11 research outputs found
Baicalein from Scutellaria baicalensis as Natural Therapeutic Agent for Glioblastoma
No full textGlioblastoma multiforme (GBM), also known as grade IV astrocytoma, remains one of the most challenging malignancies in neuro-oncology, characterized by an exceptionally poor prognosis and high recurrence rate. The multifactorial nature of glioblastoma progression—including its resistance to apoptosis, diffuse infiltration, and angiogenesis—makes it one of the most treatment-resistant tumors. Standard treatment protocols involving surgical resection followed by radiotherapy and temozolomide chemotherapy have only marginally improved survival outcomes. There is, therefore, a growing demand for novel therapeutic agents that are multi-targeted, effective across glioblastoma molecular subtypes, and capable of penetrating the blood-brain barrier (BBB).
In this context, baicalein, a naturally occurring flavonoid derived from Scutellaria baicalensis (commonly known as Chinese skullcap), has emerged as a promising candidate. With a rich ethnopharmacological history in traditional Chinese medicine, S. baicalensis has been used for centuries to treat inflammatory diseases, viral infections, and cancers. Modern scientific studies have revealed that baicalein exerts diverse pharmacological effects, including anti-inflammatory, antioxidative, neuroprotective, and anticancer properties. In glioblastoma models, baicalein demonstrates a capacity to suppress tumor proliferation, promote apoptosis, inhibit angiogenesis, and impair invasive behavior of glioma cells. The goal of this comprehensive review is to synthesize the current knowledge surrounding baicalein’s pharmacological actions in the context of glioblastoma. We explore its phytochemical composition, its molecular targets within glioblastoma signaling networks, its pharmacokinetic limitations, and the use of advanced drug delivery systems to enhance its therapeutic efficacy. In addition, we examine recent preclinical data supporting its use, the potential for combination with existing chemotherapeutic agents, and the status of clinical development.
We also address the challenges facing baicalein’s clinical translation, including solubility issues, bioavailability, and the need for regulatory oversight. Comparative analysis with other flavonoids (e.g., wogonin, luteolin, quercetin) is included to place baicalein’s unique properties in context. Ultimately, this review aims to provide a platform for further investigation and development of baicalein as a viable adjunct or primary therapeutic option for glioblastoma patients
Bilevel optimization, deep learning and fractional Laplacian regularization with applications in tomography
No full textThe article of record as published may be located at https://doi.org/10.1088/1361-6420/ab80d7Funded by Naval Postgraduate SchoolIn this work we consider a generalized bilevel optimization framework for solv- ing inverse problems. We introduce fractional Laplacian as a regularizer to improve the reconstruction quality, and compare it with the total variation regularization. We emphasize that the key advantage of using fractional Laplacian as a regularizer is that it leads to a linear operator, as opposed to the total varia- tion regularization which results in a nonlinear degenerate operator. Inspired by residual neural networks, to learn the optimal strength of regularization and the exponent of fractional Laplacian, we develop a dedicated bilevel opti- mization neural network with a variable depth for a general regularized inverse problem. We illustrate how to incorporate various regularizer choices into our proposed network. As an example, we consider tomographic reconstruction as a model problem and show an improvement in reconstruction quality, especially for limited data, via fractional Laplacian regularization. We successfully learn the regularization strength and the fractional exponent via our proposed bilevel optimization neural network. We observe that the fractional Laplacian regular- ization outperforms total variation regularization. This is specially encouraging, and important, in the case of limited and noisy data.The first and third authors are partially supported by NSF grants DMS-1818772, DMS-1913004, the Air Force Office of Scientific Research under Award No.: FA9550-19-1-0036, and the Department of Navy, Naval PostGraduate School under Award No.: N00244-20-1-0005. The third author is also partially supported by a Provost award at George Mason University under the Industrial Immersion Program. The second author is partially supported by DOE Office of Science under Contract No. DE-AC02-06CH11357.The first and third authors are partially supported by NSF grants DMS-1818772, DMS-1913004, the Air Force Office of Scientific Research under Award No.: FA9550-19-1-0036, and the Department of Navy, Naval PostGraduate School under Award No.: N00244-20-1-0005. The third author is also partially supported by a Provost award at George Mason University under the Industrial Immersion Program. The second author is partially supported by DOE Office of Science under Contract No. DE-AC02-06CH11357
High‑fidelity simulation of pathogen propagation, transmission and mitigation in the built environment
No full textAn overview of high-fidelity modeling of pathogen propagation, transmission and mitigation in the built environment is given. In order to derive the required physical and numerical models, the current understanding of pathogen, and in particular virus transmission and mitigation is summarized. The ordinary and partial differential equations that describe the flow, the particles and possibly the UV radiation loads in rooms or HVAC ducts are presented, as well as proper numerical methods to solve them in an expedient way. Thereafter, the motion of pedestrians, as well as proper ways to couple computational fluid dynamics and computational crowd dynamics to enable high-fidelity pathogen transmission and infection simulations is treated. The present review shows that high-fidelity simulations of pathogen propagation, transmission and mitigation in the built environment have reached a high degree of sophistication, offering a quantum leap in accuracy from simpler probabilistic models. This is particularly the case when considering the propagation of pathogens via aerosols in the presence
of moving pedestrians.Journal ArticleOnline ahead of prin
Fractional Deep Neural Network via Constrained Optimization
No full textFunded by Naval Postgraduate SchoolThis paper introduces a novel algorithmic framework for a deep neural network (DNN), which in a mathematically rigorous manner, allows us to incorporate history (or memory) into the network – it ensures all layers are connected to one another. This DNN, called Fractional-DNN, can be viewed as a time-discretization of a fractional in time nonlinear ordinary differential equation (ODE). The learning problem then is a minimization problem subject to that fractional ODE as constraints. We emphasize that an analogy between the existing DNN and ODEs, with standard time derivative, is well-known by now. The focus of our work is the Fractional-DNN. Using the Lagrangian approach, we provide a derivation of the backward propagation and the design equations. We test our network on several datasets for classification problems. Fractional-DNN offers various advantages over the existing DNN. The key benefits are a significant improvement to the vanishing gradient issue due to the memory effect, and better handling of nonsmooth data due to the network’s ability to approximate non-smooth functions.This work is partially supported by Department of Navy, Naval Postgraduate School - N00244-20-1-0005, Air Force Office of Scientific Research (AFOSR) under Award NO: FA9550-19-1-0036, and National Science Foundation grants DMS-1818772 and DMS-1913004. The second author is also partially supported by a Provost award at George Mason University under the Industrial Immersion Program.This work is partially supported by Department of Navy, Naval Postgraduate School - N00244-20-1-0005, Air Force Office of Scientific Research (AFOSR) under Award NO: FA9550-19-1-0036, and National Science Foundation grants DMS-1818772 and DMS-1913004. The second author is also partially supported by a Provost award at George Mason University under the Industrial Immersion Program
Hinders for Eco-friendly Media Selection
No full textThis study shows that, despite organizations claiming to care for the green environment through documented environmental policies, marketing communication such as advertising media selection does not seem to be much guided by green environmental concerns. Problems with consistency and control thus seem to exist between companies’ ideas/decisions (documented environmental policies) and their actions (advertising media selection), causing the need for justification and/or hypocrisy. This study adds to prior research on the non-use of models in practice by showing that the non-use of models also exists among marketing managers when selecting advertising media for marketing communication purposes. It was found that 64 percent of the marketing managers do not make use of media selection models. In the attempt to investigate differences in the factors guiding media selection between marketing managers who use media selection models (users) and those who do not use any model (non-users), it was found that the users take a medium’s eco-friendly characteristics less into consideration than the non-users. The paper discusses that the use of models can be viewed as attempts for making more rational decisions. The findings thus suggest that rational decision-making (users) may hinder eco-friendly media selection while non-rationality (non-users) may develop more powerful organizational ideologies such as acting responsibly towards the green environment. However, this study points out a link between the use of media selection models, previous experience and rules of thumb, i.e. the users tend to make more use of previous experience and rules of thumb than the non-users. Thus, the author argues that a new approach to model use may be needed and that the media selection should not be too much influenced by the marketing managers’ previous experience and rules of thumb. Otherwise, new factors may be overlooked such as consumers’ increasing concern for the green environment in relation to consumer advertising media attitudes. Previous studies have found that current approaches to marketing planning pay too little attention to the impact of technological advances on changes in consumer media habits. Thereby the risk may exist for focusing on mainly conventional media and not selecting “new media”. The present study seems to contradict these previous findings by showing that the selection of “new media” such as media using the Internet was found among the most selected advertising media by both the users and non-users for the two communication objectives studied, i.e. brand-building and to increase sales. Thus, the results indicate that while the marketing managers adapt their media selection to changes in technological media advances they tend to overlook consumers’ increasing concern for the green environment and the environmental aspect of advertising media. The results also show differences among the marketing managers in their selection of advertising media. At the same time as the non-users tend to be more precise with the recycling of paper, they are more inclined to select paper-based media such as catalogues and brochures than the users. The users on the other hand, tend to select more electronic media such as TV, radio and cinema than the non-users. In the attempt to explain the factors guiding media selection and in particular to what extent the environmental aspect of advertising media is considered, green environmental responsibility attitudes (GERA) of the users and non-users are assessed.Media Selection; Advertising; Green Environment; Marketing Managers; Models; Green Environmental Responsibility Attitude (GERA); Rationality; Non-rationality
Projection of rotation of insulin injection sites
No full textThesis (M.S.)--Boston UniversityPLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at [email protected]. Thank you.2999-01-0
Obraz otroka v kreolských pohádkách Patricka Chamoiseaua.
No full textv anglickém jazyce The subject of this diploma thesis is the work of the francophone writer Patrick Chamoiseau. The thesis reflects especially the theme of slavery in short stories and fairy tales of this Martinique author. The diploma thesis puts Patrick Chamoiseau's work in a historical and political context as well as the personal life of the writer. The diploma thesis describes geographic and cultural particularities of the Lesser Antilles and analyzes in more detail the story The Slave Old Man and the Giant Dog and selected fairy tales. Based on this analysis, the thesis describes typical themes and language tools used by Patrick Chamoiseau. The thesis also deals with oral literature and culture of Martinique and the current problems of society are also discussed through a reflection of another work by Patrick Chamoiseuau.v českém jazyce Předmětem diplomové práce je dílo frankofonního spisovatele Patricka Chamoiseaua. Diplomová práce reflektuje zvláště tematiku otroctví v povídkách a pohádkách martinického autora. Diplomová práce zasazuje dílo Patricka Chamoiseaua do historického a politického kontextu a také osobního života spisovatele. Diplomová práce přibližuje geografické a kulturní zvláštnosti oblasti Malých Antil. Diplomová práce dále podrobněji analyzuje povídku Otrok stařec a obří pes a vybrané pohádky. Na základě této analýzy diplomová práce nabízí typická témata a jazykové prostředky užívané Patrickem Chamoiseauem. Diplomová práce se též zabývá orální literaturou a kulturou Martiniku. Diplomová práce také pojednává o současných problémech společnosti skrze reflexi dalšího díla Patricka Chamoiseuaua.Katedra francouzského jazyka a literaturyFaculty of EducationPedagogická fakult
Harmonizing Traditional Ayurvedic Knowledge with Modern Science: A Comprehensive Review
No full textBackground:Ayurveda, an ancient Indian medical system, has provided a holistic approach to health and well-being for thousands of years. It emphasizes the balance of physical, mental, and spiritual aspects through dietary (Pathya) recommendations, daily (Dinacharya) routines, and herbal treatments. Despite its extensive historical usage and increasing modern prominence, Ayurveda often encounters skepticism from contemporary scientists.
Objective:This review aims to examine Ayurveda\u27s historical background, fundamental principles, and therapeutic procedures while comparing them with contemporary scientific knowledge. The analysis explores key Ayurvedic concepts, such as Svasthya (optimal health), Ahara (nutrition), and Agni (metabolic energy), and investigates the genetic basis of Prakriti (individual constitution) and advancements in Rasayana (rejuvenative therapies). It seeks to identify integrative approaches combining Ayurvedic pharmacology with modern biosciences.
Methods:The review critically analyzes foundational Ayurvedic texts, such as the Charaka Samhita, to understand their historical development and principles. It examines Ayurvedic approaches to nutrition, including the classification of foods based on psychological and physiological effects, food intolerances, and the role of Prakriti in determining individual health. Additionally, it incorporates insights from network pharmacology and Dravya Guna Sastra (Ayurvedic pharmacology) to bridge traditional knowledge with modern scientific methodologies.
Findings:Ayurveda offers a holistic framework for health by integrating nutrition, lifestyle, and therapeutic practices. The Ayurvedic approach to nutrition emphasizes individual constitution (Prakriti) and metabolic energy (Agni), advocating personalized dietary recommendations. Emerging research supports the genetic basis of Prakriti, validating its role in personalized medicine. Furthermore, Rasayana therapies target rejuvenation and longevity, aligning with modern therapeutic goals of preventing chronic diseases and promoting well-being. The integration of Ayurvedic pharmacology with network pharmacology offers potential for identifying novel drug targets and developing holistic pharmaceutical interventions.
Conclusion:This review highlights the significance of Ayurveda\u27s holistic principles and its potential to complement modern scientific knowledge. By integrating Ayurvedic wisdom with advanced biosciences, a synergistic approach to healthcare can be developed, offering personalized and effective treatments. Future research should focus on validating Ayurvedic principles through modern scientific frameworks to foster wider acceptance and application
Bullies and victims in a primary classroom: Scaffolding a collaborative community of practice
No full textThis paper is based on a year long research project that examined changes in participation of 31 students in a Year 4/5 classroom, where bullying was occurring. The teacher (first author and researcher) facilitated authentic learning opportunities to make the social practices explicit during weekly class meetings. A socio cultural perspective and an action research process framed this qualitative study. Data sources included school behaviour records, sociograms, semi-structured interviews, teacher observations and students' reflection logs. Rogoff's planes provided the analytical framework to examine how to scaffold a collaborative community of practice. The case studies of two students, Denis and Nathan, provide exemplars of how the teacher scaffolded students' social understandings within small social groups through collaborative leadership opportunities and values education. Results spanning the school year indicated that Nathan, like many of his peers, developed confidence to make new friends and become more assertive. Although Denis took longer to adopt pro-social goals, by the end of the school year, he refrained from bullying Nathan. The significance of this research supports recent findings that a focus on the social dynamics of the classroom can bring about positive change in student behaviour
1
No full textMarshal Arrests Owners
Tkea Tikes Nickels.
waaawtf St**** aw Oanagsl tar Oanstasnssan.
Lorsat WabaiBa at Ofna Up
Tuetday morning warrants war*
aworn oul for the arrest of all alot
machine owners and Policeman Hill
wiih Ibe prosecuting witness Curry
went lb* rounds. Km** ws* lb* brat
orte lo feel tb* heavy band of lb*
law tad bia machine wai carried cat.
Tbea tbe duo marched ap ihe avenne
and read the law to Slade. Slad* re-
tssonatrated when IU* martin.a* were
confiscated but to no aval). Then a
nearby candy atom wot looked over
and a mscbta* gobbled tap there. At
Lorkin'i stood tb* owner could aot
bc foond. Carry and HU stood
sround foe aotn* lime wthing for bim
to put ia aa appearance, (tut he had
•rrniiisgly gone, oil on an extended
visit and could not■be^und. ■ Later
la tht star Marshal ' Run si y want
around to Larfcin'a plate aad atked
for ihc ih>t mncfaines. The clerk,
Jsek Donors«, refused to allow bia
employer'! peoperty to bc carried oat
until be come bach. ~Tbe surabal
then tried lo carry cat ibe machine*
whether or ao, bul tbey were screwed
down to the counter and tb* worthy
limb of the law did not bar* bi*
■crew.driver along.
Then earn* lb* ittdicial procvaae* of
th* owners of tb* B-achmea. Pap***
are** a**** oot charging Curry with
tb* cciavertion of tbe tnacbinea sritb.
ottt due proems of law. Ha la made
defendant in two case* for tbia. An
set. in it to be brought by the toura
against Dos*o*aa for resisting officer
Early tbia afternoon Officer Ramsay
showed up at Larkin"i and after reading an order author bring him te eoa-
fsscoie certom gaaablittg dtrvicaa,
reached over foe tb* tlot tnachiai
"Hold eta," said Joe, "that** no gsta-
bling device That'* juit a money
receptacle. Don't hunli lhat klud-
faced machine by aoch IcMtbtomc ap-
pelatinaa. Fix up your search warrant
and ask for my cash register."
So osacsr Ramsay matt dowa to
Slide's Whea bis cither machine was
rern*d ott be had no diff.tally
getting another end it Stood boldly
ob tb* cctemter bearing tb* placard,
"No gambling derice." Marshal
Ramsay read hit warrant bul Slade
leaned over on bi* machine and re.
fused lo Itt it go. Mirths! Romoay
then want io report hla Inability ao
get tbe aaacbln** lo Recorder Thorn
Attorn** Roger*
caa* tor tha cigar men. Ht contend!
wilb tbem that mcrehandnc It given
in fall value tor e-ery nickel dropped
in tb* alot
"If yon get lour aces, why. I ft**
Ten a prise, that* all All tb* aaas* a
pria* boa.** aaid on* 04 tbe mt-rbinr
On lb* other band it to coal ended
ibat tb* element of ehsnee to arm
preient and lhat brings ihem under
lb* nam* aad description of gambling
. forbidden both by
r. It to ren-
cl tbat ths prosecution
ht being man*.by District Attorney
Mr. William Vargas apent Sunday
far San Jot* visliing Mist Lteato'
Clark -The Palo Allan.
FACULTY COLOMY ST ASTX0.
far Cacaaai by tb* fto-
Quite a nanaber erf tbe taraliy of
Stanford University ar* baying
building lott in Carmcl by tb* Saa
with lb* i nt ratio*, of building tnat-
mer houies there and spending Ibeir
tracatwna in tbat deligbtfal locality
Cem|roctoe Laannitlu wrewt to look
over some of lb* ls*a for Boat* of lb*
iae*uber* laat areea. and h* was ao
taban w.th tbe climate lhal be tortb-
ortth Sought four lot*. Aaatang tbooc
shf lb* faculty srho ban signified iheir
totsmtto*. of removing there daring
tb* imaaiir ar* Dr. Jordan, Professors Btannsan. Pierce. Merino. Plah,
Elntor*. Cannon. Gilbert, and Mrs.
Mr, snd Mr*. Wadc-Mahany leave
next Tuctalay lor an extended trip
through Europe. They w-iil go Irom
beta direct to K*w York City and
trom there wdr sail by way ol tbt
Strait* of Gibraltar to Naples. Alter
an extended* tour through Italy tbey
will cross the Alps and visit Switssr-
tatad. Then ifter ipending a week in
Germany. Peru will bt tb* next place
to attract the tourist*. Crossing over
to Ire-and Ihey arill there be joined
by Mr. Wadr-Mabtny'i son Harry.
wbo will occompaey tbem farms*.
They expect to bc gone aboot lour
A tnarriig* Ibat wat quietly erle-
brated took place st Mayfield Sunday. March ao\ wthn* Mbe Lila E.
Hartley, daughter of Mr. Brad Mrs
Bortley. became th* briac of Ir* A
Statu. Tb* Rtrtley home was th*
aecne of ihe ata»ttabt, the tcrvict of
which wai witnessed only by relative* Thry art both popular young
people and well known ia this community, hstring resided her* for several years After a wedding journey
through Southern California Mr.-end
Mrs. Swam will wake their bean* in
larterestiaig Meeting of Property Owners Held.
Mattta ami D***v*rft* of th* •Vopo***,
" Maraanmiaaa*. ***■*
Ara PoaVitwd Out.
One of tbt moil interesting meet
lags held In Palo Aho for a long
lime took place lo the council room
Ttmsoav evcnreig. Tht wetrrag was
call*d for the purpose of discuttmg
lb* question of th* proposed im.
prorriuent of ih* street! and to aa*
certain the itatua of tha oaittand-
faag contract! on Waverty ttreet The
talk wai spirited aad tatcreating, and
Strongly reminded sn old resident
the mreting* which u*ed*to be held
IB Nonree hall over ten year* ago,
when we used to swim a plank to get
tber*.
Tbe meeting organised by electing
W. F. Hyde chsirraon sod C E. Jt
dan secretary & F. HaJl outlatad
lb* pwrssoa* of th* atccti*«| tnd tfti
aaaatt eaptawailon of lb* hisiory of
ibe effort lo have Wavcrly at
mocadsmiied and ihc securing of
eontraeta from the owner* of a maji
icy of the fronts** by Mr. Hanrahaa
and tb* failar* after abac or Ii
■Maths of wort rag to bare aaytaiag
oon* and lb* new coo4*Uoa of tl.
fair* now coDfrontmi them, he cefcrcd
a resolEiion sikmg the board of town
truatrra not tu l»kc tny action
toward the proa*entlon of work on
Warrriy itrtet until they should b*
reqaettcd to do ao by a petition Irom
lb* Baajrority of the fronUge on th*
street Tb* taaoItKioa ara* aanaatW
•ay Trot Talk. v
It lueaasd to bc tb* aastcral sen-
limcnt of tb* Wtverly itrcei owners
Ibat thry wrri in a prertirtment by
reason of having signed contricli
with Mr. Hanmban for work which
ipeetfied no limit on the tim* they
were to run. and presided ao pen*
a! ty for failure oo the port of Htn-
rshea to do tbe not*. Mr. Caaawaa
t*tggetted lhal tbea* aresp*rty owart
csJI toother meeting end reoaett Mr.
Hanrshtn lo be pretnt and explain
what be proposed to do, and if no
saltofactory concluiion tea* arrived at
to tab* ct«p* to exneel the contracts
Mr. Morris tuted that he did not
reneasent Mr Hanrahaa, hag ia justice to tbat geatlrmsn be wished to
call attention to tb* tact ibat oa*
reason for tbe delay wst th* desire
on the pan of tb* property uwtaaia
to ace tbe gaa pap** laid before the
paving waa put in. The nutter of
laying aU gas, water and icwer pipes
so that tb* itreet wop Id aot bava to
be cat up waa argad by acrcral Bcat-
rwL It waa itsled tbat tbe pretest
a**rers were planned to carry sll tb*
Murage if tbe town arben tb* strccta
were romp.. My built np.
Mr. Malcolm and Mr. Ferguson
djtsciiSBcd Ibe legal and* of lb* matter
and Hit ed tbat the town would tab*
no action bt tb* matter until the legal
rights of Mr. Hanrahaa bad been
awcertaoioed Mr. Malcrdnt listed thu
tbe tonac roooHkma applied to Uni.
Aw. T
\W* arlin
rteni pkw.
vcroily avenue, upon wbieb a venae
there to now a petition
tatcd lo bitumeniae tb* whole length
of lb* itreet.
lb* resolution was t* bled, to be called
op at a later urne
The entertaining part of the
is the discussion of the general
work proposition. Prof. G. II
Marx stated that in lhc put, arben-
evcr the trustee! eonl em plated the
expenditure of xny Urge amount of
money for town improremtnt, they
always called public ataa* ao**tab**>
it which the full plant were prratat-
ed and every phase of ibe tjuc-*n*>n
distuned He aaid thai he
terssied in the sdvsncement of
towa aad never opposed imprav*B»etit
but he taid that. If his money was
to bc spent, ba felt tbat he had a tight
to know what it ws* to be spent for,
know what tke ptont wer* and
bow tb* work wat to bc don* a*tla
laid tbot bc wit considerably ia th*
dark through oo fault of hit own. at
he carefully read lhc town pagers.
He wai opposed to tht idea of the
trustees going iheid without in any
way consulting lha people wbo weald
be "called upon to pay to* Ih* work.
Mr. Morrto gav* an ccthcti«»tie
utk in favor of the proposed ajcyrk
snd ststed thai tbt attt ol lhc banter* bad been dontTaUolj after jftsll
coiultleraiion and publicity and il anyone did not understand it. it waathi*
own fault. Mr. Malcolm revi*|r*d
th* virion, methods ol legal ptoegstd-
mgi in itreet *> :fk tnd txplained.-uhat
lb* coatrorplated work aroald be tton*
uadcr the too., amrnehneni of tbr
Vrooman law, which provide* thst the
lot owner bat the option, for thirty
day*, io pay caih, but may grre a
bond payable in ten equal installments, at. seven per cent iatereat- (or
ibe coat of the work. He taid *hai
Ibis method was by far tb* best that
could bc tbosrn.
Con*sd*rabto or*Boaitioo waa ataa.
feiled by many of the lads** preient.
Mrs C. H. Rosebrook and Mi*. H.
K. Clapp pointed out tbat lha Itat.
laao pu-ported to repreaeat itUa^ino-
ple, but they are elected unfyby the
men, and that the women wbo own**.
a majority of property la lb* town
bad ao voic* in the rootlet at all except to pay lb* taxes. Mra. Haley,
Mr*. Cetera* and Mn Brackmae
i poke again it ibr movement because
many people here could not afford Ibe
expert**.
Dr. Baldwin etrongly favored the
proposed work bul he wa* alao
vor of the mass* meeting Idea became
it would create a Batter undemanding aad thai oar people coald bc d*
pended upon always to tnaport a good
thing. He beHeawd tint I'tlo Alio
will grow to bc aa large sa Berkeley
and will compare favorably vritb tb*
well known towna of Southern California.
Mr. Carry felt positive that lb* value of tbe lot i would b* in*3*ao*d by
ft-tving the itrc-cta j*ut aa ha* been
lb* ca*e cat Univcriny ivenue- H*
ana* that every owner wbo aaid oat
law dollari a foot would add four
dollar* a foot to tb* price of tba lota
aa aeon a* tb* srork to dona.
Mr. Fergnion alatad that he had
yet to leorn of any good to ec*a«
from tbe cndlaaa dtoanaaknt t* ■aaa
ataetiaga oad that tb* board war* too
boay to apead -anch ion* la talk He
aaid that lb* nswalioa bad already
bran diacnued for a year and that
tb* board ot.tradr had Investigated
and approved the kind of tnaeadam-
uing contemplated He Bald ba
would bc willing to have a naaa* meeting every night for the neat tea
werkt if tb* aarbllc would pay bar th*
ball tbr«c-acr*ntha of th* ttoa*.
Mr. Milcheltree aaid that bc anal
gathered tb* idea that lha timt wa*
oot sat ripe for itreet work, bnt
uncr retarnmg from Sseianveaio b*
believed tbat nine out of ten mm hs
I talked to favorabl* to tb* work.
Mid, however, that h« was aot
tb* habit of aaglaiawng bto atti-
twdc ia onVcial ■otter* ao th* paotic.
Tb* aitsaandtraBC* of a*a*iraeivt
aoaaaed to be on the side of street
improvement, but there W** enough
athwart to mike thing! intereittng.
Aa tb* meeting adopted lb* resolution asking tbat a aaaaa meeting be
called by tbe trailer*, tb* whole qucs-
wai left tor farther di*c*-**toa
at that tame aad aa adjo**nnsent waa
Tbe geireroor *f Kaaau ha* tog-
gestcd that tba new aataawartlp Kan-
tai be ehrUiened with a bottl* of oil
imtead of wine. Come to think of
ii. ft would bc rather appropriate to
celebrate tb* occasion by
s beetle of Standard rjrlt
Streets Will Be Ten Up
Next Week for Mains.
Oaa t-totapasy Activa In Pvttrwng Work.
Tan M il sa of np* Pslntsd arad
Raady for th* tsrournl.
Th* work of painting th* pipe*
hich wilt be osed by th* gaa com-
y in their mains in Palo Alto la
fiaithed' and Mr. George Campbell,
tsspstrtntendent of tb* work at this
plsc* to authority for tb* ititcmcnt
that tb* itreeti wtll be lor* Op nexl
weak and tbt pipes laid. Two large
gangs of men will ba put at work
and tb* work pushed aa rapidly a*
possible. About sixty man will bc
Band and tht company expe-ctt to
bar* Ihc mtia* in working order la
thr** weeki. A carload of tool* ar-
nvtd jtiterriay and were unloaded
on Ik* roaapoay'i f rounds. Tbe firtt
work will bc done on Uahrtnaily avenue Tb* general oflic* of the gaa
compsny will be oa University ivenue and If a suitable building cannot bc obtained lha cotnpsny to very
likelr to build.
THE HIGH PRESSURE SYSTEM.
The method of supplying gaa
Pslo Alto is the most Bvodtrn yet
drviswi It b known at the high
pretinrc ajratctn. At we* staled
Ibr Time, the gat trill bc generated
in Redound Ciiy at the plant of tke
United Gaa and Eleciric Company
with a iult.cir.ni quantity per dsy to
rnabls all resident* to ate gas If they
to desire ant Redwood plant to arm
bemg enlarged to pre/van* for thi*
Increased output
Th* gaa will be generated from
crude oil by a method Invented only
* taw yean ago and which diflcri
roniitletiHy from thr old method
coal gas manufacture. The quality
of Ihr g» to superior to lhc old H
having a greater "number of heat
suttti and tbto will roaatt In a
brtgbler light aad betlrr fuel. The
generating apparatui consuls of a
number of iron boilers tianding oa
end. The firat of lb***, called the
generator. It lined inside with a thick
wall ol fire brick to prevent iht burn-
Ing of lb* iron when lhc apparatus la
heated, la ibe circular space
tween tbe walls ftr* brick .ar* placed
loosely for the purpose of giving
heating aurfac*. These buck
railed lo aa mcandctcml heat by
meani of aa oil burner simitar to
those triad on locomoiivri with A*
difference that forced draught la
When the rtqufred bett ii ublaioad
tb* oil to ekut cat aad the gnterntor
to closed up light. Oil to then infected at tooth it point aad em coating
coniict wiih tb* betted brick it
lifted. The gas then passes from
lha generator to s nol her boiler, tbe
-visiter, filled with water where the
nrm-votatlto lubttanrti ar* removed
Irom there it to pat through a
series of tcmbbert and purifieri where
tb* remaining impuritiel ar* removed.
Tb* gat to Anally collected hi tb* gasometer a here it to stored antil used.
For Palo Alto tbe gat will be taken
front lha gasorncter and forced from
Redwood City by meant of a large
cxiraprettor or pomp which fast already been placed and trued. A
three-inch pipe tin* will convey th*
gaa to leeenl hrge tanks suitably
placed ia Palo Alto snd here ttoeed
under pressure Work hi* already
begun on the supply lira* front Red-
wnr.il City and it will b* in readlncea
at the iime time tb* pipe* ar* ready
al tbto and for connection. Tbi* wijl
be within thr** week*.
Tbe itonge laities wOl be connected io the ttreet oittas and th* proa-
Mr* wOl ba redacad at tb* point of
conncetaon by aaeaaa of Urge regulator! wbich bar* been shipped to
Ptlo Aho from PhiUdelpbii. Sufficient prrisure will always be maintained on tbe ttreet mains to insure
good tervice. Uadcr the old method
at the low pressure aytlcm,
mack trouble wa* experienced when
every patron waa as ing gaa. Tbto ia
foaad io bc the caa* ta acan* of th*
large cities now where the plant araa
put in before the discovery of tbe
ie»r graces*. For nntW ihe high
pretinr* lyitcm by meln* of the al-
lemtiing compretiori t ttetdy sap-
ply of gaa to si wty* kept an the tin*
alihrmgh every gat jet in the dry to
trnaatny of
Our windows this whK
show some of our new
children's shoes.
Snappy stylish goods built
on scientific lasts.
Fit as well as wear'
considered. Our prices?
We are never undersold
on this line of footwear.
S^OaJtaT-
174 UNIVERSITY AVENUE
PALO ALTO
.—-.->», —— W.——.w-kW-M-.-.. —WW.-—W—- -.wnt.aaw.aww
There Will Bt No Doibt of'the Result
Whan You Cast Yoar Una. nor Will Thar, bo An* Anxious
WARI toil a BITS tt You Boy Your FUMl* OtftlSl or—
m...w4-t*^»»*C> 1.1-TO HARDWARE <
Vfo bar. some Ten' lianilaono ajtlfl I—inboo rods'Tllrei tort*,
-«iah only four ouoom and oor aaaortSMOt
FLY BOOKS .
BRAIDED LINES
BAIT BOXES
FIBBlliO BASKETS
In tscl rv.r* Ihlnf In ll— flshonnsn's outllt
18 JUST ALL BIGHT. .
Palo Alto Hardware Co, 1
, i
Cor. University Ave. and Bryant SL j
I i
Phone Main 6; Palo Alto
! ' ■ . I
l^a^aaa^a^a^a^^a^a^a^^a.^^
a**—'***
£1)1
BankofPiHoJflto
Commercial
one Saving.
Sat, Dapo.lt
Boat** for Stent
Tran.acl. . C..*r.l B«nl.ln, wwalaaM,
Watch U Increase.
The amy money grow.
when it'* ont a" ' '
■Mi
... * sanaassftn
that.
cotMrntyuaut k semi.annually
Any officer or employe of
. ibit bsnk—our tree booklet.
r,*';'/ too,—will tell j"Otl aitylhifll,
more yon need or sraat ta
it now about tt* sivl oor iw.h-
00*.
TBEBrVMOT PALO ALT
