number Theory and Related Topics 2018)
No full textAlgebraic Number Theory and Related Topics 2018. November 26-30, 2018. edited by Takao Yamazaki and Shuji Yamamoto. The papers presented in this volume of RIMS Kôkyûroku Bessatsu are in final form and refereed.The Shafarevich conjecture, known as a geometric analogue of the Hermite-Minkowski theorem, states the finiteness of certain varieties over a fixed number field admitting good reduction away from a fixed finite set of finite places. In the abelian varieties of a fixed dimension case, this conjecture was proved by Faltings-Zarhin and applied to the Mordell conjecture. Moreover, the author proved a certain generalization of this conjecture in the K3 surfaces case. In the first part of this survey, we will sketch the proof of Faltings-Zarhin and its relation to the Mordell conjecture, and the second part we will present the result of the author
Protein NMR Structure Refinement Based on Bayesian Inference for Dynamical Ordering of Biomacromolecules
No full textThe efficacy of medium-to long-term anti-TNF-α antibody-based maintenance therapy in Behçet's disease patients with intestinal lesions
No full text東京女子医科大学博士(医学)博士(医学) 乙第3099号(主論文の要旨、要約、審査結果の要旨、本文)，著者名:Harutaka KAMBAYASHI, Teppei OMORI, Satomi SAITO, Shun MURASUGI, Hiroyuki KASHIWAGI, Ayumi ITO, Maria YONEZAWA, Shinichi NAKAMURA, Katsutoshi TOKUSHIGE，タイトル:The Efficacy of Medium- to Long-term Anti-TNF-α Antibody-based Maintenance Therapy in Behçet's Disease Patients with Intestinal Lesions，掲載誌:Internal Medicine(0918-2918)，巻・頁・年:59巻19号 p.2343～2351(2020)，著作権関連情報:© 2020 by The Japanese Society of Internal Medicine.，DOI:10.2169/internalmedicine.5000-20doctoral thesi
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