108 research outputs found

    Evaluasi dan Profil Disolusi Tablet Microspheres Metformin Hidroklorida-Etil Selulosa

    No full text
    Metformin hidroklorida merupakan antidiabetik yang digunakan sebagai first line terapi diabetes mellitus tipe 2. Permasalahan dalam terapi metformin hidroklorida yakni bioavaibilitas yang rendah (50-60%) , waktu paruh yang singkat (1,5–4,5 jam), dan frekuensi pemberian metformin hidroklorida yang berulang dengan dosis besar dapat meningkatkan resiko efek samping pada gastrointestinal. Perlu adanya pengembangan formulasi guna tercapaianya terapi yang optimum dan kepatuhan pasien dalam penggunaan obat. Fadila (2016), Susilowati (2016) dan Sukmaningrum (2016) telah melakukan optimasi formulasi microspheres dengan polimer etil selulosa menggunakan metode non-aqueous solvent evaporation. Micropheres merupakan salah satu bentuk multiple unit dalam sistem pelepasan obat terkendali. Microspheres berbentuk partikel kecil spheris berukuran diameter 1-1000 μm dengan sifat biocompatible, dapat meningkatkan bioavailabilitas suatu bahan aktif, dan menghasilkan partikel dalam ukuran mikron. Etil selulosa telah banyak diteliti sebagai polimer microspheres, polimer ini bersifat tidak larut dalam air, nonbiodegradable, biocompatible, tidak beracun. Pada umumnya, pemberian obat secara peroral adalah rute yang paling banyak digunakan, sediaan oral memiliki penghantaran obat konvensional dengan pelepasan dan absorpsi cepat. Tujuan dari penelitian ini adalah memformulasikan microspheres ke dalam bentuk tablet . Formula optimum microspheres metformin hidroklorida dipilih berdasarkan nilai entrapment efficiency yang paling tinggi. Dua formula microspheres dengan nilai entrapment efficiency yang tertinggi diformulasikan ke dalam sediaan tablet guna mengetahui evaluasi dan profil disolusinya. Ada tiga formula tablet yang digunakan, satu formula tablet merupakan tablet yang tidak mengandung microspheres dan dua formula merupakan tablet microspheres. Perbedaan peningkatan kecepatan dan lama pengadukan serta jumlah polimer yang sama dari masing-masing formula menghasilkan nilai entrapment efficiency dan pelepasan obat yang berbeda. Semakin tinggi kecepatan pengadukan, maka semakin tinggi nilai entrapment efficiency. Hasil penentuan ukuran microspheres menunjukkan bahwa peningkatan kecepatan dan lama pengadukan dapat memperkecil ukuran partikel. Hasil evaluasi ketiga formula tablet memiliki sifat alir yang baik. Tablet yang dihasilkan telah memenuhi persyaratan keseragaman ukuran, keseragaman kandungan, kekerasan, dan kerapuhan. Profil pelepasan tablet formula 1 lebih cepat mengalami kenaikan lalu mengalami penurunan setelah menit ke-240. Sedangkan formula 2 dan 3 mengalami kenaikan yang cepat lalu pelepasan naik secara perlahan. formula 1> formula 2> dengan hasil 59,258 %; 40,148 % dan 35,356 %. Konsep kinetika pelepasan formula 1 mengikuti model KorsmeyerPeppas, formula 2 dan 3 mengikuti orde 1. Nilai entrapment efficiency yang semakin tinggi nilai entrapment efficiency menghasilkan nilai yang juga semakin tinggi

    ANALISIS KEPUASAN KONSUMEN DILIHAT DARI KUALITAS PELAYANAN PENGINAPAN WISMA BHAYANGKARA TAWANGMANGU

    No full text
    ABSTRACT An Analysis on Customer Satisfaction Viewed from the Service Quality in Wisma Bhayangkara Tawangmangu Inn By: PURI ATIKA F 1208546 This research aims to find out the effect of service quality dimensions consisting of tangibles and intangibles on the customer satisfaction in Wisma Bhayangkara Tawangmangu Inn. The research was carried out using survey method. The data source of research was primary data and the data collection was done by distributing questionnaire. The population of research was the guests staying in wisma Bhayangkara. The sample, consisting of 100 respondents, was taken using Non- probability sampling with accidental sampling, the sampling technique based on accident, that is, whoever found accidentally by the author and can become the sample if considered as appropriate. The variables studied are tangibles and intangibles as independent variable and customer satisfaction as dependent variable. Technique of measuring variable used was 5-point Likert scale. The analysis instrument used was Multiple-linear regression employed to analyze the effect of independent and dependent variables. The examinations carried out in this research were: validity, reliability, multicolinearity, autocorrelation, heteroscedasticity, and normality tests. Meanwhile the hypothesis testing used was a multiple regression coefficient and partial regression coefficient tests (t-test). Considering the result of research, the following regression formula is obtained: Y = 1.385 + 0.420X1 + 0.257X2. Based on the statistic data analysis, indicators in this research is valid and the variable is reliable. The result of partial test shows that tangibles and intangibles variables affect the customer satisfaction. Based on the result of analysis above, the author recommends that wisma Bhayangkara Tawangmangu should always improve the service it gives, both physical facility (tangible) and employees factor (intangible) that is able and willing to give good service to all guests of wisma Bhayangkara Tawangmangu. Keywords: tangibles, intangibles, and customer satisfaction ABSTRAK Analisis Kepuasan Konsumen Dilihat dari Kualitas Pelayanan Penginapan Wisma Bhayangkara Tawangmangu Oleh : PURI ATIKA F 1208546 Penelitian ini bertujuan untuk mengetahui pengaruh dimensi dalam kualitas pelayanan yang berupa Tangibles (wujud fisik) dan Intangibles (tidak berwujud) terhadap kepuasan konsumen (customer satisfaction) di penginapan Wisma Bhayangkara Tawangmangu. Pelaksanaan penelitian menggunakan metode survey. Sumber data dalam penelitian ini adalah data primer dan pengumpulan data dilakukan dengan cara menyebar kuesioner. Populasi dalam penelitian ini adalah para tamu yang menginap di wisma Bhayangkara. Sampel yang diambil sebanyak 100 responden dengan menggunakan teknik Non-Probability Sampling dengan pendekatan Accidental sampling, yang merupakan teknik penentuan sampel berdasarkan kebetulan, yaitu siapa saja yang kebetulan dijumpai oleh peneliti dan dapat dijadikan sampel jika dipandang cocok. Variabel yang diteliti adalah Tangibles (wujud fisik) dan Intangibles (tidak berwujud) sebagai variabel independen dan kepuasan konsumen (customer satisfaction) sebagai variabel dependen. Teknik pengukuran variabel digunakan skala Likert dengan 5 skala. Alat analisis yang digunakan adalah Regresi Linier Berganda yang digunakan untuk menganalisis pengaruh variabel bebas (independent) dan variabel terikat (dependent). Pengujian yang dilakukan dalam penelitian ini adalah Uji Validitas, Uji Reliabilitas, Uji Multikolinieritas, Uji Autokorelasi, Uji Heteroskedastisitas, dan Uji Normalitas. Sedangkan untuk menguji hipotesis digunakan pengujian koefisien regresi berganda dan koefisien regresi parsial (Uji t). Berdasarkan hasil penelitian, diperoleh persamaan regresi sebagai berikut: Y = 1,385 + 0,420X1 + 0,257X2. Berdasarkan analisis data statistik, indikator- indikator pada penelitian ini bersifat valid dan variabelnya bersifat reliabel. Hasil uji secara parsial menunjukkan bahwa variabel Tangibles (wujud fisik) dan Intangibles (tidak berwujud) berpengaruh terhadap kepuasan konsumen (customer satisfaction). Berdasarkan hasil analisis di atas, maka peneliti menyarankan bahwa wisma Bhayangkara Tawangmangu harus senantiasa meningkatkan pelayanan yang diberikan, baik berupa fasilitas fisik (tangibles) maupun faktor karyawan (intangibles) yang mampu dan mau memberikan pelayanan yang baik kepada semua tamu Wisma Bhayangkara Tawangmangu. Kata kunci : tangibles, intangibles, dan customer satisfaction

    Pengaruh Lingkungan Teman Sebaya Dan Persepsi Siswa Tentang Status Sosial Ekonomi Orang Tua Terhadap Hasil Belajar Siswa Kelas X SMA 1 Pasir Penyu

    No full text
    THE EFFECT OF THE PARENTS' ENVIRONMENT AND STUDENTS' PERCEPTIONS ON THE SOCIAL ECONOMIC STATUS OF PARENTS ON STUDENT LEARNING RESULTS OF CLASS X SMAN 1 PASIR ATIKA HERLIAN SURI 176810963 ABSTRAK From the results of observations and interviews with the economics studies teacher for class X of SMAN 1 Pasir Turtle, the results of learning economics in class X of SMAN 1 Pasir Turtle are still very low. This can be seen from the semester test scores obtained from class X, only 30% of students scored above the KKM, while at SMAN 1 Pasir Turtle, the Minimum Completeness Criteria (KKM) was 75. who are indifferent, many students even talk to their classmates, play cellphones, and some are doing other activities outside the learning process. The purpose of this study was to determine the influence of the peer environment and students' perceptions of the socioeconomic status of parents on student learning outcomes. The method used by the author is a quantitative method of correlation. The population in class X SMA Negeri 1 Pasir Turtle who took 8 classes for the study amounted to 280 people. The sampling technique used proportional random sampling. So the sample in this study was 165 students. The technique of collecting data is using a questionnaire. The data analysis technique is multiple regression

    PENGARUH MEDIA FACEBOOK DALAM PEMBELAJARAN HAKIKAT ILMU SAINS DAN METODE ILMIA TERHADAP HASIL BELAJAR RANAH KOGNITIF PESERTA DIDIK

    No full text
    ABSTRAK PENGARUH MODEL PEMBELAJARAN HAKIKAT ILMU SAINS DAN METODE ILMIAH BERBANTUAN FACEBOOK SEBAGAI MEDIA PEMBELAJARAN TERHADAP HASIL BELAJAR RANAH KOGNITIF PESERTA DIDIK Oleh Atika Septiana Penelitian ini dilatar belakangi dengan adanya kendala yang di alami oleh guru yaitu Guru belum menggunakan media facebook untuk kegiatan pembelajaran daring dikelas, Hasil belajar kognitif perserta didik masih rendahPelaksanaan pembelajaran ipa dikelas masih dianggap sulit oleh peserta didik. Rumusan masalah yang terdapat dalam penelitian ini yaitu Adakah Pengaruh Media Facebook Dalam Pembelajaran Hakikat Ilmu Sains Dan Metode Ilmiah Terhadap Hasil Belajar Ranah Kognitif Peserta Didik Penelitian ini dilakukan bertujuan untuk mengetahui Pengaruh Media Facebook Dalam Pembelajaran Hakikat Ilmu Sains Dan Metode Ilmiah Terhadap Hasil Belajar Ranah Kognitif Peserta Didik kelas VII di sekolah SMPN 4 Bandar Lampung. Penelitian ini menggunakan penelitian kuantitatif dengan teknik pengumpulan data yang dilakukan yaitu angket, wawancara dan dokumentasi. kemudian teknik analisis data yang digunakan yaitu uji validitas dan uji reabilitas. Berdasarkan hasil penelitian dan pembahasan yang berkenaan dengan “Pengaruh Media Facebook Dalam Pembelajaran Hakikat Ilmu Sains Dan Metode Ilmiah Terhadap Hasil Belajar Ranah Kognitif Peserta Didik” ada pengaruh media facebook dalam pembelajaran ilmu sains terhadap hasil belajar ranah kognitif peserta didik. Dalam melakukan perhitungan data hipotesis penulis menggunakan bantuan SPSS versi 16.0. dan uji hipotesis yang dilakukan yaitu dengan manova menunjukan hasil perhitungan nilai sig yang menunjukan H1 diterima sehingga dapat disimpulkan bahwa ada ada pengaruh media facebook dalam pembelajaran ilmu sains terhadap hasil belajar ranah kognitif peserta didik Kata Kunci : Sains, Hasil Belajar ii ii ABSTRACT THE INFLUENCE OF LEARNING MODELS ON THE NATURE OF SCIENCE AND SCIENTIFIC METHODS ASSISTED WITH FACEBOOK AS LEARNING MEDIA ON STUDENTS' COGNITIVE LEARNING OUTCOMES By: Atika Septiana This research is motivated by the obstacles experienced by teachers, namely teachers have not used Facebook media for online learning activities in class, students' cognitive learning outcomes are still low. Implementation of science learning in class is still considered difficult by students. The formulation of the problem contained in this research is whether there is an influence of Facebook media in learning the essence of science and scientific methods on learning outcomes in the cognitive domain of students. This research was conducted with the aim of finding out the influence of Facebook media in learning the essence of science and scientific methods on learning outcomes in the cognitive domain of participants. Class VII student at SMPN 4 school in Bandar Lampung. In this research, quantitative research was used with data collection techniques, namely questionnaires, interviews and documentation. then the data analysis techniques used are validity testing and reliability testing. Based on the results of research and discussion regarding "The Influence of Facebook Media in Learning the Nature of Science and Scientific Methods on Learning Outcomes in the Cognitive Domain of Students" there is an influence of Facebook media in learning science on learning outcomes in the cognitive domain of students. It can be concluded that in calculating the hypothetical data the author used SPSS version 16.0. and the hypothesis test carried out, namely by MANOVA, shows the calculation results of the sig which shows that H1 is accepted so it can be concluded that there is an influence of Facebook media in science learning on students' cognitive learning outcomes. Keywords : Science, Learning Outcome

    Improving Business Performance Using Financial Planning towards Application Based Business: Study Case of Antri.in

    No full text
    Indonesia is ranked as the fifth country with the greatest number of startups in the world (Yudistira), more than 80% of those startups were an application-based business. The problem arises that startup failure rates are around 90% (Neil, 2015). In fact, the financial aspect is the second most contributing factor that causes a startup to fail (Angelucci). In addition, we found that Antri. in also faced the same problem as most startups, which is financial problems. Antri.in is an application-based startup company that provides an integrated system to do online queueing. Antri.in implements the system of subscription fee as the company’s main revenue stream and advertisement as company’s secondary revenue stream. The researchers use financial modeling projection to project the company’s finance. In 5 years, antri.in is projected to lose 7 billion rupiah as we are still in the developing / early stage. From the discussion and root cause finding, the reason for Antri.in loss is because Antri.in cash flow is bad, it needs a huge cost to operate while the company revenue and income is still limited. As the result, there are 4 solutions to prevent Antri.in’s lost, which are cost priority, human resource plan, business model expansion, and exit strategy.Keywords: Application, Financial Modeling and Planning, Business Technology, Internet of Things

    The Influence Of Behavioral Finance Towards Fintech Adoption On Small Medium Enterprises With The Case Study On Banjarmasin And Banjarbaru

    No full text
    The majority of the work force in Indonesia is employed by Small and Medium-Sized Enterprises (SMEs), which dominate the business landscape in Indonesia. Considering their enormous impact on the economy, SMEs face obstacles that inhibit their expansion. There are lot of barriers for SME to grow, both internally and externally. Lack of financial knowledge, lack of fincancial support, lack of consultant support, and others obstacles hinders SMEs growth and its enormous potential. One of the government\u27s solutions is creating numerous initiatives to promote the development of SMEs by enhancing their financial behavior and financial inclusion through the use of technology. Previous studies found that there are several factors that can affect someone\u27s intention to use mobile payment apps and the connection between behavioral finance and financial inclusion. A quantitative approach that included 164 respondents was conducted using convenience sampling technique and was analyzed by PLS-SEM. To conclude, this research in Banjarmasin and Banjarbaru cities found that stress and perceived ease of use positively affect perceived usefulness. Perceived usefulness, innovativeness and perceived trust, subjective normsinfluence intention to use. Intention to use has an impact on behavioral finance. Meanwhile, behavioral finance is not affecting financial inclusion. Behavioral Finance, Financial Inclusion, Intention to Use to fintech Keywords: Behavioral Finance, Financial Inclusion, Intention to Use to fintec

    Jurnal Manajemen dan Kewirausahaan : Volume 15, Nomor 2, September 2015

    No full text
    PERILAKU PEMBELIAN MELALUI INTERNET Ibnu Widiyanto, Sri Lestari Prasilowati ANALISIS PETA RISIKO PENGEBORAN DI WILAYAH ASSET 5 PT PERTAMINA EP Gondo Irawan, Berto Mulia Wibawa KOMUNIKASI INFORMAL; GAJI, DAN MOTIVASI KERJA KARYAWAN DI PT INDONUSA ALGAEMAS PRIMA BALI Cynthia Febriana, Eddy Madiono Sutanto HUBUNGAN LINGKUNGAN KERJA, DISIPLIN KERJA, DAN KINERJA KARYAWAN Diah Indriani Suwondo, Eddy Madiono. Sutanto MEMAHAMI EKUITAS MEREK PERGURUAN TINGGI PENELITIAN EMPIRIS PADA STIE SURAICARTA, JAWA TENGAH, INDONESIA Elia Ardyan, Wisnu Sancoyo, Oky Tira Ayunda, Deni Setiadi, Fenti Winda Sari, Atika Ayu Ismawati, Novita Yuniarti, Hafiz Kurniawan, Winata MEMBANGUN INTENSI BERWIRAUSAHA MELALUI ADVERSITY QOUTIENT, SELF EFFECACY, DAN NEED FOR ACHIEVEMENT Agung Wahyu Handaru, Widya Parimita, Inka Winarni Mufdhalifah KOMUNIKASI ANTAR KARYAWAN ETNIS JAWA DAN TIONGHOA Ferdika Tedjakusuma, Eddy Madiono Sutanto SIKAP DALAM MEMEDIASI HUBUNGAN KESABARAN LINGKUNGAN DENGAN NIAT BELI PRODUK KOSMETIK RAMAH LINGKUNGAN Nyoman Dara Paramita, Ni Nyoman Kerti Yasa MOTIVASI KERJA, KEPUASAN KERJA, DAN KOMITMEN ORGANISASIONAL KARYAWAN Steven Gondokusumo, Eddy Madiono Sutant

    The Influence Of Sharia Financial Literacy On Msmes Performance: The Study Case In Indonesian Muslim Entrepreneur Community (Kpmi) On Java Island

    No full text
    Abstract.  Maqashid Sharia is essential to benefit society, especially in business activity. Currently, Indonesia with a majority of Muslims, this country has a low number of entrepreneurs below Singapore, Malaysia, and Thailand. Based on data from the Ministry of Cooperative Small and Medium Enterprises of Indonesia in 2019, there are 65.47 MSMEs units in Indonesia. This is also not supported by financial literacy, especially in terms of Sharia Financial literacy because Indonesia has still low with a number of literacy 8.93%. In fact, Sharia financial products can have a big impact performance of MSMEs in running their business, which means Sharia financial literacy as well. The Indonesian Muslim Entrepreneur Community (KPMI) is the largest association of Muslim entrepreneurs who are running their businesses to be sustainable and improve their performance in business activity so that can reach Maqashid Sharia and this Sharia financial literacy is important for KPMI. This study used a quantitative approach with 160 respondents in Java island using a questionnaire and was analyzed using PLS-SEM. To conclude, this research on members of KPMI on Java island that proved Sharia financial literacy has a significant influence on their performance. Keywords: Maqashid Sharia, Sharia Financial Literacy, MSMEs performance

    Business Feasibility Towards Clothing Convection: A Case Study of Raiment

    No full text
    Raiment is an MSME company engaged in clothing convection which aims to provide convenience through online sales and ordering. However, currently it still does not have its own production house and is still outsourcing by collaborating with other companies in its production, as Raiment's business is considered not to meet expectations from stagnant growth and unstable revenue. Raiment wants to open its own production house so that it does not depend on other companies in its production and can maximize profits. The purpose of this study was to determine the financial feasibility of Raiment to open its own production house. This study uses a qualitative approach through interviews and company historical data as primary data, as well as secondary data from literature reviews, journals, and books. In this study, an analysis of the industry was also carried out through PESTEL analysis and porter's five forces, as well as about the company through SWOT and financial reports. To analyse the problems that exist in the company, a fishbone diagram is used. And to analyse the financial feasibility of the company's strategy to open its own production house using the payback period, net present value, and internal rate of return. The investment in opening a production house will be financed by equity of Rp66,500,000. The results show that Raiment is feasible to open its own production house, with a payback period of 1.4 years, a positive NPV of IDR 235,260,441, and an IRR of 36.08% which is more than the cost of capital of 4.18%.&nbsp

    The Effect of Cash Flow and Leverage On Cash Holding In Sharia Banking The Period 2015 - 2020

    No full text
    Cash is an asset that is very easy to liquidate by the company and can be used as soon as possible to meet the needs of the company\u27s operational activities. Cash holding in the company\u27s storage is cash that will be used for the purposes of the company\u27s operational activities such as to purchase supplies for the company\u27s inventory, to pay off company debts and also for other company activities. In general, there are important factors that will affect the company\u27s cash holding policy, namely cash flow and leverage. Thus, this study aims to determine and analyze the effect of cash flow and leverage on cash holding in Islamic banking. Overall, this study uses 12 listed Islamic banking companies consecutively listed on the Indonesia Stock Exchange for 6 periods from 2015 - 2020. Using panel data regression, this study finds that simultaneously the cash flow variable has a positive effect on cash holding in Islamic banks. However, partially the cash flow variable has a positive effect on cash holding in Islamic banks. In future research, it is possible to conduct research using variables because in this study the cash flow variable, and leverage can only provide an explanation of cash holding with a value of 36.51% so that it is possible to find new ones by using the variable net working capital, investment opportunity and others. In future research, it is possible to use different sub-sectors of companies so that they may get different results in the islamic banking sector.Keywords: Cash Flow, Leverage, Cash Holding, Sharia Bankin
    corecore