8,250 research outputs found
Proline-rich tyrosine kinase 2 mediates gonadotropin-releasing hormone signaling to a specific extracellularly regulated kinase-sensitive transcriptional locus in the luteinizing hormone beta-subunit gene
No full textG protein-coupled receptor regulation of gene transcription primarily occurs through the phosphorylation of transcription factors by MAPKs. This requires transduction of an activating signal via scaffold proteins that can ultimately determine the outcome by binding signaling kinases and adapter proteins with effects on the target transcription factor and locus of activation. By investigating these mechanisms, we have elucidated how pituitary gonadotrope cells decode an input GnRH signal into coherent transcriptional output from the LH beta-subunit gene promoter. We show that GnRH activates c-Src and multiple members of the MAPK family, c-Jun NH2-terminal kinase 1/2, p38MAPK, and ERK1/2. Using dominant-negative point mutations and chemical inhibitors, we identified that calcium-dependent proline-rich tyrosine kinase 2 specifically acts as a scaffold for a focal adhesion/cytoskeleton-dependent complex comprised of c-Src, Grb2, and mSos that translocates an ERK-activating signal to the nucleus. The locus of action of ERK was specifically mapped to early growth response-1 (Egr-1) DNA binding sites within the LH beta-subunit gene proximal promoter, which was also activated by p38MAPK, but not c-Jun NH2-terminal kinase 1/2. Egr-1 was confirmed as the transcription factor target of ERK and p38MAPK by blockade of protein expression, transcriptional activity, and DNA binding. We have identified a novel GnRH-activated proline-rich tyrosine kinase 2-dependent ERK-mediated signal transduction pathway that specifically regulates Egr-1 activation of the LH beta-subunit proximal gene promoter, and thus provide insight into the molecular mechanisms required for differential regulation of gonadotropin gene expression
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No full textauthorIn other places [Old Joe, the trapper] pointed out otter (or, as he pronounced it, "author") slidesPRINTED ITEM G.M.Story April 1959Not UsedNot UsedWithdrawn[see 'otter']Checked by Jordyn Hughes on Thu 09 Jun 201
Neutron and LIBS data behind figures in Gabriel et al. (2022). On an extensive late hydrologic event in Gale crater as indicated by water-rich fracture halos. JGR-Planets.
No full textThis repository contains datasets that allow for the reproduction of certain figures and analysis by Gabriel et al. (2022), a peer-reviewed journal article accepted in the Journal of Geophysical Research: Planets. Below are brief descriptions of the datasets.
File: TGabriel_JGR-P_DAN_Passive_NoMobility_Raw_Data_sol350-400_FigureS10.txt
Description: These are raw neutron counts from the thermal and epithermal neutron detectors as part of the Dynamic Albedo of Neutrons instrument. Only data from rover stops for sols 350 to 400 are included. Data from rover stops allows them to be readily colocated rover localization data, which includes 'site' and 'drive' numbers that are specific to each stop.
File: TGabriel_JGR-P_DAN_Passive_NoMobility_Raw_Data_sol900-1500_Figure5.txt
Description: This is similar data to the product above, however for the sol range 900 to 1500.
File: TGabriel_JGR-P_DAN_Passive_withMobility_Raw_Data_sol350-420_FigureS13.txt
Description: This is similar data to the products above, however the dataset includes passive neutron count rates acquired while the rover was traversing, smoothed over 3 meters of lateral distance traveled. This dataset allows for the analysis of environments that may be present between rover stops, and thus not detected in 'no mobility' datasets.
TGabriel_JGR-P_Kukri_CCAM_MajorOxideComposition_FigureS19TableS1.xlsx
Description: This is the result of the Major Oxide Quantification pipeline developed by the ChemCam instrument team (sPDL Tool v2.0, 25 July 2015) as run by William Rapin. Additional H quantification in Figure S19 of Gabriel et al. (2022) is not included in this dataset, but is provided in the manuscript
Jia ru ju he wu dui jun yun tuan liu ji jun yun tuan liu dui liu de ying xiang
No full textWong, Chai Kwok = 加入聚合物對均勻湍流及均勻湍流對流的影響 / 黃濟國.Thesis M.Phil. Chinese University of Hong Kong 2013.Includes bibliographical references (leaves 89-91).Abstracts also in Chinese.Title from PDF title page (viewed on 01, November, 2016).Wong, Chai Kwok = Jia ru ju he wu dui jun yun tuan liu ji jun yun tuan liu dui liu de ying xiang / Huang Jiguo
Author Correction: Manipulating anion intercalation enables a high-voltage aqueous dual ion battery
No full textThe original version of this Article did not acknowledge Prof. Jun Fan as a corresponding author. This has now been corrected in both the PDF and HTML versions of the Article.link_to_subscribed_fulltex
MSL DAN Science Investigation: Physical Simulation of DAN
No full textThe main objective of the proposed investigation is to study the characteristics (i.e., hydrogen content, soil composition, layer-structure, etc.) of sub-surface and the surface radiation (neutron in particular) environment
Author Correction: A proteomic landscape of diffuse-type gastric cancer
No full textThe original version of this Article contained an error in the email address of the corresponding author Jun Qin. The correct email is [email protected]. The error has been corrected in the HTML and PDF versions of the Article.</jats:p
Corrigendum: The taeniaticornis-group of genus Apanteles Foerster (Hymenoptera, Braconidae, Microgastrinae) from China with one new species. Journal of Hymenoptera Research 96: 21–31. doi: 10.3897/jhr.96.99649
No full textIn a paper about a new species of Apanteles (Microgastrinae)(Liu & Chen, 2023), we regret the omission of one author Jun-hua Chen in the second place of the author list who did great job in construction of the ZJUH collection for this study and the mistake in institution order and corresponding author. We provide the correct information below.Zhen Liu1, 2, Jun-hua He1, Xue-xin Chen11 Institute of Insect Sciences, Zhejiang University, Hangzhou 310058, China. 2 Zoology Key Laboratory of Hunan Higher Education, College of Life and Environmental Sciences, Hunan University of Arts and Science, Changde 415000, China
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