1,427 research outputs found
International severe asthma registry (ISAR): Protocol for a global registry
No full textBackground: Severe asthma exerts a disproportionately heavy burden on patients and health care. Due to the heterogeneity of the severe asthma population, many patients need to be evaluated to understand the clinical features and outcomes of severe asthma in order to facilitate personalised and targeted care. The International Severe Asthma Registry (ISAR) is a multi-country registry project initiated to aid in this endeavour. Methods: ISAR is a multi-disciplinary initiative benefitting from the combined experience of the ISAR Steering Committee (ISC; comprising 47 clinicians and researchers across 29 countries, who have a special interest and/or experience in severe asthma management or establishment and maintenance of severe asthma registries) in collaboration with scientists and experts in database management and communication. Patients (=18 years old) receiving treatment according to the 2018 definitions of the Global Initiative for Asthma (GINA) Step 5 or uncontrolled on GINA Step 4 treatment will be included. Data will be collected on a core set of 95 variables identified using the Delphi method. Participating registries will agree to provide access to and share standardised anonymous patient-level data with ISAR. ISAR is a registered data source on the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance. ISAR's collaborators include Optimum Patient Care, the Respiratory Effectiveness Group (REG) and AstraZeneca. ISAR is overseen by the ISC, REG, the Anonymised Data Ethics and Protocol Transparency Committee and the ISAR operational committee, ensuring the conduct of ethical, clinically relevant research that brings value to all key stakeholders. Conclusions: ISAR aims to offer a rich source of real-life data for scientific research to understand and improve disease burden, treatment patterns and patient outcomes in severe asthma. Furthermore, the registry will provide an international platform for research collaboration in respiratory medicine, with the overarching aim of improving primary and secondary care of adults with severe asthma globally. © 2020 The Author(s)
Towards a Study of the Ne-22(p,gamma)Na-23 Reaction at LUNA
No full textThe 22Ne(p,γ)23Na reaction is a part of the hydrogen burning NeNa cycle. In second-generation stars hydrogen burning may proceed via this cycle. The rate of the 22Ne(p,γ) 23Na reaction depends on the strength of several resonances in the energy range of the LUNA 400 kV accelerator which have never been observed in direct experiments. A related study is under preparation at LUNA
International severe asthma registry (ISAR): protocol for a global registry
No full textBACKGROUND: Severe asthma exerts a disproportionately heavy burden on patients and health care. Due to the heterogeneity of the severe asthma population, many patients need to be evaluated to understand the clinical features and outcomes of severe asthma in order to facilitate personalised and targeted care. The International Severe Asthma Registry (ISAR) is a multi-country registry project initiated to aid in this endeavour. METHODS: ISAR is a multi-disciplinary initiative benefitting from the combined experience of the ISAR Steering Committee (ISC; comprising 47 clinicians and researchers across 29 countries, who have a special interest and/or experience in severe asthma management or establishment and maintenance of severe asthma registries) in collaboration with scientists and experts in database management and communication. Patients (≥18 years old) receiving treatment according to the 2018 definitions of the Global Initiative for Asthma (GINA) Step 5 or uncontrolled on GINA Step 4 treatment will be included. Data will be collected on a core set of 95 variables identified using the Delphi method. Participating registries will agree to provide access to and share standardised anonymous patient-level data with ISAR. ISAR is a registered data source on the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance. ISAR's collaborators include Optimum Patient Care, the Respiratory Effectiveness Group (REG) and AstraZeneca. ISAR is overseen by the ISC, REG, the Anonymised Data Ethics & Protocol Transparency Committee and the ISAR operational committee, ensuring the conduct of ethical, clinically relevant research that brings value to all key stakeholders. CONCLUSIONS: ISAR aims to offer a rich source of real-life data for scientific research to understand and improve disease burden, treatment patterns and patient outcomes in severe asthma. Furthermore, the registry will provide an international platform for research collaboration in respiratory medicine, with the overarching aim of improving primary and secondary care of adults with severe asthma globally
Belief and Ageing: Spiritual pathways in later life
No full textBased on 40 years' interviewing experience, this book illustrates the variety of religious, spiritual and other beliefs held by older people. It provides models of research procedure, especially in the context of bereavement. Participants include not only British Christians, but also Muslims, Humanists and witnesses of the Soviet persecution of religion. The author argues that both welfare professionals and gerontologists need to pay far more consideration to belief as a constituent of well-being in later life. The book looks to the future and increasing diversity of choice in matters of belief among Britain and Europe's older citizens as a consequence of immigration and globalisation
Tanggung Jawab Hukum Terhadap Pelaksanaan Perjanjian Kerja Musiman di P.G Mojo Sragen
No full textIn a certain time work agreement involving two parties, namely the P.G Mojo Sragen party and the worker, it is called a reciprocal agreement and therefore creates rights and obligations for the parties. If in the implementation of the rights and obligations between P.G Mojo Sragen and workers, one of the parties does not carry out their achievements, it will result in legal liability. The purpose of this study was to determine the process of agreement between P.G Mojo Sragen and workers, the applicable regulations and the rights and obligations of a certain time work agreement between P.G Mojo Sragen and workers, as well as legal responsibility if one of the parties made a mistake from the work agreement. The method used in this study is a normative approach because in this study, which are legal rules, legal principles in legal responsibility between P.G Mojo Sragen and workers. The type of research used by the author in this research is descriptive research to clearly describe the legal responsibility between P.G Mojo Sragen and workers. The results of this study indicate that in the process of implementing a work agreement for a certain time, prior to the occurrence of the agreement, the administrative requirements and legal requirements in accordance with Article 1320 of the Civil Code are: (1) Agreeing (2) Legal Capability (3) A certain matter (4) An lawful cause. At the time the agreement was signed with a certain time agreement P.G Mojo Sragen with workers that had been made by P.G Mojo Sragen based on a standard agreement. After the agreement, a binding legal relationship arises and gives birth to rights and obligations. If in the implementation one of the parties does not fulfill its rights and obligations, then it must be responsible on the basis of default in accordance with Article 1243 of the Civil Code and if one of the parties violates the applicable law, it can be accounted for based on unlawful acts in accordance with Article 1365 of the Civil Code
Measuring Uncertainty
No full textThis article, authored by P.G. Moore for the Royal Statistical Society's website, provides well-defined exercises to assess the probabilities of decision-making and the degree of uncertainty. The author states the focus of the article as: "When analyzing situations which involve decisions to be made as between alternative courses of action under conditions of uncertainty, decision makers and their advisers are often called upon to assess judgmental probability distributions of quantities whose true values are unknown to them. How can this judgment be taught?" Moore provides five different exercises and even external reference for those interested in further study of the topic
Development of the International Severe Asthma Registry (ISAR): A Modified Delphi Study
No full textBackground: The lack of centralized data on severe asthma has resulted in a scarcity of information about the disease and its management. The development of a common data collection tool for the International Severe Asthma Registry (ISAR) will enable standardized data collection, subsequently enabling data interoperability. Objectives: To create a standardized list of variables for the first international registry for severe asthma via expert consensus. Methods: A modified Delphi process was used to reach consensus on a minimum set of variables to capture in ISAR: the core variables. The Delphi panel brought together 27 international experts in the field of severe asthma research. The process consisted of 3 iterative rounds. In each round, all Delphi panel members were issued an electronic ISAR Delphi workbook to complete and return to the ISAR Delphi administrator. Workbooks and result summaries were anonymously distributed by the Delphi administrator to all panel members at subsequent rounds. Finalization of the core variable list was facilitated by 2 face-to-face meetings. Results: Of the initial 747 selected variables, the Delphi panel reached a consensus on 95. The chosen variables will allow severe asthma to be assessed against patient demographics and medical history, patient-reported outcomes, diagnostic information, and clinical characteristics. Physician-reported outcomes such as nonadherence and information about treatment and management strategies will also be recorded. Conclusions: This is the first global attempt to generate an ISAR using a common set of core variables to ensure that data collected across all participating countries are standardized. © 2018 American Academy of Allergy, Asthma & Immunolog
The Eucharist - Source and Summit of the Life and Mission of P.G. Frassati
No full textŻycie i działalność bł. P.G. Frassatiego bez wątpienia wskazuje na dar i tajemnicę Eucharystii. To właśnie sakrament Eucharystii był motorem działania włoskiego studenta, miłośnika górskich wypraw, a nade wszystko człowieka bez reszty oddanego ubogim i chorym – Apostoła Miłosierdzia. Pobożność eucharystyczna staje się źródłem rozumnej służby Bożej. „Jezus przychodzi do mnie w Komunii świętej każdego dnia, a ja Mu się odwdzięczam za to w dostępny mi sposób, odwiedzając Jego biedaków”. Pier Giorgio pokazał nam, że można kochać życie ze wszystkimi treściami, zadaniami i problemami, jakie niesie, a jednocześnie kierować się ku Bogu, który jest naszym odwiecznym celem.The author shows how the life of the blessed P.G. Frassati reveals the gift and mystery of the Eucharist. It was the grace of the Eucharist that gave him the motivation to act. This Italian student and lover of mountain expeditions was totally devoted to the disadvantaged and the sick; he was an apostle of divine mercy. Eucharistic devotion becomes the source of logiké latria. “Every day Jesus comes to me in Holy Communion and I must repay Him in whatever way I can by visiting His poor”. Despite the difficult tasks and problems that life involves, Pier Giorgio proved that it is possible to love it, keeping always in mind the long-term aim of drawing closer to God
The Eucharist - Source and Summit of the Life and Mission of P.G. Frassati
No full textŻycie i działalność bł. P.G. Frassatiego bez wątpienia wskazuje na dar i tajemnicę Eucharystii. To właśnie sakrament Eucharystii był motorem działania włoskiego studenta, miłośnika górskich wypraw, a nade wszystko człowieka bez reszty oddanego ubogim i chorym – Apostoła Miłosierdzia. Pobożność eucharystyczna staje się źródłem rozumnej służby Bożej. „Jezus przychodzi do mnie w Komunii świętej każdego dnia, a ja Mu się odwdzięczam za to w dostępny mi sposób, odwiedzając Jego biedaków”. Pier Giorgio pokazał nam, że można kochać życie ze wszystkimi treściami, zadaniami i problemami, jakie niesie, a jednocześnie kierować się ku Bogu, który jest naszym odwiecznym celem.The author shows how the life of the blessed P.G. Frassati reveals the gift and mystery of the Eucharist. It was the grace of the Eucharist that gave him the motivation to act. This Italian student and lover of mountain expeditions was totally devoted to the disadvantaged and the sick; he was an apostle of divine mercy. Eucharistic devotion becomes the source of logiké latria. “Every day Jesus comes to me in Holy Communion and I must repay Him in whatever way I can by visiting His poor”. Despite the difficult tasks and problems that life involves, Pier Giorgio proved that it is possible to love it, keeping always in mind the long-term aim of drawing closer to God
Implementation of a new transition prediction method in xfoil: Predicting transition in suction boundary layers
No full textTo reduce drag on wings, aerodynamicists have long been trying to keep the boundary layer on the wings laminar and to postpone transition to a turbulent boundary layer. To achieve this laminar _ow control by means of boundary layer suction can be used. At the Delft University of Technology xfoil has been adapted to design airfoils using boundary layer suction. This version is called xfoilsuc. The use of this design program was restricted because the transition point prediction methods in xfoilsuc could not predict the damping of disturbances in the boundary layer when suction was used. The objective of this study was therefore to implement a reliable transition prediction method into xfoilsuc that could predict transition for boundary layers with and without suction. To achieve this a new database eN method was implemented into xfoilsuc. This new method, dubbed the Improved eN-method, was developed by Van Ingen with some assistance from the present author. It uses the solutions of the Orr-Sommerfeld equation as calculated by Arnal, that describe the stability diagrams for _fteen values of Re_crit . These _fteen values of Re_crit represent boundary layers with shapefactors between 2.216 and 35.944. As characteristic parameter, the boundary layer shapefactor is used to correlate arbitrary boundary layers to a Re_crit value. By scaling and shifting some parameters, the data is stored in splines suitable for interpolation and some extrapolations. It was found that when using the Improved eN-method in xfoil due to the interaction between the boundary layer iterations and the transition prediction, most solutions would not converge. A method using forced transition was developed to remedy this problem. Using this method, convergence of the boundary layer solution is achieved without a_ecting the accuracy. The Improved eN-method was found to be able to accurately predict transition in boundary layers with and without suction. After the implementation of the Improved eN method a study into the quality of xfoils laminar boundary layer calculations revealed that the shapefactor can sometimes be a bit o_, compared to a _nite di_erence method using the pressure distribution as calculated in xfoil. This has an impact on the predicted transition point. Another problem is that for high suction velocities the shapefactor can go below the value of 2, which is considered erroneous. Further research into this is recommended. A case study concerning the DU99 airfoil, originally designed for the standard class ASW-28 sailplane, was done using the Improved eN-method. For this airfoil a suction distribution is designed that results in a 50 to 75 % reduction in drag in the low drag bucket, excluding the suction drag. Also the Clmax value is increased from 1.4 to 1.7. This airfoil is therefore well suited for further testing in a windtunnel.Aerospace Engineerin
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