141 research outputs found
Modified Borggreve–Van Nes-Winkelmann rotationplasty for surgery in developing countries
No full textBACKGROUND: Amputation is still the most common therapy for patients suffering from osteosarcoma in Myanmar, despite the fact that limb salvage surgery e.g. Borggreve–Van Nes-Winkelmann rotationplasty for malignant tumors located within the distal femur or proximal tibia is the current state-of-the-art reconstructive procedure. A safe and reliable operation technique is crucial in order to perform a complex surgical procedure like the rotationplasty in lower-middle income economies with limited infrastructure and resources. The authors present seven cases of patients with osteosarcomas that received a Borggreve–Van Nes-Winkelmann rotationplasty with an evaluation of the procedures focusing on safety and sustainability. METHODS: From 2019 until 2020, seven young patients with osteosarcomas of the distal femur or proximal tibia were treated with Borggreve–Van Nes-Winkelmann rotationplasties in the Orthopaedic Hospital in Mandalay, Myanmar. As modification of the standard procedure the dissection and subsequent clamping of the femoral artery in order to minimize blood loss as well as the formation of an adipocutaneous flap that minimizes swelling and decreases the pressure on the vessels were successfully performed. This modified procedure resembles a safe and simplified surgical technique that is feasible under the circumstances of lower-middle income economies with good outcomes. RESULTS: All patients showed good functional and aesthetic results. One of the seven patients needed secondary wound closure due to wound dehiscence. CONCLUSIONS: A simplified and safe operation technique for the performance of the Van Nes-Borggreve rotationplasty was adapted to the given constraints in lower-middle income economies and proved to be successful. Trial registration All patients approved to participate in the study and have given consent to publication
"The Athens of the Pacfic". Alejandro Cicarelli and the civilized project of the Fine Arts in republican Chile
No full textThe author analyses the ideological and esthetic content of the opening speech to the Acaderny of Santiago, given by the Italian painter Alejandro Cicarelli on 17 March 1849. The speech reveals the profound influence that the German Johan Joachim Winkelmann had on the painter’s artistic ideas, whose writings influenced both the organisation and guidelines of the Academy. Thus, the speech highlights the importance of ideal beauty on l9th Century esthetics, the importance given to environmental conditioning in the development of culture, the enormous influence of the classic Greco-Roman referent, and the importance of other guiding principles of academic artistic life such as rationality, science, freedom, the importance of drawing and Christian values.La autora analiza el contenido ideológico y estético del discurso de inauguración de la Academia de Santiago realizado por el pintor italiano Alejandro Cicarelli el 17 de marzo de 1849. En él se revela la profunda influencia que sobre las ideas artísticas del pintor tenía el alemán Johan Joachim Winkelmann, cuyos textos influyeron en la organización y directrices de la mencionada Academia. Así, el discurso destaca la importancia de lo bello ideal en la estética decimonónica, la importancia dada a los condicionamientos medioambientales en el desarrollo de la cultura, la enorme influencia del referente clásico grecorromano, y la importancia de otros principios rectores de la vida artística académica como la racionalidad, la ciencia, la libertad, la importancia del dibujo y los valores cristianos
Author Correction: Root growth in light of changing magnesium distribution and transport between source and sink tissues in potato (Solanum tuberosum L.)
No full textAn amendment to this paper has been published and can be accessed via a link at the top of the paper
Negative Emotions in German idioms in the thriller „Die Lieferung“ by Andreas Winkelmann
No full textTema diplomske naloge so negativna čustva v frazemih v trilerju „Die Lieferung“ Andreasa Winkelmanna. Cilj naloge je bilo odgovoriti na vprašanji: Katera negativna čustva izražajo frazemi in katere elemente funkcije konceptualizacije je mogoče najti.
V teoretičnem delu naloge so definirani frazemi in frazeologija. Opisani so glavni pojmi in funkcije frazemov. Diplomsko delo definira in razdeli čustva na skupine, poleg tega našteje tudi negativna čustva. Opisano je razmerje med čustvi in frazemi. Na koncu sledijo definicija trilerjev, kratek življenjepis avtorja in osnovne informacije o trilerju „Die Lieferung“.
V empiričnem delu je analiziranih 55 frazemov iz knjige, ki izražajo negativna čustva. Frazemi so izpisani in postavljeni v kontekst. Najpogostejši element je element fiziologije, ki je tesno povezan z motoriko, zato so analizirani frazemi s tema dvema elementoma. Frazemi najpogosteje izražajo strah in čustva, ki so povezana s strahom kot so panika, groza in ogorčenje. Pogosta sta tudi zaskrbljenost in živčnost.The topic of the thesis are negative emotions in idioms in Andreas Winkelmann\u27s thriller „Die Lieferung". The aim was to answer the questions: Which negative emotions are expressed by the idioms used in the thriller and which elements of the conceptualization function can be found.
In the theoretical part of the thesis idioms and phraseology are defined. The main terms and functions of idioms are described. Emotions are defined and divided into groups, and negative emotions are listed. The relationship between emotions and idioms is described. Finally, there is a definition of thrillers, a short biography of the author and basic information about the thriller “Die Lieferung".
In the empirical part 55 idioms from the book that express negative emotions are analysed. The idioms are quoted and placed in context. The most common element is the element of physiology, which is closely related to the element of motoric, so idioms that contain these two elements are analysed. Phrases most commonly express fear and emotions associated with fear such as panic, horror and outrage. Concern and nervousness are also common
Ergebnisse der Clavicula pro humero-Operation nach Resektion von Knochentumoren am proximalen Humerus
No full textIn der vorliegenden Studie wurden mit Hilfe von retrospektiven Daten und Kraftmessungen dreiundzwanzig Patienten nachuntersucht, die mit einer Clavicula pro humero-Operation nach einer Tumorresektion am proximalen Humerus behandelt wurden. Es lag eine Lokalrezidivrate von 0%, eine Fünf-Jahres-Überlebensrate von 88,2% sowie eine Rate der chirurgischen Revisionen von 39% vor. Durch die Verwendung spezieller Titanplatten und einer guten, postoperativen Immobilisation konnte die Komplikationsrate reduziert werden (p = 0,030). Bei der postoperativen Funktionsüberprüfung erreichten die Patienten durchschnittlich 25,9 von maximal 30 Punkten (MSTS-Score). Die Überprüfung der Kraftentwicklung zeigte gute Ergebnisse im Vergleich zum nicht involvierten Arm. Der Bewegungsumfang im Schultergelenk war zufrieden stellend. Verglichen mit anderen Rekonstruktionsmethoden ist die Clavicula pro humero-Operation eine gute Alternative, um Defekte am proximalen Humerus nach Tumorresektionen zu rekonstruieren
Ergebnisse der Clavicula pro humero-Operation nach Resektion von Knochentumoren am proximalen Humerus
No full textIn der vorliegenden Studie wurden mit Hilfe von retrospektiven Daten und Kraftmessungen dreiundzwanzig Patienten nachuntersucht, die mit einer Clavicula pro humero-Operation nach einer Tumorresektion am proximalen Humerus behandelt wurden. Es lag eine Lokalrezidivrate von 0%, eine Fünf-Jahres-Überlebensrate von 88,2% sowie eine Rate der chirurgischen Revisionen von 39% vor. Durch die Verwendung spezieller Titanplatten und einer guten, postoperativen Immobilisation konnte die Komplikationsrate reduziert werden (p = 0,030). Bei der postoperativen Funktionsüberprüfung erreichten die Patienten durchschnittlich 25,9 von maximal 30 Punkten (MSTS-Score). Die Überprüfung der Kraftentwicklung zeigte gute Ergebnisse im Vergleich zum nicht involvierten Arm. Der Bewegungsumfang im Schultergelenk war zufrieden stellend. Verglichen mit anderen Rekonstruktionsmethoden ist die Clavicula pro humero-Operation eine gute Alternative, um Defekte am proximalen Humerus nach Tumorresektionen zu rekonstruieren
In vivo imaging of CT26 mouse tumours by using cmHsp70.1 monoclonal antibody.
No full textThe major stress-inducible heat shock protein 70 (Hsp70) is frequently present on the cell surface of human tumors, but not on normal cells. Herein, the binding characteristics of the cmHsp70.1 mouse monoclonal antibody (mAb) were evaluated in vitro and in a syngeneic tumor mouse model. More than 50% of the CT26 mouse colon carcinoma cells express Hsp70 on their cell surface at 4 degrees C. After a temperature shift to 37 degrees C, the cmHsp70.1-FITC mAb translocates into early endosomes and lysosomes Intraoperative and near-infrared fluorescence (NIRF) imaging revealed an enrichment of Cy5.5-conjugated mAb cmHsp70.1, but not an identically labelled IgG1 isotype-matched control, in i.p. and s.c. located CT26 tumors, as soon as 30min after i.v. injection into the tail vein. Due to the rapid turnover rate of membrane-bound Hsp70, the fluorescence-labelled cmHsp70.1 mAb became endocytosed and accumulated in the tumor, reaching a maximum after 24h and remained detectable at least up to 96h after a single i.v. injection. The tumor-selective internalization of mAb cmHsp70.1 at the physiological temperature of 37 degrees C might enable a targeted uptake of toxins or radionuclides into Hsp70 membrane-positive tumors. The anti-tumoral activity of the cmHsp70.1 mAb is further supported by its capacity to mediate antibody dependent cytotoxicity (ADCC)
Flavon-Effekte auf Proteom und Transkriptom von Kolonozyten <i>in vitro</i> und <i>in vivo</i> sowie dessen Relevanz für Krebs-Prävention und -Therapie
No full textFlavone is a secondary plant compound that has been shown in the present thesis to exert profound effects on the mRNA and protein expression of colonic cells in cultures and in mice treated with a chemical carcinogen for tumor induction. Flavone is able to selectively induce apoptosis in transformed cells but not in normal colonocytes. Its main action appears the induction of apoptosis in tumor cells by forcing them to conduct oxidative metabolism rather than aerobic glycolysis and this leads to increased production of reactive oxygen species and in turn to mitochondria-driven apoptosis. Flavone may therefore be considered as an effective adjuvant in colon cancer therapy.Flavon als sekundärer Pflanzeninhaltsstoff hat, wie in der vorliegenden Arbeit gezeigt, eine profunde Wirkung auf die mRNA- und Protein-Expressionsmuster in Colon-Tumorzellen in der Zellkultur und in vivo in Mausgewebe nach Behandlung der Tiere mit einem Karzinogen zur Tumorzellbildung. Die Wirkungen von Flavon zielen in erster Linie auf den Energiestoffwechsel der Zellen und darüber kann es effektiv durch vermehrte Bildung von reaktiven Sauerstoffspezies die Apoptose in Tumorzellen, nicht aber in normalen Colonocyten, induzieren. Flavon könnte daher als ein potentes Adjuvans zur Behandlung von Dickdarmkarzinomen fungieren
Living conditions and subjective well-being of farmers - An ordered response analysis of regional differences and changes over time
No full textThe liberalisation of trade with building down of tariffs and quotas, and with subsequently lower output prices, has enforced considerable structural changes in the agricultural sector. In Norway, both naturally given factors such as climate and topography, and social conditions such as a tradition for small family farms and strong governmental regulations, contribute in making this process even harder on the individual farmer. So how do the farmers respond? National farm statistics show that the amount of cultivated land stays approximately the same even though the number of farm units and agricultural employment falls annually. This implies that both farm size and productivity have increased. In this paper we utilise sample survey data on living conditions in agricultural households to examine whether we can observe changes in farmers ’experienced utility. Have contentment dropped and are there any obvious regional differences in contentment? The data consists of non-overlapping cross-sections for the years 1995 and 2002 and we make use of a standard ordered probability model in the estimations.
Reliability assessment of an OVH HV power line truss transmission tower subjected to seismic loading
No full text- …
