1,721,026 research outputs found
Developmental expression of the estrogen receptor-related receptor γ in the nervous system during mouse embryogenesis
No full textEstrogen-related receptor gamma and hearing function: evidence of a role in humans and mice.
Get PDFSince estrogen is thought to protect pre-menopausal women from age-related hearing loss, we investigated whether variation in estrogen-signalling genes is linked to hearing status in the 1958 British Birth Cohort. This analysis implicated the estrogen-related receptor gamma (ESRRG) gene in determining adult hearing function and was investigated further in a total of 6134 individuals in 3 independent cohorts: (i) the 1958 British Birth Cohort; (ii) a London ARHL case-control cohort; and (iii) a cohort from isolated populations of Italy and Silk Road countries. Evidence of an association between the minor allele of single nucleotide polymorphism (SNP) rs2818964 and hearing status was found in females, but not in males in 2 of these cohorts: p = 0.0058 (London ARHL) and p = 0.0065 (Carlantino, Italy). Furthermore, assessment of hearing in Esrrg knock-out mice revealed a mild 25-dB hearing loss at 5 weeks of age. At 12 weeks, average hearing thresholds in female mice((-/-)) were 15 dB worse than in males((-/-)). Together these data indicate ESRRG plays a role in maintenance of hearing in both humans and mice
Expression of the 100-kDa neurotensin receptor sortilin during mouse embryonal development
No full textGenetic Labeling of Car4-expressing Cells Reveals Subpopulations of Type III Taste Cells
No full textGpr85, a novel member of the G-protein coupled receptor family, prominently expressed in the developing mouse cerebral cortex
No full textIdentification of shyc, a novel gene expressed in the murine developing and adult nervous system
No full textFunction of the Neuropeptide Head Activator for Early Neural and Neuroendocrine Development
No full text
- …
