292 research outputs found
Medium response to jets in heavy ion collisions
Get PDFA short overview on recent progress in studies of medium response to jet quenching in heavy ion collisions is presented. We show the typical features of medium response and give comment on their connection to jet observables by introducing the work done by the author and collaborators as an example
Choroidal atrophy in a patient with paraneoplastic retinopathy and anti-TRPM1 antibody
No full textShinji Ueno,1 Yasuki Ito,1 Ruka Maruko,1 Mineo Kondo,2 Hiroko Terasaki1 1Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, 2Department of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Japan Abstract: The purpose of this paper is to report choroidal atrophy in a patient with cancer-associated retinopathy who had autoantibodies against the transient receptor potential cation channel, subfamily M, member 1 (TRPM1). A 69-year-old man visited our clinic in July 2010 with complaints of blurred vision and night blindness in both eyes. The full-field electroretinograms were negative type, indicating ON bipolar cell dysfunction. General physical examination revealed small cell carcinoma of the lung, and Western blot of the patient's serum showed autoantibodies against TRPM1. We diagnosed this patient with cancer-associated retinopathy and retinal ON bipolar dysfunction due to anti-TRPM1 autoantibody. We followed him for more than 2 years from the initial visit and his symptoms have not changed. However, consistent with the choroidal hypopigmentation of the fundus, spectral domain optical coherence tomography showed a decrease in choroidal thickness of about one third over a 2-year follow-up period. We suggest that this case of gradually progressive choroidal atrophy was caused by the autoantibody against TRPM1 directly, because TRPM1 is expressed not only on ON bipolar cells but also on melanocytes. These findings indicate that we should be aware of choroidal thickness in patients with paraneoplastic retinopathy who have retinal ON bipolar dysfunction with the anti-TRPM1 antibody. Keywords: choroidal thickness, melanocyte, TRPM1, cancer-associated retinopathy, paraneoplastic retinopath
The influence of triglycerides on small dense low‐density lipoprotein cholesterol levels is attenuated in low low‐density lipoprotein‐cholesterol range: Implications for the negative results of the PROMINENT trial
No full textAbstract The Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes (PROMINENT) trial failed to show the preventive effects of pemafibrate, a triglyceride (TG)‐lowering drug, on atherosclerotic cardiovascular disease in patients with type 2 diabetes and dyslipidemia. We recently reported that TG‐lowering with pemafibrate did not decrease the calculated small dense (sd) low‐density lipoprotein cholesterol (LDL‐C), and speculated that the effect of TG on sdLDL‐C is attenuated in low LDL‐C levels. This report examined this possibility in 1,508 patients with type 2 diabetes and 670 healthy controls. LDL‐C ranges were classified as ≤69, 70–99, 100–139 and 140≤ mg/dL. The slope of the regression curve between sdLDL‐C and TG was found to flatten as LDL‐C decreased; 0.18, 0.13, 0.10 and 0.04 for controls, and 0.18, 0.13, 0.09 and 0.07 for diabetes patients. Correspondingly, the lower the LDL‐C range, the lower the sdLDL‐C/TG ratio. These results suggest that when LDL‐C is tightly controlled, TG‐lowering has only a weak inhibitory effect on sdLDL‐C
The Effect of Thirst on Cognitive Performance and Mood
No full textCognitive performance and mood are often impaired during dehydration with thirst theorized to be the cause. Therefore, the purpose of the experiment is to investigate the effect of inducing thirst on cognitive performance and mood. Twelve recreationally active men (meanSE age: 29±3.6 years; body mass: 74.7±2.3 kg; height, 179.4±2.0 cm; maximal oxygen consumption [VO2max]: 49.8±1.9 ml·kg−1·min−1) performed 90 mins of cycling at 55% VO2max in an environmentally controlled chamber (ambient temperature, 34.9±0.2C; relative humidity, 30.3±0.3%; wind speed, 3.4 miles h-1) followed by a 12 km cycling time trial. Two experimental conditions were performed with: subjects drank 25 mL of water every 5 minutes (NT) and infused 25 mL of isotonic saline every 5 minutes via intravenous tube (T) to maintain hydration across conditions. Thirst was measured every 5 minutes with the visual analog scales. Additionally, rectal temperature (Trec) and skin temperature (Tsk) were recorded every 5 minutes. The Environmental Symptoms Questionnaire (ESQ), Profile of Mood States (POMS), a modified flanker task, body mass, urine specific gravity (USG), urine color, and urine osmolality were performed and recorded at the beginning (Pre) and the end (Post) of each trial. There was no significance between hydration measures such as body mass loss, USG, urine color, and urine osmolality, (p>.05) demonstrating similar hydration states between thirst intervention. Trec and thirst were significantly higher in T compared to NT after 15 minutes and throughout the 90 minutes of exercise and 12 km time trial (p<.05). Subjects reported suboptimal performance (T: 3.70.2, NT: 3.10.3, p <.05), difficulty concentrating (T: 1.80.2, NT: 1.40.1, p<.05), light headed (“I feel lightheaded” T, 1.10.1, NT, 2.10.2, p<.05), and overall subjective thermal strain (total ESQ, T: 27.331.1, NT: 24.81.0, p<.05) during T trials for the ESQ. There were no significant findings with the flanker task and POMS during T trials. In conclusion, thirst does not affect cognitive performance, however, decreases mood in men. This study suggest strategies to mitigating thirst are important to maintain mood during physical performance.Embargo status: Restricted until 06/2024. To request the author grant access, click on the PDF link
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Prolongation of Antidiuretic Response to Desmopressin Acetate by Iontophoretic Transdermal Delivery in Rats.
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Safe and Efficient Transdermal Delivery of Desmopressin Acetate by Iontophoresis in Rats.
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